OS-01 FACE Topical Supplement
Smooth and firm skin with our daily moisturizer for the face and neck, powered by the OS-01 Peptide™.01
- Boosts hydration, elasticity, and barrier function
- 96% showed an improvement in firmness and radiance
- Dermatologist tested, fragrance-free, safe for sensitive skin
- Exclusive early access to new products
- Earn 2x points on all recurring orders
- Easily change, skip or cancel anytime
Free travel-size OS-01 BODY with your first subscription
Free shipping on orders over
Try it risk-free! 45-day money back guarantee.
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Benefits
Multitasking moisturizer that addresses the common signs of aging on areas exposed most to the environment
Hydration
Boosts barrier function, allowing your skin to retain moisture and stay hydrated.02
Firmness
Switches off the cells that degrade collagen, helping skin stay firm.01,03
Radiance
Enhances skin tone and texture, helping skin look and feel smooth and radiant.02
5-STAR REVIEWS
See why customers love OS-01 FACE
“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.
"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.
"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.
"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.
The proof is in the pictures
CLINICAL DATA
Visible results, scientifically validated
100
of participants had improved smoothness 02
96
of participants had improved firmness, radiance, and tone 02
90
of participants had improved elasticity 02
86
of participants had improved appearance of fine lines and wrinkles 02
The Science Behind OS-01 FACE
With age, skin becomes thinner, produces less collagen, proliferates at a slower rate, and accumulates damage. By analyzing key aging biomarkers in human skin samples before and after treatment in the lab, our scientists found that OS-01 FACE:
- Increases epidermal thickness 01
- Supports collagen biosynthesis pathways (increase in COL1A1 and collagen levels) 01,03
- Promotes cellular proliferation (increase in MKI67) 01
Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. (Zonari, A., et al. npj Aging, 2023) Note: In npj Aging publication, "Topical Pep 14" = OS-01 FACE
6 active ingredients that complement the OS-01 peptide
Getting started with OS-01 FACE
Follow these easy steps for optimal results
- Dispense 1-2 pumps onto fingers
- Gently massage into skin on the face and neck
- Use 2 times daily
How it works
Powered by the OS-01 Senescence Blocking Peptide™
The only peptide scientifically proven to reverse skin aging at the cellular level 01,02,03
All Ingredients
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
Citations
01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
OS-01 FACE Topical Supplement
- JJenniferReviewingOS-01 FACE Topical SupplementI do not recommend this productRated 2 out of 5 stars21 hours ago2 Stars
Disappointed with the way it made my skin look and feel.
- MCMark C.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars3 days agoGreat results already
My wife and I have been taking One Skin for 3 months and have already noticed a big improvement in our skin. My wife was skeptical at first as all the previous face creams she had used made no difference. It's good to see the science give real world results.
- LLisaReviewingOS-01 FACE Topical SupplementI recommend this productRated 4 out of 5 stars4 days agoGreat product
I've been using OS-01 FACE for a few weeks now, and my skin feels noticeably softer and smoother. It absorbs well without feeling heavy or greasy, and I’ve noticed a subtle improvement in overall texture. While it’s still early to see major changes, I like how my skin feels more hydrated and balanced, just wish it was more affordable.
OneSkin26 minutes agoThank you so much for your wonderful feedback, Lisa! We are thrilled to hear that you are already noticing your skin feeling softer, smoother, and more hydrated after just a few weeks with OS-01 FACE. It's amazing that you're experiencing these improvements in texture and balance so early on! We truly appreciate you taking the time to share your experience and are always here to support you if you need anything.
- PJPatricia J.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars4 days agoPure gold
After decades of using and teaching about skincare - this has been my dependable, science-based, go-to product that I use every day and night on my face. I am totally a believer in the company and the science and research behind the work that they do!
- JRJennifer R.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars5 days agoLike the Moisturizer
I love this moisturizer...it feels great on my skin and goes on well under my makeup. I also love that there isn't as much waste by using the refill pouch.
