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Bundle

Head-to-Toe Skin Health Trio

OS-01 FACE + OS-01 EYE + OS-01 BODY

Get 12% off when you bundle

Get 20% off your first shipment of this bundle, then 13% off subsequent shipments

✭ You’re earning 262 points with OneSkin Loyalty Program ✭

SUBCRIPTION EXCLUSIVES

  • Plastic neutral refillable packaging
  • Exclusive early access to new products
  • Earn 2x points on all recurring orders
  • Easily change, skip or cancel anytime

Try it risk-free!Β 45 day money back guarantee.

  • Format Rich eye cream, lightweight facial moisturizer, nourishing body moisturizer
  • Targets Dehydration, thinning skin, loss of elasticity, dullness, barrier function
  • Suited to All skin types, safe for sensitive skin

Tackle cellular aging from head to toe with this essential bundle. Designed for the ultra-delicate skin around the eyes, OS-01 EYE improves collagen by up to 2.3x01, a root cause of sagginess, dark circles, and crow’s feet, OS-01 FACE targets cellular aging on areas most exposed to the environment02, and OS-01 BODY strengthens the skin barrier by up to 41%01 to help improve dry, crepey, and sagging skin.

OneSkin

Benefits

Everything you need to cleanse, hydrate, nourish, and protect your skin in one routine

Radiance

PREP gently exfoliates to slough away dullness and reveal brighter, healthier-looking skin.

Hydration

Topical supplements strengthen the skin barrier, allowing for better moisture retention and hydration.03,04

UV protection

OS-01 FACE SPF protects skin from UV damage, free radicals, and the effects of past aging.01

OS-01 FACE

See why customers love OS-01 FACE

β€œI stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.

"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.

"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.

"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.

OS-01 EYE

See why customers love OS-01 EYE

β€œThe concentration of peptides in this product has made a difference, especially to the circles under my eyes. I haven’t needed to use concealer since beginning to use this product. The science behind this product is solid.” – Kathy L.

"I've tried all sorts of different eye creams; the best out there. I have a very thin skin around my eyes with many expression lines and wrinkles and this product has been the most efficient in minimizing them and nourishing my skin. I all using this day and night very religiously and have no intention of ever stopping." – Archontia T.

"I simply love One Skin OS-01 Eye cream. It is silky smooth, absorbs efficiently, and never feels heavy or greasy. I have noticed the fine lines under my eyes and early crows feet slowly vanishing. It's subtle but evident the more I use it. This is the best product I have ever tried." – Bridgette G.

"OS-01 EYE is fantastic. I wish I had taken pictures when I started using this a year ago. I'm certain my eyes look better now than they did before. It absorbs immediately and yet is there moisturizing the area around my eyes all day long. It even smooths out the rough bumps around my eyes. This is a wonderful product. I love it!" – Donna G.

OS-01 BODY

See why customers love OS-01 BODY

β€œThe skin on my legs was starting to look older, dry and crepey at 46. Now it is plump and youthful like it was 10 years ago after only a few weeks.” – Jen A.

"The One skin, OS-O1 Body, has been a game changer, within a few weeks I saw a remarkable difference in the quality of my skin, and my skin's appearance continues to improve with daily application. It now has a tighter, less dry look and the texture has almost returned to my premenopause condition..more moist and fresh in appearance. Science is everything, and One Skin has got the science spot on." – Tia T.

"I love this body lotion. MyΒ crepeyΒ skin is transforming. I wish I had taken pictures before I started using it but I have tried so many different products with no results that I didn’t have much confidence that this one would be any different. Boy was I wrong. I’m hoping that it will eventually get rid of all my dark spots on my skin. I will be a forever customer..."– Myra P.

OUR APPROACH

Results that go beyond the lab

9

Years of Research

900

Peptides Screened

18

Patents & Publications

9000

5-Star Reviews

The science behind the Head-to-Toe Skin Health Trio

With age, skin becomes thinner, produces less collagen, proliferates at a slower rate, and accumulates damage. By analyzing key aging biomarkers in human skin samples before and after treatment in the lab, our scientists found that OS-01 FACE:

01 Increases epidermal thickness 02

02 Supports collagen biosynthesis pathways (increase in COL1A1 and collagen levels) 01,02

03 Promotes cellular proliferation (increase in MKI67) 02


Learn more


Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. (Zonari, A., et al. npj Aging, 2023) Note: In npj Aging publication, "Topical Pep 14" = OS-01 FACE

Active ingredients that complement the OS-01 peptide

  • Pracaxi oil
    Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.

