OneSkin launches MolClock, the first skin-specific molecular clock to determine the biological age of human skin
8 min read
JUL 15, 2020
FROM THE OS LAB
OneSkin launches MolClock, the first skin-specific molecular clock to determine the biological age of human skin
8 min read
JUL 15, 2020
FROM THE OS LAB
In conversation with MolClock lead researcher and OneSkin co-founder Mariana Boroni, PhDOneSkin is proud to announce that the renowned scientific journal Clinical Epigenetics has published the company’s first publication, “Highly accurate Skin-Specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging.”
In conversation with MolClock lead researcher and OneSkin co-founder Mariana Boroni, PhDOneSkin is proud to announce that the renowned scientific journal Clinical Epigenetics has published the company’s first publication, “Highly accurate Skin-Specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging.”
Along with this publication, OneSkin is excited to share our new application programming interface (API), MolClock, the first ever skin-specific molecular clock designed to determine the chronological age of human skin.Devised by OneSkin co-founder and Head of Bioinformatics Mariana Boroni, PhD, in partnership with the OneSkin team, MolClock has the potential to drastically transform how scientists measure an individual’s skin molecular age which indicates one’s overall health, and the efficacy of skin products and interventions from a molecular level. While OneSkin owns the proprietary rights of MolClock, the tool is available for free and public use in an effort to forward the study of molecular aging and longevity research for scientists everywhere.We spoke with Mariana Boroni, PhD, who developed the machine learning based skin-specific molecular clock algorithm, to better understand the function of MolClock and the importance of the tool in connection with advancing aging research.
Along with this publication, OneSkin is excited to share our new application programming interface (API), MolClock, the first ever skin-specific molecular clock designed to determine the chronological age of human skin.Devised by OneSkin co-founder and Head of Bioinformatics Mariana Boroni, PhD, in partnership with the OneSkin team, MolClock has the potential to drastically transform how scientists measure an individual’s skin molecular age which indicates one’s overall health, and the efficacy of skin products and interventions from a molecular level. While OneSkin owns the proprietary rights of MolClock, the tool is available for free and public use in an effort to forward the study of molecular aging and longevity research for scientists everywhere.We spoke with Mariana Boroni, PhD, who developed the machine learning based skin-specific molecular clock algorithm, to better understand the function of MolClock and the importance of the tool in connection with advancing aging research.
01
Q: Congratulations on this tremendous achievement! Can you explain the function of MolClock, and how it relates to chronological aging?
Thank you! I am very excited about our results! The algorithm behind MolClock was constructed using machine learning to detect important epigenetic alterations that occur in our skin as we age. To train and test the MolClock algorithm, we used over 500 human skin samples and over 2,000 DNA methylation (DNAm) markers, achieving a highly accurate DNAm age predictor.“MolClock allows us to predict the molecular age of someone's skin based on their methylation profiles, which correlates strongly with one’s chronological age.”
01
Q: Congratulations on this tremendous achievement! Can you explain the function of MolClock, and how it relates to chronological aging?
Thank you! I am very excited about our results! The algorithm behind MolClock was constructed using machine learning to detect important epigenetic alterations that occur in our skin as we age. To train and test the MolClock algorithm, we used over 500 human skin samples and over 2,000 DNA methylation (DNAm) markers, achieving a highly accurate DNAm age predictor.“MolClock allows us to predict the molecular age of someone's skin based on their methylation profiles, which correlates strongly with one’s chronological age.”
MolClock allows us to predict the molecular age of someone's skin based on their methylation profiles, which correlates strongly with one’s chronological age. Exceptions occur when there are ongoing processes that influence one’s DNAm age such as diseases including cancer and psoriasis, inflammatory disorders and environmental exposures or lifestyle influences, such as smoking and obesity, which in most cases, will promote an acceleration of aging and increase the skin molecular age. Therefore, the DNAm age predicted by our tool is a highly accurate indicator of overall skin health.With this new tool, we can prospect and validate new compounds and treatments that are able to rejuvenate the skin by observing their power to reduce the skin DNAm age following treatment. Our ability to scientifically measure before and after findings of treatment significantly impacts our development of new products.
