MAY 16

_LEARN

/

REFERENCE LAB

What Is Causing the Uneven Skin Tone On Your Body?





_LEARN

/

REFERENCE LAB

MAY 16

What Is Causing the Uneven Skin Tone On Your Body?






Uneven skin tone on the body is a common skin concern among men and women, especially in the aging population. It includes facial flushing, hyperpigmentation, and blotches on your skin. Several factors can cause this condition, including hormonal changes and lifestyle habits.

While some people consult a dermatologist for medical treatment, others often seek cosmetic solutions first. So what causes skin discoloration and how can you even the skin tone on your body?

Why Do I Have Uneven Skin Tone on My Body?

Uneven skin tone is caused by several internal and external factors. Some include:


#1 Sun Damage

When skin is exposed to UV rays, its cells naturally increase the production of melanin - a pigment molecule that is designed to protect your DNA from UV damage. The more sun exposure, the more melanin is produced and the darker your skin becomes, leading to skin tanning and also hyperpigmentation. Excessive sun exposure resulting in the overproduction of melanin and subsequent skin pigmentation is a leading cause of irregularities in the skin tone, especially as we age, due to its cumulative effects. As a result, many start to notice uneven coloration on several parts of their face and body when they reach their 30s and 40s, especially those who have experienced extensive sun exposure throughout their lives.


#2 Post-Inflammatory Hyperpigmentation (PIH) from Skin Injuries

Skin trauma, such as bug bites, acne, scratching wounds, or burns, can also lead to skin pigmentation on different parts of your body. These marks are known as post-inflammatory hyperpigmentation (PIH). PIH is your skin's natural reaction to inflammation as a part of the healing process. Because of this, it’s important to protect wounds and scars from sun exposure, so as to avoid exacerbating the pigmentation in skin.


#3 Aging

You may have noticed that older individuals often present with a more noticeable uneven skin tone than their younger counterparts. As you age, it's common to experience increasing visible discoloration on areas of your skin most exposed to damage, including your face, neck, and hands. These patches are often termed age spots, which are tan or dark brown spots that appear flat 4. In some cases, they can be even black or gray with a diameter of half an inch or more. The development of age spots can be caused by:

Less Collagen Production

People over 50 are more likely to experience uneven skin tone on their bodies, partly due to a decrease in their natural collagen production. Collagen is a structural protein in skin largely responsible for skin's plumpness and elasticity. Over time, as collagen production decreases, skin becomes thinner and drier. This thinner skin can make discoloration more visible.

Naturally Lighter Skin Tones

People with lighter skin tones have higher chances of developing age spots. This is because they naturally have less melanin content within the skin, which acts to protect skin cells from UV damage. Therefore, people with lighter skin are more susceptible to UV damage and subsequent hyperpigmentation, including age spots. Additionally, the contrast between their natural skin tone and age spots can be more evident.
Where

Is Uneven Skin Tone an Indicator of an Internal Issue?

Having an uneven skin tone on body and facial features can be a sign of an internal issue. For example, melasma is a skin condition that occurs due to increased hormone production, particularly during pregnancy 9.


Internal Contributors

Several internal factors can affect our skin's melanocytes (cells that produce melanin) and cause discolored patches. These include 10:
  • Genes
  • Allergies
  • Obesity
  • Diabetes
  • Hormonal changes during pregnancy or due to the use of oral contraceptives, intrauterine contraceptive devices, and hormone replacement therapy.


Skin Conditions

Multiple underlying skin conditions can also result in uneven skin tone on the body, especially as you age. These can include:
  • Seborrheic Keratosis. A skin growth commonly found in middle-aged or older people. It looks like a wart or precancerous skin growth. However, this condition is harmless. It can cause scaly, raised areas on several body parts 5.
  • Dermatosis Papulosa. A common skin condition in people with darker skin tones. The affected skin has small, discolored raised areas, often present on the skin of the face and neck. These are not dangerous, though many people seek treatment for aesthetic purposes 6.
  • Rosacea and dermatitis. These are some of the most common skin issues in people of all ages 8 and often result in an uneven skin tone that may look red.
Skin discoloration can also be due to the use of several medications, including antimalarials, nonsteroidal anti-inflammatory drugs, amiodarone, tetracyclines, cytotoxic drugs, heavy metals, and psychotropic drugs 7.
If you believe your uneven skin tone is due to an underlying condition or use of a new medication, it’s best to consult a health care professional to confirm this suspicion and ensure nothing more serious is going on.

Does Uneven Skin Tone Have Long-term Effects?

Uneven skin tone can have permanent or temporary effects. However, if you seek medical advice as soon as you spot uneven skin tone on your body, the chances are that you can reduce the discoloration more easily and quickly.

