This is a carousel. Use Next and Previous buttons to navigate

This is a carousel. Use Next and Previous buttons to navigate

Subscribe & save 15%

Free shipping on orders over $79.00 USD

Full Longevity Defense Set

OS-01 FACE + OS-01 BODY

Full Size

Regular price $342.00$290.00
Unit price
per 

A complete, head-to-toe skin longevity system, designed to support collagen and barrier strength.




  • Prevent UV-induced collagen loss, build barrier resilience, and boost visible firmness and with OS-01 FACE and OS-01 BODY Moisturizers




  • Reverse the visible signs of UV aging and protect against future exposure with OS-01 FACE SPF 30+ and OS-01 BODY SPF 30+




  • Dermatologist tested, fragrance-free, suitable for sensitive skin



✭ You’re earning 290 points with OneSkin Loyalty Program ✭

OneSkin

Free shipping on orders over $79.00 USD

OneSkin

Try it risk-free for 30 days!

OneSkin

You’re earning [potential_points] points with the OneSkin Loyalty Program

  • Limited Edition OneSkin BagLimited Edition OneSkin Bag
  • Skincare bottle labeled 'One Skin' on a beige backgroundOS-01 FACE MOISTURIZER
  • [ Light ]OS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++
  • White bottle with black pump and 'One Skin' logo on a beige backgroundOS-01 BODY MOISTURIZER
  • Tube of One Skin body SPF cream on a beige backgroundOS-01 BODY SPF BROAD SPECTRUM SPF 30 PA+++
  • Accepted National Eczema Association logo
  • Leaping bunny certified logo

OneSkin

A complete system built to protect collagen and future-proof skin

The OS-01 Peptide™
Engineered to address cellular senescence, a leading driver of visible skin aging

Non-nano zinc oxide
Protects against UV aging and damage with mineral broad spectrum SPF 30+ defense

Potent antioxidants
Combat oxidative aging from environmental stress

How it works

Powered by the OS-01 Senescence Peptide™

Born from over a decade of longevity science, OS-01 is engineered to address a key driver of visible skin aging, supporting meaningful improvements in skin health today and over time to future-proof skin.

Full Longevity Defense Set

4.6
Rated 4.6 out of 5 stars
Based on 1,756 reviews
Total 5 star reviews: 1.4k Total 4 star reviews: 173 Total 3 star reviews: 95 Total 2 star reviews: 54 Total 1 star reviews: 63
88%would recommend these products
1,756 reviews
  • M'
    Marilyn '. P.
    Verified Buyer
    Reviewing
    OS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Protective Radiant Glow

    Skin Protection is ESSENTIAL for longevity.

    OS-01 Face SPF is the extra OOOMPH against the reality of sun exposure, including for cloudy days. I use this moisturizer SPF in addition to OS-01 Face. NO zinc white appearance nor heaviness…only smooth radiant glowing skin.

    Thank you OS-01!!!!!!!!

  • JO
    Jennifer O.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    19 hours ago
    Best body moisturizer I’ve ever used

    After a couple of uses my dry scaley skin greatly improved and hyperpigmentation noticeably lightened

  • PW
    Patricia W.
    Verified Buyer
    Reviewing
    OS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++
    I recommend this product
    Rated 5 out of 5 stars
    19 hours ago
    Great product for outdoor activities

    I bike 3 times a week, this formulation is great for sports demands and doesn’t run into your eyes.

  • RB
    Rebecca B.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    19 hours ago
    OS daily moisturizer

    I’ve been using the daily moisturizer for 2 wks and I’m already seeing a difference in my crepey skin.

  • YP
    Yennifer P.
    Verified Reviewer
    Reviewing
    OS-01 FACE MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    20 hours ago
    :)

    I have very sensitive skin, so I’m careful about the products I use. Maintaining a non-toxic lifestyle is important to me, and OneSkin has stood out as a brand I feel aligned with and supported by.

    This moisturizer is light, absorbs beautifully, and isn’t greasy. The scent is extremely subtle, almost like a soft oatmeal note and feels comforting rather than perfumed. I haven’t experienced any irritation or breakouts since using it.

