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OS-01 HAIR SCALP SERUM

4.4
4.4 out of 5
4.4 (214)

OS-01 HAIR SCALP SERUM

Topical Supplement

4.4
4.4 out of 5
4.4 (214)
The first daily scalp serum powered by the OS-01 PeptideTM to help support fuller, thicker-looking hair with age and stress.



  • Nourishes the scalp, and promotes visibly thicker, fuller, denser hair01

  • 81% showed a +40% improvement in visible hair density after 6 months01

  • Dermatologist tested, fragrance-free, suitable for sensitive skin


Disclaimer: Dermaroller is for cosmetic use only. Not intended to diagnose, treat, cure, or prevent any disease.
SAVE 10%
$69.00 $62.00

1 month supply delivered every 1 month.

SAVE 20%
$217.00 $176.00

3 month supply delivered every 3 months.

SAVE 25%
$424.00 $321.00

6 month supply delivered every 6 months.

include dermaroller?

OS-01 HAIR Dermaroller

Free OneSkin Travel bag + EYE travel size + 2 dermarollers

$40 FREE
SUBSCRIPTION EXCLUSIVES
  • Plastic neutral refillable packaging
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  • Earn 2x points for free products on all recurring orders
  • Easily change, skip or cancel anytime

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BENEFITS

Daily scalp serum designed to nourish the scalp and support visibly healthier and younger-looking hair.

Promote hair longevity

Addresses visible hair changes associated with age and stress.

Hair health starts at the scalp

Suitable for sensitive skin and supports a healthy scalp microbiome to support healthy hair.

Support thicker, denser, fuller-looking hair

Key ingredients complement the OS-01 Peptide to promote strong, healthy-looking hair for progressive improvements in visible density and thickness.

CLINICAL DATA

Visible results, scientifically validated

81
of participants showed an increase in visible hair density (average +40%) after 6 months 01

78
of participants showed an increase in hair visible thickness (average +43%) after 6 months01

81
 of participants observed overall improvements in their hair after 3 months 01

78
of participants said the overall health of their hair improved after 6 months 01

5-STAR REVIEWS

See why customers love OS-01 HAIR

"Just fantastic growth in areas where I desperately needed it." — LaDonna L., Beta Tester

"It worked so well! No irritation and dried without leaving a residue." — Jodi F., Beta Tester

"This is a real solution. Others promise. This delivers. I can only imaging what I'd have to pay to have this in my daily routine—and yes, I will pay it. After a certain age, you pay what you must—not to look younger, but to look your best." — Queen E., Beta Tester

What makes OS-01 HAIR unique?

  • Proprietary ingredient
  • No harsh side effects
  • Lightweight & non-greasy
  • Drug-free
  • No prescription
  • Supports scalp health
    • OS-01 HAIR

    • Prescription Hair Treatments

    • X
    • X
    • X
    • X
    • X
    • Leading Supplement

    • X
    • N/A
    • X
    • Leading Hair Serum

    • X
    • Invasive Treatments (PRP, hair transplant, etc.)

    • X
    • X
    • N/A
    • N/A
    • DIY Oils

    • X
    • X

How to Apply OS-01 HAIR

  1. We recommend applying one full pipette (2 squeezes) to the entire scalp during each application.
  2. Fill the glass pipette by squeezing the applicator bulb, one squeeze will give you half the application dose.  Apply the serum directly to your scalp, starting at your natural part or hairline.
  3. Refill the glass pipette again, with a second squeeze, and continue applying to areas of concern to complete the full dose.
  4. Massage the serum into your scalp with your fingertips to ensure even distribution.
  5. Do not rinse. Style as usual.
  6. Use daily on dry or damp hair.

A 50 mL bottle of OS-01 HAIR should last approximately 30 days with regular use.

