Face Longevity Defense Duo
Face Longevity Defense Duo
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An essential skin longevity system for your most UV-exposed skin, built to support collagen and barrier strength.
Protect collagen, build barrier resilience, and boost visible firmness and with OS-01 FACE Moisturizer
Reverse the visible signs of UV aging and protect against future exposure with OS-01 FACE SPF 30+
Dermatologist tested, fragrance-free, suitable for sensitive skin
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Limited Edition OneSkin Bag
OS-01 FACE MOISTURIZER
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OS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++
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A complete system built to protect collagen and future-proof skin
The OS-01 Peptide™
Engineered to address cellular senescence, a leading driver of visible skin aging
Non-nano zinc oxide
Protects against UV aging and damage with mineral broad spectrum SPF 30+ defense
5 potent antioxidants
Combat oxidative aging from environmental stress
How it works
Powered by the OS-01 Senescence Peptide™
Born from over a decade of longevity science, OS-01 is engineered to address a key driver of visible skin aging, supporting meaningful improvements in skin health today and over time to future-proof skin.
Face Longevity Defense Duo
- M'Marilyn '. P.Verified BuyerReviewingOS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++I recommend this productRated 5 out of 5 stars3 minutes agoProtective Radiant Glow
Skin Protection is ESSENTIAL for longevity.
OS-01 Face SPF is the extra OOOMPH against the reality of sun exposure, including for cloudy days. I use this moisturizer SPF in addition to OS-01 Face. NO zinc white appearance nor heaviness…only smooth radiant glowing skin.
Thank you OS-01!!!!!!!!
- PWPatricia W.Verified BuyerReviewingOS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++I recommend this productRated 5 out of 5 stars19 hours agoGreat product for outdoor activities
I bike 3 times a week, this formulation is great for sports demands and doesn’t run into your eyes.
- MWMaria w.Verified BuyerReviewingOS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++I recommend this productRated 5 out of 5 starsYesterdayLove it!
Moisturizer adds a little bit of tint color, love it!
- SMSusan M.Verified BuyerReviewingOS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++I recommend this productRated 5 out of 5 starsYesterdayLike this SPF!
Feels great on.
- VCVanessa C.Verified BuyerReviewingOS-01 FACE SPF BROAD SPECTRUM SPF 30+ PA+++I recommend this productRated 5 out of 5 stars2 days agoBest tinted SPF
This is my favorite tinted moisturizer/SPF I have tried. I’m very happy they decided to do a light version, I think light/medium would have been too dark for my skin tone. And I love the finish. It is light and slightly dewy, but I don’t look wet.
Full ingredient list
OS-01 FACE Moisturizer
Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.
OS-01 FACE SPF
Active Ingredients: Zinc Oxide 17.5%
Inactive ingredients (all tints): Water (Aqua), Caprylic/Capric Triglyceride, Glycerin, Methyl Dihydroabietate, Cetearyl Alcohol, Cetyl Palmitate, Coco-Glucoside, Caprylyl/Capryl Glucoside, Sorbitan Palmitate, Sorbitan Olivate, Butyrospermum Parkii (Shea) Nut Extract, Ethyl Ferulate, Bisabolol, Allantoin, Hydrolyzed Jojoba Esters, Acacia Senegal Gum, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic Acid, Lecithin, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Decapeptide-52*, Oryza Sativa (Rice) Starch, Camellia Sinensis Leaf Extract, Euterpe Oleracea Fruit Extract, Caesalpinia Spinosa Fruit Pod Extract, Helianthus Annuus (Sunflower) Sprout Extract, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Xanthan Gum, Sodium Phytate, Propylene Glycol, Citric Acid, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, Triethoxycaprylylsilane, Iron Oxides (CI 77491, CI 77492, CI 77499). *OS-01 Peptide
Drug Facts
Active Ingredients: Zinc Oxide 17.5% …………Purpose: Sunscreen
Uses
Helps prevent sunburn
If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.
Warnings
For external use only.
Do not use on damaged or broken skin.
When using this product keep out of eyes. Rinse with water to remove.
Stop use and ask a doctor if rash occurs.
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
Citations
01Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
02 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
03 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
04 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
05 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
06 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
07 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
