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OS-01 FACE MOISTURIZER

50 mL / 1.7 fl oz

Smooth and firm skin with our daily moisturizer for the face and neck, powered by the OS-01 Peptide™.01



  • Boosts hydration, elasticity, and barrier function

  • 96% showed an improvement in firmness and radiance

  • Dermatologist tested, fragrance-free, safe for sensitive skin

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White tube of 'ONE SKIN' topical supplement on a beige background

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Travel-size OS-01 BODY with your first subscription

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  • Leaping bunny certified logo
  • Accepted National Eczema Association logo
  • Certified Plastic Neutral logo on a white background
  • Clinically Tested to Support the Skin Microbiome

OneSkin

Benefits

Multitasking moisturizer that addresses the common signs of aging on areas exposed most to the environment

Hydration

Boosts barrier function, allowing your skin to retain moisture and stay hydrated.02

Firmness

Switches off the cells that degrade collagen, helping skin stay firm.01,03

Radiance

Enhances skin tone and texture, helping skin look and feel smooth and radiant.02

5-STAR REVIEWS

See why customers love OS-01 FACE

“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.

"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.

"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.

"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.

CLINICAL DATA

Visible results, scientifically validated

100
of participants had improved smoothness 02

96
of participants had improved firmness, radiance, and tone 02

90
of participants had improved elasticity 02

86
of participants had improved appearance of fine lines and wrinkles 02

Getting started with OS-01 FACE

Follow these easy steps for optimal results

  • Dispense 1-2 pumps onto fingers
  • Gently massage into skin on the face and neck
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Blocking Peptide™

The only peptide scientifically proven to reverse skin aging at the cellular level 01,02,03

All Ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

Citations

01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

OS-01 FACE MOISTURIZER

4.7
Rated 4.7 out of 5 stars
Based on 6,382 reviews
Total 5 star reviews: 5.2k Total 4 star reviews: 807 Total 3 star reviews: 258 Total 2 star reviews: 74 Total 1 star reviews: 64
94%would recommend these products
6,382 reviews
  • BU
    Bruce U.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    2 hours ago
    Face

    Everyone tells me how much younger than my age I look

    OneSkin
    6 minutes ago

    Hi Bruce!

    Thank you for the review! We are happy to hear you are enjoying the OS-01 FACE MOISTURIZER and that people are noticing how youthful you look!

  • ZF
    Zoe F.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    Rated 3 out of 5 stars
    17 hours ago
    Nice but not worth the $

    The face cream is light and nice but I never felt like it provided enough moisture. I'm just not sure it's worth the money.

    OneSkin
    5 minutes ago

    Hi Zoe!

    Thank you so much for taking the time to share your honest feedback about the OS-01 FACE — we really appreciate the 3 stars and are glad you're finding the texture light and nice!

    We completely understand your point about moisture levels, and we know that finding the right balance for your skin's hydration needs is so important. OS-01 FACE is formulated as a longevity serum that works at the cellular level to target senescent cells and support your skin's natural renewal process, so it's designed to be lightweight and absorb quickly rather than provide heavy moisture on its own.

    Many customers find that layering OS-01 FACE under their favorite moisturizer gives them the best of both worlds — the cellular benefits of our OS-01 peptide plus the level of hydration their skin craves. You might also consider trying it in combination with our OS-01 EYE or other hydrating products in your routine to boost that moisture factor.

    We totally understand your concern about the investment, and we know that premium skincare is a real consideration. The concentrated formula means you only need a small amount per application, and the cellular benefits tend to build over time with consistent use, but we definitely want you to feel like you're getting the value you're looking for.

    Thank you for choosing OneSkin and for being so thoughtful in your review, Zoe — feedback like yours helps other customers understand what to expect and how to best use our products!

  • JF
    Jonie F.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    23 hours ago
    Unmatched.

    Unmatched in its class of skin moisturizer. Having a refill ouch feels good too. My skin is soft yet firm.

  • YP
    Yennifer P.
    Verified Reviewer
    Reviewing
    OS-01 FACE MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    :)

    I have very sensitive skin, so I’m careful about the products I use. Maintaining a non-toxic lifestyle is important to me, and OneSkin has stood out as a brand I feel aligned with and supported by.

    This moisturizer is light, absorbs beautifully, and isn’t greasy. The scent is extremely subtle, almost like a soft oatmeal note and feels comforting rather than perfumed. I haven’t experienced any irritation or breakouts since using it.

    I actually started with this product, and I loved it enough to expand to more of their line. I now use their cleanser, body lotion, and both their body and face sunscreens, and I’m looking forward to trying their lip products next. Their formulations are science-driven and thoughtfully balanced, and I also appreciate the eco-friendly packaging and overall brand ethos.

    The subscription model is easy to manage, and their customer service has been consistently helpful. Overall, I truly value this company. It feels good to support a brand prioritizing skin health and responsible formulation!

  • DD
    Deborah D.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    90-Day Review: IT WORKS!

    My 58-year-old skin looks noticeably smoother and more cohesive since using One Skin in the morning and the evening for the last three months. I'm eager to see how my skin improves over the next three months! It is now and will continue to be part of my daily skin care routine.

    OneSkin
    4 minutes ago

    Hi Deborah! Thank you so much for your incredible 5-star feedback about your 90-day experience with OS-01 FACE MOISTURIZER! We're absolutely thrilled to hear that your skin looks noticeably smoother and more cohesive after three months of consistent morning and evening use - that kind of visible transformation and dedication to your routine really means the world to all of us at OneSkin!

    We love that you're seeing such wonderful improvements in both smoothness and cohesiveness after those three months of dedicated use! Your experience with how your 58-year-old skin is responding to our science-backed OS-01 Peptide really shows how our carefully crafted formulation is working to support your skin's natural renewal process. It's so encouraging that the changes are noticeable enough that you're excited about continuing the journey and seeing even more improvements ahead.

    Your commitment to using OS-01 FACE both morning and evening really demonstrates the kind of consistent approach that leads to the best long-term results! The fact that you're already planning to continue this as part of your daily skincare routine while being excited about the next three months shows exactly the kind of confidence-building experience we hoped you'd have with the refill pouch system.

    How exciting that you're not only seeing these wonderful results but also feeling so optimistic about the continued improvements ahead! The fact that OS-01 FACE has earned such a permanent place in your daily routine while delivering these visible changes really demonstrates how our approach to skin health is supporting your skin's ongoing vitality.

    Stories like yours about seeing noticeable improvements at three months while being eager for even more progress are exactly why we're so passionate about what we do! Your enthusiasm about the results and commitment to continuing your routine really shows the wonderful foundation you've built for long-term skin health.

    Thank you for taking the time to share such encouraging feedback about your 90-day OS-01 FACE experience - your 5-star review truly means so much to us!