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Can OS-01 SHIELD replace OS-01 FACE in the morning?

Can OS-01 SHIELD replace OS-01 FACE in the morning?
Our first SPF, OS-01 SHIELD, is finally here – leaving many people wondering if it should replace OS-01 FACE in their morning ritual. While OS-01 SHIELD contains the same concentration of the OS-01 peptide as OS-01 FACE, there are some compelling scientific reasons to use both in your morning routine. Ready to check out the data? Let’s explore why using the two formulas together reduces pro-aging biomarkers more efficiently.Β 
01

OS-01 FACE Delivers More Peptide to the Skin than OS-01 SHIELD

While both formulas contain the same concentration of the OS-01 peptide, OS-01 SHIELD delivers less peptide compared to OS-01 FACE. That’s because OS-01 SHIELD contains zinc oxide–our preferred UV filter–which creates a physical barrier on the surface of the skin. While this barrier does the important work of protecting your skin against UV radiation, it also prevents the OS-01 peptide from penetrating to its maximum potential. This means that if you were to replace OS-01 FACE with OS-01 SHIELD in your morning routine, your skin would be getting less OS-01 peptide in the morning. By using the two together, your skin gets the benefits of more OS-01 peptide, plus the moisturizing benefits of OS-01 FACE and the sun protective benefits of OS-01 SHIELD.
02

Using OS-01 SHIELD & OS-01 FACE Together Enhances the Effects of the OS-01 peptide

Given that OS-01 SHIELD allows for less peptide penetration, you might be wondering which one you should use. On this, the science is clear. Using both OS-01 FACE and OS-01 SHIELD together enhances the effects of the OS-01 peptide, giving your skin more of its age-reversing benefits. Our scientists exposed ex vivo human skin samples to no treatment (NT), OS-01 SHIELD alone, or OS-01 FACE and OS-01 SHIELD, then measured the activity of pro-aging biomarkers (P16 and IL-8). They found that the combination of OS-01 FACE and OS-01 SHIELD decreased pro-aging biomarkers significantly more than OS-01 SHIELD alone. To maximize both UV protection and OS-01 delivery, we recommend layering both products in your AM skin care routine.
The expression of biomarkers associated with aging, P16 and IL-8, were measured on ex vivo human skin samples before treatement and after treatment with OS-01 FACE alone, or OS-01 FACE then OS-01 SHIELD.
03

How to add OS-01 SHIELD into Your Morning Skin Routine

To ensure your skin benefits from maximum penetration of OS-01 FACE, OS-01 SHIELD should be used as the last step in your morning routine before makeup.
  1. Optional cleanse with OneSkin PREP
  2. Tap OS-01 EYE around the eye area
  3. Apply OS-01 FACE all over the face, neck and hands
  4. Apply OS-01 SHIELD to the face, neck and hands
  5. Finish with makeup if desired
Though using both will offer the best results, if you're in a hurry or trying to keep your AM routine extra simple, using OS-01 SHIELD alone will ensure that your skin is protected and that you get benefit from the OS-01 peptide! As always, consistency is key.Still curious about the differences between OS-01 FACE and OS-01 SHIELD? We broke it down for you!
Key Takeaways:
  • OS-01 SHIELD and OS-01 FACE should be layered together in your morning routine for maximum benefit of the OS-01 peptide.
  • Both formulas contain the same concentration of the OS-01 peptide. However, because OS-01 SHIELD contains UV filter zinc oxide, it delivers less peptide to the skin.
  • By using the two together, you get the benefits of more OS-01 peptide, not less.
  • In lab tests, combining both formulas was shown to decrease pro-aging biomarkers significantly more than OS-01 SHIELD alone.
  • Use OS-01 SHIELD after OS-01 FACE as the last step in your morning routine before makeup.

Last Updated April 22, 2025

Reviewed by

Alessandra Zonari

Alessandra Zonari

PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.