How Can I Achieve Even Skin Tone on My Body?

There are many ways to reduce the appearance of discoloration on your body. These could be over-the-counter (OTC) products, lifestyle changes, and professional treatments.


Wait-and-Watch

Depending on the cause of uneven skin tone, you might just need to ride it out. In the cases of pregnancy-derived hormonal changes, hyperpigmentation usually goes away within 12 months of delivery without any treatment 11. This could also be the case with post-inflammatory hyperpigmentation.


Identify and Treat the Underlying Cause

Uneven skin tone can often result from using a new skincare product or undergoing a lifestyle change. So, the first thing to do is evaluate whether you underwent any changes prior to the hyperpigmentation.


Use Sunscreen

Since sun damage is the leading cause of skin hyperpigmentation, especially with age, sunscreen can be your best defense against uneven skin tone. Regardless of the weather and your skin tone, using sunscreen all year round should be an essential step in your daily body care routine. The American Academy of Dermatology recommends that everyone use water-resistant and broad-spectrum skin protection with an SPF of 30 or higher 13.


Find a Scientifically-Validate OTC Product

There are many a href=https://www.oneskin.co/>topical skin care products available for purchase online and in stores aimed at treating uneven skin tone on the body. Before choosing the right one, it's best to consult your dermatologist to identify any underlying conditions that may react to certain products. Most OTC products aimed at treating hyperpigmentation generally contain one of the following ingredients:
  • Vitamin C. A potent antioxidant that protects your skin against sun damage while suppressing melanin production 14.
  • Glycolic Acid. Reduces the signs of sun-related aging, acne and acne scars, and post-inflammatory hyperpigmentation 15.
  • Salicylic Acid. This ingredient can work well for post-inflammatory hyperpigmentation 16.
  • Kojic Acid. Though effective at treating hyperpigmentation, this acid is a known skin irritant. It can actually cause dermatitis, including eczema, especially for those with sensitive skin. In fact, Kojic Acid has been banned as a potential carcinogen in Japan, Korea, and Switzerland 17.
  • Retinol. Also relatively effective at treating hyperpigmentation, overuse of retinol can strip your skin too quickly and reduce barrier function significantly, potentially compromising your long-term skin health.
  • Hydroquinone. Hydroquinone is usually used to lighten the skin. However, prolonged use (over 3 months), can cause ochronosis, a disease that causes blue/black discoloration of facial tissue.
Though these ingredients are common, they might not be the most effective and they could compromise your long-term skin health. Continue reading to find out how a peptide moisturizer could be the best ingredient for reducing hyperpigmentation.

Try OneSkin’s OS-01 Topical Supplements

When choosing a topical body supplement to help improve skin tone, it's ideal to pick one that is scientifically validated, with studies and data supporting its impact on hyperpigmentation and skin tone. OneSkin's Topical Supplements are powered by their proprietary OS-01 peptide - A powerful ingredient scientifically proven to reduce hyperpigmentation in skin superior to common treatments, such as kojic acid and retinol. Additionally, in a 12-week clinical study evaluating the impact of OS-01 FACE Topical Supplement on skin health markers, 95.5% of participants experienced an improvement in skin evenness, radiance, pores, and firmness.


Medical Treatments

Depending on the severity of your uneven skin tone and the underlying cause, your dermatologist may suggest one of the medical treatments below:
    • Laser Therapy. Ablative laser therapy rejuvenates the skin by removing the upper skin layer and enabling new skin to replace it. This treatment also stimulates collagen development. Most laser treatments also reduce post-inflammatory hyperpigmentation (PIH) by lightening and depigmenting the affected skin 21.
    • Microdermabrasion. An exfoliating treatment for dead skin cells and hyperpigmentation with the use of tiny particles.
    • Chemical Peels. Another effective exfoliation treatment for uneven skin tone. Chemical peels use highly-concentrated acids to treat discolored skin. They minimize hyperpigmentation by resurfacing the epidermis (upper skin layer). More powerful chemical peels may also penetrate the dermis (middle layer) of your skin to deliver more apparent results, but with a longer recovery time. Additionally, this treatment has a risk of burning your skin if mishandled, which could result in additional skin damage.
    • With the above methods, you may see a difference in your skin within 6-12 months
12
    . However, it may take longer than that.