    I actually started with this product, and I loved it enough to expand to more of their line. I now use their cleanser, body lotion, and both their body and face sunscreens, and I’m looking forward to trying their lip products next. Their formulations are science-driven and thoughtfully balanced, and I also appreciate the eco-friendly packaging and overall brand ethos.

    The subscription model is easy to manage, and their customer service has been consistently helpful. Overall, I truly value this company. It feels good to support a brand prioritizing skin health and responsible formulation!

Full ingredient list

OS-01 BODY Moisturizer

Water, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Avena Sativa (Oat) Kernel Oil, Squalane, Prunus Domestica Seed Oil, Saccharide Isomerate, Cetearyl Olivate, d-Panthenol, Mangifera Indica (Mango) Seed Butter, Tremella Fuciformis (Mushroom) Extract, Tocopheryl acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NP, Anadenanthera Colubrina Bark Extract, Lepidium Sativum Sprout Extract, Genistein, Niacinamide, Glycerol, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Citric Acid, Sodium Citrate, Pentylene Glycol, Potassium Sorbate, Ethylhexylglycerin, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

OS-01 BODY SPF 

Active Ingredients:Zinc Oxide 14%

Inactive ingredients:Caprylic/Capric Triglyceride, Butyloctyl Salicylate, C13-15 Alkane, Stearalkonium Hectorite, Coconut Alkanes, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Propylene Carbonate, Quaternium-90 Bentonite, Butyrospermum Parkii Nut Extract, Decapeptide-52*, Camellia Oleifera (Tea) Seed Oil, Caesalpinia Spinosa Fruit Pod Extract, Helianthus Annuus (Sunflower) Sprout Extract, Aloe Barbadensis Leaf Extract, Carthamus Tinctorius Seed Oil, Lactobacillus/Acerola Cherry Ferment, Coco-Caprylate/Caprate, Ceramide NP, Ceramide AP, Ceramide EOP, Ethylhexylglycerin, Caprylyl Glycol, Hexylene Glycol, Polyhydroxystearic acid, Polyglyceryl-3 Polyricinoleate, Isostearic acid, Lecithin, Phytosphingosine, Cholesterol, Sodium lauroyl lactylate, Carbomer, Xanthan gum, Water, Propylene Glycol, Triethyl Citrate, Citric Acid, Sodium Benzoate, and Phenoxyethanol.*OS-01 Peptide

Drug Facts

Active Ingredients: Zinc Oxide 14% …………Purpose: Sunscreen

Uses

Helps prevent sunburn

If used as directed with other sun protection measures (see Directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

For external use only.

Do not use on damaged or broken skin.

When using this product keep out of eyes. Rinse with water to remove.

Stop use and ask a doctor if rash occurs.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

OS-01 FACE Moisturizer

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

OS-01 FACE SPF 

Active Ingredients: Zinc Oxide 17.5%

Inactive ingredients (all tints): Water (Aqua), Caprylic/Capric Triglyceride, Glycerin, Methyl Dihydroabietate, Cetearyl Alcohol, Cetyl Palmitate, Coco-Glucoside, Caprylyl/Capryl Glucoside, Sorbitan Palmitate, Sorbitan Olivate, Butyrospermum Parkii (Shea) Nut Extract, Ethyl Ferulate, Bisabolol, Allantoin, Hydrolyzed Jojoba Esters, Acacia Senegal Gum, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic Acid, Lecithin, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Decapeptide-52*, Oryza Sativa (Rice) Starch, Camellia Sinensis Leaf Extract, Euterpe Oleracea Fruit Extract, Caesalpinia Spinosa Fruit Pod Extract, Helianthus Annuus (Sunflower) Sprout Extract, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Xanthan Gum, Sodium Phytate, Propylene Glycol, Citric Acid, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, Triethoxycaprylylsilane, Iron Oxides (CI 77491, CI 77492, CI 77499). *OS-01 Peptide

Drug Facts

Active Ingredients: Zinc Oxide 17.5% …………Purpose: Sunscreen

Uses

Helps prevent sunburn

If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

For external use only.

Do not use on damaged or broken skin.

When using this product keep out of eyes. Rinse with water to remove.

Stop use and ask a doctor if rash occurs.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Citations

01Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

02 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042

03 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

04 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112

06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x

07 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1