This is a carousel. Use Next and Previous buttons to navigate

This is a carousel. Use Next and Previous buttons to navigate

Up to 25% off on your first 3 deliveries of a new subscription! Ends 1/19. Terms apply.

Free shipping on orders over $79.00 USD
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER
OS-01 FACE MOISTURIZER

OS-01 FACE MOISTURIZER

Topical Supplement
4.7
4.7 (6K)
Starter Kit Refill

Smooth and firm skin with our daily moisturizer for the face and neck, powered by the OS-01 Peptide™.01



  • Boosts hydration, elasticity, and barrier function

  • 96% showed an improvement in firmness and radiance

  • Dermatologist tested, fragrance-free, safe for sensitive skin

  • Exclusive early access to new products
  • Earn 2x points on all recurring orders
  • Easily change, skip or cancel anytime

Limited time offer: Stick with it, save more

1st SHIPMENT
15% off
2nd SHIPMENT
20% OFF
3RD SHIPMENT
25% OFF
OneSkin

Free shipping on orders over $79.00 USD

OneSkin

Try it risk-free! 45-day money back guarantee.

OneSkin

You’re earning [potential_points] points with the OneSkin Loyalty Program

You’re earning 99 points with OneSkin Loyalty Program

OneSkin

Benefits

Multitasking moisturizer that addresses the common signs of aging on areas exposed most to the environment

Hydration

Boosts barrier function, allowing your skin to retain moisture and stay hydrated.02

Firmness

Switches off the cells that degrade collagen, helping skin stay firm.01,03

Radiance

Enhances skin tone and texture, helping skin look and feel smooth and radiant.02

5-STAR REVIEWS

See why customers love OS-01 FACE

“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.

"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.

"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.

"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.

The proof is in the pictures

OneSkin
OneSkin
OneSkin

CLINICAL DATA

Visible results, scientifically validated

100

of participants had improved smoothness 02

96

of participants had improved firmness, radiance, and tone 02

90

of participants had improved elasticity 02

86

of participants had improved appearance of fine lines and wrinkles 02

The Science Behind OS-01 FACE

With age, skin becomes thinner, produces less collagen, proliferates at a slower rate, and accumulates damage. By analyzing key aging biomarkers in human skin samples before and after treatment in the lab, our scientists found that OS-01 FACE:

  1. Increases epidermal thickness 01
  2. Supports collagen biosynthesis pathways (increase in COL1A1 and collagen levels) 01,03
  3. Promotes cellular proliferation (increase in MKI67) 01


Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. (Zonari, A., et al. npj Aging, 2023) Note: In npj Aging publication, "Topical Pep 14" = OS-01 FACE

6 active ingredients that complement the OS-01 peptide

see all ingredients

Pracaxi Oil

Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.

Andiroba Oil

A seed oil that promotes healthy collagen and minimizes the effects of inflammation.

Niacinamide

A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.

Oleic Pau Mulato Extract

An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.

Allantoin

A skin-conditioning molecule that moisturizes and soothes irritated skin.

Hyaluronic Acid

A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.

Getting started with OS-01 FACE

Follow these easy steps for optimal results

  • Dispense 1-2 pumps onto fingers
  • Gently massage into skin on the face and neck
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Blocking Peptide™

The only peptide scientifically proven to reverse skin aging at the cellular level 01,02,03

Discover the Science

All Ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

Citations

01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

OS-01 FACE MOISTURIZER

4.7
Rated 4.7 out of 5 stars
Based on 6,083 reviews
Total 5 star reviews: 4.9k Total 4 star reviews: 774 Total 3 star reviews: 246 Total 2 star reviews: 70 Total 1 star reviews: 57
94%would recommend these products
Write a Review (Opens in a new window)
6,083 reviews
  • E
    ELizabeth
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    4 minutes ago
    5 Stars

    Love it works well

    Was this helpful?
  • TH
    Tracy h.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    7 hours ago
    Big changes!

    I have been using oneskin face and body lotion for 2 years now along with estradiol cream. I have seen big changes in texture with both my face and body and decreased dryness and skin irritation. I have recommended this to many friends. My only complaint is packaging. It is very difficult for me to change out the empty lotion canister due to thumb strength. I have even bought a new container to see if that would help. The body lotion would benefit from a longer more flexible straw or softer container so that you can get all the lotion out from the bottle.

    Was this helpful?
  • LK
    Leanna K.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Love!

    I love this product! It is transforming my skin.

    Was this helpful?
  • M
    Morgan
    Verified Buyer
    Reviewing
    OS-01 FACE MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    I like it

    I don't usually use moisturizer bc my skin doesn't need it but this is very light and absorbs well

    Was this helpful?
    OneSkin
    Yesterday

    Thank you so much for your fantastic feedback, Morgan! We are absolutely thrilled to hear that you're loving how light the OS-01 FACE feels! We truly appreciate you taking the time to share your experience with us!

  • AD
    Andrea D.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    OS-01

    Amazing results

    Was this helpful?
Show More

Related Articles

browse articles
OS-01 FACE: Clinically Validated to Support Your Skin’s Microbiome
  • SKIN SCIENCE; ONESKIN PRODUCTS

OS-01 FACE: Clinically Validated to Support Your Skin’s Microbiome

Get to Know OneSkin’s Topical Supplements: OS-01 FACE vs. OS-01 BODY
  • ONESKIN PRODUCTS

Get to Know OneSkin’s Topical Supplements: OS-01 FACE vs. OS-01 BODY

How OS-01 Can Help Your Collagen Levels As You Age
  • ONESKIN PRODUCTS

How OS-01 Can Help Your Collagen Levels As You Age

The Proof is in the Peptide: 12-Week Clinical Study Validates the Effects of OS-01
  • FROM THE ONESKIN LAB; INGREDIENTS

The Proof is in the Peptide: 12-Week Clinical Study Validates the Effects of OS-01

You may also like

NEW YEARS SUBSCRIBE AND SAVE TERMS

No code needed. Valid only on new subscriptions. Stay subscribed and save more with 15% off first shipment, 20% second shipment, 25% off third shipment of the same subscription. Ends January 19, 2026.