Lifestyle Changes that Lessen the Appearance of Uneven Skin Tone

Wondering how to boost skin moisture or how to get rid of uneven skin tone on the body without any topical products or medical treatment? The answer may lie in your lifestyle. Here are some lifestyle changes that can improve skin tone:
  • Stay hydrated and keep your skin moisturized on a daily basis.
  • Avoid sugary foods, as they contribute to the development of visible aging signs in your skin 224.
  • Reduce your intake of alcohol, spicy foods, dairy, and greasy foods, all of which have been shown to negatively impact gut health and skin health 23.
  • Include Vitamin-C-rich fruits in your diet, like oranges, strawberries, bell peppers, guava, and kiwis 24).
  • Opt for foods containing niacin, a nutrient that boosts skin and hair health 25. These include green peas, poultry, tuna, and mushrooms.
  • Avoid all tobacco products.
  • Apply witch hazel and rosehip oil to reduce discoloration 26.

Key Takeaways

  • Uneven skin tone refers to hyperpigmentation, acne scars, and facial flushing or redness. It can be temporary or permanent.
  • Several internal factors and external factors result in uneven skin tone on body and facial features, with the biggest culprit being exposure to UV rays.
  • Hyperpigmentation can be treated with OTC products, lifestyle changes, and professional treatments.
  • OneSkin’s proprietary peptide, which powers their line of Topical Supplements, has been scientifically proven to reduce hyperpigmentation superior to common topical treatments, such as Kojic Acid and Retinol.


Sources:

  1. https://www.skincancer.org/risk-factors/tanning/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921758/
  3. https://link.springer.com/article/10.1007/s40266-018-00633-w
  4. https://www.aad.org/public/cosmetic/age-spots-marks/what-causes-spots
  5. https://www.aad.org/public/diseases/a-z/seborrheic-keratoses-overview
  6. https://www.healthline.com/health/dermatosis-papulosa-nigra#appearance
  7. https://pubmed.ncbi.nlm.nih.gov/11705252/#:~:text=The%20main%20drugs%20implicated%20in,heavy%20metals%20and%20psychotropic%20drugs
  8. https://www.medicalnewstoday.com/articles/dermatitis
  9. https://dermnetnz.org/topics/skin-changes-in-pregnancy/
  10. https://www.medicinenet.com/what_causes_hyperpigmentation/article.htm
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183040/
  12. https://www.aad.org/public/everyday-care/skin-care-secrets/routine/fade-dark-spots
  13. https://www.aad.org/public/everyday-care/sun-protection/sunscreen-patients/sunscreen-faqs
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605218/
  15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875240/
  16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785964/
  17. https://www.healthline.com/health/kojic-acid
  18. https://www.aocd.org/page/Retinoidstopical
  19. https://pubmed.ncbi.nlm.nih.gov/17147561/
  20. https://www.oneskin.co/blogs/reference-lab/skin-hyperpigmentation-what-it-is-common-treatments-and-how-os-01-improves-skin-hyperpigmentation
  21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142815/
  22. https://www.healthline.com/health/beauty-skin-care/skin-diet
  23. https://www.healthline.com/nutrition/foods-that-cause-acne
  24. https://www.healthline.com/health/food-nutrition/foods-that-boost-the-immune-system
  25. https://www.healthline.com/nutrition/niacin-benefits
  26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796020/

Uneven skin tone on the body is a common skin concern among men and women, especially in the aging population. It includes facial flushing, hyperpigmentation, and blotches on your skin. Several factors can cause this condition, including hormonal changes and lifestyle habits.

While some people consult a dermatologist for medical treatment, others often seek cosmetic solutions first. So what causes skin discoloration and how can you even the skin tone on your body?

Why Do I Have Uneven Skin Tone on My Body?

Uneven skin tone is caused by several internal and external factors. Some include:


#1 Sun Damage

When skin is exposed to UV rays, its cells naturally increase the production of melanin - a pigment molecule that is designed to protect your DNA from UV damage. The more sun exposure, the more melanin is produced and the darker your skin becomes, leading to skin tanning and also hyperpigmentation. Excessive sun exposure resulting in the overproduction of melanin and subsequent skin pigmentation is a leading cause of irregularities in the skin tone, especially as we age, due to its cumulative effects. As a result, many start to notice uneven coloration on several parts of their face and body when they reach their 30s and 40s, especially those who have experienced extensive sun exposure throughout their lives.


#2 Post-Inflammatory Hyperpigmentation (PIH) from Skin Injuries

Skin trauma, such as bug bites, acne, scratching wounds, or burns, can also lead to skin pigmentation on different parts of your body. These marks are known as post-inflammatory hyperpigmentation (PIH). PIH is your skin's natural reaction to inflammation as a part of the healing process. Because of this, it’s important to protect wounds and scars from sun exposure, so as to avoid exacerbating the pigmentation in skin.


