This is a carousel. Use Next and Previous buttons to navigate

This is a carousel. Use Next and Previous buttons to navigate

Free shipping on orders over $79.00 USD

OS-01 FACE MOISTURIZER

50 mL / 1.7 fl oz

OS-01 FACE MOISTURIZER

Topical Supplement

50 mL / 1.7 fl oz

Smooth and firm skin with our daily moisturizer for the face and neck, powered by the OS-01 Peptide™.01



  • Boosts hydration, elasticity, and barrier function

  • 96% showed an improvement in firmness and radiance

  • Dermatologist tested, fragrance-free, safe for sensitive skin

SAVE 15%
  • Exclusive early access to new products
  • Earn 2x points on all recurring orders
  • Easily change, skip or cancel anytime
OS-01 BODY, Travel Size

Travel-size OS-01 BODY with your first subscription

$37 FREE
OneSkin

Free shipping on orders over $79.00 USD

OneSkin

Try it risk-free! 45-day money back guarantee.

OneSkin

You’re earning [potential_points] points with the OneSkin Loyalty Program

You’re earning 99 points with OneSkin Loyalty Program

  • Leaping bunny certified logo
  • Accepted National Eczema Association logo
  • Certified Plastic Neutral logo on a white background
  • Clinically Tested to Support the Skin Microbiome

OneSkin

Benefits

Multitasking moisturizer that addresses the common signs of aging on areas exposed most to the environment

Hydration

Boosts barrier function, allowing your skin to retain moisture and stay hydrated.02

Firmness

Switches off the cells that degrade collagen, helping skin stay firm.01,03

Radiance

Enhances skin tone and texture, helping skin look and feel smooth and radiant.02

5-STAR REVIEWS

See why customers love OS-01 FACE

“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.

"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.

"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.

"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.

CLINICAL DATA

Visible results, scientifically validated

100
of participants had improved smoothness 02

96
of participants had improved firmness, radiance, and tone 02

90
of participants had improved elasticity 02

86
of participants had improved appearance of fine lines and wrinkles 02

Getting started with OS-01 FACE

Follow these easy steps for optimal results

  • Dispense 1-2 pumps onto fingers
  • Gently massage into skin on the face and neck
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Blocking Peptide™

The only peptide scientifically proven to reverse skin aging at the cellular level 01,02,03

All Ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

Citations

01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

OS-01 FACE MOISTURIZER

4.7
Rated 4.7 out of 5 stars
Based on 6,261 reviews
Total 5 star reviews: 5.1k Total 4 star reviews: 794 Total 3 star reviews: 254 Total 2 star reviews: 72 Total 1 star reviews: 62
94%would recommend these products
6,261 reviews
  • BD
    Bridget D.
    Verified Buyer
    Reviewing
    OS-01 FACE Topical Supplement Refill
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Great product

    I have very sensitive skin + rosacea & pretty much every other facial brand I've tried inflames it. Very glad I tried this product. Unscented, no flareups, and it keeps my face nicely moisturized and healthy-looking, no longer blotchy & flaky.

  • CG
    Caroline G.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    8 hours ago
    Great product

    Visible reduction in wrinkles

  • JJ
    June J.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    great refill

    it’s such a good idea to send refill pouches and not waste materials. The product is great. The refill is a really good idea.

  • AN
    Ann n.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Refill

    Game changer. Just wish they’d come out with refillable travel sizes! I travel weekly and bringing big sizes is such a bummer. Love the product

    OneSkin
    1 hour ago

    Hi Ann!

    Thank you so much for the 5-star review and for calling the OS-01 FACE Refill Pouch a "game changer" — that's exactly what we love to hear! We're thrilled that you're loving the product and that the refill system is working well for you.

    We completely understand your wish for refillable travel sizes, especially since you're traveling weekly! Having to bring the larger sizes when you're frequently on the go can definitely be a hassle, and we really appreciate you sharing this feedback with us. You can buy individual travel sizes as a one-time purchase in your subscription portal if needed!

    Your suggestion about refillable travel sizes is something that could be such a great addition for frequent travelers like yourself, and we genuinely value hearing what would make your OneSkin routine even more convenient and travel-friendly.

    Thank you for being such a dedicated OneSkin customer and for taking the time to share both your love for the product and your ideas for how we could make the travel experience even better!

  • PR
    Paola R. D.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Very good product!!!!

    I'm so grateful to have found this cream... fragrance-free, just with the necessary ingredients! And it works! My wrinkles are less visible... Thank you, One Skin!

    OneSkin
    Yesterday

    Hi Paola! Thank you so much for your wonderful 5-star feedback about OS-01 FACE MOISTURIZER! We're absolutely thrilled to hear that you're loving how this cream is working for you - seeing those wrinkles become less visible is exactly the kind of transformation that gets us so excited!

    We love that you're appreciating the fragrance-free formulation with just the necessary ingredients! Your recognition of that clean, science-focused approach really shows, and it's so exciting to hear that those carefully chosen ingredients are translating into real results that you can see on your skin. Stories like yours about experiencing visible improvements in wrinkle appearance while loving the simple, effective formulation are exactly why we're so passionate about what we do!

    Thank you for taking the time to share such encouraging feedback about your experience - your 5-star review truly means the world to all of us at OneSkin!