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OS-01 EYE CREAM , Recurring

5.0
5.0 out of 5
5.0 out of 5
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White cylindrical container with a black pump on a beige background
OS-01 EYE CREAM Refill, Recurring
OS-01 EYE CREAM Refill, Recurring
White cylindrical container with a black pump on a beige background
OS-01 EYE CREAM Refill, Recurring
OS-01 EYE CREAM Refill, Recurring

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Details
  • Our proprietary OS-01 Senescence-Blocking Peptide™ visibly slows cellular skin aging, resulting in skin that feels and acts younger over time
  • Improves elasticity and firmness while smoothing the appearance of fine lines and wrinkles1,2
  • Clinically shown to deliver smoother, firmer, more youthful-looking eyes in 12 weeks1
  • Smooth, nourishing texture instantly absorbs into delicate eye-area skin, delivering soothing hydration with no residue
Clinical proof
  • +26% increase in elasticity after 3 months1
  • +27% increase in visible firmness after 12 months2
  • +17% increase in skin’s barrier resilience after 3 months1
  • -18% reduction in the appearance of fine lines and wrinkles after 12 months2

The Clinical Studies

3-Month Efficacy Study 

A clinical study conducted by a third-party research organization evaluated the effects of OS-01 EYE CREAM over 3 months in 22 participants aged 47–65. Participants applied OS-01 EYE CREAM to their periorbital skin 2x daily. Assessments included bioinstrumental measurements of skin hydration, barrier function, firmness, and elasticity, as well as expert photographs grading fine lines, wrinkles, under-eye puffiness, and dark circles. The study has been published in the International Journal of Cosmetic Science.

The results1:

  • +20 increase in hydration after 1 month; +32% increase in hydration after 3 months (Corenometer)
  • +14% increase in elasticity after 1 month; +26% increase in elasticity after 3 months (Cutometer)
  • +10% increase in firmness after 3 months (Cutometer)
  • +10% increase in barrier strength after 1 month; +17% increase in barrier strength after 3 months (Vapometer)

Consumer perception results:

  • 95% observed improved overall appearance after 3 months
  • 91% observed visibly more even tone and smoother texture after 3 months
  • 86% observed more radiant skin after 3 months
  • 82% observed visible improvements in firmness and elasticity after 3 months
  • 77% observed reduced visible eye puffiness after 3 months

12-Month Efficacy Study

A clinical study conducted by a third-party research organization evaluated the effects of OS-01 EYE CREAM over 12 months in 23 participants aged 47–60. Participants applied OS-01 EYE CREAM to their periorbital skin 2x daily and results were assessed by expert clinical grading.

The results2:

  • +19% increase in visible firmness after 6 months; +27% increase in visible firmness after 12 months (expert grading)
  • +23% increase in visible elasticity after 6 months; +29% increase in elasticity after 12 months (expert grading)
  • 18% reduction in the appearance of fine lines and wrinkles after 12 months (expert grading)

Consumer perception results:

  • 100% observed improved overall appearance after 12 months
  • 100% observed more radiant skin after 12 months
  • 96% observed visibly more even tone and smoother texture after 12 months
  • 95% observed improved firmness and elasticity after 12 months
  • 86% observed reduced appearance of eye bags after 12 months
  • 86% observed reduced appearance of visible dark spots after 12 months

Safety studies

OS-01 EYE CREAM is non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on its formula and clinical testing, it has been awarded the National Eczema Association Seal of Acceptance™.

Our commitment to the scientific process

OneSkin products are validated with a rigorous process from the lab to the clinic: Lab testing on human skin to evaluate the effect on the cellular level, consumer testing with real users to ensure optimal texture and feel, and third-party clinical studies to evaluate the effect on the human level over time.
Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

Ingredients
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum.
*OS-01 Peptide

How to use

Dispense ½ to 1 pump onto fingertip, then tap around eyes in a semi-circle until absorbed. Apply 2x daily.

Complete the Protocol

Concentrated longevity science for your fastest-aging, most delicate skin.

Abstract icon of an hour glass with a 3/4 circle around it

Powered by the OS-01 Peptide™

Works at the cellular level to help keep healthy cells thriving, reversing the visible effects of the senescent cells that break down collagen and elastin.

Abstract icon depicting skin layers

Improves elasticity + firmness

Supports skin's natural structure and strength, smoothing the look of fine lines and wrinkles.

Visibly smooths lines + wrinkles

Improves skin's texture and tone over time for a youthful, lifted look.

Abstract icon

Smooth, nourishing texture

Glides on and absorbs instantly, soothing delicate eye area skin with no greasy residue.

Abstract icon of an hour glass with a 3/4 circle around it

Powered by the OS-01 Peptide™

Works at the cellular level to help keep healthy cells thriving, reversing the visible effects of the senescent cells that break down collagen and elastin.

Abstract icon depicting skin layers

Improves elasticity + firmness

Supports skin's natural structure and strength, smoothing the look of fine lines and wrinkles.

Visibly smooths lines + wrinkles

Improves skin's texture and tone over time for a youthful, lifted look.