#3 Aging

You may have noticed that older individuals often present with a more noticeable uneven skin tone than their younger counterparts. As you age, it's common to experience increasing visible discoloration on areas of your skin most exposed to damage, including your face, neck, and hands. These patches are often termed age spots, which are tan or dark brown spots that appear flat 4. In some cases, they can be even black or gray with a diameter of half an inch or more. The development of age spots can be caused by:

Less Collagen Production

People over 50 are more likely to experience uneven skin tone on their bodies, partly due to a decrease in their natural collagen production. Collagen is a structural protein in skin largely responsible for skin's plumpness and elasticity. Over time, as collagen production decreases, skin becomes thinner and drier. This thinner skin can make discoloration more visible.

Naturally Lighter Skin Tones

People with lighter skin tones have higher chances of developing age spots. This is because they naturally have less melanin content within the skin, which acts to protect skin cells from UV damage. Therefore, people with lighter skin are more susceptible to UV damage and subsequent hyperpigmentation, including age spots. Additionally, the contrast between their natural skin tone and age spots can be more evident.
Where

Is Uneven Skin Tone an Indicator of an Internal Issue?

Having an uneven skin tone on body and facial features can be a sign of an internal issue. For example, melasma is a skin condition that occurs due to increased hormone production, particularly during pregnancy 9.


Internal Contributors

Several internal factors can affect our skin's melanocytes (cells that produce melanin) and cause discolored patches. These include 10:
  • Genes
  • Allergies
  • Obesity
  • Diabetes
  • Hormonal changes during pregnancy or due to the use of oral contraceptives, intrauterine contraceptive devices, and hormone replacement therapy.


Skin Conditions

Multiple underlying skin conditions can also result in uneven skin tone on the body, especially as you age. These can include:
  • Seborrheic Keratosis. A skin growth commonly found in middle-aged or older people. It looks like a wart or precancerous skin growth. However, this condition is harmless. It can cause scaly, raised areas on several body parts 5.
  • Dermatosis Papulosa. A common skin condition in people with darker skin tones. The affected skin has small, discolored raised areas, often present on the skin of the face and neck. These are not dangerous, though many people seek treatment for aesthetic purposes 6.
  • Rosacea and dermatitis. These are some of the most common skin issues in people of all ages 8 and often result in an uneven skin tone that may look red.
Skin discoloration can also be due to the use of several medications, including antimalarials, nonsteroidal anti-inflammatory drugs, amiodarone, tetracyclines, cytotoxic drugs, heavy metals, and psychotropic drugs 7.
If you believe your uneven skin tone is due to an underlying condition or use of a new medication, it’s best to consult a health care professional to confirm this suspicion and ensure nothing more serious is going on.

Does Uneven Skin Tone Have Long-term Effects?

Uneven skin tone can have permanent or temporary effects. However, if you seek medical advice as soon as you spot uneven skin tone on your body, the chances are that you can reduce the discoloration more easily and quickly.

How Can I Achieve Even Skin Tone on My Body?

There are many ways to reduce the appearance of discoloration on your body. These could be over-the-counter (OTC) products, lifestyle changes, and professional treatments.


Wait-and-Watch

Depending on the cause of uneven skin tone, you might just need to ride it out. In the cases of pregnancy-derived hormonal changes, hyperpigmentation usually goes away within 12 months of delivery without any treatment 11. This could also be the case with post-inflammatory hyperpigmentation.


Identify and Treat the Underlying Cause

Uneven skin tone can often result from using a new skincare product or undergoing a lifestyle change. So, the first thing to do is evaluate whether you underwent any changes prior to the hyperpigmentation.


Use Sunscreen

Since sun damage is the leading cause of skin hyperpigmentation, especially with age, sunscreen can be your best defense against uneven skin tone. Regardless of the weather and your skin tone, using sunscreen all year round should be an essential step in your daily body care routine. The American Academy of Dermatology recommends that everyone use water-resistant and broad-spectrum skin protection with an SPF of 30 or higher 13.


