Head-to-Toe Skin Health Duo
Full Size
Head-to-Toe Skin Health Duo
OS-01 FACE + OS-01 BODY
Full Size
Restore your skin’s health with our moisturizers for the face and body, powered by the OS-01 Peptide™.01
- Promote firmness with OS-01 FACE - 96% showed an improvement
- Revive crepey skin with OS-01 BODY - strengthens the skin barrier by up to +41%
- Dermatologist tested, fragrance-free, safe for sensitive skin
- Exclusive early access to new products
- Earn 2x points on all recurring orders
- Easily change, skip or cancel anytime
Black Travel Bag with your first subscription
✭ You’re earning 200 points with OneSkin Loyalty Program ✭
Free shipping on orders over
Try it risk-free! 45 day money back guarantee.
You’re earning [potential_points] points with the OneSkin Loyalty Program
OS-01 FACE
See why customers love OS-01 FACE
“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.
"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.
"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.
"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.
OS-01 BODY
See why customers love OS-01 BODY
“The skin on my legs was starting to look older, dry and crepey at 46. Now it is plump and youthful like it was 10 years ago after only a few weeks.” – Jen A.
"The One skin, OS-O1 Body, has been a game changer, within a few weeks I saw a remarkable difference in the quality of my skin, and my skin's appearance continues to improve with daily application. It now has a tighter, less dry look and the texture has almost returned to my premenopause condition..more moist and fresh in appearance. Science is everything, and One Skin has got the science spot on." – Tia T.
"I love this body lotion. My crepey skin is transforming. I wish I had taken pictures before I started using it but I have tried so many different products with no results that I didn’t have much confidence that this one would be any different. Boy was I wrong. I’m hoping that it will eventually get rid of all my dark spots on my skin. I will be a forever customer..."– Myra P.
OUR APPROACH
Results that go beyond the lab
9
Years of Research
900
Peptides Screened
18
Patents & Publications
9000
5-Star Reviews
The science behind the Head-to-Toe Skin Health Duo
With age, skin becomes thinner, produces less collagen, proliferates at a slower rate, and accumulates damage. By analyzing key aging biomarkers in human skin samples before and after treatment in the lab, our scientists found that OS-01 FACE:
01 Increases epidermal thickness 02
02 Supports collagen biosynthesis pathways (increase in COL1A1 and collagen levels) 01,02
03 Promotes cellular proliferation (increase in MKI67) 02
Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. (Zonari, A., et al. npj Aging, 2023) Note: In npj Aging publication, "Topical Pep 14" = OS-01 FACE
Active ingredients that complement the OS-01 peptide
-
Pracaxi oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.Andiroba oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation.Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.Oleic Pau Mulato extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin.Hyaluronic acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
Pracaxi oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.
Andiroba oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation.
Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.
Oleic Pau Mulato extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.
Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin.
Hyaluronic acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
OS-01 FACE
How to apply OS-01 FACE
Follow these easy steps for optimal results
- Dispense 1-2 pumps onto fingers.
- Gently massage into skin on the face and neck.
- Use 2 times daily.
OS-01 BODY
How to apply OS-01 BODY
Follow these easy steps for optimal results
- Apply to arms, legs, chest, back, and stomach.
- Massage until absorbed.
- Use 2 times daily.
How it works
Powered by the OS-01 Senescence Peptide™
The only peptide scientifically proven to reverse skin aging at the cellular level 02,07
All Ingredients
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
Citations
01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
02 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
03 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
04 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
07Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
Head-to-Toe Skin Health Duo
- LLisaReviewingOS-01 BODY MOISTURIZERI recommend this productRated 5 out of 5 stars4 minutes ago5 Stars
This lotion is a game changer!! And believe me Ive tried them all!!
- TDToni D.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars2 days agoMy one and only
I love one skin face moisturizer. I can't seem to live without it. It is my go-to day and night. How long with a few other regimes? I also use the eye cream which I love and the lip balm. I would recommend them to anybody that wanted smoother healthier skin
- RRyanVerified ReviewerReviewingOS-01 BODY MOISTURIZERI recommend this productRated 5 out of 5 stars2 days agoThis is magical!
I have dry, freckled, sensitive skin. I am47 years old, and this is the best lotion I have ever used. I have used every high end lotion, and this is above and beyond any of those! The texture and the way it makes my skin feel even after a few days are magical!
- CCCarrie C.Verified BuyerReviewingOS-01 BODY MOISTURIZERI do not recommend this productRated 2 out of 5 stars2 days agoNo change after 90 days
Used consistently as directed for 90 days and no change at all. Disappointed due to price and science claims but ultimately there was no change my skin texture or elasticity.
I did like that it never felt heavy.
OneSkin2 days agoHi Carrie!
Thank you for your commitment to a full 90 days and for sharing your honest experience with OS-01 BODY. We're genuinely sorry it didn't deliver the visible changes in texture and elasticity you were hoping for — that's never the outcome we want, especially given the investment you made.
We know our science claims set a high bar, and we take that seriously. While our 12-week clinical study showed meaningful improvements in hydration, barrier function, and skin texture across participants, results can vary based on individual factors like skin type, age, environment, and baseline skin condition. We recognize that's not a satisfying answer when you've been consistent and patient.
We'd love the opportunity to learn more about your experience and make this right. Please reach out to our team at support@oneskin.co so we can discuss this further!
- MNMargaret N.Verified BuyerReviewingOS-01 BODY MOISTURIZERI recommend this productRated 5 out of 5 stars2 days agoOS-01 Body Moisturiser
Light, delicately scented and smooth. The senses are uplifted.
Results? Stringy arms are disappearing and skin is rejuventating before my own eyes. Wow. Pure magic.
