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The Skincare Upgrade You Didn’t Know You Needed: Topical Supplements

The Skincare Upgrade You Didn’t Know You Needed: Topical Supplements
Have you ever wondered if your skin care products even work? Here’s the harsh truth: most skin care products aren’t grounded in science. Many brands develop their products in partnership with third-party manufacturers that rarely empirically test the efficacy of their formulas.At OneSkin, we saw a need for change. After testing the effects of popular so-called β€œanti-aging” products at the cellular level in our lab, we found that most were ineffective at slowing or reversing skin aging. What's worse, some of the most popular options are harmful at the cellular level, disrupting the skin barrier and potentially accelerating skin aging. That discovery fueled our mission to create innovative skin health products backed by objective scientific evidence. Starting in 2016, our passionate team of female PhDs embarked on an exciting journey to develop a peptide capable of reversing the biological age of skin by keeping it healthier for longer. Our team analyzed over 900 peptides using state-of-the-art computational algorithms and advanced skin age modeling, ultimately uncovering the strongest contender, OS-01, the first peptide proven to reverse skin’s biological age by reducing cellular senescence. The result is our collection of topical supplements centered around the OS-01 peptide: skin care proven to reverse the signs of skin aging from the cellular level up to visible benefits.[1]
Have you ever wondered if your skin care products even work? Here’s the harsh truth: most skin care products aren’t grounded in science. Many brands develop their products in partnership with third-party manufacturers that rarely empirically test the efficacy of their formulas.At OneSkin, we saw a need for change. After testing the effects of popular so-called β€œanti-aging” products at the cellular level in our lab, we found that most were ineffective at slowing or reversing skin aging. What's worse, some of the most popular options are harmful at the cellular level, disrupting the skin barrier and potentially accelerating skin aging. That discovery fueled our mission to create innovative skin health products backed by objective scientific evidence. Starting in 2016, our passionate team of female PhDs embarked on an exciting journey to develop a peptide capable of reversing the biological age of skin by keeping it healthier for longer. Our team analyzed over 900 peptides using state-of-the-art computational algorithms and advanced skin age modeling, ultimately uncovering the strongest contender, OS-01, the first peptide proven to reverse skin’s biological age by reducing cellular senescence. The result is our collection of topical supplements centered around the OS-01 peptide: skin care proven to reverse the signs of skin aging from the cellular level up to visible benefits.[1]
01

What is a Topical Supplement?

Think of a topical supplement like a multivitaminβ€”but for your skin. You take vitamins to keep your body running smoothly, so why not give your skin the same love? OneSkin’s topical supplements are more than just skin care–they’re designed to support whole-body health, starting with your largest organ (your skin!). When integrating them into your routine, you can treat OneSkin’s topical supplements as moisturizers, but you’ll quickly find they go far beyond your average daily skin care products.
01

What is a Topical Supplement?

Think of a topical supplement like a multivitaminβ€”but for your skin. You take vitamins to keep your body running smoothly, so why not give your skin the same love? OneSkin’s topical supplements are more than just skin care–they’re designed to support whole-body health, starting with your largest organ (your skin!). When integrating them into your routine, you can treat OneSkin’s topical supplements as moisturizers, but you’ll quickly find they go far beyond your average daily skin care products.
02

Why Are OneSkin’s Topical Supplements Unique?

What sets OneSkin’s topical supplements apart? Simpleβ€”they don't just address your skin's visible needs; they transform how it ages. Powered by our groundbreaking OS-01 peptide, antioxidants, and other proven longevity-boosting ingredients, our topical supplements target the root causes of aging at the cellular level. Whether you’re battling dryness, fine lines, or uneven skin tone, our formulas get to the root of your skin needs.[1]Backed by lab and clinical testing to validate their benefits, our topical supplements harness the power of OS-01 to give you skin that looks, feels, and acts healthier. Here’s a quick look at how the age-reversing action of OS-01 shows up on your skin:
02

Why Are OneSkin’s Topical Supplements Unique?