Find a Scientifically-Validate OTC Product

There are many a href=https://www.oneskin.co/>topical skin care products available for purchase online and in stores aimed at treating uneven skin tone on the body. Before choosing the right one, it's best to consult your dermatologist to identify any underlying conditions that may react to certain products. Most OTC products aimed at treating hyperpigmentation generally contain one of the following ingredients:
  • Vitamin C. A potent antioxidant that protects your skin against sun damage while suppressing melanin production 14.
  • Glycolic Acid. Reduces the signs of sun-related aging, acne and acne scars, and post-inflammatory hyperpigmentation 15.
  • Salicylic Acid. This ingredient can work well for post-inflammatory hyperpigmentation 16.
  • Kojic Acid. Though effective at treating hyperpigmentation, this acid is a known skin irritant. It can actually cause dermatitis, including eczema, especially for those with sensitive skin. In fact, Kojic Acid has been banned as a potential carcinogen in Japan, Korea, and Switzerland 17.
  • Retinol. Also relatively effective at treating hyperpigmentation, overuse of retinol can strip your skin too quickly and reduce barrier function significantly, potentially compromising your long-term skin health.
  • Hydroquinone. Hydroquinone is usually used to lighten the skin. However, prolonged use (over 3 months), can cause ochronosis, a disease that causes blue/black discoloration of facial tissue.
Though these ingredients are common, they might not be the most effective and they could compromise your long-term skin health. Continue reading to find out how a peptide moisturizer could be the best ingredient for reducing hyperpigmentation.

Try OneSkin’s OS-01 Topical Supplements

When choosing a topical body supplement to help improve skin tone, it's ideal to pick one that is scientifically validated, with studies and data supporting its impact on hyperpigmentation and skin tone. OneSkin's Topical Supplements are powered by their proprietary OS-01 peptide - A powerful ingredient scientifically proven to reduce hyperpigmentation in skin superior to common treatments, such as kojic acid and retinol. Additionally, in a 12-week clinical study evaluating the impact of OS-01 FACE Topical Supplement on skin health markers, 95.5% of participants experienced an improvement in skin evenness, radiance, pores, and firmness.


Medical Treatments

Depending on the severity of your uneven skin tone and the underlying cause, your dermatologist may suggest one of the medical treatments below:
    • Laser Therapy. Ablative laser therapy rejuvenates the skin by removing the upper skin layer and enabling new skin to replace it. This treatment also stimulates collagen development. Most laser treatments also reduce post-inflammatory hyperpigmentation (PIH) by lightening and depigmenting the affected skin 21.
    • Microdermabrasion. An exfoliating treatment for dead skin cells and hyperpigmentation with the use of tiny particles.
    • Chemical Peels. Another effective exfoliation treatment for uneven skin tone. Chemical peels use highly-concentrated acids to treat discolored skin. They minimize hyperpigmentation by resurfacing the epidermis (upper skin layer). More powerful chemical peels may also penetrate the dermis (middle layer) of your skin to deliver more apparent results, but with a longer recovery time. Additionally, this treatment has a risk of burning your skin if mishandled, which could result in additional skin damage.
    • With the above methods, you may see a difference in your skin within 6-12 months
12
    . However, it may take longer than that.

Lifestyle Changes that Lessen the Appearance of Uneven Skin Tone

Wondering how to boost skin moisture or how to get rid of uneven skin tone on the body without any topical products or medical treatment? The answer may lie in your lifestyle. Here are some lifestyle changes that can improve skin tone:
  • Stay hydrated and keep your skin moisturized on a daily basis.
  • Avoid sugary foods, as they contribute to the development of visible aging signs in your skin 224.
  • Reduce your intake of alcohol, spicy foods, dairy, and greasy foods, all of which have been shown to negatively impact gut health and skin health 23.
  • Include Vitamin-C-rich fruits in your diet, like oranges, strawberries, bell peppers, guava, and kiwis 24).
  • Opt for foods containing niacin, a nutrient that boosts skin and hair health 25. These include green peas, poultry, tuna, and mushrooms.
  • Avoid all tobacco products.
  • Apply witch hazel and rosehip oil to reduce discoloration 26.

Key Takeaways

  • Uneven skin tone refers to hyperpigmentation, acne scars, and facial flushing or redness. It can be temporary or permanent.
  • Several internal factors and external factors result in uneven skin tone on body and facial features, with the biggest culprit being exposure to UV rays.
  • Hyperpigmentation can be treated with OTC products, lifestyle changes, and professional treatments.
  • OneSkin’s proprietary peptide, which powers their line of Topical Supplements, has been scientifically proven to reduce hyperpigmentation superior to common topical treatments, such as Kojic Acid and Retinol.


