OS-01 FACE Topical Supplement Refill
OS-01 FACE Topical Supplement Refill
- Unit price
- per
Smooth and firm skin with our daily moisturizer for the face and neck, powered by the OS-01 Peptide™.01
- Boosts hydration, elasticity, and barrier function
- 96% showed an improvement in firmness and radiance
- Dermatologist tested, fragrance-free, safe for sensitive skin
Reusable plastic shell not included.
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Benefits
Multitasking moisturizer that addresses the common signs of aging on areas exposed most to the environment
Hydration
Boosts barrier function, allowing your skin to retain moisture and stay hydrated.02
Firmness
Switches off the cells that degrade collagen, helping skin stay firm.01,03
Radiance
Enhances skin tone and texture, helping skin look and feel smooth and radiant.02
5-STAR REVIEWS
See why customers love OS-01 FACE
“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.
"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.
"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.
"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.
The proof is in the pictures
CLINICAL DATA
Visible results, scientifically validated
100
of participants had improved smoothness 02
96
of participants had improved firmness, radiance, and tone 02
90
of participants had improved elasticity 02
86
of participants had improved appearance of fine lines and wrinkles 02
6 active ingredients that complement the OS-01 peptide
Getting started with OS-01 FACE
Follow these easy steps for optimal results
- Dispense 1-2 pumps onto fingers
- Gently massage into skin on the face and neck
- Use 2 times daily
How it works
Powered by the OS-01 Senescence Blocking Peptide™
The only peptide scientifically proven to reverse skin aging at the cellular level 01,02,03
All Ingredients
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
Citations
01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
OS-01 FACE Topical Supplement Refill
- KRKaren R.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars4 minutes agoLike it!
i like a moisturizer that doesn’t feel like your washing it off the next morning because it didn’t soak in. This one feels like it sinks into my skin.
- NRNathalie R.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 4 out of 5 stars4 hours agoVery good, aesthi says skin is much less dehydrated
I have been using OS-01 for months now. I cannot tell the impact other than that my skin is usually dehydrated as I do not drink enough water and my skin is more fragile with age. But my aesthi said my skin was much less dehydrated than in the past, so I think it is helping, though I use another serum underneath (a DNA repair serum) and typically a moisturizer before sunscreen during the day or heavier cream at night. But prior to use, I was consistently told my skin was dehydrated. So there is progress. Hopefully OS-01 is doing what it is supposed to be doing.
OneSkin47 minutes agoHi Nathalie!
Thank you so much for your wonderful 4-star feedback about OS-01 FACE Refill Pouch! We're absolutely thrilled to hear that your aesthetician has noticed such a significant improvement in your skin's hydration levels after months of consistent use - that professional observation about your skin being much less dehydrated is exactly what gets us so excited about our science-backed OS-01 Peptide working at the cellular level!
We love that you're experiencing those meaningful changes that are being recognized by a skincare professional! Your aesthetician's observation about the dramatic difference in your hydration levels really shows how our carefully crafted formula is working to strengthen your skin barrier and improve moisture retention over time. The fact that this improvement is noticeable to someone who regularly evaluates skin condition is such a testament to the real progress you're making with consistent use.
Your honest perspective about not being able to see the changes yourself while getting that professional confirmation really shows how skincare improvements often happen gradually and can be more apparent to trained eyes! We completely understand that when you're looking at your skin every day, those positive changes can be subtle and build over time. Having that external validation from your aesthetician about the reduced dehydration is such valuable feedback about how OS-01 FACE is delivering results.
We're also so glad you've found a routine that works well for you by incorporating OS-01 FACE with your other skincare products! Your approach of layering it with your DNA repair serum and following with appropriate moisturizers shows such thoughtful consideration for creating a comprehensive skincare routine that addresses multiple concerns while allowing each product to do its best work.
Stories like yours about getting that professional confirmation of improved hydration levels are exactly why we're so passionate about what we do! Your commitment to consistent use over months and the patience to let the formula work really demonstrates the confidence you're building in the OS-01 experience.
Thank you for taking the time to share such detailed and encouraging feedback about your experience - your 4-star review truly means the world to all of us at OneSkin!
