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OS-01 LIP Duo

The only 24-hour system powered by the OS-01 Peptide™ to shield and restore your lips at the cellular level01.



  • OS-01 LIP SPF protects against UV and cellular aging by day

  • OS-01 LIP Mask promotes collagen, elastin, and hyaluronic acid at night


  • Dermatologist tested, fragrance-free, safe for sensitive skin


  • 15% off recurring shipments
  • Exclusive early access to new products
  • Earn 2x points on all recurring orders
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OS-01 LIP SPF

Daytime:

Gently squeeze a small amount of OS-01 LIP SPF onto the applicator tip and apply a thin layer directly to lips prior to sun exposure.

OS-01 LIP Mask

Nighttime:

Using the metal applicator, apply a generous layer of OS-01 LIP Mask onto clean, dry lips before bed and leave on overnight.

*Applies clear. Due to natural ingredients, color in compact may vary slightly.

HOW OS-01 WORKS

The science to unlock your healthiest skin

Backed by over a decade of longevity research, the OS-01 Peptide™ targets the cells that speed up the visible signs of aging.02

OS-01 is scientifically proven to:

  • Support repair by reducing the buildup of senescent “zombie” cells
  • Improve how skin behaves, stimulating collagen and hyaluronic acid production
  • Build resilience, keeping your skin healthy and youthful as you age

Full ingredient list

OS-01 LIP SPF ingredients

Active ingredients: Zinc Oxide 5.5%

Inactive Ingredients: Simmondsia, Chinensis (Jojoba) Seed Oil, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Water (Aqua), Garcinia Indica Seed Butter, Tocopheryl Acetate, Butylene/Ethylene/Styrene Copolymer, Glyceryl Oleate, Glyceryl Dioleate, Glycerin, Oleic Acid, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1, Dipalmitoyl Hydroxyproline, Trihydroxystearin, Sodium Hyaluronate, Glucomannan, Tetrahexyldecyl Ascorbate, Bisabolol, Decapeptide-52*, Ethylhexylglycerin, Caprylyl/Capryl Glucoside, Propanediol, Ectoin, Centella Asiatica Extract, Hippophae Rhamnoides Oil, Helianthus Annuus (Sunflower) Seed Oil, Copernicia Cerifera (Carnauba) Wax, Tocopherol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic acid, Lecithin, Beta-Sitosterol, Squalene, Lactic Acid, Palmitic acid. *OS-01 Peptide™

OS-01 LIP ingredients

Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan. *OS-01 Peptide™

OS-01 LIP Duo

4.8
Rated 4.8 out of 5 stars
Based on 89 reviews
Total 5 star reviews: 74 Total 4 star reviews: 11 Total 3 star reviews: 4 Total 2 star reviews: 0 Total 1 star reviews: 0
96%would recommend this product
89 reviews
  • DZ
    Diana Z.
    Verified Buyer
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 5 out of 5 stars
    17 seconds ago
    Very moisturizing

    I really do love this lip duo. The night time treatment is very moisturizing, especially on dry winter lips.

  • DJ
    DELORES J.
    Verified Buyer
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 5 out of 5 stars
    5 hours ago
    Perfect lip duo

    I was very anxious to try this after reading so many great reviews. I have extremely dry lips and nothing has really been effective at moisturizing them until I tried One Skin. I have this on auto delivery now. I love it!

  • S
    Sandi
    Verified Buyer
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Silky smooth lips

    Love this duo! My lips feel soft and moisturized even during this extra dry Colorado winter.

  • CD
    Cathy D.
    Verified Buyer
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    PURRFect LIPS....

    The night lip container fit in the pot and stayed in the pot better than the last one I purchased... I love how it moisturizes my lips and then I use the day lip treatment during the day. , I am a senior and I fell the night treatment really softens my lips.. I have ordered twice....

  • MD
    Marilyn d. K.
    Verified Buyer
    Reviewing
    OS-01 LIP Duo
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    Lucious lips!

    I've been putting the lip balm on my lips overnight and wake up to plump moist lips all day. Its great. Have not needed the sunblock yet but summer is coming.

Citations

01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims.
02 Zonari, A.,et al.Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models.npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1