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RICH, BODY + LIP PROTOCOL

4.6
4.6 out of 5
4.6 out of 5
(4,246)

Deep hydration clinically proven to visibly firm + replenish.

  • Age-Reversal Peptide
  • Fine lines
  • Wrinkles
  • Firmness
RICH, BODY + LIP PROTOCOL
Save 10%
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
Save 10%
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL
RICH, BODY + LIP PROTOCOL

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  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

Details
  • Hydrate, smooth, and replenish skin with a hydrating trio for face, body, and lips powered by our proprietary OS-01 Senescence-Blocking Peptide™
  • OS-01 FACE RICH CREAM delivers lasting hydration while supporting skin's visible firmness, resilience, and density1
  • OS-01 LIP MASK works overnight to deliver visibly smoother, fuller, plumper lips2
  • OS-01 BODY MOISTURIZER improves skin's resilience while visibly smoothing texture for younger-looking, healthier body skin3
  • Hydrating textures melt into skin with no residue
Clinical proof

OS-01 FACE RICH CREAM

  • 100% saw improved hydration after 6 weeks1
  • 93% agreed their skin retains hydration better over time1
  • 97% saw a reduced appearance of fine lines and wrinkles after 6 weeks1
  • 93% saw improved visible firmness and elasticity after 6 weeks1
  • +38% increase in skin’s hydration after 12 weeks1

OS–01 LIP MASK

  • 98% agreed their lips stayed moisturized overnight2
  • 81% saw reduced appearance of wrinkles around the lips after 4 weeks2
  • 81% reported visibly fuller lips after 8 weeks2

OS-01 BODY MOISTURIZER 

  • +41% increase in skin’s barrier resilience after 12 weeks3
  • +38% increase in hydration after 12 weeks3
  • 70% reported visibly smoother texture and improved general appearance3

The Clinical Studies

OS-01 FACE RICH CREAM: 12-Week Efficacy Study1

A 12-week, third-party, double-blind clinical study evaluated the effects of OS-01 FACE RICH CREAM in 29 female participants ages 43-65 with mild to moderate facial skin sagging, firming, contouring, nasolabial folds, and expression lines. Participants applied OS-01 FACE RICH CREAM 2x daily to their face and neck. Barrier function and hydration were measured with instrumental devices (Corneometer, TEWL measurement), while radiance, texture,and hydration were evaluated visually and tactilely by expert clinical graders. Participants also provided subjective assessments via a self-reported questionnaire.

The results after 6 weeks:

  • 100% saw improved hydration
  • 93% agreed their skin retains hydration better over time
  • 97% saw a reduced appearance of fine lines and wrinkles
  • 93% saw improved visible firmness and elasticity
  • 97% reported smoother, softer, more radiant skin

The results after 12 weeks:

  • +38% increase in skin’s hydration
  • 97% had more hydrated skin
  • 97% reported improved overall appearance
  • 90% reported more nourished skin with improved skin quality
  • +37% improvement in skin smoothness
  • 83% agree their skin looks, feels, and acts more youthful
  • 81% saw reduced visible redness and irritation
  • +13% increase in barrier strength

OS-01 LIP MASK: 12-Week Consumer Perception Study2

A 12-week consumer perception study evaluated the effects of OS-01 LIP MASK on hydration, smoothness, visible fullness, and the appearance of fine lines around and on the lips with nightly application.

Immediate results:

  • 98% agreed lips feel instantly hydrated upon application
  • 98% agreed lips feel hydrated and moisturized 8+ hours after application
  • 95% agreed it applies smoothly and is ultra-hydrating

4 weeks:

  • 95% agreed lips feel smoother
  • 81% reported reduced appearance of fine lines around the lip border
  • 80% reported reduced appearance of fine lines on the lips
  • 78% reported improved visible lip fullness

12 weeks:

  • 97% agreed lips feel smoother
  • 94% agreed lips retain hydration longer
  • 87% reported reduced appearance of fine lines and wrinkles on the lips
  • 81% agreed lips feel more resilient
  • 72% agreed the natural color of their lips improved


OS-01 BODY MOISTURIZER: 3-Month Efficacy Study3

A 12-week, double-blind, third-party clinical study evaluated the effects of OS-01 BODY MOISTURIZER on body skin hydration, barrier function, texture, and appearance. 60 participants were divided into two groups: one applied OS-01 BODY twice daily, while the other applied a placebo moisturizer twice daily. Hydration and trans-epidermal water loss (TEWL) were measured with instrumental devices (Corneometer and Tewameter). Participants also reported subjective improvements. Published in the Journal of Cosmetic Dermatology, Zonari et al., 2025.

