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The only 24-hour system powered by the OS-01 Peptide™ to shield and restore healthy looking and feeling lips.


  • OS-01 LIP Shield SPF 15+ defends against the 3 main drivers of lip aging by day

  • OS-01 LIP Mask deeply hydrates and helps support smoother, fuller-looking lips at night

  • Dermatologist tested, fragrance-free, suitable for sensitive skin

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  • Accepted National Eczema Association logo
  • Leaping bunny certified logo

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Ingredients that complement the OS-01 PeptideTM


Bisabolol

A chamomile-derived antioxidant that soothes irritation, calms signs of inflammation, and enhances ingredient absorption.


Vitamin E
A potent antioxidant that helps neutralize oxidative stress and supports daily repair from UV and environmental exposure.


Hyaluronic acid
A highly bioavailable form that delivers immediate hydration and long-lasting moisture retention for skin prone to dryness due to a thinner barrier and lack of natural sebum production.

How it works

Powered by the OS-01 Senescence Peptide™

Born from over a decade of longevity science, OS-01 is engineered to address a key driver of visible skin aging, supporting meaningful improvements in skin health today and over time to future-proof skin.

DAY + NIGHT LIP DUO

4.6
Rated 4.6 out of 5 stars
Based on 859 reviews
Total 5 star reviews: 673 Total 4 star reviews: 77 Total 3 star reviews: 49 Total 2 star reviews: 32 Total 1 star reviews: 28
87%would recommend these products
859 reviews
  • NK
    Natalie K.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    2 hours ago
    Finally a clean/plastic free lip option

    Love the metal applicator, the formula is nice, not too sticky, it doesn’t cake like other products, goes on smooth. PLEASE MAKE MORE COLORS!!!

  • BM
    Barbara M.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    7 hours ago
    Lip mask

    While I have only used the lip mask for a short time, my lips seem more hydrated. I do enjoy this product and will continue to use it.

  • BL
    Barbara L.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    18 hours ago
    Lip treatment

    Lip SPF 15+ what a lovely lip treatment. This product is quite nourishing. The cooling metal applicator blends the creamy product as it melts into your lips.

    Makes my lips very soft and supple.

    I definitely recommend this lip treatment.

  • PW
    Patricia W.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    23 hours ago
    Perfect for outdoor coverage

    I use this during my workouts in the sun, provides great benefits without being gummy or anything fake in it.

  • JO
    Jennifer O.
    Verified Buyer
    Reviewing
    DAY + NIGHT LIP DUO
    I recommend this product
    Rated 5 out of 5 stars
    23 hours ago
    This really works!

    Works great but the circular packaging is weird and unnecessary

    OneSkin
    7 minutes ago

    Hi Jennifer!

    Thank you so much for this wonderful 5-star review and for letting us know that the DAY + NIGHT LIP DUO is really working for you — that's exactly what we love to hear!

    We really appreciate your honest feedback about the circular packaging too! We know that the round format can feel a bit different from traditional lip product packaging, and we totally understand that it might seem unnecessary at first glance. The circular design was actually chosen to make the duo easy to grab and go while keeping both products securely together, but we definitely value hearing when customers find certain design elements less intuitive.

    The most important thing is that you're getting those great results from the formula itself — the OS-01 LIP SHIELD SPF 15+ during the day and OS-01 LIP MASK at night work together to provide 24-hour cellular support for your lips, protecting against environmental damage while promoting overnight restoration.

    Thank you for taking the time to share your experience and for encouraging others by letting them know it really works! Feedback like yours about both the performance and the packaging helps us continue to improve and helps other customers know what to expect.

    We're so glad your lips are loving the results, Jennifer!

Full ingredient list

OS-01 LIP SPF ingredients

Active ingredients: Zinc Oxide 5.5%

Inactive ingredients: Simmondsia Chinensis (Jojoba) Seed Oil, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Water (Aqua), Garcinia Indica Seed Butter, Tocopheryl Acetate, Butylene/Ethylene/Styrene Copolymer, Glyceryl Oleate, Glyceryl Dioleate, Glycerin, Oleic Acid, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1, Dipalmitoyl Hydroxyproline, Trihydroxystearin, Sodium Hyaluronate, Glucomannan, Tetrahexyldecyl Ascorbate, Bisabolol, Decapeptide-52*, Ethylhexylglycerin, Caprylyl/Capryl Glucoside, Propanediol, Ectoin, Centella Asiatica Extract, Hippophae rhamnoides (Sea Buckthorn) Oil, Helianthus Annuus (Sunflower) Seed Oil, Copernicia cerifera (Carnauba) Wax, Tocopherol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic Acid, Lecithin, Lactic Acid, Octyldodecanol, Sorbitan Oleate, Alumina, Magnesium Oxide, Palmitic Acid, Iron oxides (CI 77491, CI 77492, CI 77499), Titanium Dioxide (CI 77891), Red 33 Lake (CI 17200), Red 7 Lake (CI 15850).

Drug Facts

Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen

Uses

  • Helps prevent sunburn
  • If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

  • For external use only.
  • Do not use on damaged or broken skin.
  • Stop use and ask a doctor if rash occurs.
  • Keep out of reach of children.

OS-01 LIP MASK ingredients

Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan. *OS-01 Peptide™