    Andiroba oil
    A seed oil that promotes healthy collagen and minimizes the effects of inflammation.

    Niacinamide
    A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.

    Oleic Pau Mulato extract
    An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.

    Allantoin
    A skin-conditioning molecule that moisturizes and soothes irritated skin.

    Hyaluronic acid
    A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.

    See All Ingredients

Pracaxi oil
Known for its moisturizing, anti-inflammatory, antioxidant, anti-bacterial, and anti-fungal properties.

Andiroba oil
A seed oil that promotes healthy collagen and minimizes the effects of inflammation.

Niacinamide
A form of vitamin B that improves skin texture by promoting protein synthesis at the epidermal layer.

Oleic Pau Mulato extract
An Amazonian tree extract that smooths wrinkles, minimizes skin stress and supports skin healing.

Allantoin
A skin-conditioning molecule that moisturizes and soothes irritated skin.

Hyaluronic acid
A hydrating acid included in three molecular weights so that it can boost collagen and elastin, support epidermal regeneration, and maintain moisture in every layer of the skin.

See All Ingredients

OS-01 EYE

How to apply OS-01 EYE

Follow these easy steps for optimal resultsΒ 

  • Dispense 1 pump onto tip of finger.
  • Gently tap in a semi-circle around each eye, from the under eye to the eyelid and underneath the brow bone.
  • Use 2 times daily.

OS-01 FACE

How to apply OS-01 FACE

Follow these easy steps for optimal results

  • Dispense 1-2 pumps onto fingers.
  • Gently massage into skin on the face and neck.
  • Use 2 times daily.

OS-01 BODY

How to apply OS-01 BODY

Follow these easy steps for optimal results

  • Apply to arms, legs, chest, back, and stomach.
  • Massage until absorbed.
  • Use 2 times daily.

How it works

Powered by the OS-01 Senescence Peptideβ„’

The only peptide scientifically proven to reverse skin aging at the cellular levelΒ 02,07

All Ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

Citations

01 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

02 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age Β  and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

03 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

04 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042

05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112

06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x

07Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1

Head-to-Toe Skin Health Trio

4.7
Rated 4.7 out of 5 stars
Based on 4,840 reviews
Total 5 star reviews: 3.9k Total 4 star reviews: 594 Total 3 star reviews: 195 Total 2 star reviews: 77 Total 1 star reviews: 85
93%would recommend these products
4,840 reviews
  • CS
    Chris S.
    Verified Buyer
    Reviewing
    OS-01 EYE Refill
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Eyelids

    I have heavy eyelids and this works like magic to lift the skin up so it looks like I have a lid.

    Thank you for this product

  • MV
    Melissa V.
    Verified Buyer
    Reviewing
    OS-01 BODY
    I recommend this product
    Rated 5 out of 5 stars
    1 hour ago
    Love

    On my second bottle. Easy to apply, absorbs quickly leaving my skin smooth and well hydrated.

  • MG
    Megan G.
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    1 hour ago
    So Far, So Good

    I've only been using OneSkin for a few weeks, but so far I really like it. It's moisturizing without being greasy, and my skin feels very soft and hydrated. It smell vaguely of oatmeal to me, which is perfectly fine. It's not a strong scent at all.

    I'm using it on my hands as well because that will be the best way to see if it's working as it's supposed to. My hands look pretty decent for my age, but there is always room for improvement!

  • LC
    Lauri C.
    Verified Buyer
    Reviewing
    OS-01 EYE Refill
    I recommend this product
    Rated 5 out of 5 stars
    4 hours ago
    Lines have definitely softened

    I’ve been using the eye cream for several months and I have noticed a softening of crows feet.

  • AL
    Amy L.
    Verified Buyer
    Reviewing
    Head-to-Toe Skin Health Trio
    I recommend this product
    Rated 5 out of 5 stars
    20 hours ago
    Nothing else compares

    I have searched far and wide for a product that would rid me of creppy skin so I can achieve smooth plump skin again….and this set is it! My body has no more creppiness, my bags under my eyes are going away and the wrinkles Diminished! I am a believer!!!!xoxo