This is a carousel. Use Next and Previous buttons to navigate

This is a carousel. Use Next and Previous buttons to navigate

Free shipping on orders over $79.00 USD

OS-01 FACE Topical Supplement

OS-01 FACE Topical Supplement

Smooth and firm skin with our daily moisturizer for the face and neck, powered by the OS-01 Peptide™.01



  • Boosts hydration, elasticity, and barrier function

  • 96% showed an improvement in firmness and radiance

  • Dermatologist tested, fragrance-free, safe for sensitive skin

Subscription Exclusives

  • Plastic neutral refillable packaging
  • Exclusive early access to new products
  • Earn 2x points on all recurring orders
  • Easily change, skip, or cancel anytime
OneSkin

Free shipping on orders over $79.00 USD

OneSkin

Try it risk-free! 45-day money back guarantee.

OneSkin

You’re earning [potential_points] points with the OneSkin Loyalty Program

You’re earning 99 points with OneSkin Loyalty Program

OneSkin

Benefits

Multitasking moisturizer that addresses the common signs of aging on areas exposed most to the environment

Hydration

Boosts barrier function, allowing your skin retain moisture and stay hydrated.02

Firmness

Switches off the cells that degrade collagen, helping skin stay firm.01,03

Radiance

Enhances skin tone and texture, helping skin look and feel smooth and radiant.02

5-STAR REVIEWS

See why customers love OS-01 FACE

“I stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smooth…and now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.” – Tova N.

"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" – Laura E.

"It’s working great!!! It absorbs quickly. I see and feel a significant difference in my skin’s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." – Ildiko C.

"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." – Sarah B.

CLINICAL DATA

Visible results, scientifically validated

100

of participants had improved smoothness 02

95.5

of participants had improved firmness, radiance, and tone 02

90

of participants had improved elasticity 02

86

of participants had improved appearance of fine lines and wrinkles 02

The Science Behind OS-01 FACE

With age, skin becomes thinner, produces less collagen, proliferates at a slower rate, and accumulates damage. By analyzing key aging biomarkers in human skin samples before and after treatment in the lab, our scientists found that OS-01 FACE:

  1. Increases epidermal thickness 01
  2. Supports collagen biosynthesis pathways (increase in COL1A1 and collagen levels) 01,03
  3. Promotes cellular proliferation (increase in MKI67) 01


Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. (Zonari, A., et al. npj Aging, 2023) Note: In npj Aging publication, "Topical Pep 14" = OS-01 FACE

Getting started with OS-01 FACE

Follow these easy steps for optimal results

  • Dispense 1-2 pumps onto fingers
  • Gently massage into skin on the face and neck
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Blocking Peptide™

The only peptide scientifically proven to reverse skin aging at the cellular level 01,02,03

All Ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

Citations

01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

OS-01 FACE Topical Supplement

4.7
Rated 4.7 out of 5 stars
Based on 5,889 reviews
Total 5 star reviews: 4.8k Total 4 star reviews: 756 Total 3 star reviews: 241 Total 2 star reviews: 68 Total 1 star reviews: 57
94%would recommend these products
5,889 reviews
  • AW
    Anne W.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    4 minutes ago
    Removes dark age spots!

    I've now used OneSkin for several years and I have seen a gradual lightening of old sun damage and age spots on my face. Also the skin on the rest of my body is much softer and feels and looks so much healthier--my husband has noticed!

    LOVE the new refill pouch---hope you will consider that for the Body as well!

  • ND
    Nancy D.
    Verified Buyer
    Reviewing
    OS-01 FACE Topical Supplement Refill
    I recommend this product
    Rated 5 out of 5 stars
    21 hours ago
    OS-01 Face

    My skin feels smoother & more hydrated. Definitely recommend using this product

  • RT
    RobinAnn T.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    I love this!

    I really notice the difference when I run out. It has had a significant impact on my residual 50 year old acne.

  • KG
    Kathleen G.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Appreciate having this refill option and LOVE the product line

    I love the One Skin product line and very much appreciate the environmental consciousness of the refill products. Very easy to swap in & out!

  • PW
    Peggy W.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Excellent !

    Best product I’ve ever used on my skin. I love the way it rubs into skin, not greasy or oily residue. My face feels so smooth and healthy.