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Best Sellers Set

Full Size

Best Sellers Set

OS-01 FACE + OS-01 EYE

Full Size

Firm and hydrate with our top-selling duo for the face and delicate skin around the eyes, powered by the OS-01 PeptideTM.01



  • Promote firmness with OS-01 FACE - 96% showed an improvement

  • Increase hydration with OS-01 EYE - 88% showed an improvement

  • Dermatologist tested, fragrance-free, safe for sensitive skin

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OS-01 FACE

See why customers love OS-01 FACE

“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.

"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.

"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.

"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.

OS-01 EYE

See why customers love OS-01 EYE

“The concentration of peptides in this product has made a difference, especially to the circles under my eyes. I haven’t needed to use concealer since beginning to use this product. The science behind this product is solid.” – Kathy L.

"I've tried all sorts of different eye creams; the best out there. I have a very thin skin around my eyes with many expression lines and wrinkles and this product has been the most efficient in minimizing them and nourishing my skin. I all using this day and night very religiously and have no intention of ever stopping." – Archontia T.

"I simply love One Skin OS-01 Eye cream. It is silky smooth, absorbs efficiently, and never feels heavy or greasy. I have noticed the fine lines under my eyes and early crows feet slowly vanishing. It's subtle but evident the more I use it. This is the best product I have ever tried." – Bridgette G.

"OS-01 EYE is fantastic. I wish I had taken pictures when I started using this a year ago. I'm certain my eyes look better now than they did before. It absorbs immediately and yet is there moisturizing the area around my eyes all day long. It even smooths out the rough bumps around my eyes. This is a wonderful product. I love it!" – Donna G.

Active ingredients that complement the OS-01 peptide

    1. Pracaxi Oil
      Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.
    2. Andiroba Oil
      A seed oil that promotes healthy collagen and minimizes the effects of inflammation.
    3. Niacinamide
      A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.
    4. Oleic Pau Mulato Extract
      An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.
    5. Allantoin
      A skin-conditioning molecule that moisturizes and soothes irritated skin.
    6. Hyaluronic Acid
      A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.
  1. Pracaxi Oil
    Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.
  2. Andiroba Oil
    A seed oil that promotes healthy collagen and minimizes the effects of inflammation.
  3. Niacinamide
    A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.
  4. Oleic Pau Mulato Extract
    An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.
  5. Allantoin
    A skin-conditioning molecule that moisturizes and soothes irritated skin.
  6. Hyaluronic Acid
    A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.

OS-01 EYE

How to apply OS-01 EYE

Follow these easy steps for optimal results

  • Dispense 1 pump onto tip of finger.
  • Gently tap in a semi-circle around each eye, from the under eye to the eyelid and underneath the brow bone.
  • Use 2 times daily.

OS-01 FACE

How to apply OS-01 FACE

Follow these easy steps for optimal results

  • Dispense 1-2 pumps onto fingers.
  • Gently massage into skin on the face and neck.
  • Use 2 times daily.

How it works

Powered by the OS-01 Senescence Peptide™

The only peptide scientifically proven to reverse skin aging at the cellular level. 03,07

All Ingredients

OS-01 FACE:
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

OS-01 EYE:

Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum. *OS-01 Peptide.

Citations

01Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

02 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042

03 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

04 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112

06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x

07 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1

Best Sellers Set

4.8
Rated 4.8 out of 5 stars
Based on 5,018 reviews
Total 5 star reviews: 4.3k Total 4 star reviews: 487 Total 3 star reviews: 164 Total 2 star reviews: 56 Total 1 star reviews: 60
94%would recommend these products
5,018 reviews
  • KR
    Karen R.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Like it!

    i like a moisturizer that doesn’t feel like your washing it off the next morning because it didn’t soak in. This one feels like it sinks into my skin.

  • CL
    Corey L.
    Verified Buyer
    Reviewing
    Best Sellers Set
    Rated 3 out of 5 stars
    2 hours ago
    Works fine but is overpriced

    This product works ok, but is definitely not a miracle. It is, however, pretty expensive relative to its efficacy.

    OneSkin
    48 minutes ago

    Hi Corey,

    Thank you for being honest with us — we genuinely appreciate it, and feedback like yours helps us show up better for every customer.