Sources:

  1. https://www.skincancer.org/risk-factors/tanning/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921758/
  3. https://link.springer.com/article/10.1007/s40266-018-00633-w
  4. https://www.aad.org/public/cosmetic/age-spots-marks/what-causes-spots
  5. https://www.aad.org/public/diseases/a-z/seborrheic-keratoses-overview
  6. https://www.healthline.com/health/dermatosis-papulosa-nigra#appearance
  7. https://pubmed.ncbi.nlm.nih.gov/11705252/#:~:text=The%20main%20drugs%20implicated%20in,heavy%20metals%20and%20psychotropic%20drugs
  8. https://www.medicalnewstoday.com/articles/dermatitis
  9. https://dermnetnz.org/topics/skin-changes-in-pregnancy/
  10. https://www.medicinenet.com/what_causes_hyperpigmentation/article.htm
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183040/
  12. https://www.aad.org/public/everyday-care/skin-care-secrets/routine/fade-dark-spots
  13. https://www.aad.org/public/everyday-care/sun-protection/sunscreen-patients/sunscreen-faqs
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605218/
  15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875240/
  16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785964/
  17. https://www.healthline.com/health/kojic-acid
  18. https://www.aocd.org/page/Retinoidstopical
  19. https://pubmed.ncbi.nlm.nih.gov/17147561/
  20. https://www.oneskin.co/blogs/reference-lab/skin-hyperpigmentation-what-it-is-common-treatments-and-how-os-01-improves-skin-hyperpigmentation
  21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142815/
  22. https://www.healthline.com/health/beauty-skin-care/skin-diet
  23. https://www.healthline.com/nutrition/foods-that-cause-acne
  24. https://www.healthline.com/health/food-nutrition/foods-that-boost-the-immune-system
  25. https://www.healthline.com/nutrition/niacin-benefits
  26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796020/

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

Discover More

Managing Combination Skin
A Comprehensive Guide to Understanding and Managin...
What Is Causing the Uneven Skin Tone On Your Body?
closeup portrait of a model
Celebrating Black History Month: A Discussion With...
Closeup of a sun spot
Skin Hyperpigmentation 101: What It Is & How To Tr...
Good Genes vs. Good Habits: Which Impacts Your Lon...
How Do Our Products Work Together?
How to Reduce Skin Inflammation
How to Reduce Skin Inflammation & Redness
How to Strengthen Your Skin
How to Strengthen Your Skin: A Guide to Thicker, H...
Better Elasticity, More Firmness: Discover OS-01 E...
The Top 4 Prickly Pear Benefits for Skin
How To Get Rid of Crepey Skin: 7 Solutions
Managing Combination Skin
Moved - A Comprehensive Guide to Understanding and...
Why cellular senescence is more than just one of t...
How OS-01 Works on Mature Skin
How OS-01 Works on Mature Skin
Crepey Skin Under Eyes
7 Causes For Crepey Skin Under Eyes
What Does Hyaluronic Acid Do For Your Skin
What Does Hyaluronic Acid Do For Your Skin?
Longevity Lifestyle #4 - Sleep Optimization
When to Apply Sunscreen: Before or After Moisturizer
When to Apply Sunscreen: Before or After Moisturiz...
This is the Data to Look For When Choosing Skin Ca...
Senotherapeutics, Senolytics, and Senomorphics -- ...
This is the Data to Look For When Choosing Skin Ca...
How is OS-01 EYE different from OS-01 FACE?
Biological Age: What is Biological Age, Why Does i...
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Difference Between Hydrating and Moisturizing
Exploring the Difference Between Hydrating and Moi...
How OS-01 Can Help Your Collagen Levels As You Age
Retinol 101: Debunking Retinol as the Gold Standar...
what-is-glycerin
An In-Depth Look at Glycerin: What is it and What ...
Different colored, transparent skincare products
Peptides vs Retinol: Is One Better For Increasing ...
Benefits Of Moringa Oil
Moved - An In-Depth Look At The Benefits Of Moring...
Is Fragrance Bad for Your Skin
Is Fragrance Bad for Your Skin?
Cell Turnover & Why It Slows As We Age
What your skincare routine is missing (Hint. It’s ...
OneSkin launches MolClock, the first skin-specific molecular clock to determine the biological age of human skin - One Skin Technologies
OneSkin launches MolClock, the first skin-specific...
Is This The Root Cause of Aging?
The Top 10 Best Foods for Skin Repair
The 101 Guide To Understanding Acne-Prone Skin
Three Ways To Extend Your Skinspan Starting With Your Body Care Routine
Three Ways To Extend Your Skinspan Starting With Y...
UV Damage Increases Cellular Senescence. Here's Ho...
What is Skin Cycling
What is Skin Cycling? Understanding, Embracing, an...
How to Tighten the Skin Under Your Eyes
Moved - How to Tighten the Skin Under Your Eyes
How To Boost Skin Moisture For Your Entire Body Fr...
Calorie Restriction And Intermittent Fasting: Eati...
Gut Health and Skin: How Are They Connected?
How Aging Science Will Help Us Fight Future Pandemics - One Skin Technologies
How Aging Science Will Help Us Fight Future Pandem...
What Foods Cause Acne and Which Fight Against It?
What Foods Cause Acne and Which Fight Against It?
Perfect Skin Care Routine for Combination Skin
4 Steps to Crafting the Perfect Skin Care Routine ...
How to Prevent Skin Aging Before It Starts
Keep Your Skin Hydrated
3 Natural Ways to Keep Your Skin Hydrated and Glow...
4 Essential Face Cleansing Steps to Achieving a Ra...
A Simplified Guide To The Different Skin Texture Types
A Simplified Guide To The Different Skin Texture T...
How to Brighten Eyes and Under-Eyes
Yes, You Need Sunscreen During Winter
Moved - UV Damage Increases Cellular Senescence. H...
Navigating Anti-Aging Skincare: The industry, the ...
Clean Beauty: What “clean” really means and why “s...
101 Guide on The Benefits of Cleansing Your Face
Get to Know OneSkin’s Topical Supplements:

