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DAY + NIGHT LIP DUO

4.6
(964)

Multi-benefit lip care duo that smooths, protects + restores.

  • Age-Reversal Peptide
  • Smoothing
  • UV Protection
  • Fragrance Free
Skincare product packaging with black disc and white tube on a beige background
Black round compact and white tube with brand logo on a beige background
One Skin sunscreen tube and black container on a beige background with text about zinc oxide and collagen production.
Lip mask product with user testimonials on a dark background
Woman applying lip balm with product features highlighted on a peach background
Two lip products, OS-01 Lip Mask and OS-01 Lip SPF, on a light gray background with text describing their textures.
Refillable compact with custom applicator on a blue background
Close-up of a person's lips and nose
Cosmetic products with OS-01 Peptide text on a light gray background
Woman applying lip shield with product features listed on a light gray background
Lip mask product with a woman holding it, showing text about its benefits on a light gray background.
Two lip products labeled 'Bare Blush Lip Shield' and 'OS-01 Lip Mask' on a white background.
Black refillable compact with a custom applicator on a gray background
Skincare product packaging with black disc and white tube on a beige background
Black round compact and white tube with brand logo on a beige background
One Skin sunscreen tube and black container on a beige background with text about zinc oxide and collagen production.
Lip mask product with user testimonials on a dark background
Woman applying lip balm with product features highlighted on a peach background
Two lip products, OS-01 Lip Mask and OS-01 Lip SPF, on a light gray background with text describing their textures.
Refillable compact with custom applicator on a blue background
Close-up of a person's lips and nose
Cosmetic products with OS-01 Peptide text on a light gray background
Woman applying lip shield with product features listed on a light gray background
Lip mask product with a woman holding it, showing text about its benefits on a light gray background.
Two lip products labeled 'Bare Blush Lip Shield' and 'OS-01 Lip Mask' on a white background.
Black refillable compact with a custom applicator on a gray background

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  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

Details
  • Hydrate, smooth, and protect lips from visible signs of aging with a lip care duo powered by our proprietary OS-01 Senescence-Blocking Peptide™
  • OS-01 LIP SPF hydrates and protects lips from the visible effects of UV-induced damage by day
  • OS-01 LIP MASK delivers visibly smoother, fuller lips in 4 weeks with a rich, non-sticky overnight formula1
  • Lightweight textures instantly absorb into skin with no residue
Ingredients

Formulated without
Non-comedogenic and formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 LIP MASK Ingredients
Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan.
*OS-01 Peptide

OS-01 LIP SPF 15 Ingredients

Active Ingredient
 Zinc Oxide 5.5%

Inactive Ingredients
Aqua (Water), Beta-Sitosterol, Bisabolol, Butylene/Ethylene/Styrene Copolymer, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Caprylyl/Capryl Glucoside, Centella Asiatica Extract, Copernicia Cerifera Cera (Carnauba) Wax, Decapeptide-52*, Dipalmitoyl Hydroxyproline, Ectoin, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Ethylhexylglycerin, Garcinia Indica Seed Butter, Glucomannan, Glycerin, Glyceryl Dioleate, Glyceryl Oleate, Helianthus Annuus (Sunflower) Seed Oil, Hippophae Rhamnoides (Sea Buckthorn) Seed Oil, Isostearic Acid, Lactic Acid, Lecithin, Oleic Acid, Palmitic Acid, Palmitoyl Tripeptide-1, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Polyglyceryl-3 Polyricinoleate, Polyhydroxystearic Acid, Propanediol, Simmondsia Chinensis (Jojoba) Seed Oil, Sodium Hyaluronate, Sorbitan Isostearate, Squalene, Tetrahexyldecyl Ascorbate, Tocopherol, Tocopheryl Acetate, Tribehenin, Trihydroxystearin.

*OS-01 Peptide

Drug Facts

Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen

Uses

  • Helps prevent sunburn

  • If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

  • For external use only.

  • Do not use on damaged or broken skin.

  • Stop use and ask a doctor if rash occurs.

  • Keep out of reach of children.

This set includes

Tube of One Skin sunscreen on a light beige background

Day

OS-01 LIP SPF 15

Hydrating SPF lip balm that hydrates, protects, and restores.

Size

12 mL / 0.41 fl oz

How to use

Apply generously to lips before sun exposure. Reapply throughout the day, especially after eating, drinking, swimming, sweating, or towel drying.

An open black One Skin cushion foundation compact, showing the warm beige foundation powder and the built-in mirror inside the lid, set against a clean off-white background.

Night

OS-01 LIP MASK

Overnight lip care for visibly smoother, fuller lips over time.

Size

7 mL / 0.24 fl oz

How to use

Using the metal applicator, apply a generous layer onto clean, dry lips as needed. For a deep treatment, apply before bed and leave on overnight.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.2

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

OS-01 LIP MASK delivers clinically validated results that build over time.

Close-up before-and-after comparison of a person's lips, showing a matte pink lip color applied in the after photo after 4 weeks. The top panel is labeled BEFORE and shows natural, uncolored lips, while the bottom panel is labeled AFTER 4 WEEKS and shows the colored, hydrated lips.

78%

reported improved visible fullness after 4 weeks1

Close-up before-and-after comparison of a person's lips, with the top labeled BEFORE and the bottom labeled AFTER 12 WEEKS. The lower lip appears more hydrated and glossy in the after view.

97%

agreed lips feel and look smoother after 12 weeks1

Close-up before-and-after comparison of lips, with the top panel labeled BEFORE and the bottom panel labeled AFTER 12 WEEKS. The image shows skin texture and lip condition over time.