Abstract icon

Smooth, nourishing texture

Glides on and absorbs instantly, soothing delicate eye area skin with no greasy residue.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.5

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

Clinically validated results that build over time

Before-and-after comparison of under-eye dark circles on a person's face, with the top labeled BEFORE and the bottom labeled AFTER 12 WEEKS. The image shows close-up views of the left eye area with a dotted circle highlighting the skin region.

95%

reported smoother-looking and more even-toned skin after 4 weeks1

Before-and-after comparison of a person's eye area showing skin texture and wrinkles around the eye, with text reading 'BEFORE' and 'AFTER 12 WEEKS' on a beige sidebar.

95%

reported improved overall appearance after 12 weeks2

Before-and-after comparison of a closed eye showing skin texture and wrinkles around the eyelid, with dotted white outlines highlighting the treated area. The top panel is labeled BEFORE and the bottom panel is labeled AFTER 12 WEEKS.

86%

had improved elasticity after 12 weeks2

WEEK 1

Instant hydration you can feel 

  • OS-01 Peptide™ gets to work reversing the visible effects of senescent (dysfunctional, aging) cells
  • Supporting ingredients instantly hydrate and smooth
  • Caffeine visibly stimulates circulation
Month 1

Visibly smoother, firmer, more even-toned skin

  • +20% boost in hydration1
  • 95% observed visibly smoother texture and a more even tone1
  • 86% had improved elasticity after 12 weeks1
Month 12

Visibly healthier, firmer skin that looks, feels, + acts younger

  • +27% improvement in visible firmness2
  • +29% improvement in visible elasticity2
  • -18% reduced appearance of fine lines and wrinkles 
  • +25% improved radiance2 
  • 95% saw improvements in general appearance2

Key ingredients

A thick, creamy white swatch of cosmetic cream or lotion on a solid black background.
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Moringa oleifera seed extract

Protects skin cells against environmental pollutants that can trigger visible skin aging.

Biomimetic vegan collagen

This biodesigned vegan collagen peptide visibly boosts elastin, laminin, collagen, and fibronectin while most topical collagen fails to reach the deeper layers. 

Fucus vesiculosus algae extract

Helps reduce the appearance of dark circles and crow’s feet while enhancing overall skin luminosity.

All Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

Ingredients
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum.
*OS-01 Peptide

OneSkin Longevity Protocol

OS-01 EYE CREAM Refill, Recurring

Write a Review (Opens in a new window)
2 reviews
  • PB
    PAT B.
    Verified Buyer
    Reviewing
    OS-01 EYE CREAM Refill, Recurring
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    WOW!

    This eye cream is amazing! I ❤️ One Skin products and this incredible eye treatment does not disappoint!

    After a few weeks of use I can see a plumping of fine laugh lines and dark circles are completely gone!!

    In all of my (almost 83 years), I have never experienced such positive visibility of a skin care product.

    Thanks One Skin, you’re the best!!!

    Was this helpful?
    OneSkin
    1 month ago

    Hi Pat! Thank you so much for your incredible feedback, we love you!

    We're absolutely thrilled to hear that you're experiencing such amazing results with the plumping of fine laugh lines and the complete disappearance of dark circles after just a few weeks - that kind of visible transformation really means the world to all of us at OneSkin!

    What an incredible milestone to celebrate these results as you approach your 83rd birthday! Your enthusiasm and the "WOW!" really captures exactly the kind of transformative experience we hope our science-backed eye treatment delivers.

    We love that you're such a loyal OneSkin fan and that OS-01 EYE continues to exceed your expectations alongside our other products! Your dedication to the routine and the remarkable results you're seeing with the eye area plumping and dark circle improvement shows exactly how our targeted formulations can support your skin's natural processes.

    Thank you for all of your support!

  • VM
    Valerie M.
    Verified Buyer
    Reviewing
    OS-01 EYE CREAM Refill, Recurring
    I recommend this product
    Rated 5 out of 5 stars
    3 months ago
    Healing my keloid!!

    I’ve been using this cream on my eyes, yes, but also on a really significant keloid. Keloids are really hard to treat, if you know, you know. I’m shocked because my keloid has reduced in size by half.

    Was this helpful?

Frequently Asked Questions

What does OS-01 EYE CREAM actually do?

The skin around your eyes is often the first place visible aging appears due to higher levels of senescence and thinner skin.3,4 OS-01 EYE CREAM is formulated with a concentrated level of the OS-01 Peptide™ to address this accelerated aging and strengthen the skin barrier in this delicate area. The result is healthier, more resilient skin around the eyes with a visibly firmer, more lifted appearance over time.

Can I use OS-01 EYE CREAM with my other skincare products?

Yes. OS-01 EYE CREAM has not been shown to cause adverse reactions with other common actives, including retinol, vitamin C, or hyaluronic acid. Patch test when introducing any new product.

How long will one bottle last?

The 20 ml bottle lasts approximately 1–2 months when used as directed.

Citations

  1. Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025.) 
  2. Based on a third-party 12-month clinical study with 23 participants aged 47–60. 
  3. New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
  4. Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
  5. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)