The results after 12 weeks:

  • 93% of participants reported improved skin hydration
  • +38% improvement in forearm and upper arm hydration (corneometer)
  • +41% improvement in skin barrier on forearm and +35% on upper arm (tewameter)
  • 70% reported improved skin texture
  • 70% reported improved overall appearance

Safety studies

OS-01 FACE RICH CREAM, OS-0 BODY MOISTURIZER, and OS-01 LIP MASK are non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance-free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on their formulas and clinical testing, they have been awarded the National Eczema Association Seal of Acceptance™.

Our commitment to the scientific process

OneSkin products are validated with a rigorous process from the lab to the clinic: Lab testing on human skin to evaluate the effect on the cellular level, consumer testing with real users to ensure optimal texture and feel, and third-party clinical studies to evaluate the effect on the human level over time.
Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 RICH CREAM

Water (Aqua), Glycerin, Caprylic/Capric Triglyceride, Butyrospermum Parkii (Shea) Nut Extract, Lauryl Olivate, Cetearyl Olivate, Euterpe Oleracea Fruit Oil, Squalane, C10-18 Triglycerides, Glyceryl Stearate SE, Linoleic/Oleic/Palmitic Triglyceride, Saccharide Isomerate, Sorbitan Olivate, Coconut Alkanes, 1,2-Hexanediol, Panthenol, Butyrospermum Parkii (Shea) Butter, Sodium PCA, Collagen Amino Acids, Ectoin, Citrullus Lanatus (Watermelon) Fruit Extract, Ceramide NP, Haematococcus Pluvialis Extract, Lens Esculenta (Lentil) Fruit Extract, Betaine, Coco-Caprylate/Caprate, Pyrus Malus (Apple) Fruit Extract, Moringa Oleifera Seed Oil, Decapeptide-52,* Hexapeptide-9, Tamarindus Indica Seed Polysaccharide, Limnanthes Alba (Meadowfoam) Seed Oil, Macadamia Integrifolia Seed Oil, Phytosphingosine, Sodium Lactate, Tremella Fuciformis Sporocarp Extract, Citric Acid, Sodium Citrate, Caprylyl Glycol, Phaeodactylum Tricornutum Extract, Cholesterol, Lecithin, Caprylhydroxamic Acid, Tocopherol, Propanediol, Sorbitan Oleate, Sorbitan Palmitate, Cetyl Palmitate, Dilinoleic Acid/Propanediol Copolymer, Sodium Phytate, Xanthan Gum, Cetearyl Alcohol, Hydroxyacetophenone, Sodium Benzoate.
*OS-01 Peptide™

OS-01 BODY MOISTURIZER:

Water (Aqua), Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Squalane, Avena Sativa (Oat) Kernel Oil, Prunus Domestica Seed Oil, Cetearyl Olivate, Mangifera Indica (Mango) Seed Butter, Saccharide Isomerate, Panthenol, Tremella Fuciformis Sporocarp Extract, Tocopheryl Acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NG, Galactoarabinan, Lepidium Sativum Sprout Extract, Soy Isoflavones, Niacinamide, Betaine, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin,  Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol.
*OS-01 Peptide™

OS-01 LIP MASK:

Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan.
*OS-01 Peptide™

This set includes

A clear cosmetic jar of ONE SKIN 05-01 Face Rich Cream with a black lid and white label, set against a clean light gray background.

STEP 1

OS-01 FACE RICH CREAM

Deep hydration clinically shown to firm, strengthen + replenish.

Size

50 mL / 1.7 fl oz

How to use

Smooth a generous layer onto clean, dry skin on the face, neck, and chest. Use 2x daily, morning and evening. Results require consistency.

An open black One Skin cushion foundation compact, showing the warm beige foundation powder and the built-in mirror inside the lid, set against a clean off-white background.

STEP 2

OS-01 LIP MASK

Overnight lip care for visibly smoother, fuller lips over time.

Size

7 mL / 0.24 fl oz

How to use

Using the metal applicator, apply a generous layer onto clean, dry lips as needed. For a deep treatment, apply before bed and leave on overnight.

White bottle with black pump and 'One Skin' logo on a beige background

STEP 3

OS-01 BODY MOISTURIZER

Nourishing hydration designed to strengthen crepey skin.

Size

250 mL / 8.45 fl oz

How to use

Apply to arms, legs, chest, back, and stomach and massage until absorbed. Use 2x daily.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.5

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

93%

saw improved visible firmness and elasticity after 12 weeks1

+37%

improvement in skin smoothness after 12 weeks1

Clinically validated results that build over time.

