Skin Care is Health Care: Why Extending Your Skinspan is the Key to Longevity
3 min read
April 13,2022
LONGEVITY
Skin Care is Health Care: Why Extending Your Skinspan is the Key to Longevity
3 min read
April 13,2022
LONGEVITY
Consider this: skin is our body's largest organ. Skin is our first line of defense against external stressors. It's not just there for looks - skin serves a real biological function, without which we would be defenseless against the outside world.Yet when asked what we want from our skincare products, most of us will say: fewer wrinkles, smoother texture, radiant tone. It’s no wonder: with marketing buzzwords like tightening, youthful glow, perfecting and brightening, the skincare industry has taught us that the products we use every day serve just one purpose–improving our appearance. For decades, the comestic industry has been missing an essential truth: our skin is a vital organ that―like the heart, the brain and the liver―is central to our overall health and longevity. At OneSkin, we believe the purpose of skincare is not just to improve how we look, but to optimize our skin biology so that it is more resilient to the aging process. We create longevity skin care products, next level skin care for healthier skin.
Consider this: skin is our body's largest organ. Skin is our first line of defense against external stressors. It's not just there for looks - skin serves a real biological function, without which we would be defenseless against the outside world.Yet when asked what we want from our skincare products, most of us will say: fewer wrinkles, smoother texture, radiant tone. It’s no wonder: with marketing buzzwords like tightening, youthful glow, perfecting and brightening, the skincare industry has taught us that the products we use every day serve just one purpose–improving our appearance. For decades, the comestic industry has been missing an essential truth: our skin is a vital organ that―like the heart, the brain and the liver―is central to our overall health and longevity. At OneSkin, we believe the purpose of skincare is not just to improve how we look, but to optimize our skin biology so that it is more resilient to the aging process. We create longevity skin care products, next level skin care for healthier skin.
01
How Skin Aging Impacts Longevity
At two square meters in size and making up over fifteen percent of our body weight, skin plays an essential role in the protection and preservation of our bodies. Not only does it shield our internal systems from external pathogens, the skin also provides key homeostatic functions that help the body regulate temperature and water balance.[1]For years, scientists have known that skin strength deteriorates as we age, leaving the body more susceptible to infections that can have negative health effects system-wide. [2] But new research suggests that mature skin aging may also be a silent trigger of systemic inflammation– revealing that skin care may just be the missing link in extending human longevity.To keep ourselves well as we get older, most of us consider a similar approach: eating a diverse diet rich in fruits and vegetables, exercising regularly, and keeping our minds active. But few of us consider our daily skincare regimen as a tool for lowering our risk of age-related diseases. It’s time to shift that thinking: a recent study on aging and skin health found that age-related changes in the skin can contribute to systemic inflammation and related diseases like cardiovascular disease and diabetes. [3]Because the skin is directly vulnerable to both intrinsic and extrinsic aging factors like oxidative stress, sun damage and UV exposure, there is a strong link between skin health and inflammaging, an age-related and continuous state of body-wide inflammation. [4] The root of this link begins when skin tries to repair age-related damage. In an attempt to restore hydration and mend vulnerabilities in its barrier function, aging skin increases the production of inflammatory molecules known as cytokines. As cytokine levels increase, they begin to accumulate in the blood, resulting in a body-wide state of inflammation that has direct connections to chronic conditions like Alzheimer’s disease and heart disease.[5]
01
How Skin Aging Impacts Longevity
At two square meters in size and making up over fifteen percent of our body weight, skin plays an essential role in the protection and preservation of our bodies. Not only does it shield our internal systems from external pathogens, the skin also provides key homeostatic functions that help the body regulate temperature and water balance.[1]For years, scientists have known that skin strength deteriorates as we age, leaving the body more susceptible to infections that can have negative health effects system-wide. [2] But new research suggests that mature skin aging may also be a silent trigger of systemic inflammation– revealing that skin care may just be the missing link in extending human longevity.To keep ourselves well as we get older, most of us consider a similar approach: eating a diverse diet rich in fruits and vegetables, exercising regularly, and keeping our minds active. But few of us consider our daily skincare regimen as a tool for lowering our risk of age-related diseases. It’s time to shift that thinking: a recent study on aging and skin health found that age-related changes in the skin can contribute to systemic inflammation and related diseases like cardiovascular disease and diabetes. [3]Because the skin is directly vulnerable to both intrinsic and extrinsic aging factors like oxidative stress, sun damage and UV exposure, there is a strong link between skin health and inflammaging, an age-related and continuous state of body-wide inflammation. [4] The root of this link begins when skin tries to repair age-related damage. In an attempt to restore hydration and mend vulnerabilities in its barrier function, aging skin increases the production of inflammatory molecules known as cytokines. As cytokine levels increase, they begin to accumulate in the blood, resulting in a body-wide state of inflammation that has direct connections to chronic conditions like Alzheimer’s disease and heart disease.[5]
