Best Sellers Set
Full Size
Best Sellers Set
OS-01 FACE + OS-01 EYE
Full Size
Firm and hydrate with our top-selling duo for the face and delicate skin around the eyes, powered by the OS-01 PeptideTM.01
- Promote firmness with OS-01 FACE - 96% showed an improvement
- Increase hydration with OS-01 EYE - 88% showed an improvement
- Dermatologist tested, fragrance-free, safe for sensitive skin
- Exclusive early access to new products
- Earn 2x points on all recurring orders
- Easily change, skip or cancel anytime
✭ You’re earning 172 points with OneSkin Loyalty Program ✭
Limited time: Spend $150+, get free SPF.
Try it risk-free! 45 day money back guarantee.
You’re earning [potential_points] points with the OneSkin Loyalty Program
OS-01 FACE
See why customers love OS-01 FACE
“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.
"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.
"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.
"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.
OS-01 EYE
See why customers love OS-01 EYE
“The concentration of peptides in this product has made a difference, especially to the circles under my eyes. I haven’t needed to use concealer since beginning to use this product. The science behind this product is solid.” – Kathy L.
"I've tried all sorts of different eye creams; the best out there. I have a very thin skin around my eyes with many expression lines and wrinkles and this product has been the most efficient in minimizing them and nourishing my skin. I all using this day and night very religiously and have no intention of ever stopping." – Archontia T.
"I simply love One Skin OS-01 Eye cream. It is silky smooth, absorbs efficiently, and never feels heavy or greasy. I have noticed the fine lines under my eyes and early crows feet slowly vanishing. It's subtle but evident the more I use it. This is the best product I have ever tried." – Bridgette G.
"OS-01 EYE is fantastic. I wish I had taken pictures when I started using this a year ago. I'm certain my eyes look better now than they did before. It absorbs immediately and yet is there moisturizing the area around my eyes all day long. It even smooths out the rough bumps around my eyes. This is a wonderful product. I love it!" – Donna G.
Active ingredients that complement the OS-01 peptide
-
- Pracaxi Oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties. - Andiroba Oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation. - Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer. - Oleic Pau Mulato Extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing. - Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin. - Hyaluronic Acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
- Pracaxi Oil
- Pracaxi Oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties. - Andiroba Oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation. - Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer. - Oleic Pau Mulato Extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing. - Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin. - Hyaluronic Acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
OS-01 EYE
How to apply OS-01 EYE
Follow these easy steps for optimal results
- Dispense 1 pump onto tip of finger.
- Gently tap in a semi-circle around each eye, from the under eye to the eyelid and underneath the brow bone.
- Use 2 times daily.
OS-01 FACE
How to apply OS-01 FACE
Follow these easy steps for optimal results
- Dispense 1-2 pumps onto fingers.
- Gently massage into skin on the face and neck.
- Use 2 times daily.
How it works
Powered by the OS-01 Senescence Peptide™
The only peptide scientifically proven to reverse skin aging at the cellular level. 03,07
All Ingredients
OS-01 FACE:
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
OS-01 EYE:
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum. *OS-01 Peptide.
Citations
01Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
02 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
03 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
04 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
07 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
Best Sellers Set
- HHeatherReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 stars1 hour ago5 Stars
Great so far
- CFCassie F.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars3 hours agoFirmer, Feels healthier
I've been using the OS-1 face for almost a year. I see results with OS-1 face over other pharmaceutical grade products face producta tried. No redness or peeling like I have with retinol.
- AQAnn Q.Verified BuyerReviewingOS-01 FACE Topical Supplement RefillI recommend this productRated 5 out of 5 stars12 hours agoLove this product!
Love this product. The refill is so convenient.
- RBRaymond B.Verified BuyerReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 stars18 hours agoNo more crows feet
Excellent product my crows feet are disappearing
- JMJennifer M.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars19 hours agoMy Skin Loves This!
The OS-01 Face Moisturiser is thoughtfully formulated and lightweight in texture. It absorbs beautifully without feeling greasy or heavy, delivering hydration in a way that feels balanced and comfortable rather than overly rich. The finish is smooth and natural, leaving the skin looking fresh and well-moisturised without excess shine. It layers well with other skincare and sits comfortably under makeup, which makes it easy to use consistently both morning and night. What’s particularly appealing is the understated approach. It doesn’t rely on fragrance, flashy textures, or exaggerated promises. Instead, it focuses on supporting the skin barrier and long-term skin health in a way that feels calm, modern, and evidence-driven. Overall, this is a polished, well-formulated product that combines hydration with a more science-led philosophy around ageing and skin health. Ideal for those of us who appreciate skincare that feels intelligent, refined, and quietly effective.
All Ingredients
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
Citations
01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
02 Zonari, A., et al. npj Aging, 2023 03https://www.fda.gov/news-events/press-announcements/fda-advances-new-proposed-regulation-make-sure-sunscreens-are-safe-and-effective 04 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651070/ 05 https://academic.oup.com/bbb/article/72/12/3211/5941013 06 https://pubmed.ncbi.nlm.nih.gov/32522955/ 07 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068194/ `https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886