WEEK 1

Deep, replenishing hydration

  • The OS-01 Peptide™ gets to work immediately
  • Bioactive humectants draw hydration deep into skin
  • Skin-identical lipids seal the moisture barrier
WEEK 6

Firmer, more resilient skin

  • 100% saw improved hydration1
  • 93% agreed their skin retains hydration better over time1
  • 97% saw a reduced appearance of fine lines and wrinkles1
  • 93% saw improved visible firmness1
WEEK 12

Smoother, more youthful skin

  • +38% increase in skin’s hydration1
  • +37% smoother skin1
  • 97% reported improved overall appearance1
  • 90% reported more nourished skin with improved skin quality1
  • 83% agree their skin looks, feels, and acts more youthful1

Key ingredients

OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Palmless™ torula oil

A nourishing emollient power-packed with antioxidants that boosts barrier strength + reduces the appearance of fine lines and wrinkles.

Tremella fuciformis mushroom extract

A naturally derived extract that helps skin hold more hydration while supporting antioxidant defense.

Vegan collagen amino acids

Spermidine-rich upcycled microalgae shown to visibly boost collagen synthesis and volumize skin’s matrix.

All Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 RICH CREAM

Water (Aqua), Glycerin, Caprylic/Capric Triglyceride, Butyrospermum Parkii (Shea) Nut Extract, Lauryl Olivate, Cetearyl Olivate, Euterpe Oleracea Fruit Oil, Squalane, C10-18 Triglycerides, Glyceryl Stearate SE, Linoleic/Oleic/Palmitic Triglyceride, Saccharide Isomerate, Sorbitan Olivate, Coconut Alkanes, 1,2-Hexanediol, Panthenol, Butyrospermum Parkii (Shea) Butter, Sodium PCA, Collagen Amino Acids, Ectoin, Citrullus Lanatus (Watermelon) Fruit Extract, Ceramide NP, Haematococcus Pluvialis Extract, Lens Esculenta (Lentil) Fruit Extract, Betaine, Coco-Caprylate/Caprate, Pyrus Malus (Apple) Fruit Extract, Moringa Oleifera Seed Oil, Decapeptide-52,* Hexapeptide-9, Tamarindus Indica Seed Polysaccharide, Limnanthes Alba (Meadowfoam) Seed Oil, Macadamia Integrifolia Seed Oil, Phytosphingosine, Sodium Lactate, Tremella Fuciformis Sporocarp Extract, Citric Acid, Sodium Citrate, Caprylyl Glycol, Phaeodactylum Tricornutum Extract, Cholesterol, Lecithin, Caprylhydroxamic Acid, Tocopherol, Propanediol, Sorbitan Oleate, Sorbitan Palmitate, Cetyl Palmitate, Dilinoleic Acid/Propanediol Copolymer, Sodium Phytate, Xanthan Gum, Cetearyl Alcohol, Hydroxyacetophenone, Sodium Benzoate.
*OS-01 Peptide™

OS-01 BODY MOISTURIZER:

Water, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Avena Sativa (Oat) Kernel Oil, Squalane, Prunus Domestica Seed Oil, Saccharide Isomerate, Cetearyl Olivate, d-Panthenol, Mangifera Indica (Mango) Seed Butter, Tremella Fuciformis (Mushroom) Extract, Tocopheryl acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NP, Anadenanthera Colubrina Bark Extract, Lepidium Sativum Sprout Extract, Genistein, Niacinamide, Glycerol, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Citric Acid, Sodium Citrate, Pentylene Glycol, Potassium Sorbate, Ethylhexylglycerin, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol.
*OS-01 Peptide™

OS-01 LIP MASK:

Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan.
*OS-01 Peptide™

OneSkin Longevity Protocol

RICH, BODY + LIP PROTOCOL

Write a Review (Opens in a new window)
4,246 reviews
  • KM
    Karen M.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    4 minutes ago
    Excellent Moisturizer

    Light yet moisturizing and non greasy. Soaks in immediately leaving skin softer and smoother! Easy to apply! Love to use it on my hands too.

    Was this helpful?
  • LB
    Leslie B.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    4 hours ago
    Amazed

    Genuinely surprised at how great with stuff works! I can instantly see how well it works and it lasts all day.

    Was this helpful?
  • R
    Roni
    Reviewing
    OS-01 BODY MOISTURIZER
    Rated 3 out of 5 stars
    5 hours ago
    3 Stars

    Delivery person just left package in front of garage door. Lucky that someone didn’t run over it. The walkway to my porch/front door was two steps away!

    Was this helpful?
  • H
    Helen
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    5 hours ago
    5 Stars

    The best lip balm ever!

    Was this helpful?
  • KB
    Kim B.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    11 hours ago
    Lotion

    Amazing

    Was this helpful?
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Citations

  1. Based on a double-blind, third-party 12-week clinical study with 29 participants aged 43-65.
  2. Based on a 12-week consumer perception study with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK.
  3. Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025.)