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OS-01 EYE OTP Refill Cartridge
OS-01 EYE OTP Refill Cartridge

OS-01 EYE Refill Cartridge

Topical Supplement
20 mL / 0.68 fl oz

Formulated with the highest concentration of our OS-01 peptide to help target aging at the molecular level, OS-01 EYE strengthens and visibly firms the delicate skin around the eyes.

*This purchase does not include the clear bottle or the pump. Please ensure you already have the reusable packaging components before purchasing the refill cartridge.

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We are currently low in stock. As such, we are temporarily only offering 60 day subsciptions. 30 day and 90 day subscriptions will be be available once stock is replenished. Once you receive your 50 mL bottle, you will be able to modify your subscription to 30 or 90 days.

01 Firmer Skin Powered By Longevity Science

The skin around your eyes is approximately 5x thinner than the rest of your body, making it more susceptible to the effects of aging. OS-01 EYE reduces the appearance of crow’s feet and gives under-eyes a lifted look by targeting the root cause of skin aging at the molecular level.
  • Developed by Longevity Scientists
  • Classified as a Non-Irritant on the OptiSafe Irritation Scale
  • Safe & Clean
  • Vegan & Cruelty-Free
  • For All Skin Types
  • Fragrance-Free


02 The OS-01 Peptide, By The Numbers

Peptide
OS-01 EYE is super-powered by our proprietary OS-01 peptide, which is scientifically proven to help address skin aging at the molecular level so skin doesn’t just look younger–it also acts and feels like younger skin.
-2.5
Biological Years01

REVERSES CELLULAR AGING MARKERS


Reduces skin’s biological age01 by preventing the accumulation of senescent cells02 that would otherwise accelerate skin aging, so skin stays healthier and younger for longer.

Exposure to the OS-01 peptide over 5 days reduced skin’s biological age by 2.5 years, as measured by MolClock.01 Exposure to the OS-01 peptide over 2 days reduced the number of senescent cells by up to 50% in in vitro fibroblast cultures from patient derived samples.02
1.7x02

SUPPORTS COLLAGEN BIOSYNTHESIS PATHWAYS


Minimizes the look of crow’s feet, fine lines, and wrinkles around the eye.04

Topical application of the OS-01 peptide and OS-01 EYE increased the activity of COL1A1, a key gene associated with collagen production, in ex vivo human skin models.03 Topical application of OS-01 EYE also decreased the activity of MMP1, a key gene associated with collagen degradation, in ex vivo human skin models.03
3.5x03

INCREASES HYDRATION


Supports hyaluronic acid biosynthesis pathways in skin, so skin stays hydrated from the inside out.03

Topical application of the OS-01 peptide increased that activity of HAS2, a key gene associated with hyaluronic acid production, in ex vivo human skin models.03 91.7% of consumer testers reported an improvement in dryness after 4 weeks of 2x daily application of OS-01 EYE.04

  • Measured by analyzing DNA methylation after exposing ex vivo human skin models to the OS-01 peptide, and using MolClock, a proprietary algorithm that predicts skin’s biological age based on DNA methylation
  • Shown in vitro fibroblast cultures from patient derived samples
  • Show in lab-grown ex vivo human skin models
  • Shown in three consumer studies

HERO INGREDIENTS

3 active ingredients specifically selected to support the OS-01 peptide and reverse visible signs of aging around the eyes.
01 OS-01 Pepitide Scientifically proven to reduce the accumulation of senescent cells01, support DNA repair capacity02, increase epidermal thickness02, and strengthen the skin barrier02.

  • Shown in vitro fibroblast cultures from patient derived samples
  • Shown in lab-grown ex vivo human skin models

01 Moringa Oleifera
Seed Extract
Extracted from the seeds of the moringa tree, this extract protects skin cells against environmental pollutants that can trigger skin aging.
02 Fucus Vesiculosus
Extract
This algae-derived extract helps reduce the appearance of dark circles and crow’s feet while enhancing overall skin luminosity.
03 Biomimetic Vegan
Collagen
This biodesigned vegan collagen peptide is the first human mimetic and boosts elastin, laminin, collagen and fibronectin while most topical collagen fails to penetrate the skin barrier.

SCIENCE

Some Call it Magic,
We Call it Science
01 Why did we
create OS-01 EYE?
The area around the eyes is some of the thinnest skin on our bodies–including an exceptionally thin dermal layer responsible for maintaining skin firmness and a similarly delicate stratum corneum that provides a barrier to the outside world. In fact, the stratum corneum around the eyes is on average just 3 layers thick, compared to 15+ layers on other areas of the face and body. This fact explains why skin around the eyes is more delicate, sensitive, and susceptible to sagging and wrinkles.

We created OS-01 EYE to address the unique needs of this ultra-delicate skin. To improve skin texture and firmness around the eye, we used a higher concentration of our OS-01 peptide, which has been shown to increase epidermal thickness and reverse aging markers in ex vivo human skin models.01 To validate its efficacy on eye-area skin, we tested OS-01 EYE on ex vivo human skin models grown in the lab from eyelid donor cells, making OS-01 EYE the first eye product to be tested on eyelid skin cultures.


02 OS-01 EYE reduces the activity of cellular senescence & inflammation genes01 Our scientists exposed ex vivo eyelid skin to either nothing (No Treatment) or OS-01 EYE, then performed a genetic expression analysis to evaluate the effect on genes associated with cellular senescence and inflammation.

