What is Epidermal Thickness & Why Does it Matter?
2 min read
SKIN SCIENCE
What is Epidermal Thickness & Why Does it Matter?
2 min read
SKIN SCIENCE
Take a second to pinch the skin on the back of your hand and notice how thin it seems. Now, flip your hand over and pinch your palm. Much thicker, right? This is a practical way to observe the differences in epidermal thickness that occur naturally across our bodies. This outermost layer of our skin naturally tends to get thinner as we get older, leading to telltale signs of aging like skin laxity and increased vulnerability to injury. Maintaining epidermal thickness throughout our lives ensures better skin health and enhanced protection from environmental pathogens. So what causes epidermal thinning in the first place? Let’s take a closer look at this universal skin phenomenon and what you can do to support epidermal thickness in your own skin.
Take a second to pinch the skin on the back of your hand and notice how thin it seems. Now, flip your hand over and pinch your palm. Much thicker, right? This is a practical way to observe the differences in epidermal thickness that occur naturally across our bodies. This outermost layer of our skin naturally tends to get thinner as we get older, leading to telltale signs of aging like skin laxity and increased vulnerability to injury. Maintaining epidermal thickness throughout our lives ensures better skin health and enhanced protection from environmental pathogens. So what causes epidermal thinning in the first place? Let’s take a closer look at this universal skin phenomenon and what you can do to support epidermal thickness in your own skin.
01
Why Does Epidermal Thickness Matter?
The epidermis is the thinnest of the three main skin layers. This essential outer layer plays a number of important roles including maintaining overall hydration levels, producing new skin cells, and protecting our bodies from environmental pathogens and UV radiation. As the epidermis thins, it becomes less efficient at providing these essential functions and can leave the entire body more vulnerable to injury. [1]
01
Why Does Epidermal Thickness Matter?
The epidermis is the thinnest of the three main skin layers. This essential outer layer plays a number of important roles including maintaining overall hydration levels, producing new skin cells, and protecting our bodies from environmental pathogens and UV radiation. As the epidermis thins, it becomes less efficient at providing these essential functions and can leave the entire body more vulnerable to injury. [1]
02
How Does Epidermal Thickness Vary Across Skin?
The epidermis contains five layers, the outermost of which is called the stratum corneum. The stratum corneum averages about 15 layers over most of the body, but is much thinner and thicker in some areas. For example, the skin around the eyes has a stratum corneum that is just 3 layers thick while the palms and soles of the feet contain over 50 layers of stratum corneum. This variation in thickness is just one of the reasons why thinner skin on the eye-area, neck, and hands starts to show signs of aging earlier in most people. [2]
02
How Does Epidermal Thickness Vary Across Skin?
The epidermis contains five layers, the outermost of which is called the stratum corneum. The stratum corneum averages about 15 layers over most of the body, but is much thinner and thicker in some areas. For example, the skin around the eyes has a stratum corneum that is just 3 layers thick while the palms and soles of the feet contain over 50 layers of stratum corneum. This variation in thickness is just one of the reasons why thinner skin on the eye-area, neck, and hands starts to show signs of aging earlier in most people. [2]
03
What Does Epidermal Thickness Have To Do With Barrier Function?
The stratum corneum, also called the skin barrier, is a layer of dry, dead skin cells that are joined together by lipids. This layer creates a water-resistant seal on the surface of the skin, which keeps the right amount of moisture locked into the skin’s vital layers while preventing excess water, pathogens, or other aggressors from entering. [1]
03
What Does Epidermal Thickness Have To Do With Barrier Function?
The stratum corneum, also called the skin barrier, is a layer of dry, dead skin cells that are joined together by lipids. This layer creates a water-resistant seal on the surface of the skin, which keeps the right amount of moisture locked into the skin’s vital layers while preventing excess water, pathogens, or other aggressors from entering. [1]
04
How Does Epidermal Thickness Change with Age?
As we get older, our epidermis begins to thin. One study found that it thins at a rate of about 5-7% per decade. [3] This may be partly due to the fact that skin cell turnover – the production of new skin cells at the basal layer of the epidermis–slows as we age. With fewer new skin cells being produced at the base of the epidermis, the entire epidermal layer becomes thinner. [5]
04
How Does Epidermal Thickness Change with Age?
