OS-01 LIP Duo
OS-01 LIP Duo
The only 24-hour system powered by the OS-01 Peptide™ to shield and restore your lips at the cellular level01.
- OS-01 LIP SPF protects against UV and cellular aging by day
- OS-01 LIP Mask promotes collagen, elastin, and hyaluronic acid at night
Dermatologist tested, fragrance-free, safe for sensitive skin
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Benefits
Delivers immediate hydration and advanced protection from 3 types of aging for visibly healthier, more resilient lips.01
100% mineral protection
Non-nano zinc oxide prevents UV-induced damage including inflammation and collagen loss.01
Soothing + nourishing
92% agreed it feels instantly moisturizing upon application, keeping lips healthy and hydrated.01
Fuller, smoother lips
Boosts a key elastin production biomarker by +47%, helping preserve volume and minimizing the appearance of lines and wrinkles.01
5-star reviews
See why customers love OS-01 LIP SPF
“My lips appear plumper and deeper in color in an incredibly healthy and youthful appearance. I have tried high end and low end brands and nothing compares to the efficacy of this product.” – Caroline W.
"My lips have constantly felt softer. And I also had a special case because I had an eczema patch on my lips before I started using this product, and I was worried it would make it worse but it actually made it better! My eczema patch cleared up after a couple weeks of use. Huge fan of this product overall.” – Victoria Z.
“This definitely helped my chronically dry and chapped lips. I would make this my go to moving forward.” – Adam P.
CONSUMER PERCEPTION DATA
Real results that speak volumes
92
agree it delivers immediate hydration and moisture 01
88
agree it makes their lips feel soothed and protected 01
84
agree their lips felt nourished after 2 weeks 01
78
agree it provides long-lasting hydration and moisture 01
The science behind OS-01 LIP SPF
As you age, your lips lose resilience, structure, and regenerative capacity—especially under daily UV exposure. OS-01 LIP SPF is uniquely formulated to not only protect against sun damage but also support lip rejuvenation by addressing inflammation, aging markers, and structural decline at the cellular level.
In lab studies on ex vivo human skin samples, OS-01 LIP SPF:
- Shields lips from UV-induced damage, including inflammation (IL-8), tissue damage (MMP3), and aging (CDKN1A/p21) biomarkers
- Promotes elastin production (ELN) and reduces signs of existing aging (CDKN1A/P21 & CDKN2A/P16)
- Significantly increases epidermal thickness to support stronger, more resilient lips
Shown in lab studies on ex vivo human skin samples by measuring the relative expression levels of the ELN gene (2^-ddCt), which encodes elastin, in the dermis 24 hours after topical application.
5 active ingredients that complement the OS-01 peptide
How it works
Powered by the OS-01 Senescence Blocking Peptide™
The first and only peptide scientifically proven to reverse skin’s biological age.02,03
All ingredients
Active ingredients: Zinc Oxide 5.5%
Inactive Ingredients: Simmondsia, Chinensis (Jojoba) Seed Oil, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Water (Aqua), Garcinia Indica Seed Butter, Tocopheryl Acetate, Butylene/Ethylene/Styrene Copolymer, Glyceryl Oleate, Glyceryl Dioleate, Glycerin, Oleic Acid, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1, Dipalmitoyl Hydroxyproline, Trihydroxystearin, Sodium Hyaluronate, Glucomannan, Tetrahexyldecyl Ascorbate, Bisabolol, Decapeptide-52*, Ethylhexylglycerin, Caprylyl/Capryl Glucoside, Propanediol, Ectoin, Centella Asiatica Extract, Hippophae Rhamnoides Oil, Helianthus Annuus (Sunflower) Seed Oil, Copernicia Cerifera (Carnauba) Wax, Tocopherol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic acid, Lecithin, Beta-Sitosterol, Squalene, Lactic Acid, Palmitic acid. *OS-01 Peptide
Drug Facts
Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen
Uses
- Helps prevent sunburn
- If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.
Warnings
- For external use only.
- Do not use on damaged or broken skin.
- Stop use and ask a doctor if rash occurs.
- Keep out of reach of children.
OS-01 LIP Duo
Citations
01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims.
02 Zonari, A.,et al.Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models.npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
03 Zonari A.,et al.Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation.J Cosmet Dermatol.2024; 23: 2135-2144. doi:10.1111/jocd.16242