OS-01 EYE Topical Supplement Refill
- Unit price
- per
Hydrate and firm ultra-delicate skin with our daily eye cream, formulated with the highest concentration of the OS-01 Peptide™.01
- Improves texture, tone, and elasticity
- Increase collagen by an average of +130% in lab studies
- Dermatologist tested, fragrance-free, safe for sensitive skin
Reusable plastic shell not included.
✭ You’re earning 106 points with OneSkin Loyalty Program ✭
Free shipping on orders over
Try it risk-free for 30 days!
You’re earning [potential_points] points with OneSkin Loyalty Program
BENEFITS
Our most potent formula, specially designed for the delicate skin around the eyes, which is prone to accelerated aging 03
Wrinkle reduction
Boosts collagen to visibly smooth lines and wrinkles.01
Firmness
Supports skin health for a firmer, more lifted appearance.01
Hydration
Strengthens the skin barrier to lock in moisture and keep skin hydrated.01
5-star reviews
See why customers love OS-01 EYE
“The concentration of peptides in this product has made a difference, especially to the circles under my eyes. I haven’t needed to use concealer since beginning to use this product. The science behind this product is solid.” – Kathy L.
"I've tried all sorts of different eye creams; the best out there. I have a very thin skin around my eyes with many expression lines and wrinkles and this product has been the most efficient in minimizing them and nourishing my skin. I all using this day and night very religiously and have no intention of ever stopping." – Archontia T.
"I simply love One Skin OS-01 Eye cream. It is silky smooth, absorbs efficiently, and never feels heavy or greasy. I have noticed the fine lines under my eyes and early crows feet slowly vanishing. It's subtle but evident the more I use it. This is the best product I have ever tried." – Bridgette G.
"OS-01 EYE is fantastic. I wish I had taken pictures when I started using this a year ago. I'm certain my eyes look better now than they did before. It absorbs immediately and yet is there moisturizing the area around my eyes all day long. It even smooths out the rough bumps around my eyes. This is a wonderful product. I love it!" – Donna G.
The proof is in the pictures
CLINICAL DATA
Visible results, scientifically validated
96
of participants reported improved texture and tone 01
91
of participants reported improved radiance 01
88
of participants showed improved hydration 01
86
of participants had improved elasticity 01
3 active ingredients complement the OS-01 peptide
Getting started with OS-01 EYE
Follow these easy steps for optimal results
- Dispense 1 pump onto tip of finger
- Gently tap in a semi-circle around each eye, from the under eye to the eyelid and underneath the brow bone
- Use 2 times daily
How it works
Powered by the OS-01 Senescence Blocking Peptide™
The first and only peptide scientifically proven to reverse skin’s biological age.05,06
All Ingredients
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum. *OS-01 Peptide.
Citations
01 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
02 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
03 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
04 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
05 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
06 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
OS-01 EYE Topical Supplement Refill
- LBLaura B.Verified BuyerReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 stars4 minutes agoBest eye cream ever
Been using this for almost a year. It’s expensive so I kind of hoped it could not be as good as it is. Tried to use another, even more expensive, French brand. Saw my skin deteriorate within weeks, and ran back to OneSkin.
- HHHelen H.Verified BuyerReviewingOS-01 EYE RefillRated 3 out of 5 stars2 days agoWould not reorder
Does it reduce puffiness? No. Is it moisturizing? Yes. There’s no way that I can use two pumps for two eyes. I have the original eye cream and the replacement eye cream neither of which I will replace
OneSkin2 days agoHi Helen!
Thank you so much for taking the time to share your honest feedback about OS-01 EYE — we genuinely appreciate you letting us know about your experience, and we're truly sorry to hear that you haven't seen the puffiness reduction you were hoping for.
We completely understand how disappointing it must be when a product doesn't address your specific concerns, especially when puffiness is something you're actively trying to improve. That's absolutely not the experience we want for anyone, and your concerns are completely valid.
We're glad to hear that you've found the product moisturizing, though we know that's only part of what you were looking for. Eye puffiness can be influenced by so many factors — genetics, sleep, allergies, fluid retention — and unfortunately, what works for some people doesn't always provide the same results for others.
Regarding the amount needed — we typically recommend one pump for both eyes, but we completely understand that application preferences can vary from person to person, and some people do find they prefer using a bit more product for their comfort and coverage needs.
We'd love to connect with you personally to better understand your experience and see if there's anything we can do to help. Please feel free to reach out to support@oneskin.co — we're here to assist and want you to feel confident in every product you choose.
Thank you for choosing OneSkin and for sharing this important feedback with us, Helen!
- KHKarla H.Verified BuyerReviewingOS-01 EYE CREAMI recommend this productRated 5 out of 5 stars2 days agoLove love!
Love this new tool to protect and reverse damage around my eyes, definitely worth the investment!
- PCPhyllis C.Verified BuyerReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 stars3 days agoLove the One Skin product
Honestly I would prefer to get the real product, not the new product which is a fake looking package!
OneSkin2 days agoHi Phyllis,
Thank you so much for your feedback — we completely understand the surprise, and we want to explain what you received and why!
What arrived with your second order is not a different or lesser product — it contains the exact same formula you know and love. As part of our commitment to sustainability, OneSkin uses a refillable packaging system for OS-01 FACE, OS-01 EYE, and PREP. Here's how it works:
• Your first order comes with the full starter kit — the durable outer vessel (shell and pump) plus the product inside.
• From your second order onward, you receive the refill only — a lightweight cartridge or pouch designed to simply click or slot into the outer shell you already have. The formula inside is identical.This system is intentional — the outer shell is built to last and be reused, while the refill cartridge uses significantly less packaging material, making it lighter to ship and much kinder to the planet. In fact, a significant portion of our refill packaging is made from aluminum, which is far more recyclable than plastic.
To assemble your refill, simply insert the new cartridge or pouch into your existing outer shell — it clicks right in. You can also watch our step-by-step assembly video here: https://www.oneskin.co/collections/extras-collection
We hope this clears things up — same great product, just a little greener! Please don't hesitate to reach out with any other questions.
- SPSharon P.Verified BuyerReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 stars3 days agoGreat product. Helps under eye a lot.
Great product and a foundational piece of my skin care routine
