What your skincare routine is missing (Hint. It’s a topical supplement)

4 min read

DEC 10, 2020
December 10,2020
SKIN SCIENCE

What your skincare routine is missing (Hint. It’s a topical supplement)

4 min read

DEC 10, 2020
December 10,2020
SKIN SCIENCE
Have you ever wondered, "What should I add to my skin care routine?" The truth is, the majority of skincare products out there lack scientific backing. In fact, most skin care companies formulate their products in partnership with third-party manufacturers that rarely test the efficacy of their formulas. At OneSkin, we got our start as a scientific research company dedicated to testing the effects of popular anti-aging products at the cellular level. What we discovered was shocking: most anti-aging products don’t actually work to reverse skin aging. And some even make things worse. That’s why we set out to do things differently–creating face and body skin care products backed by real scientific evidence and proven to reverse skin aging at the cellular level. The result is our collection of Topical Supplements, first-of-their-kind innovations backed by longevity research.
Have you ever wondered, "What should I add to my skin care routine?" The truth is, the majority of skincare products out there lack scientific backing. In fact, most skin care companies formulate their products in partnership with third-party manufacturers that rarely test the efficacy of their formulas. At OneSkin, we got our start as a scientific research company dedicated to testing the effects of popular anti-aging products at the cellular level. What we discovered was shocking: most anti-aging products don’t actually work to reverse skin aging. And some even make things worse. That’s why we set out to do things differently–creating face and body skin care products backed by real scientific evidence and proven to reverse skin aging at the cellular level. The result is our collection of Topical Supplements, first-of-their-kind innovations backed by longevity research.
01

What is a Topical Supplement?

You take a multivitamin every day to keep your body healthy for years to come. We think of our products in much the same way. That’s why we decided to name them Topical Supplements. Packed with our OS-01 peptide and everything your skin needs for peak longevity, our formulas are more than just skin care–they’re designed to support whole-body health starting with your largest organ (your skin!).
01

What is a Topical Supplement?

You take a multivitamin every day to keep your body healthy for years to come. We think of our products in much the same way. That’s why we decided to name them Topical Supplements. Packed with our OS-01 peptide and everything your skin needs for peak longevity, our formulas are more than just skin care–they’re designed to support whole-body health starting with your largest organ (your skin!).
02

What makes OS-01 different from other skin care actives?

Unlike other active skin care ingredients, OS-01 is proven to reverse skin aging at the cellular level, as shown in ex vivo human skin samples.* Our research on OS-01 goes far beyond what most skin care companies do. In fact, our research was recently published in npj Aging, a prestigious scientific journal. So how does OS-01 stack up against common skin care ingredients? To find out, we put OS-01 in a head-to-head test with retinol, a form of vitamin A that’s commonly considered the gold standard of anti-aging ingredients. In our tests, both OS-01 and retinol significantly increased a key biomarker associated with collagen production, COL1A1. However, only retinol also created a tenfold activity increase in a biomarker linked to aging, CDKN2A.* This shows that while retinol improves collagen production, it may increase other signs of skin aging – not what you want in an anti-aging product! You can learn more about how retinol stacks up against OS-01 here.
02

What makes OS-01 different from other skin care actives?

Unlike other active skin care ingredients, OS-01 is proven to reverse skin aging at the cellular level, as shown in ex vivo human skin samples.* Our research on OS-01 goes far beyond what most skin care companies do. In fact, our research was recently published in npj Aging, a prestigious scientific journal. So how does OS-01 stack up against common skin care ingredients? To find out, we put OS-01 in a head-to-head test with retinol, a form of vitamin A that’s commonly considered the gold standard of anti-aging ingredients. In our tests, both OS-01 and retinol significantly increased a key biomarker associated with collagen production, COL1A1. However, only retinol also created a tenfold activity increase in a biomarker linked to aging, CDKN2A.* This shows that while retinol improves collagen production, it may increase other signs of skin aging – not what you want in an anti-aging product! You can learn more about how retinol stacks up against OS-01 here.
03

How does OS-01 reverse aging on the cellular level?

