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Hair

OS-01 HAIR

A breakthrough for thicker, denser, healthier hair.01 Introducing the first scalp serum powered by OS-01, proven to target cellular senescence02, a biological process linked to hair loss and thinning.03-08

Try it risk-free! 90 day money back guarantee.

OneSkin

BENEFITS

Daily serum designed to nourish the scalp and reactivate your hair’s natural growth cycle01

Prevent a root cause of hair thinning

Prevents the accumulation of the cells that contribute to a disrupted hair growth cycle due to age, stress, and genetics.03-09

Scalp health

Safe for sensitive skin and promotes a healthy scalp microbiome, which can help foster healthy follicle function and hair density.01,09

Thicker, denser, fuller hair

Key ingredients complement the OS-01 peptide to promote strong, healthy hair.01

CLINICAL DATA

Visible results, scientifically validated

86.67

of participants showed an increase in hair density (average +39.62%) after 6 months 01

83.33

participants showed an increase in hair thickness (average +42.58%) after 6 months 01

80

 of participants observed overall improvements in their hair after 3 months 01

76.67

of participants said the overall health of their hair improved after 6 months 01

5-STAR REVIEWS

See why customers love OS-01 HAIR

"Just fantastic regrowth in areas where I desperately needed it." — LaDonna L., Beta Tester

"It worked so well! No irritation and dried without leaving a residue." — Jodi F., Beta Tester

"This is a real solution. Others promise. This delivers. I can only imaging what I'd have to pay to have this in my daily routine—and yes, I will pay it. After a certain age, you pay what you must—not to look younger, but to look your best." — Queen E., Beta Tester

What makes OS-01 HAIR unique?

  • Proprietary ingredient
  • No harsh side effects
  • Lightweight & non-greasy
  • Drug-free
  • No prescription
  • Supports scalp health
    • OS-01 HAIR

    • Prescription Hair Treatments

    • X
    • X
    • X
    • X
    • X
    • Leading Supplement

    • X
    • N/A
    • X
    • Leading Hair Serum

    • X
    • Invasive Treatments (PRP, hair transplant, etc.)

    • X
    • X
    • N/A
    • N/A
    • DIY Oils

    • X
    • X
OneSkin

The science behind OS-01 HAIR

Emerging research shows that senescence in hair follicles is linked to age-related thinning, stress-induced thinning, and pattern balding. 03-08

New research also shows that reducing senescent cells in hair follicles can stimulate regeneration.10,11 That's how our OS-01 peptide, proven to decrease cellular senescence in both hair and skin models, targets hair loss and thinning at its source.02,09

To test OS-01 HAIR’s ability to address senescence, our scientists treated senescence-induced cells with OS-01 HAIR. The results showed significantly reduced senescence levels, making OS-01 HAIR a promising candidate for addressing a key biological process linked to hair thinning and loss.03-09

Getting started with OS-01 HAIR

Follow these easy steps for optimal results

  • Apply 1 mL of serum (approximately 2 full droppers) directly to your scalp and massage in with fingertips
  • Leave on, do not rinse
  • Use up to 2 times daily

Your OS-01 HAIR questions answered

HOW IT WORKS

Powered by the OS-01 Senescence Blocking Peptide™

The first and only peptide scientifically proven to target cellular senescence02,09, a biological process linked to hair loss and thinning.03-08

All Ingredients

Water, Glycerin, 1,2-Hexanediol, Butylene Glycol, Hydroxyacetophenone, Panthenol, Inulin, Helianthus Annuus (Sunflower) Sprout Extract, Cellulose Gum, Alpha-Glucan Oligosaccharide, Tetrasodium Glutamate Diacetate, Propanediol, Morus Nigra Leaf Extract, Arginine, Acetyl Tyrosine, Rehmannia Chinensis Root Extract, Pentylene Glycol, Sodium PCA, Erythritol, Chondrus Crispus, PEG-12 Dimethicone, Oryza Sativa (Rice) Bran Water, Decapeptide-52*, Calcium Pantothenate, Zinc Gluconate, Sodium Benzoate, Niacinamide, Ornithine HCL, Caprylyl Glycol, Polyquaternium-11, Citrulline, Hydrolyzed Soy Protein, Xanthan Gum, Glucosamine HCL, Disodium Succinate, Fisetin, Raspberry Ketone, Sodium Benzoate, Citric Acid, Potassium Sorbate, Arctium Majus Root Extract, Panax Ginseng Root Extract, Biotin. *OS-01 Peptide.

