A well-curated skincare regimen goes beyond mere beauty—it’s a commitment to longevity.
Let’s explore the fascinating science behind biological age and discover how OneSkin's OS-01 BODY slows the biomarkers of aging.
Understanding Biological Age
Biological age is about more than just the years you’ve been alive; it quantifies how well your body functions. When compared to your chronological age, it can provide insight into whether your habits and environment are working for you or against you.[1,2]
The GlycanAge Clock: A Revolutionary Approach
There are various biological, or molecular, clocks that are designed to measure the biological age of a complete body based on epigenetics and other biological signals. Since each organ has its own biological age, OneSkin has even pioneered a skin-specific molecular clock, MolClock, to predict skin’s biological age.
To measure our products' effects on aging across the entire body, we teamed up with GlycanAge, one of the most advanced and promising methods for measuring the biological age of the entire body.
The GlycanAge Clock leverages over 30 years of scientific research and more than 200,000 tests to assess biological age comprehensively. Similar to how MolClock measures methyl groups on DNA, GlycanAge measures the levels of complex sugar groups, known as glycan structures. Glycans attach themselves to proteins involved with immune function, called Immunoglobulin G (IgG), inhibiting their function. This process of glycosylation is known to accumulate with age, and by comparing baseline results to those after 12 weeks, subjects' relative change in biological age can be measured.[3]
The Connection Between Skin Aging and Longevity
Skin aging and overall longevity are intricately linked. As your skin ages, it reflects broader systemic changes that can impact your health. The mechanisms underlying skin aging are closely tied to cellular processes that affect your entire body. For example:
- Inflammation: Continued exposure to environmental pollutants and UV rays damages key structural proteins, like collagen, weakening the skin barrier and triggering skin inflammation. This inflammatory response is not isolated to the skin; it can spread throughout the body, leading to chronic inflammation and accelerated aging.[4]
- Cellular Senescence: External aggressors such as UV radiation can induce cellular senescence in skin cells. These cells accumulate over time and release inflammatory cytokines, further damaging surrounding tissues and weakening the skin barrier.[5]
In fact, a weakened skin barrier is considered a critical factor in the pathology of whole-body aging. Addressing these factors through skincare and lifestyle interventions can potentially influence your skin’s appearance and overall health and longevity.
OS-01 BODY: A Topical Longevity Supplement For Skin and Body
OS-01 BODY rewrites the rules of aging by tackling it at the source, ensuring your skin and health stay unstoppable.
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OS-01 BODY Reduces Systemic Inflammation
OS-01 BODY is clinically validated to reduce markers of systemic inflammation. After 12 weeks, participants using OS-01 BODY showed a reduction in overall inflammatory markers (cytokines), including a significant decrease in IL-8. In contrast, the control group showed a slight increase in inflammation, with significant rises in TNF-ɑ and IFN-γ levels.[6]
This indicates that OS-01 BODY may help reduce systemic inflammation and points to the skin’s pivotal role in whole-body inflammation.[6]
Chronic inflammation is a key contributor to aging and various age-related diseases. We hypothesize that by targeting cellular senescence in the skin with the OS-01 peptide, OS-01 BODY may alleviate circulating inflammation levels throughout the body.[7,8]
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OS-01 BODY May Slow Overall Biological Aging
Each participant's biological age was compared to their baseline statistics after 12 weeks. During this time, their biological age was expected to increase on average by +0.25 years. Instead, the experimental group using OS-01 BODY saw their biological age on average decrease by -0.07 years. This suggests that OS-01 BODY may have paused biological aging in participants. In contrast, the control group, which used a standard moisturizer for 12 weeks, saw increases in biological age by +0.72 years.[6]
Because of the small sample size, these changes in biological age were not statistically significant. However, it highlights the critical role that skin plays in overall longevity and OS-01’s potential to influence the aging process.
The Broader Implications: A Holistic Approach to Healthy Aging
At OneSkin, our mission is to improve the health of your largest organ, elevating skin care to health care. With our topical supplements, you’re not just investing in your skin; you’re embracing skin’s impact on your overall health and making skin care an aspect of a holistic approach to health.
Takeaways
- Choosing the right skincare is vital for beauty and enhancing long-term health.
- OneSkin’s partnership with GlycanAge to measure the effects of OS-01 BODY showed a slowdown of biological age across the entire body.
- OS-01 BODY improves barrier function, which may help reduce systemic inflammation, a major contributor to aging and age-related diseases.
- OneSkin redefines skin care as a form of health care, offering a holistic approach that merges scientific innovation with practical health solutions.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10726867/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996955/
- https://pubmed.ncbi.nlm.nih.gov/24325898/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8344376/
- https://onlinelibrary.wiley.com/doi/10.1111/jocd.70169
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15. 2023.