OS-

...
Invasive vs. Non-Invasive Skincare: The pros and c...
4 Foods To Avoid During Wound Healing & Why
Do You Know What Clinical Claims Really Mean?
Mineral vs Chemical Sunscreen
Making Sense of Sunscreen: Understanding the Diffe...
Symptoms and Causes of Melasma on Face
two types of face wrinkles
2 Types of Wrinkles and Tips for Treating Them
Are There Dangers of Retinol Cream Use
Discover Why Our New SPF Outperforms the Rest
sunscreen-ingredients-to-avoid
Navigating Sunscreen Labels: Unwanted Ingredients ...
Benefits of Sunscreen
Beyond UV Protection: 7 Surprising Ways Sunscreen ...
how-much-sunscreen-to-use-on-face
The Science of Sunscreen: Understanding the Optima...
Marionette Lines
Understanding Marionette Lines: Causes and Prevent...
Hands and Dermal Elasticity: Understanding and Man...
The Top 5 Benefits of Zinc Oxide for Skin
What is Epidermal Thickness & Why Does it Matter?
Winter Skincare - How To Prevent Dry Skin this Sea...
Can a Plant-Based Diet Really Increase Your Health...
How to Know if Your Skin Barrier is Damaged
Tight Feeling Skin
Tight Feeling Skin: 3 Reasons Why
Our Story: Learn more about the history of OneSkin...
How to Strengthen Your Skin
How to Strengthen Your Skin: A Guide to Thicker, H...
What is the Function of Skin as a Protective Barrier
What is the Function of Skin as a Protective Barri...
Can You Use Hyaluronic Acid with Retinol?
Life Force book
OneSkin Featured In Tony Robbins’ Life Force
Thick Skin vs Thin Skin
A Comprehensive Guide to Understanding the Differe...
Stressed Skin
Stressed Skin: 4 Stress Effects on the Skin
How Relationships, Community, & Social Interaction...
How OneSkin Developed the OS-01 Peptide
Better Elasticity, More Firmness: Discover OS-01 E...
Exploring the skin’s purpose in whole-body health
What Are The Causes Of Dry, Flaky Skin On Your Fac...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Dry Skin 101: How To Identify This Skin Type Moved
Are Parabens Bad for Your Skin
Are Parabens Bad for Your Skin?
How To Smooth Skin Texture On The Face: 4 Expert T...
What is Tinted Sunscreen?
What is Tinted Sunscreen?
Face vs. Body Sunscreen: Can You Use Body Sunscreen On Your Face?
Face vs. Body Sunscreen: Can You Use Body Sunscree...
Sun spots
Sun Spots: Causes & 3 Prevention Tips
free radicals
What Are Free Radicals and How Do They Impact Skin...
Our Research Has Been Published in npj Aging
6 Factors That Contribute to Slow Skin Healing
Hydrating Skin Care Routine For Dry Skin
How To Create A Hydrating Skin Care Routine For Dr...
More Than Skin Deep: How Physical Touch Predicts L...
What is a peptide?
Peptides: the first piece o
...
What happens to skin as a person ages?
How to Address Stomach Wrinkles
How to Address Stomach Wrinkles For Smoother Skin
Target Cellular Senescence with the Highest Concen...
The Science of Gratitude
Restoring Dry Skin Around The Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How To Reduce Hyperpigmentation by Targeting Cellu...
How to Prevent Skin Aging Before It Starts Moved
The Science Behind Why The Skin Around the Eyes Ag...
The Top 6 Best Antioxidants For Skin Health and Longevity
The Top 6 Best Antioxidants For Skin Health and Lo...
Hallmarks Of Aging - One Skin Technologies
Hallmarks Of Aging
4 Essential Face Cleansing Steps to Achieving a Ra...
What is Sustainable Packaging for Cosmetic Products?
What is Sustainable Packaging for Cosmetic Product...
SKIN CARE IS HEALTH CARE: WHY EXTENDING YOUR SKINS...
What is Skin Inflammation? What Causes it?
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Restoring Dry Skin Around The Eyes
101 Guide To Restoring Dry Skin Around The Eyes Mo...
How Do You Know When to Stop Using Retinol?