81%

saw reduced appearance of wrinkles around the lips after 4 weeks1

Week 1

Instant hydration you can feel 

  • Melts into a non-sticky overnight layer
  • 98% agreed lips feel instantly hydrated on application1
  • The OS-01 Peptide™ begins working on contact
Week 4

Smoother lips, fewer fine lines

  • 95% agreed lips feel smoother1
  • 81% saw reduced appearance of fine lines around the lip border1
  • 80% saw reduced appearance of fine lines on the lips¹
Week 12

Resilient, fuller, healthier lips

  • 97% agreed lips feel smoother1
  • 87% reported reduced appearance of fine lines and wrinkles on the lips1
  • 94% agreed lips retain hydration for longer1

Key ingredients

Combining the OS-01 Peptide™ with clinically studied actives for healthier skin today and over time

A glossy, smooth swipe of coral pink cosmetic cream or lip gloss on a solid black background.
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Non-nano zinc oxide

Protects against UV aging and damage with mineral broad spectrum SPF 15+ defense.

Bisabolol

A chamomile-derived antioxidant that soothes irritation, calms signs of inflammation, and enhances ingredient absorption.

Vitamin E

A potent antioxidant that helps neutralize oxidative stress and supports daily repair from UV and environmental exposure.

Hyaluronic acid

A highly bioavailable form that delivers immediate hydration and long-lasting moisture retention.

All Ingredients

Formulated without
Non-comedogenic and formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.


OS-01 LIP MASK Ingredients
Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan.
*OS-01 Peptide


OS-01 LIP SPF 15 Ingredients


Active Ingredient
 Zinc Oxide 5.5%


Inactive Ingredients
Aqua (Water), Beta-Sitosterol, Bisabolol, Butylene/Ethylene/Styrene Copolymer, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Caprylyl/Capryl Glucoside, Centella Asiatica Extract, Copernicia Cerifera Cera (Carnauba) Wax, Decapeptide-52*, Dipalmitoyl Hydroxyproline, Ectoin, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Ethylhexylglycerin, Garcinia Indica Seed Butter, Glucomannan, Glycerin, Glyceryl Dioleate, Glyceryl Oleate, Helianthus Annuus (Sunflower) Seed Oil, Hippophae Rhamnoides (Sea Buckthorn) Seed Oil, Isostearic Acid, Lactic Acid, Lecithin, Oleic Acid, Palmitic Acid, Palmitoyl Tripeptide-1, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Polyglyceryl-3 Polyricinoleate, Polyhydroxystearic Acid, Propanediol, Simmondsia Chinensis (Jojoba) Seed Oil, Sodium Hyaluronate, Sorbitan Isostearate, Squalene, Tetrahexyldecyl Ascorbate, Tocopherol, Tocopheryl Acetate, Tribehenin, Trihydroxystearin.


*OS-01 Peptide


Drug Facts


Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen
















Uses


  • Helps prevent sunburn




  • If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings


  • For external use only.




  • Do not use on damaged or broken skin.




  • Stop use and ask a doctor if rash occurs.




  • Keep out of reach of children.

OneSkin Longevity Protocol

DAY + NIGHT LIP DUO

Write a Review (Opens in a new window)
964 reviews
  • MG
    Mary G.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Lip Mask

    This lip mask is amazing!! My lips are no longer dehydrated ever!! Game changer

    Was this helpful?
  • LD
    Laura D.
    Verified Buyer
    Reviewing
    OS-01 LIP SPF 15
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Perfect

    The light tint is a perfect natural pink, the texture is very nice and the bonus is SPF with no flavor!

    Was this helpful?
  • L
    Lindsey
    Verified Buyer
    Reviewing
    OS-01 LIP SPF 15
    Rated 3 out of 5 stars
    2 days ago
    More colors please!

    My natural lip color is much darker than this pink. Would love to see this product in a wider color range so it would be wearable.

    Was this helpful?
    OneSkin
    2 days ago

    Hi Lindsey! Thank you so much for your feedback on OS-01 LIP SPF 15 — we really appreciate you taking the time to share what would make this product work better for you!

    We completely hear you on wanting a wider color range. Right now OS-01 LIP SPF comes in Untinted and Bare Blush, so we totally understand that Bare Blush might not be the right match for deeper natural lip tones. That's genuinely valuable feedback, and I'll be passing your request along to our team as we think about expanding our tint options.

    In the meantime, a lot of our customers layer the Untinted version with their own lip liners or colors to get exactly the shade they're looking for — that might be a workaround worth exploring if you'd like to give it a try!

    Thanks again for letting us know what you'd love to see. Feedback like yours really does shape our product development, and we're grateful for it!

  • DS
    Deborah S.
    Verified Buyer
    Reviewing
    OS-01 LIP Mask, Recurring
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    Lip mask

    I bought this because One Skin has been such a fabulous staple skincare line that I’ve been using for almost two years. I have noticed such a more even & balanced tone to my skin & finished depth of wrinkles.

    Mt hope was that the lip mask would not only feel nourishing, but over time deliver similar results. I’m only a few months in, but love how hydrating it feels!

    Was this helpful?
  • DJ
    Dana J.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    Lips feel fuller

    I’ve only been using this for a two weeks but they look fuller.

    Was this helpful?
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Citations

  1. Based on a 12-week consumer perception study with 31 participants aged 35–74, using nightly application of OS-01 LIP MASK.
  2. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)