Your OS-01 HAIR questions answered

HOW IT WORKS

Powered by the OS-01 Senescence Blocking Peptide™

Born from over a decade of longevity science, OS-01 is engineered to address a key driver of visible skin, scalp, and hair aging, for skin and hair that looks and feels younger and healthier over time.02

All Ingredients

Water, Glycerin, 1,2-Hexanediol, Butylene Glycol, Hydroxyacetophenone, Panthenol, Inulin, Helianthus Annuus (Sunflower) Sprout Extract, Cellulose Gum, Alpha-Glucan Oligosaccharide, Tetrasodium Glutamate Diacetate, Propanediol, Morus Nigra Leaf Extract, Arginine, Acetyl Tyrosine, Rehmannia Chinensis Root Extract, Pentylene Glycol, Sodium PCA, Erythritol, Chondrus Crispus, PEG-12 Dimethicone, Oryza Sativa (Rice) Bran Water, Decapeptide-52*, Calcium Pantothenate, Zinc Gluconate, Sodium Benzoate, Niacinamide, Ornithine HCL, Caprylyl Glycol, Polyquaternium-11, Citrulline, Hydrolyzed Soy Protein, Xanthan Gum, Glucosamine HCL, Disodium Succinate, Fisetin, Raspberry Ketone, Sodium Benzoate, Citric Acid, Potassium Sorbate, Arctium Majus Root Extract, Panax Ginseng Root Extract, Biotin. *OS-01 Peptide.

OS-01 HAIR SCALP SERUM

4.4
Rated 4.4 out of 5 stars
Based on 214 reviews
Total 5 star reviews: 143 Total 4 star reviews: 38 Total 3 star reviews: 20 Total 2 star reviews: 6 Total 1 star reviews: 7
85%would recommend these products
214 reviews
  • NB
    Norma B.
    Verified Buyer
    Reviewing
    OS-01 HAIR
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Is Nice!!

    It gives my scalp a calm sensation and now that I’m my 2nd bottle I can see hair growing on my hairline so far so good

    Let’s see what happens in a few months im hopeful

  • GS
    Grace S.
    Verified Buyer
    Reviewing
    OS-01 HAIR SCALP SERUM
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    It’s working?!

    I lost a lot of hair after giving birth and I was starting to see a lot of my scalp. I’ve tried an handful of topical serums, shampoos, and even prescription pills and I haven’t really seen a difference in my hair growth in the past 3-4 years. After a recommendation from my sister, I tried the one skin serum along with micro needling and I’m now finally seeing little hairs sprouting!!!

  • T
    Tea
    Verified Buyer
    Reviewing
    OS-01 HAIR SCALP SERUM
    I do not recommend this product
    Rated 1 out of 5 stars
    2 days ago
    Worst Dandruff of my Life!

    At first I did not think it was this product that was causing my dandruff, but then after an intensive and successful anti-dandruff treatment (rotating through 3 different products at the direction of my doctor) I tired the scalp serum again and BAM! terrible dandruff returned in <24 hours. So I've since given up, despite having 2 more full bottles of serum waiting for me. It's just not worth the itching and other awful side effects. Apparently some people are "just more sensitive to yeast" (my doctor) and it looks like I'm one of those people! I recommend only ordering one bottle until you know how it is going to effect you!

    OneSkin
    5 minutes ago

    Hi Tea!

    Thank you so much for taking the time to share your experience in such detail — we are truly, deeply sorry to hear what you've been through. This is absolutely not the experience we ever want for any of our customers, and we genuinely apologize for the discomfort and frustration that OS-01 HAIR SCALP SERUM has caused you.

    We completely understand how distressing it must have been to go through an intensive treatment only to have the symptoms return so quickly. Your health and comfort always come first, and it's clear that OS-01 HAIR SCALP SERUM is simply not the right fit for your skin's unique sensitivities — and that truly breaks our hearts to hear.

    We also want to say that your advice to other customers to order just one bottle before committing is such a thoughtful and generous thing to share, and we really appreciate your care for others in the community.

    Again, we are so sorry that your experience with OS-01 HAIR SCALP SERUM was not a positive one. Your feedback is something we take very seriously, and we are grateful to you for sharing it so openly and honestly with us.

