OS-01 LIP Mask
OS-01 LIP Mask
A deeply hydrating overnight lip mask powered by the OS-01 Peptide™ to restore smoother, fuller, healthier lips.01
- Stimulates collagen, elastin, and hyaluronic acid production
- 98% agreed their lips stayed hydrated for 8+ hours; 100% saw fewer wrinkles around the lips
- Dermatologist tested, fragrance-free, safe for sensitive skin
*Applies clear. Due to natural ingredients, color in compact may vary slightly.
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Benefits
Delivers immediate hydration and advanced protection from 3 types of aging for visibly healthier, more resilient lips.01
100% mineral protection
Non-nano zinc oxide prevents UV-induced damage including inflammation and collagen loss.01
Soothing + nourishing
92% agreed it feels instantly moisturizing upon application, keeping lips healthy and hydrated.01
Fuller, smoother lips
Boosts a key elastin production biomarker by +47%, helping preserve volume and minimizing the appearance of lines and wrinkles.01
5-star reviews
See why customers love OS-01 LIP SPF
“My lips appear plumper and deeper in color in an incredibly healthy and youthful appearance. I have tried high end and low end brands and nothing compares to the efficacy of this product.” – Caroline W.
"My lips have constantly felt softer. And I also had a special case because I had an eczema patch on my lips before I started using this product, and I was worried it would make it worse but it actually made it better! My eczema patch cleared up after a couple weeks of use. Huge fan of this product overall.” – Victoria Z.
“This definitely helped my chronically dry and chapped lips. I would make this my go to moving forward.” – Adam P.
CONSUMER PERCEPTION DATA
Real results that speak volumes
92
agree it delivers immediate hydration and moisture 01
88
agree it makes their lips feel soothed and protected 01
84
agree their lips felt nourished after 2 weeks 01
78
agree it provides long-lasting hydration and moisture 01
The science behind OS-01 LIP SPF
As you age, your lips lose resilience, structure, and regenerative capacity—especially under daily UV exposure. OS-01 LIP SPF is uniquely formulated to not only protect against sun damage but also support lip rejuvenation by addressing inflammation, aging markers, and structural decline at the cellular level.
In lab studies on ex vivo human skin samples, OS-01 LIP SPF:
- Shields lips from UV-induced damage, including inflammation (IL-8), tissue damage (MMP3), and aging (CDKN1A/p21) biomarkers
- Promotes elastin production (ELN) and reduces signs of existing aging (CDKN1A/P21 & CDKN2A/P16)
- Significantly increases epidermal thickness to support stronger, more resilient lips
Shown in lab studies on ex vivo human skin samples by measuring the relative expression levels of the ELN gene (2^-ddCt), which encodes elastin, in the dermis 24 hours after topical application.
5 active ingredients that complement the OS-01 peptide
How it works
Powered by the OS-01 Senescence Blocking Peptide™
The first and only peptide scientifically proven to reverse skin’s biological age.02,03
All ingredients
Active ingredients: Zinc Oxide 5.5%
Inactive Ingredients: Simmondsia, Chinensis (Jojoba) Seed Oil, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Water (Aqua), Garcinia Indica Seed Butter, Tocopheryl Acetate, Butylene/Ethylene/Styrene Copolymer, Glyceryl Oleate, Glyceryl Dioleate, Glycerin, Oleic Acid, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1, Dipalmitoyl Hydroxyproline, Trihydroxystearin, Sodium Hyaluronate, Glucomannan, Tetrahexyldecyl Ascorbate, Bisabolol, Decapeptide-52*, Ethylhexylglycerin, Caprylyl/Capryl Glucoside, Propanediol, Ectoin, Centella Asiatica Extract, Hippophae Rhamnoides Oil, Helianthus Annuus (Sunflower) Seed Oil, Copernicia Cerifera (Carnauba) Wax, Tocopherol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic acid, Lecithin, Beta-Sitosterol, Squalene, Lactic Acid, Palmitic acid. *OS-01 Peptide
Drug Facts
Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen
Uses
- Helps prevent sunburn
- If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.
Warnings
- For external use only.
- Do not use on damaged or broken skin.
- Stop use and ask a doctor if rash occurs.
- Keep out of reach of children.
OS-01 LIP Mask
- AAstridVerified ReviewerReviewingOS-01 LIP MaskI recommend this productRated 5 out of 5 stars19 hours agoGreat lip mask
I was part of the beta testing for this product. It’s one of the best lip masks I’ve used. Product stays on all night and isn’t sticky. My lips feel great in the morning. I’m seeing continuous improvements in wrinkles and softness of my lips.
- SSeptemberVerified ReviewerReviewingOS-01 LIP MaskI recommend this productRated 5 out of 5 starsYesterdayFuller, younger looking lips.
I participated in the beta testing program for this product, and this product works!
I'm 70, with thinning lips, especially noticeable in my upper lip. I used the product daily at night and within minutes after application, I sensed a warm feeling that felt like improved circulation of the entire lip area. After approximately one month, my bottom lip is definitely fuller.
After a few months of using this product, I have noticed that should I "smack" my lips, they feel so much fuller and my lip lines are less noticeable, and my upper lip is now looking fuller. I highly recommend this product!
- LLaurenVerified ReviewerReviewingOS-01 LIP MaskI recommend this productRated 5 out of 5 stars3 days agoLove this product
I love this product so much already. My lips already look better after just a couple of weeks, and I love the way the product feels. Definitely a new favorite!
- SWShari W.Verified ReviewerReviewingOS-01 LIP MaskI recommend this productRated 5 out of 5 stars1 week agoBy far the BEST lip product I've ever used
I was excited to be selected to beta test this new lip product and I was blown away! I live in an arid climate and lips are always dry, chapped and peeling...or should I say, they were. That instantly became a thing of the past. Upon the first application, my lips softened and I woke up with them still feeling soft and hydrated. At first, I would still need to apply some type of lip balm during the day, but in about a week that was no longer the case. My lips retain their moisture and feel soft and hydrated all day. I didn't notice a huge difference in the fullness of my lips, but I do see some added fullness. But honestly, I don't even care about that since it's been such a game-changer for the dry, cracked and peeling issues I had.
- NRNicole R.Verified ReviewerReviewingOS-01 LIP MaskI recommend this productRated 5 out of 5 stars1 week agoHoly Grail for dry lips!
I was fortunate enough to be a beta tester and I LOVE this product, it's the only one that keeps my lips moisturized at night (I'm a mouth breather). I do need to reapply during the day to maintain the lip moisture. I will definitely keep using this product. I 'm so excited for it to become available online. This will be my holy grail product- my lips suffer without it!
Citations
01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims.
02 Zonari, A.,et al.Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models.npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
03 Zonari A.,et al.Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation.J Cosmet Dermatol.2024; 23: 2135-2144. doi:10.1111/jocd.16242