MolClock allows us to predict the molecular age of someone's skin based on their methylation profiles, which correlates strongly with one’s chronological age. Exceptions occur when there are ongoing processes that influence one’s DNAm age such as diseases including cancer and psoriasis, inflammatory disorders and environmental exposures or lifestyle influences, such as smoking and obesity, which in most cases, will promote an acceleration of aging and increase the skin molecular age. Therefore, the DNAm age predicted by our tool is a highly accurate indicator of overall skin health.With this new tool, we can prospect and validate new compounds and treatments that are able to rejuvenate the skin by observing their power to reduce the skin DNAm age following treatment. Our ability to scientifically measure before and after findings of treatment significantly impacts our development of new products.
02
Q: What is methylation and how does it impact molecular age?
Methylation is a common epigenetic signaling tool that cells use to control the gene's expression. DNA is made up of the nitrogenated bases adenine, cytosine, thymine and guanine - ATCGs. One of the bases (cytosine) has the ability to harbor methyl groups (CH3).These methyl groups can be added (methylation) or removed (demethylation) from specific regions of our DNA due to both intrinsic (aging, genetics) and extrinsic (environmental) factors, changing how our body reads the DNA segment, thus changing gene expression, without changing the DNA sequence. In this way, methylation of DNA coding regions for a certain gene can silence gene expression. The removal of the markers can lead to the opposite effect, activating the expression of genes that were not previously expressed. [1]What we find very interesting is that during aging, there is a global loss of DNA methylation. However, specific sites become hypermethylated and certain genes that are active when we are younger, turn off and therefore become dormant due to age-induced hypermethylation [2]. One example is collagen - as we age, a gene that produces a protein important for collagen production, SEC31, becomes hypermethylated, with more and more methyl groups added to the piece of DNA coding for this gene [2]. This gene hypermethylation-associated silencing plays an important role in the age-associated skin phenotype, likely leading to a reduced capacity of the cell to export the collagen protein. This reduction in collagen in our skin is one reason why our skin tends to be less firm when we get older.Although epigenetic alterations naturally occur as we age, scientists have proven that exogenous stimuli deriving from lifestyle, diet, and environmental exposure (such as UV radiation, smoking, physical activity, antioxidant intake, caloric restriction) or disease conditions, rather than genetics, pose greater influence over the methylation patterns of a person. [1,2,3]
02
Q: What is methylation and how does it impact molecular age?
Methylation is a common epigenetic signaling tool that cells use to control the gene's expression. DNA is made up of the nitrogenated bases adenine, cytosine, thymine and guanine - ATCGs. One of the bases (cytosine) has the ability to harbor methyl groups (CH3).These methyl groups can be added (methylation) or removed (demethylation) from specific regions of our DNA due to both intrinsic (aging, genetics) and extrinsic (environmental) factors, changing how our body reads the DNA segment, thus changing gene expression, without changing the DNA sequence. In this way, methylation of DNA coding regions for a certain gene can silence gene expression. The removal of the markers can lead to the opposite effect, activating the expression of genes that were not previously expressed. [1]What we find very interesting is that during aging, there is a global loss of DNA methylation. However, specific sites become hypermethylated and certain genes that are active when we are younger, turn off and therefore become dormant due to age-induced hypermethylation [2]. One example is collagen - as we age, a gene that produces a protein important for collagen production, SEC31, becomes hypermethylated, with more and more methyl groups added to the piece of DNA coding for this gene [2]. This gene hypermethylation-associated silencing plays an important role in the age-associated skin phenotype, likely leading to a reduced capacity of the cell to export the collagen protein. This reduction in collagen in our skin is one reason why our skin tends to be less firm when we get older.Although epigenetic alterations naturally occur as we age, scientists have proven that exogenous stimuli deriving from lifestyle, diet, and environmental exposure (such as UV radiation, smoking, physical activity, antioxidant intake, caloric restriction) or disease conditions, rather than genetics, pose greater influence over the methylation patterns of a person. [1,2,3]
03
Q: Why is skin so important as a measure of our overall health?
Skin is the largest organ in the human body, and is also our natural barrier against water loss, physical and chemical injury, and pathogenic infection. Our skin aide in our temperature regulation, vitamin production, protection against UV radiation, and sensation. Overall, our skin serves so many important functions, and is often overlooked as a vital component in keeping us safe and healthy.“...our skin serves so many important functions, and is often overlooked as a vital component in keeping us safe and healthy.”Unfortunately, our skin is highly influenced by environmental factors such as sun and pollution exposure, which is why it is extremely important to keep our skin healthy to promote overall health. Ultraviolet radiation (UVR) derived from sun exposure is well-known to be the most important cause of skin cancer and its association with environmental pollutants (including cigarette smoke) significantly increases the risk of skin cancer. [4,5] As the incidence rate of melanoma and non-melanoma skin cancer is dramatically increasing worldwide, it is essential that we change our habits in order to prevent the onset of the disease.