Skin Care Routine for Oily Skin
A Step-by-Step Guide to Creating the Perfect Skin ...
Special Announcement: OneSkin to Donate 1% of Tota...
a smiling woman washing her face
Cleanser Vs. Face Wash: Which Should I Reach For?
Retinol 101: Debunking Retinol as the Gold Standar...
Health Is The New Wealth - One Skin Technologies
Health Is The New Wealth
Young skin - how to keep it not just looking young...
How to Reverse (or Prevent) Aging Skin
What is Normal Skin & Do I Have This Skin Type?
Understanding Oily Skin: Causes & Characteristics
OneSkin’s 12-Week Clinical Study to Validate the E...
How chronic stress makes you age faster
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Crepey Skin Under Eyes
7 Causes For Crepey Skin Under Eyes Moved
7 Benefits of Andiroba Oil For Skin
How to Use Peptides In Your Skincare Regimen to Optimize Your Health
How to Use Peptides In Your Skincare Regimen to Op...
what-is-glycerin
An In-Depth Look at Glycerin: What is it and What ...
What Is Sensitive Skin
What is Sensitive Skin? Moved
What Causes Dark Circles Under and Around Your Eyes?
What Causes Dark Circles Under and Around Your Eye...
What Causes Crepey Skin & Can It Be Avoided Altoge...
Difference Between Hydrating and Moisturizing
Exploring the Difference Between Hydrating and Moi...
Hydrating Skin Care Routine For Dry Skin
How To Create A Hydrating Skin Care Routine For Dr...
Does Niacinamide Help With Acne & Scarring?
How to Repair & Restore Your Skin Barrier
How to Repair & Restore Your Skin Barrier
Skin Care Routine for Oily Skin
Moved - A Step-by-Step Guide to Creating the Perfe...
OneSkin Notable Mention: Dave Asprey's The Human U...
The Lip Lineage
The Lip Lineage: Exploring the Why Behind Wrinkled...
How OS-01 Works With Different Skin Types
What Is Exfoliation & Is It A Necessary Measure For Long-Term Skin Health?
What Is Exfoliation & Is It A Necessary Measure Fo...
What Do Antioxidants Do For Skin and Why Should You Care?
What Do Antioxidants Do For Skin and Why Should Yo...
Glycerin Benefits for Skin
Exploring the Benefits of Glycerin for Skin Health...
How Does Sunscreen Work? How Long Does it Last?
How Does Sunscreen Work? How Long Does it Last?
A Journey Through the Skin: How UV Radiation Cause...
Skin Microbiome: What It Is, Why it’s Important, A...
Why We Want Skin To Be More, Not Less
Why We Want Skin To Be More, Not Less
You’re only as old as you feel, scientists are fin...
What is the Best Skin Care Regimen for Aging Skin
What is the Best Skin Care Regimen for Aging Skin?
Ceramides For Skin: Everything You Need to Know
Longevity Lifestyle #3 - Exercise & Mitochondrial ...
6 Benefits of Jojoba Oil
6 Benefits of Jojoba Oil
101 Guide To Skin Tightening
101 Guide To Skin Tightening + 7 Noninvasive Metho...
How to Skin Cycle: A Guide to Optimize Your Skin C...
Longevity Lifestyle #1 - Cold Exposure: Hype or Lo...
Sleep: Nature’s Restart Button? - One Skin Technologies
Sleep: Nature’s Reset Button?
What is Skin Elasticity & How Can You Improve It?
Where Skin Health Meets Longevity
Allantoin For Skin: A Comprehensive Guide
5 Common Perimenopause Skin Problems
Five Common Skin Problems Experienced in Perimenop...
The Top 3 Benefits of Peptides for Skin
How OS-01 Can Help Your Collagen Levels As You Age...
Moved - Our Research Has Been Published in npj Agi...
Decoding the Connections Between Intrinsic & Extri...
Zombie Cells
What are Zombie Cells & How Can We Remove Them?
The Connection Between Mental Health, Age Percepti...
Perfect Skin Care Routine for Combination Skin
Moved - 4 Steps to Crafting the Perfect Skin Care ...
Keep Your Skin Hydrated
3 Natural Ways to Keep Your Skin Hydrated and Glow...