OUR SCIENCE
POWERED BY OS-01, the peptide that can reverse skin’s biological age
The first peptide proven to reverse skin’s biological age 01
by preventing the accumulation of senescent cells.02
Only 20-30% of how we age is determined by genetics. The rest is up to you.
70-80% of longevity is driven by processes that can be mediated. The most promising of which is cellular senescence.
- Measured in lab-based studies by analyzing DNA methylation after exposing ex vivo human skin samples to the OS-01 peptide, and using MolClock, a proprietary algorithm that predicts skin’s biological age based on DNA methylation (Zonari, et al)
- Shown in lab-based studies analyzing in vitro fibroblast cultures from patient derived samples (Zonari, et al)
senescent cells
Cellular senescence is a central driver of skin aging.
Cells become senescent when they accumulate enough intrinsic and extrinsic damage, driving them into a zombie-like state of dysfunction. Senescent cells secrete harmful biochemical signals, called SASP, that driving the aging process.
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| Inflammation |
Suppressed Immune Function |
Increased Activity of Pro-Aging Genes |
Senescent cells induce widespread damage on skin.
Like rotten apples that spoil the bunch, senescent cells drive neighboring cells into senescence by secreting SASP. This triggers an acceleration of the biological aging process.
The more senescent cells you have, the older your skin will behave.
When we’re young, our immune system can quickly clear away senescent cells, limiting their impact. But as we grow older, our bodies become less efficient at removing senescent cells, leading to key characteristics of aging.
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| Reduced production of collagen, elastin, and hyaluronic acid | Decreased epidermal thickness | Compromised barrier function | Decreased elasticity & strength |
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| Reduced production of collagen, elastin, and hyaluronic acid | Decreased epidermal thickness |
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| Compromised barrier function | Decreased elasticity & strength |
By targeting cellular senescence, it's now possible to slow or even reverse the aging process.
Scientists have identified a class of molecules, called senotherapeutics, which can slow and even reverse the aging process by selectively eliminating senescent cells or preventing their development.
meet os-01
Meet OS-01, a peptide that targets cellular senescence.
Our founders spent 5+ years in the lab developing the OS-01 peptide, a senotherapeutic molecule that reverses skin’s biological age 01 by preventing the accumulation of senescent cells02 – so skin looks and feels younger.
- Measured in lab-based studies by analyzing DNA methylation after exposing ex vivo human skin samples to the OS-01 peptide, and using MolClock, a proprietary algorithm that predicts skin’s biological age based on DNA methylation (Zonari, et al)
- Shown in lab-based studies analyzing in vitro fibroblast cultures from patient derived samples (Zonari, et al)
OS-01, by the numbers
By targeting aging at the source, the OS-01 peptide improves key skin health markers.
BIOLOGOCIAL YEARS 01
-2.5
DNA methylation age of ex vivo human skin samples (79yr) treated with 12.5uM peptide for 5 days calculated using the Skin-Specific DNA Methylation Clock, MolClok. OS-01 peptide treatment significantly reduced the DNA methylation age (p<0.01).
EPIDERMAL THICKNESS 02
Epidermal thickness analysis of ex vivo human skin samples from a 55 year old donor exposed to the OS-01 peptide (12.5uM). Epidermal thickness analysis revealed a 28% increase following treatment with the OS-01 peptide.02
COLLAGEN 03
1.7X
Gene expression analysis of ex vivo human skin samples (35, 55, and 79 yr) exposed to the OS-01 peptide (12.5uM) over 5 days, analyzed in the dermis. A key marker associated with collagen production, COL1A1, significantly increased (p<0.01).
- Measured in lab-based studies by analyzing DNA methylation after exposing ex vivo human skin samples to the OS-01 peptide (12.5uM), and using MolClock, a proprietary algorithm that predicts skin’s biological age based on DNA methylation (Zonari, et al).
- Shown in lab-based studies by analyzing ex vivo human skin samples (55yr) treated with 12.5 μM peptide over 5 days (Zonari, et al).
- Shown in lab based studies via mRNA expression analysis of ex vivo human skin samples (35, 55, and 79 yr) exposed to the OS-01 peptide (12.5uM) over 5 days, analyzed in the dermis (Zonari, et al).
Hallmarks of aging
CELLULAR SENESCENE IS A CENTRAL PILLAR OF AGING
