Discover the science behind OS-01

OS-01 is the first peptide proven to reduce cellular senescence, a key driver of aging in the skin and hair.^01-03

WHAT CAUSES AGING?

A main culprit: cellular senescence

With age and exposure to environmental stressors, some cells enter a dysfunctional state known as senescence.⁰⁴

Often called “zombie cells,” these cells release inflammatory factors that trigger nearby healthy cells to become senescent. As the body becomes less efficient at clearing them out, their buildup leads to:⁰⁴

Increased Inflammation

Suppressed Immune Function

Accelerated aging

Learn More

HALLMARKS OF AGING⁰⁴

Cellular senescence

Genomic instability

Telomere attrition

Epigenetic alterations

Loss of proteostasis

Deregulated nutrient sensing

Mitochondrial dysfunction

Stem cell exhaustion

Altered intercellular communication

Chronic inflammation

Disabled macroautophagy

Dysbiosis

“By preventing senescent cells from releasing pro-aging factors, we can prevent healthy cells from becoming “zombies”–containing the spread of senescence and slowing down skin aging.”

–Alessandra Zonari, PhD OneSkin Co-Founder & Chief Scientific Officer

THE SOLUTION

Target skin aging at the source with OS-01

Our patented OS-01 peptide prevents the accumulation of senescent cells, reducing the spread of these dysfunctional cells in the skin.⁰¹ The result? Healthier, more vibrant skin and hair that looks, feels, and acts younger for longer.^08,09

This study changed everything

BLOG

The Reference Lab

browse articles

FROM THE ONESKIN LAB; INGREDIENTS

The Proof is in the Peptide: 12-Week Clinical Study Validates the Effects of OS-01

LONGEVITY

Why cellular senescence is more than just one of the 12 hallmarks of aging - It’s a central pillar of aging

LIFE STYLE

How OneSkin Developed the OS-01 Peptide

SKIN SCIENCE

Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01?

FROM THE ONESKIN LAB

Target Cellular Senescence with the Highest Concentration of the OS-01 Peptide

Citations

⁰¹ Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
⁰² Mirmirani, Paradi., et al. Age-related hair changes in men: Mechanisms and management of alopecia and graying. Maturitas, 80(1), 58 - 62. 2015. https://www.sciencedirect.com/science/article/abs/pii/S0378512214003259
⁰³ Shin, Wisoo et al. Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss. Developmental Cell, 53(2), 185 - 198. 2020 https://www.sciencedirect.com/science/article/pii/S1534580720302318
⁰⁴ López-Otín, C., et al. Hallmarks of aging: An expanding universe. Cell 186(2) , 243-278. 2023. doi:10.1016/j.cell.2022.11.001
⁰⁵ Ogata Y, Yamada T, Hasegawa S, Sugiura K, Akamatsu H. Changes of senescent cell accumulation and removal in skin tissue with ageing. Exp Dermatol. 2023; 32: 1159-1161. doi:10.1111/exd.14818
⁰⁶ Dorf, N., et al. Skin senescence-from basic research to clinical practice. Frontiers in medicine, 11(1484345). 2024. doi:10.3389/fmed.2024.1484345
⁰⁷ Huang, Wen-Yen., et al. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction. Journal of Dermatological Science, 86(2), 114 - 122. 2017https://www.sciencedirect.com/science/article/abs/pii/S0923181117300269
⁰⁸ Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
⁰⁹ Based on data from clinical studies, consumer perception studies, and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
¹⁰ Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1

Discover how the OS-01 peptide works