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FACE + LIP DUO

4.7
(3,752)

Hydrating face and lip duo that smooths, protects + restores.

  • Age-Reversal Peptide
  • Smoothing
  • UV Protection
  • Fragrance Free
Two skincare products from the brand 'ONE SKIN' on a light beige background
Two cosmetic swatches labeled 'OS-01 Face Moisturizer' and 'Bare Blush Lip Shield' on a white background.
Close-up of a woman's face with OS-01 Face Moisturizer applied, showing reduced fine lines and wrinkles.
Close-up of a person's face with a focus on the lips, showing immediate hydration with text overlay.
Cosmetic product with customer testimonials on a white background
Skincare product with 'ONE SKIN' branding on a gray background
Lip balm tube with a swatch of pink lip balm on a metallic surface
Two skincare products from the brand 'ONE SKIN' on a light beige background
Two cosmetic swatches labeled 'OS-01 Face Moisturizer' and 'Bare Blush Lip Shield' on a white background.
Close-up of a woman's face with OS-01 Face Moisturizer applied, showing reduced fine lines and wrinkles.
Close-up of a person's face with a focus on the lips, showing immediate hydration with text overlay.
Cosmetic product with customer testimonials on a white background
Skincare product with 'ONE SKIN' branding on a gray background
Lip balm tube with a swatch of pink lip balm on a metallic surface

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  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

Details
  • Hydrate, smooth, and protect skin and lips from visible signs of aging with a duo powered by our proprietary OS-01 Senescence-Blocking Peptide™
  • OS-01 FACE MOISTURIZER visibly smooths and softens texture, evens skin tone, and strengthens skin’s protective barrier1
  • OS-01 LIP SPF protects against 3 main drivers of lip skin aging with a sheer blush tint
  • Dermatologist tested, fragrance free, suitable for sensitive skin
Ingredients

Formulated without
Non-comedogenic and formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 FACE MOISTURIZER Ingredients
Water (Aqua), Glycerin, Sorbitan Olivate, Helianthus Annuus (Sunflower) Seed Oil, Squalane, Cetearyl Olivate, Carapa Guianensis Seed Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba Seed Oil, Rosa Canina Fruit Oil, Prunus Domestica Seed Oil, Calycophyllum Spruceanum Bark Extract, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

OS-01 LIP SPF 15 Ingredients

Active Ingredient
 Zinc Oxide 5.5%

Inactive Ingredients
Aqua (Water), Beta-Sitosterol, Bisabolol, Butylene/Ethylene/Styrene Copolymer, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Caprylyl/Capryl Glucoside, Centella Asiatica Extract, Copernicia Cerifera Cera (Carnauba) Wax, Decapeptide-52*, Dipalmitoyl Hydroxyproline, Ectoin, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Ethylhexylglycerin, Garcinia Indica Seed Butter, Glucomannan, Glycerin, Glyceryl Dioleate, Glyceryl Oleate, Helianthus Annuus (Sunflower) Seed Oil, Hippophae Rhamnoides (Sea Buckthorn) Seed Oil, Isostearic Acid, Lactic Acid, Lecithin, Oleic Acid, Palmitic Acid, Palmitoyl Tripeptide-1, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Polyglyceryl-3 Polyricinoleate, Polyhydroxystearic Acid, Propanediol, Simmondsia Chinensis (Jojoba) Seed Oil, Sodium Hyaluronate, Sorbitan Isostearate, Squalene, Tetrahexyldecyl Ascorbate, Tocopherol, Tocopheryl Acetate, Tribehenin, Trihydroxystearin.

*OS-01 Peptide

Drug Facts

Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen

Uses

  • Helps prevent sunburn

  • If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

  • For external use only.

  • Do not use on damaged or broken skin.

  • Stop use and ask a doctor if rash occurs.

  • Keep out of reach of children.

This set includes

Skincare bottle labeled 'One Skin' on a beige background

STEP 1

OS-01 FACE MOISTURIZER

Lightweight hydration clinically shown to firm and smooth skin.

Size

50 mL / 1.7 fl oz

How to use

Gently massage 1-2 pumps into the face, neck, and chest.

Tube of One Skin sunscreen on a light beige background

STEP 2

OS-01 LIP SPF 15

Hydrating SPF lip balm that hydrates, protects, and restores.

Size

12 mL / 0.41 fl oz

How to use

Apply generously to lips before sun exposure. Reapply throughout the day, especially after eating, drinking, swimming, sweating, or towel drying.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.2

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

Clinically validated results that build over time

Side-by-side close-up of an older woman's eye area labeled 'BEFORE' and 'AFTER 12 WEEKS,' showing skin texture and wrinkle improvement with dotted white outlines highlighting treated areas.

100%

showed smoother-looking skin in 12 weeks1

A side-by-side close-up comparison of an older person's eye and surrounding skin, labeled 'BEFORE' on the left and 'AFTER 12 WEEKS' on the right, showing visible skin improvement.

96%

had improved visible firmness, radiance, and tone after 12 weeks1

A side-by-side before and after comparison of an older person's forehead and eyebrow area, showing wrinkles and sun damage. The left panel is labeled BEFORE and shows more wrinkles around the eyebrow and forehead; the right panel is labeled AFTER 12 WEEKS and shows visibly smoother skin and reduced wrinkles.

