OS-01 FACE Topical Supplement
OS-01 AGE REVERSALTM TECHNOLOGY 50mL
A daily longevity treatment for areas most exposed to the environment, OS-01 FACE improves skin elasticity, hydration, and texture in as little as 12 weeks.02
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Powered by Longevity Science
Meet OS-01, the first peptide proven to target a root cause of skin aging—cellular senescence.01
End-to-end product development run by our in-house team of scientists.
Quantified by our proprietary MolClock and Skin Age Modeling methods.
Conducted by independent, third-party research organizations.
The gold standard for scientific research and in skin care.


"We only develop what’s proven to be effective—because the real impact of our science isn’t just in the lab, but in how it helps people feel their best every day.”
OS-01 AGE REVERSALTM TECHNOLOGY 50mL
A daily longevity treatment for areas most exposed to the environment, OS-01 FACE improves skin elasticity, hydration, and texture in as little as 12 weeks.02
OUR BREAKTHROUGH PEPTIDE
Caused by a decline in collagen and elastin production.
Decreased elastin also contributes to lack of firmness.
Irregular melanin production leads to hyperpigmentation.
Compromised skin cell renewal leaves a dry, uneven surface.
Linked to a decrease in hyaluronic acid, collagen, and elastin.
Slower cell turnover contributes to a weakened skin barrier.


Gently cleanse and exfoliate without irritation
Support delicate skin with the highest concentration of OS-01
A daily longevity serum and lightweight moisturizer in one
Repair UV aging while protecting against new UV-damage01
Peptides are short chains of amino acids. They represent a broad class of molecules with many jobs, from forming the building blocks of larger proteins to acting as cellular messengers. Peptides found naturally in the body (called endogenous peptides), play a crucial role in tissue growth, hormone regulation, and other biological processes. Exogenous peptides, which can be injected, ingested or delivered topically like OS-01, can send out signals to skin cells to trigger collagen and hyaluronic acid production, aid in cellular repair, and help strengthen the skin barrier.01,02,03
OS-01 reduces the accumulation of senescent cells. These cells release inflammatory chemicals that cause neighboring cells to become dysfunctional, kicking off a domino effect in skin and accelerating skin aging. By reducing this inflammatory response, OS-01 helps prevent the accumulation of senescent cells in skin, improving key skin aging biomarkers and keeping other skin cells healthy and thriving.01,02,03
OneSkin is for everyone. Whether you’re taking a preventative approach or want your skin’s health and appearance to reflect how you feel on the inside, our scientifically proven products work at the cellular level to keep your skin looking, feeling, and acting younger and healthier as you age.01,02,03
Through lab studies and clinical studies, our products have been shown to combat the visible and invisible signs of aging, from collagen loss and thinning skin to a compromised barrier function.01,02,03
To learn more about the specific benefits of each product, visit oneskin.co/claims.
With daily use, you can expect to see visible results within 12 weeks, though some people see changes even sooner. This time frame allows OS-01 to work at the cellular level, improving the long-term health and appearance of your skin.01,02,04
01Zonari, A.,et al.Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models.npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
02Zonari A.,et al.Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation.J Cosmet Dermatol.2024; 23: 2135-2144. doi:10.1111/jocd.16242
03Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more atoneskin.co/claims
04Zonari, A.,et al.Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging.Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042

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change the way humans experience aging
We donate a portion of sales to the Aging Forward (formerly Shepherd's Center of America), which provides enriching opportunities for lifelong learning, volunteer service, healthy living, and community connections - all of the things that give life meaning.