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The only 24-hour system powered by the OS-01 Peptide™ to shield and restore healthy looking and feeling lips.


  • OS-01 LIP Shield SPF 15+ defends against the 3 main drivers of lip aging by day

  • OS-01 LIP Mask deeply hydrates and helps support smoother, fuller-looking lips at night

  • Dermatologist tested, fragrance-free, suitable for sensitive skin

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  • Accepted National Eczema Association logo
  • Leaping bunny certified logo

OneSkin

Ingredients that complement the OS-01 PeptideTM


Bisabolol

A chamomile-derived antioxidant that soothes irritation, calms signs of inflammation, and enhances ingredient absorption.


Vitamin E
A potent antioxidant that helps neutralize oxidative stress and supports daily repair from UV and environmental exposure.


Hyaluronic acid
A highly bioavailable form that delivers immediate hydration and long-lasting moisture retention for skin prone to dryness due to a thinner barrier and lack of natural sebum production.

How it works

Powered by the OS-01 Senescence Peptide™

Born from over a decade of longevity science, OS-01 is engineered to address a key driver of visible skin aging, supporting meaningful improvements in skin health today and over time to future-proof skin.

DAY + NIGHT LIP DUO

4.6
Rated 4.6 out of 5 stars
Based on 904 reviews
Total 5 star reviews: 708 Total 4 star reviews: 84 Total 3 star reviews: 50 Total 2 star reviews: 33 Total 1 star reviews: 29
88%would recommend these products
904 reviews
  • LC
    Leslee C. P.
    Verified Buyer
    Reviewing
    OS-01 LIP Mask, Recurring
    I recommend this product
    Rated 5 out of 5 stars
    3 minutes ago
    Does it hydrate?

    Yes it does!!! I’ve been experiencing autoimmune issues and it affected my lips and surrounding skin. I’ve been using this product for two months and am very pleased!

  • DS
    denise s.
    Verified Buyer
    Reviewing
    DAY + NIGHT LIP DUO
    I recommend this product
    Rated 5 out of 5 stars
    14 minutes ago
    Great!

    I love the moisture and how my lips feel when using this product!

  • SG
    Steven G.
    Verified Buyer
    Reviewing
    OS-01 LIP Mask Refill
    I recommend this product
    Rated 5 out of 5 stars
    2 hours ago
    Amazing lip mask

    I dont usually like lip masks, they tend to be too sticky and no real difference the next morning. Not this mask. This one goes on smooth and a little goes a long way. I’ve noticed a difference in my lip color, softness and a reduction in deep lip lines. By the 3rd week using it and enjoying the results I ordered a refill, that way I'm not without this lip mask.

  • JU
    Josephine U.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I recommend this product
    Rated 5 out of 5 stars
    3 hours ago
    Long lasting

    Long lasting shine and smoothness!

  • BP
    Beverly P.
    Verified Buyer
    Reviewing
    OS-01 LIP SHIELD SPF 15+
    I do not recommend this product
    Rated 2 out of 5 stars
    Yesterday
    I like the idea -

    but I'm not sure how useful it is.

    OneSkin
    4 hours ago

    Hi Beverly!

    Thank you for taking the time to share your feedback about OS-01 LIP SHIELD SPF 15+ — and we appreciate your honesty about being uncertain about its usefulness. That kind of feedback really helps us understand how customers are experiencing the product.

    We completely understand that it can be hard to gauge the value of lip protection, especially since the benefits aren't always immediately visible like they might be with other skincare products.

    Here's what OS-01 LIP SHIELD is designed to do that may help clarify its purpose:

    • Daily protection — your lips are constantly exposed to UV rays, wind, and environmental stressors that can cause premature aging and damage. The broad spectrum SPF 15+ mineral protection helps shield against that daily exposure.
    • Cellular support — the OS-01 peptide works at the cellular level to target senescent cells in lip tissue, supporting long-term lip health and resilience from the inside out.
    • Antioxidant defense — the formula includes six antioxidants that help neutralize free radicals throughout the day, protecting against environmental damage that can lead to dryness, fine lines, and texture changes over time.

    The benefits are often more about prevention and long-term lip health rather than dramatic immediate changes, which can make it feel less obvious than other products. Think of it like sunscreen for your face — the real value is in what it's preventing rather than what you see right away.