91%

had improved elasticity after 12 weeks1

Side by side images of a person's skin with more elasticity, the left image is before and the right image is after 12 weeks

86%

showed reduced appearance of fine lines and wrinkles after 12 weeks1

Week 1

Instant hydration you can feel

  • The OS-01 Peptide™ gets to work immediately
  • Supporting ingredients instantly hydrate skin
  • Skin feels soft, plump, and nourished
6 WEEKS

Visibly smoother, firmer, more resilient skin

  • +19% improvement in barrier strength1
  • 91% showed visibly firmer skin1
  • 86% showed smoother-looking skin1
12 WEEKS

Visibly healthier skin that looks, feels + acts younger

  • 100% showed visibly firmer skin1
  • 96% showed more radiant, even-toned, firmer-looking skin1
  • 91% showed improved elasticity1

Key ingredients

A thick, creamy white swatch of cosmetic cream or lotion on a solid black background.
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Hyaluronic acid

Three molecular weights hydrate each layer of the skin.

Niacinamide

Improves skin tone and fortifies the barrier for a smoother, more even-looking texture.

Oleic pau mulato extract

An Amazonian antioxidant that minimizes visible signs of skin stress and supports skin’s natural repair processes.

Pracaxi oil

A nourishing Amazonian oil that provides potent antioxidant support and deep moisturization.

Andiroba oil

A lightweight, nourishing oil rich in fatty acids that supports the look of natural collagen and soothes skin.

All Ingredients

Formulated without
Non-comedogenic and formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.


OS-01 FACE MOISTURIZER Ingredients
Water (Aqua), Glycerin, Sorbitan Olivate, Helianthus Annuus (Sunflower) Seed Oil, Squalane, Cetearyl Olivate, Carapa Guianensis Seed Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba Seed Oil, Rosa Canina Fruit Oil, Prunus Domestica Seed Oil, Calycophyllum Spruceanum Bark Extract, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.


OS-01 LIP SPF 15 Ingredients


Active Ingredient
 Zinc Oxide 5.5%


Inactive Ingredients
Aqua (Water), Beta-Sitosterol, Bisabolol, Butylene/Ethylene/Styrene Copolymer, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Caprylyl/Capryl Glucoside, Centella Asiatica Extract, Copernicia Cerifera Cera (Carnauba) Wax, Decapeptide-52*, Dipalmitoyl Hydroxyproline, Ectoin, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Ethylhexylglycerin, Garcinia Indica Seed Butter, Glucomannan, Glycerin, Glyceryl Dioleate, Glyceryl Oleate, Helianthus Annuus (Sunflower) Seed Oil, Hippophae Rhamnoides (Sea Buckthorn) Seed Oil, Isostearic Acid, Lactic Acid, Lecithin, Oleic Acid, Palmitic Acid, Palmitoyl Tripeptide-1, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Polyglyceryl-3 Polyricinoleate, Polyhydroxystearic Acid, Propanediol, Simmondsia Chinensis (Jojoba) Seed Oil, Sodium Hyaluronate, Sorbitan Isostearate, Squalene, Tetrahexyldecyl Ascorbate, Tocopherol, Tocopheryl Acetate, Tribehenin, Trihydroxystearin.


*OS-01 Peptide


Drug Facts


Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen
















Uses


  • Helps prevent sunburn




  • If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings


  • For external use only.




  • Do not use on damaged or broken skin.




  • Stop use and ask a doctor if rash occurs.




  • Keep out of reach of children.

OneSkin Longevity Protocol

FACE + LIP DUO

Write a Review (Opens in a new window)
3,752 reviews
  • AQ
    Ann Q.
    Verified Buyer
    Reviewing
    OS-01 FACE MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Face Moisturizer

    This moisturizer has really made a difference in reducing fine lines and improving overall tone of my skin.

    Was this helpful?
  • S
    selena
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    5 hours ago
    5 Stars

    Love it

    Was this helpful?
  • CB
    Corinne B.
    Verified Buyer
    Reviewing
    OS-01 FACE MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    23 hours ago
    face moisturizer

    I have used a few other moisturizers but these products are lighter and they seem to go deeper into my skin. It stays looking hydrated all day and then I put it on again in the evening and even when I wake up in the morning my skin still feels moisturized.

    Was this helpful?
  • YF
    Yvonne F. D.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Caring for our environment

    Less plastic waste. Easy to remove older packaging.

    Was this helpful?
  • BV
    Beth V.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Great face lotion

    I have been using this lotion for at least a year. I had a facial not too long ago and the esthetician asked what I had been doing for my skin, she thought my skin looked amazing. I really like the lotion. And it's really nice that they have these refill pouches which reduces some plastic.

    Was this helpful?
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Citations

  1. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)
  2. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)

End of summer sale terms

No code needed. Spend $145+, get 1 free 200mL of Prep Cleanser; spend $215+, get 1 free Lip Mask. Offer valid on new orders only. Not valid on existing subscriptions. Ends September 7, 2026 at 11:59pm PT. Dollar values are in USD.