As we get older, our epidermis begins to thin. One study found that it thins at a rate of about 5-7% per decade. [3] This may be partly due to the fact that skin cell turnover – the production of new skin cells at the basal layer of the epidermis–slows as we age. With fewer new skin cells being produced at the base of the epidermis, the entire epidermal layer becomes thinner. [5]
05
What Factors Impact Epidermal Thickness?
In addition to normal skin aging, a number of other factors contribute to epidermal thinning throughout our lifetimes. Avoidable lifestyle factors like unprotected sun exposure or smoking cigarettes can increase the rate at which your skin ages, quickening the rate of epidermal thinning that your skin experiences. But there are also some unavoidable factors: a drop in estrogen after menopause can decrease epidermal thickness, as can certain medications including topical steroids. [5]
05
What Factors Impact Epidermal Thickness?
In addition to normal skin aging, a number of other factors contribute to epidermal thinning throughout our lifetimes. Avoidable lifestyle factors like unprotected sun exposure or smoking cigarettes can increase the rate at which your skin ages, quickening the rate of epidermal thinning that your skin experiences. But there are also some unavoidable factors: a drop in estrogen after menopause can decrease epidermal thickness, as can certain medications including topical steroids. [5]
06
How Does Epidermal Thickness Impact Skin’s Appearance?
As the epidermis thins, the skin loses volume, leading to signs of aging like wrinkles, crepiness and skin sagging. Epidermal thinning can also make skin much more vulnerable to injury. Your skin might scratch, tear, or bruise much more easily in your later years as your epidermis continues to get thinner. [5]
06
How Does Epidermal Thickness Impact Skin’s Appearance?
As the epidermis thins, the skin loses volume, leading to signs of aging like wrinkles, crepiness and skin sagging. Epidermal thinning can also make skin much more vulnerable to injury. Your skin might scratch, tear, or bruise much more easily in your later years as your epidermis continues to get thinner. [5]
07
Boost Epidermal Thickness with OneSkin
To prevent your epidermis from thinning prematurely, wear sunscreen (ideally mineral SPF 30+ like OS-01 SHIELD and OS-01 BODY SPF, coming soon!), and practice healthy habits. Already noticing signs of thinning? You can actually reverse them with the OS-01 peptide, scientifically proven to increase skin's epidermal thickness and clinically validated to improve skin's barrier function. [6, 7, 8] OneSkin's line of topical products are powered by the OS-01 peptide. In fact, like the OS-01 peptide, OS-01 FACE is scientifically proven to promote a significant increase in the epidermal thickness and clinically validated to boost skin's barrier function. [6, 7, 8] To address epidermal thinning from the neck down, reach for OS-01 BODY, which is also scientifically proven to promote a significant increase in the epidermal thickness of ex vivo human skin samples. [8] And for the ultra-delicate skin around your eyes, OS-01 EYE is super-charged by the highest concentration of the OS-01 peptide and clinically validated to boost skin's barrier function by an average of +17% in 12 weeks. [8]
07
Boost Epidermal Thickness with OneSkin
To prevent your epidermis from thinning prematurely, wear sunscreen (ideally mineral SPF 30+ like OS-01 SHIELD and OS-01 BODY SPF, coming soon!), and practice healthy habits. Already noticing signs of thinning? You can actually reverse them with the OS-01 peptide, scientifically proven to increase skin's epidermal thickness and clinically validated to improve skin's barrier function. [6, 7, 8] OneSkin's line of topical products are powered by the OS-01 peptide. In fact, like the OS-01 peptide, OS-01 FACE is scientifically proven to promote a significant increase in the epidermal thickness and clinically validated to boost skin's barrier function. [6, 7, 8] To address epidermal thinning from the neck down, reach for OS-01 BODY, which is also scientifically proven to promote a significant increase in the epidermal thickness of ex vivo human skin samples. [8] And for the ultra-delicate skin around your eyes, OS-01 EYE is super-charged by the highest concentration of the OS-01 peptide and clinically validated to boost skin's barrier function by an average of +17% in 12 weeks. [8]
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Key Takeaways:
- The epidermis is the outermost layer of our skin. It maintains overall hydration levels, produces new skin cells, and protects against pathogens and UV radiation.
