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The complete longevity trio for your most exposed skin - face, eyes, and lips.



  • Protect against 3 main drivers of lip skin aging with Bare Blush Lip Shield SPF 15+

  • Boosts visible radiance, firmness, and barrier resilience with OS-01 FACE Moisturizer

  • Strengthen delicate eye skin and boost visible elasticity with OS-01 EYE Cream

  • Dermatologist tested, fragrance-free, suitable for sensitive skin

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  • Skincare bottle labeled 'One Skin' on a beige backgroundOS-01 FACE MOISTURIZER
  • Clear bottle with black pump and 'One Skin' label on a light beige backgroundOS-01 EYE CREAM
  • Accepted National Eczema Association logo
  • Leaping bunny certified logo

OneSkin

Ingredients that complement the OS-01 PeptideTM

Hyaluronic acid
Supports hydration, plumpness, and elasticity in both facial skin and lips.

Vitamin E
A potent antioxidant that helps neutralize oxidative stress and supports daily repair from UV and environmental exposure.

Barrier-supporting lipids & oil
A tailored blend of biomimetic lipids and nourishing oils strengthens the skin barrier across facial skin, eye skin, and lips, helping improve comfort, softness, and long-term resilience.

How it works

Powered by the OS-01 Senescence Peptide™

Born from over a decade of longevity science, OS-01 is engineered to address a key driver of visible skin aging, supporting meaningful improvements in skin health today and over time to future-proof skin.

FACE, EYE + LIP TRIO

4.5
Rated 4.5 out of 5 stars
Based on 912 reviews
Total 5 star reviews: 702 Total 4 star reviews: 101 Total 3 star reviews: 42 Total 2 star reviews: 34 Total 1 star reviews: 33
88%would recommend these products
912 reviews
  • SK
    Sheila K.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Lip shield

    Have used it once because I forgot about it. Easy application and feels good, not thick.

  • NK
    Natalie K.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Finally a clean/plastic free lip option

    Love the metal applicator, the formula is nice, not too sticky, it doesn’t cake like other products, goes on smooth. PLEASE MAKE MORE COLORS!!!

  • TK
    Tamara K.
    Verified Buyer
    Reviewing
    OS-01 EYE CREAM
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Delightful!

    Am pleased to report this cream not only helps noticeably with wrinkles and fine lines, but I’m wearing less concealer now too. Customer service from this company has been five star too. Bravo!

  • BL
    Barbara L.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Lip treatment

    Lip SPF 15+ what a lovely lip treatment. This product is quite nourishing. The cooling metal applicator blends the creamy product as it melts into your lips.

    Makes my lips very soft and supple.

    I definitely recommend this lip treatment.

  • PW
    Patricia W.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Perfect for outdoor coverage

    I use this during my workouts in the sun, provides great benefits without being gummy or anything fake in it.

Full ingredient list

OS-01 FACE ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

OS-01 EYE Ingredients

Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum. *OS-01 Peptide.

OS-01 LIP SHIELD SPF 15+ BARE BLUSH ingredients

Active ingredients: Zinc Oxide 5.5%

Inactive ingredients: Simmondsia Chinensis (Jojoba) Seed Oil, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Water (Aqua), Garcinia Indica Seed Butter, Tocopheryl Acetate, Butylene/Ethylene/Styrene Copolymer, Glyceryl Oleate, Glyceryl Dioleate, Glycerin, Oleic Acid, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1, Dipalmitoyl Hydroxyproline, Trihydroxystearin, Sodium Hyaluronate, Glucomannan, Tetrahexyldecyl Ascorbate, Bisabolol, Decapeptide-52*, Ethylhexylglycerin, Caprylyl/Capryl Glucoside, Propanediol, Ectoin, Centella Asiatica Extract, Hippophae rhamnoides (Sea Buckthorn) Oil, Helianthus Annuus (Sunflower) Seed Oil, Copernicia cerifera (Carnauba) Wax, Tocopherol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic Acid, Lecithin, Lactic Acid, Octyldodecanol, Sorbitan Oleate, Alumina, Magnesium Oxide, Palmitic Acid, Iron oxides (CI 77491, CI 77492, CI 77499), Titanium Dioxide (CI 77891), Red 33 Lake (CI 17200), Red 7 Lake (CI 15850).

Drug Facts

Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen

Uses

  • Helps prevent sunburn
  • If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

  • For external use only.
  • Do not use on damaged or broken skin.
  • Stop use and ask a doctor if rash occurs.
  • Keep out of reach of children.

Citations

01Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

02 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042

03 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

04 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112

06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x

07 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1