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The only 24-hour system powered by the OS-01 Peptide™ to shield and restore healthy looking and feeling lips.


  • OS-01 LIP Shield SPF 15+ defends against the 3 main drivers of lip aging by day

  • OS-01 LIP Mask deeply hydrates and helps support smoother, fuller-looking lips at night

  • Dermatologist tested, fragrance-free, suitable for sensitive skin

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  • Accepted National Eczema Association logo
  • Leaping bunny certified logo

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Ingredients that complement the OS-01 PeptideTM


Bisabolol

A chamomile-derived antioxidant that soothes irritation, calms signs of inflammation, and enhances ingredient absorption.


Vitamin E
A potent antioxidant that helps neutralize oxidative stress and supports daily repair from UV and environmental exposure.


Hyaluronic acid
A highly bioavailable form that delivers immediate hydration and long-lasting moisture retention for skin prone to dryness due to a thinner barrier and lack of natural sebum production.

How it works

Powered by the OS-01 Senescence Peptide™

Born from over a decade of longevity science, OS-01 is engineered to address a key driver of visible skin aging, supporting meaningful improvements in skin health today and over time to future-proof skin.

DAY + NIGHT LIP DUO

4.6
Rated 4.6 out of 5 stars
Based on 882 reviews
Total 5 star reviews: 689 Total 4 star reviews: 82 Total 3 star reviews: 50 Total 2 star reviews: 32 Total 1 star reviews: 29
87%would recommend these products
882 reviews
  • LA
    Leslie A.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD BARE BLUSH, EARLY ACCESS
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Love it!

    Natural color and feels great on my lips!

  • HM
    H M.
    Verified Buyer
    Reviewing
    OS-01 LIP Mask, Recurring
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    The absolute best lip mask!

    I've been using this lip mask for 2 months every night before I go to bed. I've not used a better lip mask that is thick enough that stays on my lips all night. I have not had one chapped lip, dryness or cracked lips since I've been using this product. I have it on auto delivery and never want to run out. I also use their moisturizing cream and it is excellent as well.

  • RM
    Rachel M.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 4 out of 5 stars
    Yesterday
    Feels great!

    I like this but it still comes out white. I need the tinted version.

    OneSkin
    14 hours ago

    Hi Rachel!

    Thank you so much for taking the time to share your feedback about the OS-01 LIP SHIELD SPF 15+ and for the fantastic 4-star rating! We're thrilled to hear that it feels great on your lips — that's exactly what we want to hear about the texture and application experience.

    You're absolutely right that having options to match different preferences and skin tones would be ideal, and feedback like yours is incredibly valuable as we continue to develop our product line to meet what our customers are looking for.

    SPF 15+ protection, combined with our OS-01 Peptide, helps protect and support your lip skin at the cellular level, even if the appearance isn't quite what you were hoping for.

    Thank you for choosing OneSkin and for being so thoughtful in your review, Rachel — we're grateful you're giving our lip protection a try!

  • JH
    Julie H.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    I never leave the house without it.

    I love in Arizona where SPF is a must all year around. This is by far my favorite lip protection. It keeps my lips both covered and safe, but leaves the nicest matte shine on them making me feel pretty even when I’m bare faced.

  • KB
    Kassandra B.
    Verified Buyer
    Reviewing
    OS-01 LIP MASK
    I recommend this product
    Rated 5 out of 5 stars
    4 days ago
    OS Lip Mask

    This lip mask is a must have I use it every night right before bed. I’ve been in the beauty industry for years and have never used a lip treatment that delivers such moisture.

Full ingredient list

OS-01 LIP SPF ingredients

Active ingredients: Zinc Oxide 5.5%

Inactive ingredients: Simmondsia Chinensis (Jojoba) Seed Oil, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Water (Aqua), Garcinia Indica Seed Butter, Tocopheryl Acetate, Butylene/Ethylene/Styrene Copolymer, Glyceryl Oleate, Glyceryl Dioleate, Glycerin, Oleic Acid, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1, Dipalmitoyl Hydroxyproline, Trihydroxystearin, Sodium Hyaluronate, Glucomannan, Tetrahexyldecyl Ascorbate, Bisabolol, Decapeptide-52*, Ethylhexylglycerin, Caprylyl/Capryl Glucoside, Propanediol, Ectoin, Centella Asiatica Extract, Hippophae rhamnoides (Sea Buckthorn) Oil, Helianthus Annuus (Sunflower) Seed Oil, Copernicia cerifera (Carnauba) Wax, Tocopherol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic Acid, Lecithin, Lactic Acid, Octyldodecanol, Sorbitan Oleate, Alumina, Magnesium Oxide, Palmitic Acid, Iron oxides (CI 77491, CI 77492, CI 77499), Titanium Dioxide (CI 77891), Red 33 Lake (CI 17200), Red 7 Lake (CI 15850).

Drug Facts

Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen

Uses

  • Helps prevent sunburn
  • If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

  • For external use only.
  • Do not use on damaged or broken skin.
  • Stop use and ask a doctor if rash occurs.
  • Keep out of reach of children.

OS-01 LIP MASK ingredients

Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan. *OS-01 Peptide™