02
Shifting Skin Care from Symptoms to Root Causes
When it comes to skin care, treating the symptoms of aging rather than the causes of aging has long been the norm. Just look at the Botox industry, which has now reached a whopping $3.5 billion per year. Consider for a moment what Botox is actually treating: wrinkles, which are just the surface symptoms of an underlying decline in skin health. Just as you wouldn't treat an aged heart with injectable plumper to make it appear healthier, the goal of skin care shouldn't be to just treat appearances of mature skin and wish for it to be more youthful. Instead, we need to prioritize skin health first and experience better-looking, stronger skin as a result.This concept is the foundation of our mission at OneSkin. Our goal is to treat the root causes of skin aging and degeneration, so skin doesn’t just look younger and healthier, it also behaves like younger and healthier skin. We call this extending your skinspan.
02
Shifting Skin Care from Symptoms to Root Causes
When it comes to skin care, treating the symptoms of aging rather than the causes of aging has long been the norm. Just look at the Botox industry, which has now reached a whopping $3.5 billion per year. Consider for a moment what Botox is actually treating: wrinkles, which are just the surface symptoms of an underlying decline in skin health. Just as you wouldn't treat an aged heart with injectable plumper to make it appear healthier, the goal of skin care shouldn't be to just treat appearances of mature skin and wish for it to be more youthful. Instead, we need to prioritize skin health first and experience better-looking, stronger skin as a result.This concept is the foundation of our mission at OneSkin. Our goal is to treat the root causes of skin aging and degeneration, so skin doesn’t just look younger and healthier, it also behaves like younger and healthier skin. We call this extending your skinspan.
03
How OneSkin Extends Your Skinspan
Your skin has both a chronological age (how old you actually are) and a biological age (how old your skin cells act). Unlike chronological age, your skin’s biological age can be reversed or accelerated. For example, if you smoke cigarettes, your skin cells might act older than you actually are. By reducing your skin’s biological age, OneSkin extends your skinspan so your skin stays healthier for longer–forestalling the chronic inflammation that can trigger a system-wide decline in longevity.The secret is our OS-01 peptide, a revolutionary molecule that has been shown to decrease key biomarkers of skin aging and increase epidermal thickness thereby improving barrier function -- an effect that has been clinically validated.[6][7] OS-01 is the cornerstone of our research and our products. In fact, OS-01 FACE, OS-01 EYE, and OS-01 BODY are all clinically proven to improve barrier function*, a key indicator of skin health.*https://www.oneskin.co/pages/disclaimers
03
How OneSkin Extends Your Skinspan
Your skin has both a chronological age (how old you actually are) and a biological age (how old your skin cells act). Unlike chronological age, your skin’s biological age can be reversed or accelerated. For example, if you smoke cigarettes, your skin cells might act older than you actually are. By reducing your skin’s biological age, OneSkin extends your skinspan so your skin stays healthier for longer–forestalling the chronic inflammation that can trigger a system-wide decline in longevity.The secret is our OS-01 peptide, a revolutionary molecule that has been shown to decrease key biomarkers of skin aging and increase epidermal thickness thereby improving barrier function -- an effect that has been clinically validated.[6][7] OS-01 is the cornerstone of our research and our products. In fact, OS-01 FACE, OS-01 EYE, and OS-01 BODY are all clinically proven to improve barrier function*, a key indicator of skin health.*https://www.oneskin.co/pages/disclaimers
04
The Other 97%: Rethinking the Skin Below Your Neck
The majority of "anti-aging" skin care focuses on the face, aligning with our key insecurities about aging. But in order to truly treat our body’s largest organ, we must address the fact that the majority (97% to be exact) of our skin is below the neck.Given the skin's vital role in the rest of your health and longevity, we hypothesized that by delivering the benefits of OS-01 across the entire body, subsequent health and longevity could benefit. That's why we investiagted the effects of using OS-01 BODY for 12 weeks via a clincial study performed by a third-party research organization. In this study, blood samples of 52 participants 52 were collected at baseline and after 12 weeks of using OS-01 BODY or a control formulation (an average drugstore moisturizer). Levels of circulating cytokines were measured at baseline and after 12 weeks of using OS-01 BODY or the control formulation. The biological age of participants was also measured using GlycanAge. The results were fascinating. Not only did levels of IL-8 significantly decrease compared to baseline, the biological age of participants using OS-01 BODY (n=27) did not change, while the biological age of participants using the control formula (n=25) increased compared to baseline. This means that by treating the body skin with OS-01 BODY, powered by the OS-01 peptide, the elevl of circulating inflammation was decreased and the biological age of participants was effectively paused. This data further confirms the fact that with the full OS-01 product line, we are continuing our mission of bringing longevity science to your body’s largest organ in order to improve the way you experience aging.