OS-01 reverses skin aging by targeting cellular senescence*, a root cause of systemic aging. Over time and with increasing environmental exposure, our cells experience DNA damage. As this damage accumulates, they enter a state of dysfunction called senescence. Often called “zombie cells,” senescent cells secrete biochemical signals called SASP that drive healthy neighboring cells into senescence. As more senescent cells accumulate, your skin experiences accelerated skin aging, including visible signs like wrinkles, loss of elasticity and firmness, crepiness, and thinning. OS-01 boosts DNA damage repair in early-stage senescent cells, preventing them from entering late-stage senescence and secreting SASP.* This stops the spread of senescence and reduces your skin’s biological age at the cellular level. The result? Healthier skin that looks, feels, and acts like younger skin for longer.
03

How does OS-01 reverse aging on the cellular level?

OS-01 reverses skin aging by targeting cellular senescence*, a root cause of systemic aging. Over time and with increasing environmental exposure, our cells experience DNA damage. As this damage accumulates, they enter a state of dysfunction called senescence. Often called “zombie cells,” senescent cells secrete biochemical signals called SASP that drive healthy neighboring cells into senescence. As more senescent cells accumulate, your skin experiences accelerated skin aging, including visible signs like wrinkles, loss of elasticity and firmness, crepiness, and thinning. OS-01 boosts DNA damage repair in early-stage senescent cells, preventing them from entering late-stage senescence and secreting SASP.* This stops the spread of senescence and reduces your skin’s biological age at the cellular level. The result? Healthier skin that looks, feels, and acts like younger skin for longer.
Disclaimers
* Shown in lab studies on human skin cells and/or samples (Zonari, et al., 2023)
Disclaimers
* Shown in lab studies on human skin cells and/or samples (Zonari, et al., 2023)
04

What can I expect from OneSkin Topical Supplements?

Backed by both lab and clinical testing to validate their benefits, our Topical Supplements harness the power of OS-01 to extend your skin longevity. Here’s a quick look at how the age-reversing action of OS-01 shows up on your skin.
04

What can I expect from OneSkin Topical Supplements?

Backed by both lab and clinical testing to validate their benefits, our Topical Supplements harness the power of OS-01 to extend your skin longevity. Here’s a quick look at how the age-reversing action of OS-01 shows up on your skin.

OS-01 FACE

  • 100% of users showed improved skin smoothness & appearance
  • 95.5% of users showed improved skin evenness, radiance, pores, & firmness
  • 90% of users showed improved skin elasticity
  • 87% of users showed diminished appearance of fine lines & wrinkles
  • Barrier function improved by an average of 15%
  • Shown in a 12-week clinical study

    OS-01 FACE

    • 100% of users showed improved skin smoothness & appearance
    • 95.5% of users showed improved skin evenness, radiance, pores, & firmness
    • 90% of users showed improved skin elasticity
    • 87% of users showed diminished appearance of fine lines & wrinkles
    • Barrier function improved by an average of 15%
    • Shown in a 12-week clinical study

      OS-01 EYE

      • The two types of sunscreens are based on their ac86% of users showed improved under-eye skin elasticity
      • 73% of users showed a significant improvement in skin firmness
      • 95% of users reported that the overall appearance of their under-eye skin improved with the daily use
      • Shown in a 12-week clinical study

        OS-01 EYE

        • The two types of sunscreens are based on their ac86% of users showed improved under-eye skin elasticity
        • 73% of users showed a significant improvement in skin firmness
        • 95% of users reported that the overall appearance of their under-eye skin improved with the daily use
        • Shown in a 12-week clinical study

          OS-01 BODY

          • Promotes a significant increase in epidermal thickness, which helps give skin a firmer look.
          • Shown in lab studies on ex vivo human skin samplesThese visible benefits just scratch the surface of what OS-01 could do for your whole-body wellness. As your body’s largest organ, skin is essential to living a longer life in good health. With OS-01, you’re doing more than just reducing wrinkles. You’re extending your skin longevity so your entire body can thrive.