03
Q: Why is skin so important as a measure of our overall health?
Skin is the largest organ in the human body, and is also our natural barrier against water loss, physical and chemical injury, and pathogenic infection. Our skin aide in our temperature regulation, vitamin production, protection against UV radiation, and sensation. Overall, our skin serves so many important functions, and is often overlooked as a vital component in keeping us safe and healthy.“...our skin serves so many important functions, and is often overlooked as a vital component in keeping us safe and healthy.”Unfortunately, our skin is highly influenced by environmental factors such as sun and pollution exposure, which is why it is extremely important to keep our skin healthy to promote overall health. Ultraviolet radiation (UVR) derived from sun exposure is well-known to be the most important cause of skin cancer and its association with environmental pollutants (including cigarette smoke) significantly increases the risk of skin cancer. [4,5] As the incidence rate of melanoma and non-melanoma skin cancer is dramatically increasing worldwide, it is essential that we change our habits in order to prevent the onset of the disease.
04
Q: What inspired you to create MolClock?
The first molecular clock based on epigenetic alterations that predicted DNAm age with high accuracy across almost all human tissues and cell types was published in 2013 by Steve Horvath. [6] This algorithm, however, failed to accurately calculate the chronological age of cultured fibroblasts and epithelial cells [6,7] which are the cells that largely makeup our skin. Recently, other important and improved epigenetic clocks were published including The Skin & Blood Clock [7], DNA methylation PhenoAge [8], and DNA methylation GrimAge [9].Research has continued to show that each tissue (including our skin!) harbors a tissue-specific methylation landscape required for the stable maintenance of cell-type identity. Not only are overall methylation landscapes particular to each tissue, but age-related methylation changes are limited to specific local alterations highly dependent on tissue type as well. For this reason, each tissue in our body requires a tissue-specific molecular clock in order to increase measures of health accuracy and predictability.This motivated me to develop a skin-specific algorithm that calculates DNAm age of skin samples with higher accuracy and a lower error compared to existing molecular age estimators.
04
Q: What inspired you to create MolClock?
The first molecular clock based on epigenetic alterations that predicted DNAm age with high accuracy across almost all human tissues and cell types was published in 2013 by Steve Horvath. [6] This algorithm, however, failed to accurately calculate the chronological age of cultured fibroblasts and epithelial cells [6,7] which are the cells that largely makeup our skin. Recently, other important and improved epigenetic clocks were published including The Skin & Blood Clock [7], DNA methylation PhenoAge [8], and DNA methylation GrimAge [9].Research has continued to show that each tissue (including our skin!) harbors a tissue-specific methylation landscape required for the stable maintenance of cell-type identity. Not only are overall methylation landscapes particular to each tissue, but age-related methylation changes are limited to specific local alterations highly dependent on tissue type as well. For this reason, each tissue in our body requires a tissue-specific molecular clock in order to increase measures of health accuracy and predictability.This motivated me to develop a skin-specific algorithm that calculates DNAm age of skin samples with higher accuracy and a lower error compared to existing molecular age estimators.
05
Q: Can researchers outside of the OneSkin team use MolClock to further their own studies?
Yes, we encourage scientists outside our internal team to use MolClock! Our team’s ability to share our algorithm with the scientific community at large was actually an important motivator in my development of the algorithm.“Our new skin-specific molecular clock presents a valuable tool to investigate human skin aging, detect skin pathological conditions, and develop strategies to extend human life and healthspan.”The team at OneSkin is committed to advancing the science and knowledge underlying human aging which extends beyond the consumer products that we develop. We specifically built MolClock as a user-friendly platform where anyone across the globe can easily upload their methylation data to get the DNAm age prediction for each sample.
05
Q: Can researchers outside of the OneSkin team use MolClock to further their own studies?