    We completely understand that "works ok" isn't the experience we're aiming to give you, and we believe there's more in store. OS-01 FACE and OS-01 EYE are designed to work at the cellular level — targeting the senescent cells that quietly drive skin thinning, loss of firmness, and dehydration over time. That kind of deep, lasting change builds gradually, and many customers find that the results really start to compound the longer they stay consistent.

    The science behind the Best Sellers Set is genuinely exciting: in our 12-week clinical study, 96% of participants showed improvement in firmness with OS-01 FACE, and 88% showed improvement in hydration with OS-01 EYE. Those numbers give us a lot of confidence that meaningful results are within reach for you too — it's often just a matter of giving the formula the time it needs to do its best work.

    We'd love to connect with you personally and make sure your routine is set up for success. Sometimes small adjustments — application technique, layering, or timing — can make a real difference in how quickly you start to see and feel the changes. Please reach out to us at support@oneskin.co and our team will be happy to walk through everything with you.

    We're rooting for you, Corey — the best results may still be just around the corner!

  • MS
    Maxine S.
    Verified Buyer
    Reviewing
    OS-01 EYE Refill
    I recommend this product
    Rated 5 out of 5 stars
    4 hours ago
    Love it!

    I love this product. After years of trying different products, this is my go to. It’s light, non- irritating and a little goes a long way.

  • NR
    Nathalie R.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 4 out of 5 stars
    4 hours ago
    Very good, aesthi says skin is much less dehydrated

    I have been using OS-01 for months now. I cannot tell the impact other than that my skin is usually dehydrated as I do not drink enough water and my skin is more fragile with age. But my aesthi said my skin was much less dehydrated than in the past, so I think it is helping, though I use another serum underneath (a DNA repair serum) and typically a moisturizer before sunscreen during the day or heavier cream at night. But prior to use, I was consistently told my skin was dehydrated. So there is progress. Hopefully OS-01 is doing what it is supposed to be doing.

    OneSkin
    47 minutes ago

    Hi Nathalie!

    Thank you so much for your wonderful 4-star feedback about OS-01 FACE Refill Pouch! We're absolutely thrilled to hear that your aesthetician has noticed such a significant improvement in your skin's hydration levels after months of consistent use - that professional observation about your skin being much less dehydrated is exactly what gets us so excited about our science-backed OS-01 Peptide working at the cellular level!

    We love that you're experiencing those meaningful changes that are being recognized by a skincare professional! Your aesthetician's observation about the dramatic difference in your hydration levels really shows how our carefully crafted formula is working to strengthen your skin barrier and improve moisture retention over time. The fact that this improvement is noticeable to someone who regularly evaluates skin condition is such a testament to the real progress you're making with consistent use.

    Your honest perspective about not being able to see the changes yourself while getting that professional confirmation really shows how skincare improvements often happen gradually and can be more apparent to trained eyes! We completely understand that when you're looking at your skin every day, those positive changes can be subtle and build over time. Having that external validation from your aesthetician about the reduced dehydration is such valuable feedback about how OS-01 FACE is delivering results.

    We're also so glad you've found a routine that works well for you by incorporating OS-01 FACE with your other skincare products! Your approach of layering it with your DNA repair serum and following with appropriate moisturizers shows such thoughtful consideration for creating a comprehensive skincare routine that addresses multiple concerns while allowing each product to do its best work.

    Stories like yours about getting that professional confirmation of improved hydration levels are exactly why we're so passionate about what we do! Your commitment to consistent use over months and the patience to let the formula work really demonstrates the confidence you're building in the OS-01 experience.

    Thank you for taking the time to share such detailed and encouraging feedback about your experience - your 4-star review truly means the world to all of us at OneSkin!

  • CM
    Celeste M.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    19 hours ago
    Smoother Skin

    After using One Skin Face cream for 6 months, it is obvious to me that my skin feels smoother, softer, and fewer fine lines.

    The product goes on clean and last throughout the day. I’m hooked!

All Ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

Citations

01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
02 Zonari, A., et al. npj Aging, 2023 03https://www.fda.gov/news-events/press-announcements/fda-advances-new-proposed-regulation-make-sure-sunscreens-are-safe-and-effective 04 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651070/ 05 https://academic.oup.com/bbb/article/72/12/3211/5941013 06 https://pubmed.ncbi.nlm.nih.gov/32522955/ 07 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068194/ `https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886