Best Sellers Set
Full Size
Best Sellers Set
OS-01 FACE + OS-01 EYE
Full Size
Firm and hydrate with our top-selling duo for the face and delicate skin around the eyes, powered by the OS-01 PeptideTM.01
- Promote firmness with OS-01 FACE - 96% showed an improvement
- Increase hydration with OS-01 EYE - 88% showed an improvement
- Dermatologist tested, fragrance-free, safe for sensitive skin
- Exclusive early access to new products
- Earn 2x points on all recurring orders
- Easily change, skip or cancel anytime
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OS-01 FACE
See why customers love OS-01 FACE
“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.
"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.
"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.
"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.
OS-01 EYE
See why customers love OS-01 EYE
“The concentration of peptides in this product has made a difference, especially to the circles under my eyes. I haven’t needed to use concealer since beginning to use this product. The science behind this product is solid.” – Kathy L.
"I've tried all sorts of different eye creams; the best out there. I have a very thin skin around my eyes with many expression lines and wrinkles and this product has been the most efficient in minimizing them and nourishing my skin. I all using this day and night very religiously and have no intention of ever stopping." – Archontia T.
"I simply love One Skin OS-01 Eye cream. It is silky smooth, absorbs efficiently, and never feels heavy or greasy. I have noticed the fine lines under my eyes and early crows feet slowly vanishing. It's subtle but evident the more I use it. This is the best product I have ever tried." – Bridgette G.
"OS-01 EYE is fantastic. I wish I had taken pictures when I started using this a year ago. I'm certain my eyes look better now than they did before. It absorbs immediately and yet is there moisturizing the area around my eyes all day long. It even smooths out the rough bumps around my eyes. This is a wonderful product. I love it!" – Donna G.
Active ingredients that complement the OS-01 peptide
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- Pracaxi Oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties. - Andiroba Oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation. - Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer. - Oleic Pau Mulato Extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing. - Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin. - Hyaluronic Acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
- Pracaxi Oil
- Pracaxi Oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties. - Andiroba Oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation. - Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer. - Oleic Pau Mulato Extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing. - Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin. - Hyaluronic Acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
OS-01 EYE
How to apply OS-01 EYE
Follow these easy steps for optimal results
- Dispense 1 pump onto tip of finger.
- Gently tap in a semi-circle around each eye, from the under eye to the eyelid and underneath the brow bone.
- Use 2 times daily.
OS-01 FACE
How to apply OS-01 FACE
Follow these easy steps for optimal results
- Dispense 1-2 pumps onto fingers.
- Gently massage into skin on the face and neck.
- Use 2 times daily.
How it works
Powered by the OS-01 Senescence Peptide™
The only peptide scientifically proven to reverse skin aging at the cellular level. 03,07
All Ingredients
OS-01 FACE:
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
OS-01 EYE:
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum. *OS-01 Peptide.
Citations
01Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
02 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
03 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
04 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
07 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
Best Sellers Set
- TTiffanyReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars11 hours ago5 Stars
Love this moisturizer! I ran out for a few days and could feel a big difference.
- BNBarbara N.Verified BuyerReviewingBest Sellers SetI recommend this productRated 4 out of 5 stars14 hours agoTime will tell
I haven’t used long enough to notice any difference. I wish it felt a little more moisturizing.
OneSkin3 minutes agoHi Barbara!
Thank you so much for taking the time to share your feedback about the Best Sellers Set — we genuinely appreciate you giving our products a try, and we completely understand that it's still early in your skincare journey with OneSkin!
You're absolutely right that time will tell — skincare results, especially the cellular-level changes that our OS-01 Peptide creates, do take time to become visible. In OneSkin's clinical studies, participants typically start seeing improvements around the 4-6 week mark, with the most significant results appearing at 12 weeks of consistent use. We know it can feel like a leap of faith in those early weeks!
We also completely understand your feedback about wanting more moisture. Our OS-01 products are intentionally formulated with a lightweight consistency so the OS-01 Peptide can absorb effectively into the skin rather than sitting on top of it. One tip that many of our customers find helpful is applying the products on clean, slightly damp skin and allowing them to fully absorb before layering any additional moisturizer on top if your skin needs that extra hydration boost.
Since you're using the Best Sellers Set, you have multiple products working together — the PREP Facial Cleanser helps enhance absorption, while the OS-01 FACE and OS-01 EYE work at the cellular level to target senescent cells and support your skin's natural renewal process. That combination effect often becomes more noticeable with continued use.
We really appreciate the 4 stars and your patience as you give the products time to work! If you have any questions about your routine or need tips for getting the most out of your set, please feel free to reach out to support@oneskin.co — we're here to help.
Thank you for choosing OneSkin, Barbara!
- PMPeggy M.Verified BuyerReviewingOS-01 FACE Refill PouchI recommend this productRated 5 out of 5 stars18 hours agoFresh New Feeling
My skin feels moist and nourished. The environmentally packaging is also a nice touch and saves a little money.
- KKaseyReviewingOS-01 FACE MOISTURIZERI recommend this productRated 5 out of 5 starsYesterday5 Stars
Love this moisturizer. My skin feels and looks more firm and moisturized.
- MDMarilyn D.Verified BuyerReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 stars2 days agoLove this product
There is no better eye cream than One Skin.
All Ingredients
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
Citations
01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
02 Zonari, A., et al. npj Aging, 2023 03https://www.fda.gov/news-events/press-announcements/fda-advances-new-proposed-regulation-make-sure-sunscreens-are-safe-and-effective 04 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651070/ 05 https://academic.oup.com/bbb/article/72/12/3211/5941013 06 https://pubmed.ncbi.nlm.nih.gov/32522955/ 07 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068194/ `https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886
