Discover the science behind the OS-01 Peptide™

It's the first peptide proven to reduce cellular senescence, a key driver of aging in the skin and hair.^1-3

WHAT CAUSES AGING?

A main culprit: cellular senescence

With age and exposure to environmental stressors, cells enter a dysfunctional state known as senescence.

Often called “zombie cells,” senescent cells release inflammatory factors and enzymes that break down tissue and push neighboring healthy cells into premature senescence, triggering a cascade of cellular aging.

As the body becomes less efficient at clearing them out, their build up leads to:

Increased Inflammation

Suppressed Immune Function

Accelerated aging

Learn More

“By preventing senescent cells from releasing pro-aging factors, we can prevent healthy cells from becoming “zombies”–containing the spread of senescence and slowing down skin aging.”

– Alessandra Zonari, PhD OneSkin Co-Founder & Chief Scientific Officer

THE SOLUTION

Target skin aging at the source with the OS-01 Peptide™

Built on a decade of longevity science, our proprietary peptide reverses skin's visible biological age by reducing the visible effects of senescent cells.^1,4 The result? Healthier, more vibrant skin and hair that not only looks younger, but feels and acts younger over time.^5-7

This study changed everything

BLOG

The Reference Lab

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FROM THE ONESKIN LAB; INGREDIENTS

The Proof is in the Peptide: 12-Week Clinical Study Validates the Effects of OS-01

LONGEVITY

Why cellular senescence is more than just one of the 12 hallmarks of aging - It’s a central pillar of aging

LIFE STYLE

How OneSkin Developed the OS-01 Peptide

SKIN SCIENCE

Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01?

FROM THE ONESKIN LAB

Target Cellular Senescence with the Highest Concentration of the OS-01 Peptide

Citations

¹ Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
² Mirmirani, Paradi., et al. Age-related hair changes in men: Mechanisms and management of alopecia and graying. Maturitas, 80(1), 58 - 62. 2015. https://www.sciencedirect.com/science/article/abs/pii/S0378512214003259
³ Shin, Wisoo et al. Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss. Developmental Cell, 53(2), 185 - 198. 2020 https://www.sciencedirect.com/science/article/pii/S1534580720302318
⁴ López-Otín, C., et al. Hallmarks of aging: An expanding universe. Cell 186(2) , 243-278. 2023. doi:10.1016/j.cell.2022.11.001
⁵ Ogata Y, Yamada T, Hasegawa S, Sugiura K, Akamatsu H. Changes of senescent cell accumulation and removal in skin tissue with ageing. Exp Dermatol. 2023; 32: 1159-1161. doi:10.1111/exd.14818
⁶ Dorf, N., et al. Skin senescence-from basic research to clinical practice. Frontiers in medicine, 11(1484345). 2024. doi:10.3389/fmed.2024.1484345
⁷ Huang, Wen-Yen., et al. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction. Journal of Dermatological Science, 86(2), 114 - 122. 2017https://www.sciencedirect.com/science/article/abs/pii/S0923181117300269
⁸ Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
⁹ Based on data from clinical studies, consumer perception studies, and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
¹⁰ Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1