What sets OneSkin’s topical supplements apart? Simpleβ€”they don't just address your skin's visible needs; they transform how it ages. Powered by our groundbreaking OS-01 peptide, antioxidants, and other proven longevity-boosting ingredients, our topical supplements target the root causes of aging at the cellular level. Whether you’re battling dryness, fine lines, or uneven skin tone, our formulas get to the root of your skin needs.[1]Backed by lab and clinical testing to validate their benefits, our topical supplements harness the power of OS-01 to give you skin that looks, feels, and acts healthier. Here’s a quick look at how the age-reversing action of OS-01 shows up on your skin:

OS-01 FACE

A typical moisturizer may hydrate your skin, but OS-01 FACE does so much more. Over time, skin aging diminishes the thickness and strength of the epidermis, leaving skin more fragile and prone to visible signs of aging. OS-01 FACE combats this process by actively promoting skin's natural collagen production and increasing skin’s epidermal thickness.[1,2] This helps relieve visible signs of agingβ€”like fine lines and wrinklesβ€”while allowing your skin to better resist long-term signs of aging.[3]In addition to our lab testing, OneSkin’s OS-01 FACE clinical study has been published in the peer-reviewed Journal of Cosmetic Dermatology. Here are some of the exciting results:
  • 100% of users experienced smoother, better appearing skin.[3]
  • 95.5% exhibited a boost in radiance, evenness, and firmness.[3]
  • 90% experienced improved elasticity.[3]
  • 86% displayed a reduction in fine lines and wrinkles.[3]
Supported by ingredients proven to slow skin aging, like niacinamide and antioxidants, and our OS-01 Senescence Blocking Peptideβ„’, OS-01 FACE, helps keep your skin looking, feeling, and acting like its younger self. Unlike moisturizers that only enhance your skin’s appearance, OneSkin’s OS-01 FACE topical supplement targets the root causes of visible skin aging so you can enjoy vibrant, healthy skin every day.

OS-01 FACE

A typical moisturizer may hydrate your skin, but OS-01 FACE does so much more. Over time, skin aging diminishes the thickness and strength of the epidermis, leaving skin more fragile and prone to visible signs of aging. OS-01 FACE combats this process by actively promoting skin's natural collagen production and increasing skin’s epidermal thickness.[1,2] This helps relieve visible signs of agingβ€”like fine lines and wrinklesβ€”while allowing your skin to better resist long-term signs of aging.[3]In addition to our lab testing, OneSkin’s OS-01 FACE clinical study has been published in the peer-reviewed Journal of Cosmetic Dermatology. Here are some of the exciting results:
  • 100% of users experienced smoother, better appearing skin.[3]
  • 95.5% exhibited a boost in radiance, evenness, and firmness.[3]
  • 90% experienced improved elasticity.[3]
  • 86% displayed a reduction in fine lines and wrinkles.[3]
Supported by ingredients proven to slow skin aging, like niacinamide and antioxidants, and our OS-01 Senescence Blocking Peptideβ„’, OS-01 FACE, helps keep your skin looking, feeling, and acting like its younger self. Unlike moisturizers that only enhance your skin’s appearance, OneSkin’s OS-01 FACE topical supplement targets the root causes of visible skin aging so you can enjoy vibrant, healthy skin every day.

OS-01 EYE

The skin around your eyes works overtime to express your emotions and endure environmental stressβ€”it even accumulates a higher amount of senescent cellsβ€”this means it's often the first part of your skin to show the signs of aging.[4] That’s where OS-01 EYE steps in. OneSkin’s most potent formula, OS-01 EYE, is enriched with the highest concentration of the OS-01 peptideβ€”and other skin-longevity boosting ingredients like argirilene and CoQ10β€”and is specifically designed to slow the visible and invisible signs of skin aging around the eyes.[1]We've recently published the results of our OS-01 EYE clinical study. These are some of the results that we think you'll love:
  • 86% of users experienced improved skin elasticity.[5]
  • 87.5% of participants saw hydration levels increase by an average of 32%.[5]
  • 17% average improvement in skin barrier function.[5]
  • 96% of users noticed an enhanced overall appearance.[4]

