What Makes OS-01 EYE Unique?
How the Study Was Conducted?
Instrumental Evaluation
- Corneometer: Corneometers use changes in skin capacitance and conductance to measure changes in skin hydration. To ensure reliable results, measurements were conducted in triplicate at each assessment. (5)
- Evaporimeter: Trans-epidermal water loss is a key indicator of skin barrier function; a weakened skin barrier will lose more water to the environment. By assessing the vapor pressure gradient between the skin and surrounding air, evaporimeters help our researchers ascertain improvements in skin barrier function, with lower TEWL indicating enhanced hydration retention. These measurements were taken twice for accuracy. (5)
- Cutometer: Skin is a complex system containing contrasting elastic and viscous fibers, elastin, and collagen. The cutometer uses gentle suction to mechanically deform the skin and provide insights into the biomechanical properties of each subject's periorbital skin. (5)
- Clinical Photography: Clinical before and after photographs of each subject's face were taken using a VISIA-CR scanner. These photographs' accuracy, high quality, and standardized nature allow for a more comprehensive visual analysis of skin condition changes from various angles. (5)
Blinded Expert Clinical-Grade Evaluation
Self Perception Surveys
What Were the Results of OS-01 EYE’s Clinical Study?
- Improved hydration: 87.5% of users showed an impressive 32.5% average improvement in skin hydration.
- Enhanced skin barrier function: By strengthening the skin barrier, 70% of users showed, on average, a 17% improvement in preventing trans-epidermal water loss.
- Better elasticity: 86% of users showed a marked improvement in under-eye skin elasticity with an average improvement of +23.58%
- Firmer skin: 73% of users showed a significant improvement in skin firmness with an average improvement of +10.19%.
- Improved skin appearance: After just 4 weeks, 90.91% of users reported that the overall appearance of their under-eye skin improved with the daily use of OS-01 EYE.
How do these results confirm lab findings?

The results are the average of testing in 3 different ex vivo eyelid skin samples grown from 42y, 59y, and 84y donors.

The results are the average of testing in 3 different ex vivo eyelid skin samples grown from 42y, 59y, and 84y donors.

Shown in lab studies on ex vivo human eyelid skin samples (70 yr) by analyzing levels of collagen in skin treated with OS-01 EYE compared to no treatment. Skin treated with OS-01 EYE displayed a significant increase compared to skin with no treatment. Data was measured in triplicate.
What Long-Term Impacts Can You Expect From OS-01 EYE?
Key Takeaways:
- Eye area skin shows higher levels of senescent cells and advanced aging, requiring a specialized formula that will target the root cause of skin aging, like the OS-01 peptide.
- Before launching OS-01 EYE, we conducted extensive lab testing to validate its impacts at the cellular level.
- These tests showed that OS-01 EYE increased collagen levels in ex vivo human skin samples by 2.3x, giving us the confidence that our treatment functionally improves under-eye aging.
- We’re happy to report that OS-01 EYE has been proven in clinical studies on human participants to improve firmness, elasticity, and the overall appearance of skin.
- This data confirms what we already suspected: by blocking inflammatory signals from senescent cells and increasing collagen levels in the skin, OS-01 EYE can help the skin resist signs of aging, including skin sagging & laxity.
References
- New biological insights into skin aging around the eye. J. Am. Acad. Dermatol. 74, AB28 (2016).
- Wang, A. S. & Dreesen, O. Biomarkers of Cellular Senescence and Skin Aging. Front. Genet. 9, 247 (2018).
- Varani, J. et al. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am. J. Pathol. 168, 1861–1868 (2006).
- Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. Npj Aging, 9(1), 1-15 (2023).
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims