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OS-01 LIP Duo

The only 24-hour system powered by the OS-01 Peptide™ to shield and restore your lips at the cellular level01.



  • OS-01 LIP SPF protects against UV and cellular aging by day

  • OS-01 LIP Mask promotes collagen, elastin, and hyaluronic acid at night


  • Dermatologist tested, fragrance-free, safe for sensitive skin


  • Exclusive early access to new products
  • Earn 2x points on all recurring orders
  • Easily change, skip or cancel anytime

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OS-01 LIP SPF

Daytime:

Gently squeeze a small amount of OS-01 LIP SPF onto the applicator tip and apply a thin layer directly to lips prior to sun exposure.

OS-01 LIP Mask

Nighttime:

Using the metal applicator, apply a generous layer of OS-01 LIP Mask onto clean, dry lips before bed and leave on overnight.

*Applies clear. Due to natural ingredients, color in compact may vary slightly.

HOW OS-01 WORKS

The science to unlock your healthiest skin

Backed by over a decade of longevity research, the OS-01 Peptide™ targets the cells that speed up the visible signs of aging.02

OS-01 is scientifically proven to:

  • Support repair by reducing the buildup of senescent “zombie” cells
  • Improve how skin behaves, stimulating collagen and hyaluronic acid production
  • Build resilience, keeping your skin healthy and youthful as you age

Full ingredient list

OS-01 LIP SPF ingredients

Active ingredients: Zinc Oxide 5.5%

Inactive Ingredients: Simmondsia, Chinensis (Jojoba) Seed Oil, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Water (Aqua), Garcinia Indica Seed Butter, Tocopheryl Acetate, Butylene/Ethylene/Styrene Copolymer, Glyceryl Oleate, Glyceryl Dioleate, Glycerin, Oleic Acid, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1, Dipalmitoyl Hydroxyproline, Trihydroxystearin, Sodium Hyaluronate, Glucomannan, Tetrahexyldecyl Ascorbate, Bisabolol, Decapeptide-52*, Ethylhexylglycerin, Caprylyl/Capryl Glucoside, Propanediol, Ectoin, Centella Asiatica Extract, Hippophae Rhamnoides Oil, Helianthus Annuus (Sunflower) Seed Oil, Copernicia Cerifera (Carnauba) Wax, Tocopherol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic acid, Lecithin, Beta-Sitosterol, Squalene, Lactic Acid, Palmitic acid. *OS-01 Peptide™

OS-01 LIP ingredients

Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan. *OS-01 Peptide™

OS-01 LIP Duo

4.8
Rated 4.8 out of 5 stars
Based on 52 reviews
Total 5 star reviews: 43 Total 4 star reviews: 6 Total 3 star reviews: 3 Total 2 star reviews: 0 Total 1 star reviews: 0
94%would recommend this product
52 reviews
  • KB
    Kathleen B.
    Verified Buyer
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 5 out of 5 stars
    18 hours ago
    A good investment!

    I just got this and have been using it daily. Very rich & moisturizing. No winter chapped lips for me.

  • CR
    Carrie R.
    Verified Buyer
    Reviewing
    OS-01 LIP Duo
    Rated 3 out of 5 stars
    4 days ago
    Average and leaves a white cast

    Not for me and won’t buy it again. I disliked the texture, feel, and the way it made my lips look pasty and white (I am olive toned)

    OneSkin
    Yesterday

    Thank you for trying OS-01 LIP Duo and sharing your honest feedback, Carrie. We’re sorry the texture and finish didn’t work for you, especially with it appearing pasty on your lips. A few tips that may help: applying a thinner layer, warming the product between your fingers before use, or pairing it with a tinted balm can improve the look and feel.

  • C
    Cynthia
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    5 Stars

    The lip products go on thick, but quickly absorb. My lips feel more moisturized than with other products.

  • M
    Martin
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    5 Stars

    Absolutely amazing product! Visible improvements in overall hydration, giving my lips the plumpness and preventing from dark spots.

    I highly recommend this product!

  • M
    Molly
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 4 out of 5 stars
    2 weeks ago
    Seems to help when nothing else did...

    I've had chapped lips for a few months and nothing I put on overnight seemed to help. The lip mask is the first thing that seems to make a difference. My only complaint is the overly complex packaging. The clips holding the weird figure-8 shaped metal "applicator" were broken when I received the product. And you have to open two different tops to get to the tiny amount of lip mask inside. It is a small hassle every evening to put it on, but I keep doing it because it seems to work.

    OneSkin
    1 week ago

    Hi Molly! Thank you so much for your feedback and for taking the time to share your experience with the OS-01 LIP Duo. We're so glad to hear that the OS-01 LIP Mask is making a difference for your chapped lips! We really appreciate your honest thoughts about the packaging and understand your concerns about the complexity and the broken clips on the applicator. We'll definitely pass all of this feedback along to our product team as we are always looking to improve and will have a member of our customer support team reach out to help replace the exterior packaging for you since those clips broke off. Thank you for your patience and time!

Citations

01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims.
02 Zonari, A.,et al.Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models.npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1