OS-01 HAIR

4.5
Rated 4.5 out of 5 stars
Based on 157 reviews
Total 5 star reviews: 103 Total 4 star reviews: 32 Total 3 star reviews: 16 Total 2 star reviews: 2 Total 1 star reviews: 4
86%would recommend these products
157 reviews
  • JH
    Jordan H.
    Verified Buyer
    Reviewing
    OS-01 HAIR peptide scalp serum
    I recommend this product
    Rated 4 out of 5 stars
    5 days ago
    Just started the product

    I can only give this four stars because I've only just started using it. Based on my research and what I've seen so far, it's definitely a special product. As for results, it's too early to tell because I've only just received my first bottle and haven't finished it yet.

    OneSkin
    5 days ago

    Hi Jordan! Thank you so much for your feedback and for taking the time to share your early experience with the OS-01 HAIR! We really appreciate you mentioning that it's still early in your journey (results typically become more noticeable with consistent use over time).Thanks for giving us a try, and we're excited for you to experience the results as you continue using it!

  • DB
    Diane B.
    Verified Buyer
    Reviewing
    OS-01 HAIR
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    Think it’s working

    I’m using this a scalp treatment for psoriasis and I think there has been an improvement

  • LS
    Lisa S.
    Verified Buyer
    Reviewing
    OS-01 HAIR peptide scalp serum
    I do not recommend this product
    Rated 2 out of 5 stars
    2 weeks ago
    Not cost effective.

    Why did a bottle only lasted 10 days with once a day application? Guess I won’t be able to see if it even works after 3 months.

    OneSkin
    2 weeks ago

    Hi Lisa! Thank you for reaching out. We really appreciate your feedback and can help here! You should be using 1mL of OS-01 HAIR per application, which would be about a full dropper or half the dropper 2x each application. With 50mL in the bottle this should have lasted you 25 days. You can reach us at https://www.oneskin.co/pages/contact-us and we can help if you still need assistance!

  • SA
    Stephani A.
    Verified Buyer
    Reviewing
    OS-01 HAIR peptide scalp serum
    I recommend this product
    Rated 5 out of 5 stars
    2 weeks ago
    Feeling good

    Do feel like I’ve noticed less “baldy” areas. Still too soon to tell.

  • C
    Carla
    Reviewing
    OS-01 HAIR
    I recommend this product
    Rated 5 out of 5 stars
    3 weeks ago
    5 Stars

    A new OneSkin night time lip balm was on my wish list. Thanks.

Citations

01 Shown in 6 month double-blind, independent, third-party clinical study with 30 participants using OS-01 HAIR and dermaroller daily. Results based on self-perception reporting and clinical measurements of anagen hairs per cm2, intermediate terminal hairs, hair shaft thickness, inter follicular mean distance, hair count per cm2, and scalp microbiome.

02 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

03 Mirmirani, Paradi., et al. Age-related hair changes in men: Mechanisms and management of alopecia and graying. Maturitas, 80(1), 58 - 62. 2015.https://www.sciencedirect.com/science/article/abs/pii/S0378512214003259

04 Shin, Wisoo et al. Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss. Developmental Cell, 53(2), 185 - 198. 2020https://www.sciencedirect.com/science/article/pii/S1534580720302318

05 Huang, Wen-Yen., et al. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction. Journal of Dermatological Science, 86(2), 114 - 122. 2017
https://www.sciencedirect.com/science/article/abs/pii/S0923181117300269 

06 Lee, Sunhyoung et al. Ganoderma lucidum extract attenuates corticotropin-releasing hormone-induced cellular senescence in human hair follicle cells. iScience 27(5), 2024https://pmc.ncbi.nlm.nih.gov/articles/PMC11068553/

07 Lingna Chen, Y.M.Y.F., et al. Cellular senescence: ageing and androgenetic alopecia. Dermatology, 239, 533-541. 2023.
https://karger.com/drm/article/239/4/533/836627/Cellular-Senescence-Ageing-and-Androgenetic 

08Bahta, Adiam W., et al. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression. Journal of Investigative Dermatology, 128(5), 1088 - 1094.2008.
https://www.jidonline.org/article/S0022-202X(15)33852-5/fulltext 

09 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

10 Pappalardo, Alberto., et al. Restoration of hair follicle inductive properties by depletion of senescent cells. Aging cell, 24(1). 2025.
https://pubmed.ncbi.nlm.nih.gov/39614601/ 

11 Baar, Marjolein P et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell, 169(1), 132-147. 2017.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5556182/  

12 Shown in a 3 month beta test (brand led consumer perception study) with 22 participants and daily application of OS-01 HAIR (no dermaroller).