            OS-01 BODY

            • Promotes a significant increase in epidermal thickness, which helps give skin a firmer look.
            • Shown in lab studies on ex vivo human skin samplesThese visible benefits just scratch the surface of what OS-01 could do for your whole-body wellness. As your body’s largest organ, skin is essential to living a longer life in good health. With OS-01, you’re doing more than just reducing wrinkles. You’re extending your skin longevity so your entire body can thrive.
              05

              How does OS-01 Work with Different Skin Types

              The OS-01 peptide revolutionizes skin care routines for individuals with varying skin types, from normal skin to acne-prone skin, and even sensitive or combination skin. Recognizing that different skin types have unique needs, our Topical Supplements cater to the demands of oily skin by balancing excess sebum production, while simultaneously providing essential hydration to combat dry skin concerns. For those navigating the intricacies of combination skin, OS-01 ensures balanced care for each skin zone. And, if you're exploring options for combating aging skin, OS-01 offers a comprehensive approach by targeting skin cells at the cellular level, reversing the signs of aging without compromising the delicate balance of the skin barrier.If you’re wondering "what should I add to my skin care routine?", OS-01 emerges as the answer, promoting healthier skin. For those leading busy lives or with unpredictable schedules, our travel-size skin care products provide convenient solutions to maintain your routine on the go.With OneSkin, achieving glowing skin becomes a natural outcome of our comprehensive and tailored approach to skin care, irrespective of your skin type or specific skin concerns.
              05

              How does OS-01 Work with Different Skin Types

              The OS-01 peptide revolutionizes skin care routines for individuals with varying skin types, from normal skin to acne-prone skin, and even sensitive or combination skin. Recognizing that different skin types have unique needs, our Topical Supplements cater to the demands of oily skin by balancing excess sebum production, while simultaneously providing essential hydration to combat dry skin concerns. For those navigating the intricacies of combination skin, OS-01 ensures balanced care for each skin zone. And, if you're exploring options for combating aging skin, OS-01 offers a comprehensive approach by targeting skin cells at the cellular level, reversing the signs of aging without compromising the delicate balance of the skin barrier.If you’re wondering "what should I add to my skin care routine?", OS-01 emerges as the answer, promoting healthier skin. For those leading busy lives or with unpredictable schedules, our travel-size skin care products provide convenient solutions to maintain your routine on the go.With OneSkin, achieving glowing skin becomes a natural outcome of our comprehensive and tailored approach to skin care, irrespective of your skin type or specific skin concerns.
              Key Takeaways:
              • Most skin care is backed by very little scientific evidence.
              • Powered by our OS-01 peptide, our Topical Supplements are fundamentally different because they don’t just address surface-level signs of skin aging, they extend skin longevity.
              • Proven to reverse skin aging at the cellular level, OS-01 has been shown to outperform retinol, skin care’s most common anti-aging ingredient.
              • OS-01 reverses skin aging by targeting cellular senescence, a root cause of aging throughout our bodies.
              • In clinical studies, the benefits of OS-01 appear as firmer skin, diminished wrinkles, improved tone and more.
              • OS-01’s benefits may support whole-body wellbeing by reducing a key marker of systemic aging in the body’s largest organ.
              Key Takeaways:
              • Most skin care is backed by very little scientific evidence.
              • Powered by our OS-01 peptide, our Topical Supplements are fundamentally different because they don’t just address surface-level signs of skin aging, they extend skin longevity.
              • Proven to reverse skin aging at the cellular level, OS-01 has been shown to outperform retinol, skin care’s most common anti-aging ingredient.
              • OS-01 reverses skin aging by targeting cellular senescence, a root cause of aging throughout our bodies.
              • In clinical studies, the benefits of OS-01 appear as firmer skin, diminished wrinkles, improved tone and more.
              • OS-01’s benefits may support whole-body wellbeing by reducing a key marker of systemic aging in the body’s largest organ.
              References
              1. https://askwonder.com/research/cosmetic-brands-case-studies-part-2-z53gwn5n9
              2. https://pubmed.ncbi.nlm.nih.gov/22052267/
              3. https://pubmed.ncbi.nlm.nih.gov/29495517/
              4. https://pubmed.ncbi.nlm.nih.gov/22361190/
              5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257951/
              6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921764/
              7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910557/
              References
              1. https://askwonder.com/research/cosmetic-brands-case-studies-part-2-z53gwn5n9
              2. https://pubmed.ncbi.nlm.nih.gov/22052267/
              3. https://pubmed.ncbi.nlm.nih.gov/29495517/
              4. https://pubmed.ncbi.nlm.nih.gov/22361190/
              5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257951/
              6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921764/
              7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910557/

              Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

              Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

              Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

              Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

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