- As we get older, the epidermis thins at a rate of 5-7% per decade.
- As the epidermis thins, it becomes more vulnerable to injury and shows signs of aging like wrinkles and sagging.
- In lab studies and clincial studies, OneSkin’s OS-01 BODY, OS-01 FACE, and OS-01 EYE were scientifically proven to promote a significant increase in epidermal thickness and/or boost barrier function, reversing this central sign of skin aging.
Key Takeaways:
- The epidermis is the outermost layer of our skin. It maintains overall hydration levels, produces new skin cells, and protects against pathogens and UV radiation.
- As we get older, the epidermis thins at a rate of 5-7% per decade.
- As the epidermis thins, it becomes more vulnerable to injury and shows signs of aging like wrinkles and sagging.
- In lab studies and clincial studies, OneSkin’s OS-01 BODY, OS-01 FACE, and OS-01 EYE were scientifically proven to promote a significant increase in epidermal thickness and/or boost barrier function, reversing this central sign of skin aging.
References
- https://my.clevelandclinic.org/health/body/21901-epidermis
- https://pubmed.ncbi.nlm.nih.gov/14690333/
- https://pubmed.ncbi.nlm.nih.gov/2384222/
- https://www.nature.com/articles/s41514-021-00060-z%20
- https://alastin.com/blogs/intheglow/what-causes-thin-skin-and-how-to-treat-it
- https://www.nature.com/articles/s41514-023-00109-1
- https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16242
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
References
- https://my.clevelandclinic.org/health/body/21901-epidermis
- https://pubmed.ncbi.nlm.nih.gov/14690333/
- https://pubmed.ncbi.nlm.nih.gov/2384222/
- https://www.nature.com/articles/s41514-021-00060-z%20
- https://alastin.com/blogs/intheglow/what-causes-thin-skin-and-how-to-treat-it
- https://www.nature.com/articles/s41514-023-00109-1
- https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.16242
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
The Science Behind Why The Skin Around the Eyes Ag...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
6 Factors That Contribute to Slow Skin Healing
4 Foods To Avoid During Wound Healing & Why
A Complete Guide to the 4 Stages of Wound Healing
Collagen And Elastin: What Role Do They Play In Sk...
What is the Function of Skin as a Protective Barri...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
How Does Sunscreen Work? How Long Does it Last?
What is the Best Skin Care Regimen for Aging Skin?
What happens to skin as a person ages?
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Invasive vs. Non-Invasive Skincare: The pros and c...
6 Benefits of Jojoba Oil
What are the Benefits of Sulforaphane?
What is Sustainable Packaging for Cosmetic Product...
7 Benefits of Andiroba Oil For Skin
Why is my Skin Peeling on My Face?
What Are The Causes Of Dry, Flaky Skin On Your Fac...
PREP enhances the effects of OS-01 FACE, and the p...
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
Allantoin For Skin: A Comprehensive Guide
Ceramides For Skin: Everything You Need to Know
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
What Causes Crepey Skin & Can It Be Avoided Altoge...
Does Niacinamide Help With Acne & Scarring?
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide on The Benefits of Cleansing Your Face
How OneSkin Developed the OS-01 Peptide
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
You’re only as old as you feel, scientists are fin...
Collagen For Menopause: Why Is It Necessary For He...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Connection Between Mental Health, Age Percepti...
The Top 6 Best Antioxidants For Skin Health and Lo...
What are Zombie Cells & How Can We Remove Them?
SKIN CARE IS HEALTH CARE: WHY EXTENDING YOUR SKINS...
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
What Is Causing the Uneven Skin Tone On Your Body?
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Skin Hyperpigmentation 101: What It Is & How To Tr...
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
Celebrating Black History Month: A Discussion With...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Where Skin Health Meets Longevity
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
OneSkin launches MolClock, the first skin-specific...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging