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LIP MASK

4.5
(331)

Overnight lip care for visibly smoother, fuller lips over time.

  • Age-Reversal Peptide
  • Smoothing
  • Plumping
  • Fragrance Free
An open black One Skin cushion foundation compact, showing the warm beige foundation powder and the built-in mirror inside the lid, set against a clean off-white background.
A close-up texture shot of a smooth, creamy beige cosmetic cream with elegant diagonal ridges and soft highlights.
An open black cosmetic compact with a warm yellow-orange product visible inside, stacked on top of two closed black compacts against a light gray background. Text on the left reads: 'Fullness + smoothness', 'Deep hydration', and 'Rich, nourishing texture'.
Close-up of glossy lips with a silver lip product applicator being pulled outward by a hand, plus a text overlay reading '98% reported deep hydration that lasted overnight'.
Before-and-after comparison of lips showing reduced fine lines and wrinkles after 12 weeks. The top panel is labeled BEFORE and shows dry, creased lips; the bottom panel is labeled AFTER 12 WEEKS and shows smoother, shinier lips.
A black cosmetic smear or lip-protecting ingredient swatch centered on a black background, with white text callouts reading PALMITOYL HEXAPEPTIDE-12, MICROALGAE, CERAMIDES + SQUALANE, and benefits for visibly firmer, more resilient lips.
A close-up of a clear circular container filled with transparent gel or serum, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
Instruction graphic showing a reusable black shell, a reusable metal applicator, and a discard refill cartridge with a tan center, labeled with green, red, and black text on a light gray background.
An open black One Skin cushion foundation compact, showing the warm beige foundation powder and the built-in mirror inside the lid, set against a clean off-white background.
A close-up texture shot of a smooth, creamy beige cosmetic cream with elegant diagonal ridges and soft highlights.
An open black cosmetic compact with a warm yellow-orange product visible inside, stacked on top of two closed black compacts against a light gray background. Text on the left reads: 'Fullness + smoothness', 'Deep hydration', and 'Rich, nourishing texture'.
Close-up of glossy lips with a silver lip product applicator being pulled outward by a hand, plus a text overlay reading '98% reported deep hydration that lasted overnight'.
Before-and-after comparison of lips showing reduced fine lines and wrinkles after 12 weeks. The top panel is labeled BEFORE and shows dry, creased lips; the bottom panel is labeled AFTER 12 WEEKS and shows smoother, shinier lips.
A black cosmetic smear or lip-protecting ingredient swatch centered on a black background, with white text callouts reading PALMITOYL HEXAPEPTIDE-12, MICROALGAE, CERAMIDES + SQUALANE, and benefits for visibly firmer, more resilient lips.
A close-up of a clear circular container filled with transparent gel or serum, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
Instruction graphic showing a reusable black shell, a reusable metal applicator, and a discard refill cartridge with a tan center, labeled with green, red, and black text on a light gray background.
Starter set 7 mL / 0.24 fl oz Refill 7 mL / 0.24 fl oz

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  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

Details
  • Our proprietary OS-01 Senescence-Blocking Peptide™ visibly slows cellular skin aging, resulting in skin that feels and acts younger over time
  • Delivers visibly smoother, fuller-looking lips in as little as 4 weeks¹
  • Rich, non-sticky, and fragrance free—an overnight formula that melts into lips and works while you sleep
Clinical proof
  • 98% agreed their lips stayed moisturized overnight¹
  • 81% saw reduced appearance of wrinkles around the lips after 4 weeks¹
  • 81% reported visibly fuller lips after 8 weeks¹

Science

Consumer Perception Study1

A 12-week consumer perception study evaluated the effects of OS-01 LIP MASK on hydration, smoothness, visible fullness, and the appearance of fine lines around and on the lips with nightly application.

Immediate results:

  • 98% agreed lips feel instantly hydrated upon application
  • 98% agreed lips feel hydrated and moisturized 8+ hours after application
  • 95% agreed it applies smoothly and is ultra-hydrating

4 weeks:

  • 95% agreed lips feel smoother
  • 81% reported reduced appearance of fine lines around the lip border
  • 80% reported reduced appearance of fine lines on the lips
  • 78% reported improved visible lip fullness

12 weeks:

  • 97% agreed lips feel smoother
  • 94% agreed lips retain hydration longer
  • 87% reported reduced appearance of fine lines and wrinkles on the lips
  • 81% agreed lips feel more resilient
  • 72% agreed the natural color of their lips improved

Safety studies

OS-01 LIP MASK is non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on its formula and clinical testing, it has been awarded the National Eczema Association Seal of Acceptance™.

Our commitment to the scientific process

OneSkin products are validated with a rigorous process from the lab to the clinic: Lab testing on human skin to evaluate the effect on the cellular level, consumer testing with real users to ensure optimal texture and feel, and third-party clinical studies to evaluate the effect on the human level over time.
Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

Ingredients
Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan.
*OS-01 Peptide

How to use

Using the metal applicator, apply a generous layer onto clean, dry lips as needed. For a deep treatment, apply before bed and leave on overnight.

Complete the Protocol

Overnight restoration for your most exposed and overlooked skin.

Powered by the OS-01 Peptide™

Works at the cellular level to help keep healthy cells thriving, reversing the visible effects of the senescent cells that break down collagen and elastin.

Restores fullness + smoothness

Rebuilds visibly smoother, fuller lips over time.

Delivers deep hydration

Wraps lips in moisture while smoothing the appearance of fine lines and wrinkles in the lip area.

Rich, nourishing texture

Ultra-rich texture glides on clear and locks in lasting moisture and nourishment until morning.

Powered by the OS-01 Peptide™

Works at the cellular level to help keep healthy cells thriving, reversing the visible effects of the senescent cells that break down collagen and elastin.

Restores fullness + smoothness

Rebuilds visibly smoother, fuller lips over time.

Delivers deep hydration

Wraps lips in moisture while smoothing the appearance of fine lines and wrinkles in the lip area.

Rich, nourishing texture

Ultra-rich texture glides on clear and locks in lasting moisture and nourishment until morning.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.2

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

Clinically validated results that build over time

Close-up before-and-after comparison of a person's lips, showing a matte pink lip color applied in the after photo after 4 weeks. The top panel is labeled BEFORE and shows natural, uncolored lips, while the bottom panel is labeled AFTER 4 WEEKS and shows the colored, hydrated lips.

78%

reported improved visible fullness after 4 weeks1

Close-up before-and-after comparison of a person's lips, with the top labeled BEFORE and the bottom labeled AFTER 12 WEEKS. The lower lip appears more hydrated and glossy in the after view.

97%

agreed lips feel and look smoother after 12 weeks1

Close-up before-and-after comparison of lips, with the top panel labeled BEFORE and the bottom panel labeled AFTER 12 WEEKS. The image shows skin texture and lip condition over time.

81%

saw reduced appearance of wrinkles around the lips after 4 weeks1

Week 1

Instant hydration you can feel

  • Melts into a non-sticky overnight layer
  • 98% agreed lips feel instantly hydrated on application1
  • The OS-01 Peptide™ begins working on contact
Week 4

Smoother lips, fewer fine lines

  • 95% agreed lips feel smoother1
  • 81% saw reduced appearance of fine lines around the lip border1
  • 80% saw reduced appearance of fine lines on the lips¹
Week 12

Resilient, fuller, healthier lips

  • 97% agreed lips feel smoother1
  • 87% reported reduced appearance of fine lines and wrinkles on the lips1
  • 94% agreed lips retain hydration for longer1

Key ingredients

A single irregular dark brown to black textured piece, resembling a dried mushroom cap or a piece of dark cured meat, isolated on a solid black background.
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Microalgae

Shown to be up to 6,000x more potent than vitamin C for visibly smoother and firmer lips over time.

Ceramides and squalane

Naturally derived biomimetic lipids that reinforce the lips’ protective barrier to lock in moisture.

Palmitoyl Hexapeptide-12

An additional peptide that works synergistically with the OS-01 Peptide™ to support visibly firmer, more resilient lips.

All Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

Ingredients
Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan.
*OS-01 Peptide

OneSkin Longevity Protocol

OS-01 LIP MASK

Write a Review (Opens in a new window)
331 reviews
  • MG
    Mary G.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    22 seconds ago
    Lip Mask

    This lip mask is amazing!! My lips are no longer dehydrated ever!! Game changer

    Was this helpful?
  • DJ
    Dana J.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    Lips feel fuller

    I’ve only been using this for a two weeks but they look fuller.

    Was this helpful?
  • RF
    Rachael F.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    Relief

    On my second order of this lip mask, it is the best thing for overnight protection

    Was this helpful?
  • JH
    Jill H.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    2 weeks ago
    Great lip mask

    I have been using the lip mask for a couple of weeks and have noticed a difference in my lips retaining moisture throughout the day. Can’t wait to see the long term results.

    Was this helpful?
  • TB
    Tracey B.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    3 weeks ago
    Must have one skin!

    All skin care products are amazing!

    Was this helpful?
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Frequently Asked Questions

What is the difference between OS-01 LIP MASK and OS-01 LIP SPF?

OS-01 LIP SPF is your daytime defense, powered by non-nano zinc oxide to protect against UV damage—one of the biggest accelerators of lip aging. It also targets the visible effects of oxidative stress and cellular aging to help maintain your lips' natural volume and resilience.

 

OS-01 LIP MASK is your nighttime restoration treatment, designed to work with your skin's peak repair window at night. Powered by the OS-01 Peptide™, it helps support visibly smoother, fuller, more hydrated lips over time.

 

Used together, they provide 24-hour cellular support for your most vulnerable skin.

Does OS-01 LIP MASK have any scent or flavor?

No, OS-01 LIP MASK is fragrance and flavor free. It is tasteless, goes on clear, and any scent comes from the natural ingredients.

Can OS-01 LIP MASK be used during the day?

Yes! While we designed OS-01 LIP SPF to be used during the day due to its environmental and UV protection, OS-01 LIP MASK can be used anytime your lips need extra hydration even though it’s designed for nighttime use. We always recommend SPF protection during the day.

Is OS-01 LIP MASK easily absorbed, or will it stay on top of the lips?

OS-01 LIP MASK will absorb into the lips. Due to its rich formula your lips will still appear hydrated, smooth, and plump.

How do I wash the applicator?

We recommend giving it a quick rinse with soap and water, or using an alcohol wipe to clean when needed.

Citations

  1. Based on a 12-week consumer perception study with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK.
  2. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)