Yes, we encourage scientists outside our internal team to use MolClock! Our team’s ability to share our algorithm with the scientific community at large was actually an important motivator in my development of the algorithm.“Our new skin-specific molecular clock presents a valuable tool to investigate human skin aging, detect skin pathological conditions, and develop strategies to extend human life and healthspan.”The team at OneSkin is committed to advancing the science and knowledge underlying human aging which extends beyond the consumer products that we develop. We specifically built MolClock as a user-friendly platform where anyone across the globe can easily upload their methylation data to get the DNAm age prediction for each sample.
06
Q: Describe how OneSkin utilized MolClock when developing their newest skin supplement OS-1.
Our skin-specific algorithm has put us at a real advantage in our ability to drive research and gather insights in the development of our newest skin formulation, OS-1. We applied our skin-specific DNAm age predictor to identify new strategies to promote skin rejuvenation by comparing the predicted age of skin tissues before and after treatment with new compounds. It is important to mention that we used samples from different donors across various ages. This screening strategy led us to the conclusion that our topical product, OS-1, featuring our proprietary peptide, can actually reduce the molecular age of skin.Using our MolClock, we have also studied the validity of another compound frequently used in skincare ingredients on the market that claim to rejuvenate skin. Our findings have proven that the power of rejuvenating skin by reducing the DNAm age generated by our OneSkin proprietary peptide is superior than the compound most frequently used in the market. For this reason, we really value the scientific markers behind our OS-1 product, and we feel confident sharing the science behind our proprietary formulation, as it is scientifically supported.
06
Q: Describe how OneSkin utilized MolClock when developing their newest skin supplement OS-1.
Our skin-specific algorithm has put us at a real advantage in our ability to drive research and gather insights in the development of our newest skin formulation, OS-1. We applied our skin-specific DNAm age predictor to identify new strategies to promote skin rejuvenation by comparing the predicted age of skin tissues before and after treatment with new compounds. It is important to mention that we used samples from different donors across various ages. This screening strategy led us to the conclusion that our topical product, OS-1, featuring our proprietary peptide, can actually reduce the molecular age of skin.Using our MolClock, we have also studied the validity of another compound frequently used in skincare ingredients on the market that claim to rejuvenate skin. Our findings have proven that the power of rejuvenating skin by reducing the DNAm age generated by our OneSkin proprietary peptide is superior than the compound most frequently used in the market. For this reason, we really value the scientific markers behind our OS-1 product, and we feel confident sharing the science behind our proprietary formulation, as it is scientifically supported.
References
- https://pubmed.ncbi.nlm.nih.gov/27518561/
- https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000971
- https://pubmed.ncbi.nlm.nih.gov/28198702/
- https://pubmed.ncbi.nlm.nih.gov/24281212/
- https://pubmed.ncbi.nlm.nih.gov/19651790/
- https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-10-r115
- https://pubmed.ncbi.nlm.nih.gov/30048243/
- https://pubmed.ncbi.nlm.nih.gov/29676998/
- https://pubmed.ncbi.nlm.nih.gov/30669119/
References
- https://pubmed.ncbi.nlm.nih.gov/27518561/
- https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000971
- https://pubmed.ncbi.nlm.nih.gov/28198702/
- https://pubmed.ncbi.nlm.nih.gov/24281212/
- https://pubmed.ncbi.nlm.nih.gov/19651790/
- https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-10-r115
- https://pubmed.ncbi.nlm.nih.gov/30048243/
- https://pubmed.ncbi.nlm.nih.gov/29676998/
- https://pubmed.ncbi.nlm.nih.gov/30669119/
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Why Is My Neck Aging So Fast?
6 Tips and Tricks for a Youthful Neck
Addressing the Need for Indoor Sun Protection
The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
OS-01 F...
Can Air Quality Affect Skin? Exploring the Impact ...
Understanding the Relationship Between Sleep and U...
Exploring the Effects of Quality Sleep on Your Ski...
How to Improve Gut Microbiome
Exploring Caloric Restriction and Its Effects on A...
What’s the Connection Between Quality Sleep and Lo...
Unlocking the Skin Benefits of Intermittent Fastin...
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
Cold Exposure: Hype or Longevity Boosting?
Eat Better, Live Longer: Top Foods for Longevity
How to Protect Your Skin from Everyday Environment...
Gut Health and Skin: How Are They Connected?
Pressing the Pause Button on Aging Skin: OS-01 BOD...
Lip Balm Ingredients: What to Look for and What to...
Exploring Blue Zones: How Can We Optimize Our Heal...
Sun Exposure and Your Skin: 6 Things You Need to K...