    We'd love to connect with you to learn more about your specific experience and see how we can make this right, especially since you have those two unopened bottles. A support team member will be reaching out shortly to learn more and help you further!

  • L
    Leah
    Verified Buyer
    Reviewing
    OS-01 HAIR SCALP SERUM
    I do not recommend this product
    Rated 2 out of 5 stars
    2 days ago
    No big results

    I have waited until I have almost used up all the product.

    I’ve been using it for 6 months. I have noticed less shedding, but absolutely no growth. I was really hoping to notice some change in my hair line but instead I think it actually looks thinner. For the cost, I was hoping for something. Definitely won’t be rebuying.

    OneSkin
    3 minutes ago

    Hi Leah!

    Thank you so much for your patience in using OS-01 HAIR SCALP SERUM for six full months and for sharing such detailed feedback with us — we really appreciate you taking the time to let us know about your experience.

    We're genuinely sorry that after this significant commitment, you're not seeing the hair growth and hairline improvements you were hoping for. We know our products represent a substantial investment, and we take that seriously — especially when you've been consistent and patient for this long.

    It's encouraging to hear that you've noticed less shedding, as that can be an important first step in the hair health journey, but we completely understand that it's not the visible progress you were looking for, particularly around your hairline. We know that's not the satisfying result you deserve after six months of dedication.

    Hair growth and regrowth can be influenced by many individual factors like genetics, hormones, age, stress levels, and underlying scalp conditions, and unfortunately results can vary significantly from person to person. We recognize that's not the answer you want to hear when you've invested both time and money into your hair care routine.

    We'd love the opportunity to learn more about your specific experience and see how we can make this right. Please reach out to our team at support@oneskin.co so we can discuss this further and find a better solution for you!

  • SW
    Stacy W.
    Verified Buyer
    Reviewing
    OS-01 HAIR
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    So far so good

    I am happy with this product as I have already noticed less shedding in just 2 weeks. I like the way I can use it on my scalp even in between hair wash’s. It leaves no residue!

Citations

01 Shown in 6 month double-blind, independent, third-party clinical study with 30 participants using OS-01 HAIR and dermaroller daily. Results based on self-perception reporting and clinical measurements of anagen hairs per cm2, intermediate terminal hairs, hair shaft thickness, inter follicular mean distance, hair count per cm2, and scalp microbiome.

02 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

More Scientific Resources

Mirmirani, Paradi., et al. Age-related hair changes in men: Mechanisms and management of alopecia and graying. Maturitas, 80(1), 58 - 62. 2015.https://www.sciencedirect.com/science/article/abs/pii/S0378512214003259

Shin, Wisoo et al. Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss. Developmental Cell, 53(2), 185 - 198. 2020https://www.sciencedirect.com/science/article/pii/S1534580720302318

Huang, Wen-Yen., et al. Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction. Journal of Dermatological Science, 86(2), 114 - 122. 2017
https://www.sciencedirect.com/science/article/abs/pii/S0923181117300269 

Lee, Sunhyoung et al. Ganoderma lucidum extract attenuates corticotropin-releasing hormone-induced cellular senescence in human hair follicle cells. iScience 27(5), 2024https://pmc.ncbi.nlm.nih.gov/articles/PMC11068553/

Lingna Chen, Y.M.Y.F., et al. Cellular senescence: ageing and androgenetic alopecia. Dermatology, 239, 533-541. 2023.
https://karger.com/drm/article/239/4/533/836627/Cellular-Senescence-Ageing-and-Androgenetic 

Bahta, Adiam W., et al. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression. Journal of Investigative Dermatology, 128(5), 1088 - 1094.2008.
https://www.jidonline.org/article/S0022-202X(15)33852-5/fulltext 

Pappalardo, Alberto., et al. Restoration of hair follicle inductive properties by depletion of senescent cells. Aging cell, 24(1). 2025.
https://pubmed.ncbi.nlm.nih.gov/39614601/ 

Baar, Marjolein P et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell, 169(1), 132-147. 2017.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5556182/