    We'd love to help you get the most out of the product while you have it — applying it as your daily lip protection, especially before heading outdoors, gives you the best opportunity to experience what it's designed to do.

    Thank you for choosing OneSkin, and please don't hesitate to reach out at support@oneskin.co if you have any questions about how to incorporate it into your routine!

Full ingredient list

OS-01 LIP SPF ingredients

Active ingredients: Zinc Oxide 5.5%

Inactive ingredients: Simmondsia Chinensis (Jojoba) Seed Oil, Ethylene/Propylene/Styrene Copolymer, Ethylhexyl Palmitate, Butyloctyl Salicylate, Caprylic/Capric Triglyceride, Water (Aqua), Garcinia Indica Seed Butter, Tocopheryl Acetate, Butylene/Ethylene/Styrene Copolymer, Glyceryl Oleate, Glyceryl Dioleate, Glycerin, Oleic Acid, Tribehenin, Sorbitan Isostearate, Palmitoyl Tripeptide-1, Dipalmitoyl Hydroxyproline, Trihydroxystearin, Sodium Hyaluronate, Glucomannan, Tetrahexyldecyl Ascorbate, Bisabolol, Decapeptide-52*, Ethylhexylglycerin, Caprylyl/Capryl Glucoside, Propanediol, Ectoin, Centella Asiatica Extract, Hippophae rhamnoides (Sea Buckthorn) Oil, Helianthus Annuus (Sunflower) Seed Oil, Copernicia cerifera (Carnauba) Wax, Tocopherol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate, Polyhydroxystearic Acid, Polyglyceryl-3 Polyricinoleate, Isostearic Acid, Lecithin, Lactic Acid, Octyldodecanol, Sorbitan Oleate, Alumina, Magnesium Oxide, Palmitic Acid, Iron oxides (CI 77491, CI 77492, CI 77499), Titanium Dioxide (CI 77891), Red 33 Lake (CI 17200), Red 7 Lake (CI 15850).

Drug Facts

Active Ingredients: Zinc Oxide 5.5% …………Purpose: Sunscreen

Uses

  • Helps prevent sunburn
  • If used as directed with other sun protection measures (see directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

  • For external use only.
  • Do not use on damaged or broken skin.
  • Stop use and ask a doctor if rash occurs.
  • Keep out of reach of children.

OS-01 LIP MASK ingredients

Bis-Diglyceryl Polyacyladipate-2, Hydrogenated Polyisobutene, Diisostearyl Malate, Phytosteryl/Isostearyl/Cetyl/Stearyl/Behenyl Dimer Dilinoleate, Water (Aqua), Polyglyceryl-2 Diisostearate, Hydroxystearic Acid, Butyrospermum Parkii (Shea) Nut Extract, Squalane, 1,2-Hexanediol, Glycerin, Glyceryl Oleate, Cucumis Sativus (Cucumber) Seed Oil, Pentaerythrityl Tetraisostearate, Cetearyl Alcohol, Glyceryl Dioleate, Simmondsia Chinensis (Jojoba) Seed Oil, Euphorbia Cerifera (Candelilla) Wax, Helianthus Annuus (Sunflower) Seed Wax, Ethylhexylglycerin, Ethylhexyl Palmitate, Citrullus Lanatus (Watermelon) Fruit Extract, Panthenol, Lens Esculenta (Lentil) Fruit Extract, C10-18 Triglycerides, Tocopherol, Bisabolol, Punica Granatum Flower Extract, Pyrus Malus (Apple) Fruit Extract, Sodium Hyaluronate, Ceramide NP, Polyglyceryl-3 Diisostearate, Propanediol, Triolein, Caprylic/Capric Triglyceride, Sodium Lactate, Tamarindus Indica Seed Polysaccharide, Sodium Benzoate, Sodium PCA, Phaeodactylum Tricornutum Extract, Haematococcus Pluvialis Extract, Trihydroxystearin, Lecithin, Potassium Sorbate, Stearalkonium Hectorite, Propylene Carbonate, Allantoin, Olea Europaea (Olive) Fruit Oil, Pantolactone, Decapeptide-52*, Oleic Acid, Palmitoyl Hexapeptide-12, Glucomannan. *OS-01 Peptide™