Nurturing Your Lips: How to Keep Them Moisturized ...
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care Products
The Importance of Sunscreen: Why Should You Wear I...
Lip Sunscreen: Do Lips Need SPF Protection?
The Science of Gratitude
Removing Sunscreen: Tips for Clean and Healthy Ski...
Skin Explained: Is Skin An Organ?
UV Light and Skin: Effects and Protection Strategi...
Understanding The Epidermis: Functions, Compositio...
Diving into Dermis: Functions and Significance
Unlocking the Science of Wrinkles: Causes, Formati...
Ingredient Spotlight: Bentonite Uses, Benefits, & ...
Why Skin Barrier is Important
Hypodermis: Exploring Its Vital Functions
The EU is Limiting Retinol in Skincare: Here’s Eve...
Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
A Journey Through the Skin: How UV Radiation Cause...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
How Do Our Products Work Together?
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
The Top 5 Benefits of Zinc Oxide for Skin
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
This is the Data to Look For When Choosing Skin Ca...
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
Beyond UV Protection: 7 Surprising Ways Sunscreen ...
Making Sense of Sunscreen: Understanding the Diffe...
Navigating Anti-Aging Skincare: The industry, the ...
Sun Spots: Causes & 3 Prevention Tips
Navigating Sunscreen Labels: Unwanted Ingredients ...
How to Prevent Skin Aging Before It Starts
Face vs. Body Sunscreen: Can You Use Body Sunscree...
Sun Damaged Skin: What it is, how you can prevent ...
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Difference Between Hydrating and Moi...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
How OS-01 Can Help Your Collagen Levels As You Age...
4 Essential Face Cleansing Steps to Achieving a Ra...
Cleansing 101: How to Wash Your Face the Right Way...
4 Essential Face Cleansing Steps to Achieving a Ra...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
Moved - What is Normal Skin & Do I Have This Skin ...
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
What Do Antioxidants Do For Skin and Why Should Yo...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
101 Guide To Restoring Dry Skin Around The Eyes Mo...
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
What is Epidermal Thickness & Why Does it Matter?
Hallmarks of Aging
What is Sensitive Skin?
Cell Turnover & Why It Slows As We Age
How to Reduce Skin Inflammation & Redness
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Are Parabens Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
The Science Behind Why The Skin Around the Eyes Ag...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
6 Factors That Contribute to Slow Skin Healing
4 Foods To Avoid During Wound Healing & Why
A Complete Guide to the 4 Stages of Wound Healing
Collagen And Elastin: What Role Do They Play In Sk...
What is the Function of Skin as a Protective Barri...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
How Does Sunscreen Work? How Long Does it Last?
What is the Best Skin Care Regimen for Aging Skin?
What happens to skin as a person ages?
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Invasive vs. Non-Invasive Skincare: The pros and c...
6 Benefits of Jojoba Oil
What are the Benefits of Sulforaphane?
What is Sustainable Packaging for Cosmetic Product...
7 Benefits of Andiroba Oil For Skin
Why is my Skin Peeling on My Face?
What Are The Causes Of Dry, Flaky Skin On Your Fac...
PREP enhances the effects of OS-01 FACE, and the p...
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
Allantoin For Skin: A Comprehensive Guide
Ceramides For Skin: Everything You Need to Know
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
What Causes Crepey Skin & Can It Be Avoided Altoge...
Does Niacinamide Help With Acne & Scarring?
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide on The Benefits of Cleansing Your Face
How OneSkin Developed the OS-01 Peptide
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
You’re only as old as you feel, scientists are fin...
Collagen For Menopause: Why Is It Necessary For He...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Connection Between Mental Health, Age Percepti...
The Top 6 Best Antioxidants For Skin Health and Lo...
What are Zombie Cells & How Can We Remove Them?
SKIN CARE IS HEALTH CARE: WHY EXTENDING YOUR SKINS...
How chronic stress makes you age faster
OneSkin Notable Mention: OneSkin Featured In Tony ...
Niacinamide Vs Retinol: How Do They Compare?
What Is Causing the Uneven Skin Tone On Your Body?
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Skin Hyperpigmentation 101: What It Is & How To Tr...
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
Celebrating Black History Month: A Discussion With...
Celebrating Black History Month: A Discussion With...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Where Skin Health Meets Longevity
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
OneSkin launches MolClock, the first skin-specific...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging