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Can OS-01 FACE SPF replace OS-01 FACE in the morning?

Can OS-01 FACE SPF replace OS-01 FACE in the morning?

OS-01 FACE SPF is now available in deeper tints to complement a wider range of skin tones. Which may leave you wondering if it can replace OS-01 FACE in your morning routine.

Both formulas contain our breakthrough OS-01 peptide, but their delivery systems differ, making them more effective when used together. Let’s take a closer look at how this duo works to reduce pro-aging biomarkers better than OS-01 FACE SPF alone.

OS-01 FACE Delivers More Peptide to the Skin Than OS-01 FACE SPF

While they both contain the same concentration of the OS-01 peptide, OS-01 FACE SPF delivers less peptide compared to OS-01 FACE. That’s because OS-01 FACE SPF is formulated with zinc oxide–our preferred UV filter–which creates a physical barrier on the surface of the skin. While this barrier does the important work of protecting your skin against UV radiation, it also inhibits the penetration of the OS-01 peptide and other actives.

This means that if you were to fully replace OS-01 FACE with OS-01 FACE SPF in your morning routine, your skin would be getting a reduced dose of the OS-01 peptide in the morning. By using the two together, your skin gets the benefits of more OS-01 peptide, plus the moisturizing benefits of OS-01 FACE and the sun protective benefits of OS-01 FACE SPF.

Using OS-01 FACE SPF & OS-01 FACE Together Enhances OS-01’s Effects

Peptide delivery alone doesn’t guarantee better results—there’s a threshold where more doesn’t translate to improved efficacy. What matters is outcomes. Research confirms that layering OS-01 FACE with OS-01 FACE SPF amplifies the peptide’s impact, enhancing cellular signs of skin health.

To test this, our scientists exposed ex vivo human skin samples to no treatment (NT), OS-01 FACE SPF alone, or OS-01 FACE and OS-01 FACE SPF, then measured the activity of pro-aging biomarkers (P16 and IL-8). They found that the combination of OS-01 FACE and OS-01 FACE SPF decreased pro-aging biomarkers significantly more than OS-01 FACE SPF alone. To maximize both UV protection and OS-01 delivery, we recommend layering both products in your AM skin care routine.[1]

Shown in lab studies by measuring a key senescence biomarker (P16) and inflammation biomarker (IL-8) on ex vivo human skin samples treated with nothing or OS-01 FACE SPF. Skin treated with OS-01 FACE SPF displayed significantly lower levels of P16 and close to significant levels of IL-8 compared to skin with no treatment.

At OneSkin, we prioritize efficacy, safety, and stability in every product, and OS-01 FACE SPF is no exception. We never compromise on these core values, ensuring that every product performs as promised, and providing exceptional results without sacrificing integrity.

How to Add OS-01 FACE SPF Into Your Morning Skin Routine

To make sure your skin benefits from maximum penetration of OS-01 FACE, OS-01 FACE SPF should be used as the last step in your morning routine before makeup.

  • Optional cleanse with OneSkin PREP
  • Tap OS-01 EYE around the eye area
  • Apply OS-01 FACE over the face and neck
  • Wait for OS-01 FACE to set/dry (around 10-15 minutes)
  • Apply OS-01 FACE SPF to the face and neck (don’t forget your ears!)
  • If you wear makeup, avoid disrupting the barrier created by OS-01 FACE SPF by tapping it in instead of rubbing

What if You Have Sensitive Skin or a Short Routine?

While the combination of OS-01 FACE and OS-01 FACE SPF offers the most effective results by targeting multiple skin aging pathways simultaneously, OS-01 FACE SPF is still a powerful standalone tool. In a hurry or trying to keep your morning routine extra simple? OS-01 FACE SPF alone still offers effective protection and a meaningful dose of the OS-01 peptide. It's a great option for simplified mornings.

And if you're worried about irritation from layering, don't be. All OneSkin formulas are non-comedogenic and safe for sensitive skin, so you can use them together with confidence.

Key Takeaways:

  • Both products contain the same concentration of OS-01 peptide, but OS-01 FACE SPF blocks some peptide penetration.
  • Our research shows that layering OS-01 FACE with OS-01 FACE SPF reduces aging biomarkers more effectively than either product alone.
  • Even when used alone, OS-01 FACE SPF offers meaningful peptide delivery and excellent skin protection.

References:

  1. Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims.
  2. https://www.sciencedirect.com/science/article/pii/S221475002200172X

Last Updated July 15, 2025