The results are the average of testing in 3 different ex vivo eyelid skins from donors of 42y, 59y, and 84y.


We found that topical application of OS-01 EYE decreased the activity of a key senescence marker (P16) and a key gene associated with inflammation (IL-8).01

With a higher concentration of the OS-01 peptide, OS-01 EYE is designed to decrease senescent burden and inflammation around the eyes at the molecular level–thereby reducing visible signs of aging and soothing periocular skin.
03 OS-01 EYE Improves Collagen Biosynthesis & Maintenance01 Our scientists exposed ex vivo eyelid skin to either nothing (No Treatment) or OS-01 EYE, then performed a genetic expression analysis to evaluate the effect on genes associated with collagen production and degradation.

The results are the average of testing in 3 different ex vivo eyelid skins from donors of 42y, 59y, and 84y.


We found that topical application of OS-01 EYE increased the activity of a key gene associated with collagen production (COL1A1) and decreased the activity of a key gene associated with collagen degradation (MMP1).01

This means that OS-01 EYE supports skin’s firmness around the eyes by promoting collagen biosynthesis and retention at the molecular level.
04 The Results Go Beyond the Lab We’re currently conducting a clinical study on OS-01 EYE and we can’t wait to share the results! In the meantime, here are some encouraging results from our beta testers, who self-reported based on their experience with OS-01 EYE.

After 2 weeks of consistent use of OS-01 EYE (2x daily), beta testers observed the following visible improvements:
  • Crow’s Feet (91.7%)
  • Under eye fine lines/wrinkles (84.6%)


After 4 weeks of consistent use of OS-01 EYE (2x daily), beta testers observed the following additional visible improvements:
  • Dryness (91.7%)
  • Puffiness (66.7%)
  • Sagging under the eyes (66.7%)
  • Sagging eyelids (66.7%)


88.5% of beta testers would recommend OS-01 EYE to a friend

01Shown in lab-grown ex vivo human skin models

HOW TO USE

For best results, cleanse your face with OneSkin PREP prior to use. Gently tap one pump of OS-01 EYE in a semi-circle around each eye. Follow with OS-01 FACE Topical Supplement.
  • Where: From the under-eye to the eyelid
    and underneath the brow bone.
  • When: Morning & evening

FULL INGREDIENT LIST

Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum. *OS-01 Peptide.

FAQs

Is OS-01 EYE safe / clean?

Like all OneSkin products, OS-01 EYE is clean, vegan and cruelty-free. Using our high standards for scientific rigor, we formulate the safest, most effective products possible.

The Environmental Working Group (EWG) rates skincare ingredients on a scale of 1-10, with a score of 1 being the safest. OS-01 EYE was calculated with an average score of 1.2 and a weighted average of 1.08 based on the EWG’s SkinDeep Cosmetics Database scoring guidelines. OS-O1 EYE was also tested for human sensitization (RIPT - a clinical study to assess skin irritation) and no adverse effects were found.

How should I integrate OS-01 EYE into my current skincare routine?

For optimal results, OS-01 EYE should be applied twice daily (AM and PM) and used in conjunction with PREP and OS-01 FACE.

For your evening routine, we recommend cleansing your face with OneSkin PREP, then gently tapping one pump of OS-01 EYE in a semi-circle around each eye. Follow with OS-01 FACE Topical Supplement.

For your morning routine, use PREP to cleanse or skip straight to applying OS-01 EYE. Follow with OS-01 FACE and your favorite SPF.

OS-01 EYE has not been shown to produce adverse reactions when used with other products and can be safely incorporated into your current routine.

Remember, it’s always best to patch test any new skincare product.

What is the approximate shelf life for OS-01 EYE?

OS-01 EYE has a shelf life of 16 months.

How should OS-01 EYE be stored?

OS-01 EYE can be stored at room temperature.

Is OS-01 EYE packaging recyclable?

Yes! The OS-01 EYE packaging is 100% recyclable, with the exception of the reusable pump. OS-01 EYE also uses refillable packaging, with a reusable bottle and pump, and a disposable cartridge.

How long will one bottle of OS-01 EYE last?

The 20 ml bottle will last approximately 1-2 months, when used as directed.

Have any more questions

For our comprehensive FAQ list click here.

REFILLABLE PACKAGING

Not only does OS-01 EYE deliver longevity science to your skin, it also protects the longevity of our planet.


TESTIMONIALS

Proof that goes beyond the lab
(See what our beta testers had to say!)


"I have very sensitive eyes, and this is one of the only products that does not irritate my eyes! It’s definitely made a difference in lines and wrinkles, and keeps my under eye very hydrated!"
- Merete E.


"The skin around my eyes remained noticeably firmer and my usual dryness was dramatically reduced for most of the day. After three weeks, the skin quality around my eyes looks smoother and reacts more youthfully (more elastic)."
- Kevin J.B.


"The product obliterated my crow's feet."
- Janet H.


"The thing I noticed the most was that my skin around my whole eye is much whiter. The age spots and freckles are gone… I feel like you can notice a little more of my actual eyelid. The upper one is lifted a little. And my crows feet have diminished."
- Gail S.


"My under eye area just feels thicker, firmer, less saggy."
- Tina L.


"Great product -crows feet reduced after 1 week of use. Can’t wait to keep using this!"
- Robert H.

Reviews

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