Every product we create begins with a question: how can we develop innovative products that enhance skin health at its cellular level? When it came to developing OS-01 LIP Mask, the opportunity to create a breakthrough in lip aging was there. In a market filled with products that offer only temporary relief without addressing deeper biological changes, we knew our proprietary OS-01 Peptide™ could unlock new possibilities for lip skin.
But the journey from concept to execution wasn’t linear. It involved rigorous science, unexpected detours, and a willingness to return to the lab until we were confident that we had created a product that aligned with our core values and mission.
Why Did We Set Out To Develop a Lip Product?
Unlike the rest of your face, lip skin is thinner, lacks sebaceous (oil) glands, and produces no natural protective layer. This means that lips are extremely prone to damage, like UV radiation or pollution, which accelerates the aging process. Because they're so susceptible to this damage, the lips are among the first places to show signs of aging, including a loss of volume, wrinkles, and changes in texture and color.[1,2]
Since our proprietary OS-01 Peptide™ has been proven to extend skin health and reverse biological aging in skin, we set out to create a lip formula that not only hydrates but also restores long-term lip health at the cellular level.[3]
Scientific Research Isn't Always Linear
Innovation rarely moves in a straight line. OS-01 LIP Mask was no exception. While our formulation met our expectations in the lab, it didn't feel hydrating enough to beta testers.
For us, this was a defining moment. While some brands may be satisfied with formulas that pass for “good enough,” offering nice texture but little impact, for us, efficacy isn’t optional; it’s one of our core guiding principles. Hydration is non-negotiable when it comes to lip care, and without exceptional results in this category, we weren't satisfied. We aimed to create a final formula that wasn’t just deeply hydrating but also enjoyable to use, making it a natural part of your daily routine rather than just another product on your shelf.
How Is OneSkin’s R&D Process Different
Instead of launching, we decided to go back to the lab and reformulate until we developed a product that could deliver both usability and the cellular benefits you can expect from any OneSkin product. In most of the beauty industry, products are released after just a few rounds of reformulation, guided more by texture than by measurable skin health outcomes. At OneSkin, we take a different path. Our process is grounded in longevity science, with rigorous testing at every stage.
That commitment meant going through more than 30 iterations of OS-01 LIP Mask before arriving at a formula that not only met but exceeded our standards.
And The Results?
We knew that creating a lip treatment meant delivering benefits on two levels: measurable improvements at the cellular level, and real-world results that people could see and feel.
Lab Results
When the final OS-01 LIP Mask formula was put to the test in our lab, the results validated every round of extra work:
- Promotes hydration at the cellular level: OS-01 LIP Mask increased a key hyaluronic acid production biomarker (HAS2) by 51% on average compared to untreated skin. Since hyaluronic acid is responsible for attracting and holding onto moisture within the skin, this translates to a boost in the skin's ability to hydrate.[4]
- Protects against tissue damage: OS-01 LIP Mask decreased the expression of MMP3, a marker of tissue breakdown, by 34% compared to the leading peptide lip treatment, while boosting a key collagen production biomarker by 138% on average.[4]
Beta Testing
For OS-01 LIP Mask to become a daily ritual, it also needed to deliver results that people could feel within hours, days, and weeks of consistent use.
In consumer studies, participants experienced immediate and long-lasting hydration for over 8 hours, with 98% agreeing their lips stayed moisturized overnight. Over time, the improvements became even more noticeable: 81% of participants reported fewer wrinkles around the lips after 4 weeks, and 84% noted a reduction in lines directly on the lips after 8 weeks.[4]
The result? A lip treatment that delivers on both sides of the equation: cutting-edge longevity science and a rich, hydrating experience.
From Our Lab to Your Nightstand
The journey to OS-01 LIP Mask was neither fast nor simple. It required us to pause, listen, test, and start again—until we created a product that reflects our uncompromising mission: skincare that goes beyond beauty, targeting aging at the root cause.
OS-01 LIP Mask is here with deep overnight hydration and collagen support for smoother, fuller, healthier lips.
Ready to make OS-01 LIP Mask part of your daily ritual? Try using it with OS-01 LIP SPF, so your most vulnerable skin is protected, night and day.
Key Takeaways:
- Unlike facial skin, lips lack natural defenses, leaving them especially vulnerable to dehydration and visible signs of aging.
- Powered by the OS-01 peptide, OS-01 LIP Mask was designed to restore lip health at the root, not just provide temporary relief.
- Rather than compromise, OneSkin paused its first launch and re-engineered OS-01 LIP Mask to ensure that OS-01 LIP Mask provides excellent hydration and cellular benefits.
- In the lab, OS-01 LIP Mask proved its power: increasing hydration and collagen biomarkers and protecting against markers of tissue damage.
References:
- https://www.ncbi.nlm.nih.gov/books/NBK507900/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8251770/
- Zonari, A., et al. npj Aging, 2023
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