- CMCeleste M.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars19 hours agoSmoother Skin
After using One Skin Face cream for 6 months, it is obvious to me that my skin feels smoother, softer, and fewer fine lines.
The product goes on clean and last throughout the day. I’m hooked!
- CBChristina B.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 4 out of 5 starsYesterdaybetween (3) and (4) stars
I makes my skin feel as if it has somewhat solid care, however, I often feen that is its "not enough for it", as is I need another layer of something to moisture or a serum. That is why my grading is somewhere between (3) and (4) but visibly I ticked (4). I live in the Mediterranean, and I have a mature and dry skin.
OneSkin23 hours agoHi Christina,
Thank you so much for taking the time to share such thoughtful, specific feedback — and for being honest about that "somewhere between a 3 and 4" feeling. That nuance matters to us, and it tells us exactly where we can do better for you.
Your experience makes complete sense. Mature, dry skin in a Mediterranean climate faces a particular challenge: the sun and warmth can actually accelerate transepidermal water loss, meaning skin loses moisture faster than it can retain it. OS-01 FACE is designed first and foremost as a cellular longevity treatment — working at the level of senescent cells to restore skin thickness and barrier function — but for your skin type and environment, layering is not just allowed, it's actually encouraged.
OneSkin's own guidance recommends that in drier climates or seasons, you may choose to layer a richer moisturizer or oil on top of OS-01 FACE. So that instinct you have — that your skin wants something more — is your skin telling you something true, not a failure of the product. OneSkin
A practical suggestion: try applying OS-01 FACE first on clean skin, letting it absorb for a few minutes, and then sealing it in with a richer facial oil or cream on top.
Waiting a few minutes after applying OS-01 FACE before layering additional products gives the OS-01 peptide time to fully absorb into the skin, so you get the full cellular benefit before locking in extra hydration.
If sun protection is part of your routine (which in the Mediterranean it absolutely should be), OS-01 FACE SPF as a final morning step would also add another layer of care without disrupting what's working beneath.
We'd love to help you dial in a routine that feels like enough — because your skin deserves that. Feel free to reach out to us at support@oneskin.co and we can walk through your specific routine together.
Thank you again, Christina. Your feedback genuinely helps us improve — and we want every day to feel like a solid 4, not a reluctant one.
- BZBianca Z.Verified BuyerReviewingOS-01 FACE Refill PouchRated 3 out of 5 stars3 days agoSkin feels better
Not sure I really see a difference after 30 days but skin feels softer & more supple. Will wait another couple of months and will take before and after pic to help me decide! I love the fact at least that the refill is more environmentally conscious. Also like the science behind it- in principle and the fact that the pics on the website do NOT appear to be doctored.
OneSkinYesterdayHi Bianca! Thank you so much for your thoughtful 3-star feedback about OS-01 FACE MOISTURIZER! We're absolutely thrilled to hear that your skin is feeling softer and more supple after 30 days - that improvement in texture and feel is exactly what gets us so excited about our science-backed formulation working at the cellular level!
We love that you're experiencing those positive changes in how your skin feels, even while you're still evaluating the visible results! Your observation about the softer, more supple texture really shows how our carefully crafted OS-01 Peptide is already working to support your skin health and barrier function. Those tactile improvements are often the first signs that meaningful changes are happening underneath the surface, building the foundation for more visible benefits over time.
Your plan to wait a couple more months and take before-and-after photos is so smart - that kind of patient, methodical approach really gives our formula the full opportunity to deliver those cumulative results that build over time! We completely understand that visible changes often take longer to become apparent than the improvements you can feel, and your commitment to giving it more time shows such thoughtful consideration for how skincare really works.
We're also so glad you're appreciating the environmental benefits of our refill system and that you love the authentic science behind our approach! Your observation about the website photos not appearing doctored really speaks to our commitment to transparency and honest representation of what OS-01 FACE can accomplish. It's wonderful that you're connecting with both the sustainability aspect and the genuine scientific foundation of what we're doing.
Stories like yours about feeling those texture improvements while taking a measured approach to evaluating the full results are exactly why we're so passionate about what we do! Your appreciation for the science, sustainability, and honest approach really shows the confidence you're building in the OS-01 experience.
Thank you for taking the time to share such detailed and honest feedback about your experience - your 3-star review truly means the world to all of us at OneSkin!