04
The Other 97%: Rethinking the Skin Below Your Neck
The majority of "anti-aging" skin care focuses on the face, aligning with our key insecurities about aging. But in order to truly treat our body’s largest organ, we must address the fact that the majority (97% to be exact) of our skin is below the neck.Given the skin's vital role in the rest of your health and longevity, we hypothesized that by delivering the benefits of OS-01 across the entire body, subsequent health and longevity could benefit. That's why we investiagted the effects of using OS-01 BODY for 12 weeks via a clincial study performed by a third-party research organization. In this study, blood samples of 52 participants 52 were collected at baseline and after 12 weeks of using OS-01 BODY or a control formulation (an average drugstore moisturizer). Levels of circulating cytokines were measured at baseline and after 12 weeks of using OS-01 BODY or the control formulation. The biological age of participants was also measured using GlycanAge. The results were fascinating. Not only did levels of IL-8 significantly decrease compared to baseline, the biological age of participants using OS-01 BODY (n=27) did not change, while the biological age of participants using the control formula (n=25) increased compared to baseline. This means that by treating the body skin with OS-01 BODY, powered by the OS-01 peptide, the elevl of circulating inflammation was decreased and the biological age of participants was effectively paused. This data further confirms the fact that with the full OS-01 product line, we are continuing our mission of bringing longevity science to your body’s largest organ in order to improve the way you experience aging.
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Key Takeaways:
- As our body’s largest organ, the skin plays several key protective roles in maintaining good health.
- Age-related skin changes have strong correlations with increased risk of infection, systemic inflammation, and chronic diseases.
- Extending your skinspan, the length of time your skin is healthy, is key!
- This includes treating not just your face but also your body (the other 97%) to truly reduce the impact of skin aging on your entire system.
- Iin a 12-week clincial study, the use of OS-01 BODY helped reduce circulating inflammation marker, IL-8, and effectively paused participants' biological age
Key Takeaways:
- As our body’s largest organ, the skin plays several key protective roles in maintaining good health.
- Age-related skin changes have strong correlations with increased risk of infection, systemic inflammation, and chronic diseases.
- Extending your skinspan, the length of time your skin is healthy, is key!
- This includes treating not just your face but also your body (the other 97%) to truly reduce the impact of skin aging on your entire system.
- Iin a 12-week clincial study, the use of OS-01 BODY helped reduce circulating inflammation marker, IL-8, and effectively paused participants' biological age
References
- https://www.nursinghero.com/study-guides/boundless-ap/functions-of-the-integumentary-system
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082166/
- https://pubmed.ncbi.nlm.nih.gov/30835878/
- https://www.ucsf.edu/news/2019/03/413576/skin-repair-eliminates-inflamm-aging-linked-chronic-disease
- https://www.nature.com/articles/s41514-023-00109-1
- https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16242
References
- https://www.nursinghero.com/study-guides/boundless-ap/functions-of-the-integumentary-system
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840548/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082166/
- https://pubmed.ncbi.nlm.nih.gov/30835878/
- https://www.ucsf.edu/news/2019/03/413576/skin-repair-eliminates-inflamm-aging-linked-chronic-disease
- https://www.nature.com/articles/s41514-023-00109-1
- https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16242
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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