OS-01 EYE

The skin around your eyes works overtime to express your emotions and endure environmental stressβ€”it even accumulates a higher amount of senescent cellsβ€”this means it's often the first part of your skin to show the signs of aging.[4] That’s where OS-01 EYE steps in. OneSkin’s most potent formula, OS-01 EYE, is enriched with the highest concentration of the OS-01 peptideβ€”and other skin-longevity boosting ingredients like argirilene and CoQ10β€”and is specifically designed to slow the visible and invisible signs of skin aging around the eyes.[1]We've recently published the results of our OS-01 EYE clinical study. These are some of the results that we think you'll love:
  • 86% of users experienced improved skin elasticity.[5]
  • 87.5% of participants saw hydration levels increase by an average of 32%.[5]
  • 17% average improvement in skin barrier function.[5]
  • 96% of users noticed an enhanced overall appearance.[4]

OS-01 BODY

Your skin is your body’s largest organ, yet traditional skin care routines focus almost exclusively on the face, leaving most of your skin overlooked. The OS-01 BODY topical supplement strengthens and rejuvenates body skin, addressing age-related vulnerabilities with science-backed precision.[1]By targeting some of the most prominent age-related skin issues like thinning and dryness, OS-01 BODY provides some impressive results in just 12 weeks:
  • 41.49% average improvement in skin barrier function.[1]
  • 93% of users saw their skin hydration improve by an average of +38.34%.[1]
  • OS-01 BODY significantly reduces circulating inflammatory cytokine, IL-8, a key biomarker of systemic inflammation.[1]
Not only can OS-01 BODY make your skin feel younger, but it may also slow or even pause overall biological aging by improving the health of your largest organ.[1] This means OS-01 BODY is more than just a moisturizer; it’s a powerful longevity-boosting tool.

OS-01 BODY

Your skin is your body’s largest organ, yet traditional skin care routines focus almost exclusively on the face, leaving most of your skin overlooked. The OS-01 BODY topical supplement strengthens and rejuvenates body skin, addressing age-related vulnerabilities with science-backed precision.[1]By targeting some of the most prominent age-related skin issues like thinning and dryness, OS-01 BODY provides some impressive results in just 12 weeks:
  • 41.49% average improvement in skin barrier function.[1]
  • 93% of users saw their skin hydration improve by an average of +38.34%.[1]
  • OS-01 BODY significantly reduces circulating inflammatory cytokine, IL-8, a key biomarker of systemic inflammation.[1]
Not only can OS-01 BODY make your skin feel younger, but it may also slow or even pause overall biological aging by improving the health of your largest organ.[1] This means OS-01 BODY is more than just a moisturizer; it’s a powerful longevity-boosting tool.


Key Takeaways:
  • Skin care meets science with topical supplements, delivering proven longevity benefits to address aging at the cellular level and improve key skin health markers.
  • Powered by the OS-01 peptide, OneSkin’s topical supplements target aging at the cellular level, ensuring stronger, healthier skin over time.
  • Backed by extensive lab research and peer-reviewed clinical studies, OS-01 FACE, OS-01 EYE, and OS-01 BODY deliver targeted care to keep your skin barrier healthy and youthful from head to toe.
Key Takeaways:
  • Skin care meets science with topical supplements, delivering proven longevity benefits to address aging at the cellular level and improve key skin health markers.
  • Powered by the OS-01 peptide, OneSkin’s topical supplements target aging at the cellular level, ensuring stronger, healthier skin over time.
  • Backed by extensive lab research and peer-reviewed clinical studies, OS-01 FACE, OS-01 EYE, and OS-01 BODY deliver targeted care to keep your skin barrier healthy and youthful from head to toe.
Disclaimers
This article was initially published in December 2020 and has been updated.
Disclaimers
This article was initially published in December 2020 and has been updated.
References
  1. Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
  2. Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
  3. Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
  4. https://www.jaad.org/article/S0190-9622(16)00242-5/abstract
  5. Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
References
  1. Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
  2. Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
  3. Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242
  4. https://www.jaad.org/article/S0190-9622(16)00242-5/abstract
  5. Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042




Last Updated May 01, 2025

Reviewed by

Alessandra Zonari

Alessandra Zonari

PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.