Discover Why Our New SPF Outperforms the Rest
6 min read
Sep 18th, 2023
Discover Why Our New SPF Outperforms the Rest
6 min read
Sep 18th, 2023
The science is clear: wearing SPF every day is the single best way to protect your skin. But with thousands of sunscreens on the market, conflicting advice on social media, and even occasional FDA warnings, it can be tricky to figure out which sunscreen will actually work for you. Ready to clear up the confusion? Discover why our new SPF, OS-01 SHIELD, outperforms other sunscreens by not just preventing–but also reversing–UV aging. Along the way, we’ll explore the science behind sun protection and demystify which ingredients work best to fight sun damage.
The science is clear: wearing SPF every day is the single best way to protect your skin. But with thousands of sunscreens on the market, conflicting advice on social media, and even occasional FDA warnings, it can be tricky to figure out which sunscreen will actually work for you. Ready to clear up the confusion? Discover why our new SPF, OS-01 SHIELD, outperforms other sunscreens by not just preventing–but also reversing–UV aging. Along the way, we’ll explore the science behind sun protection and demystify which ingredients work best to fight sun damage.
01
OS-01 SHIELD prevents UV-induced skin damage with Zinc Oxide
Let’s start with the part of choosing a sunscreen that leaves most people confused: UV filters. We formulated OS-01 SHIELD with zinc oxide, our preferred mineral filter.
Zinc oxide is gentler than common chemical filters
Unlike chemical UV filters like oxybenzone and avobenzone, zinc oxide starts working right away and is gentle on even the most sensitive skin, which means you don’t have to worry about stinging or redness. By creating a physical shield on the surface of the skin, mineral filters deflect UV radiation away from the skin. We prefer this to chemical filters, which absorb UV radiation and convert it into heat. Another bonus: mineral filters don’t readily absorb into the skin, so you don’t have to worry about them reaching your bloodstream.
01
OS-01 SHIELD prevents UV-induced skin damage with Zinc Oxide
Let’s start with the part of choosing a sunscreen that leaves most people confused: UV filters. We formulated OS-01 SHIELD with zinc oxide, our preferred mineral filter.
Zinc oxide is gentler than common chemical filters
Unlike chemical UV filters like oxybenzone and avobenzone, zinc oxide starts working right away and is gentle on even the most sensitive skin, which means you don’t have to worry about stinging or redness. By creating a physical shield on the surface of the skin, mineral filters deflect UV radiation away from the skin. We prefer this to chemical filters, which absorb UV radiation and convert it into heat. Another bonus: mineral filters don’t readily absorb into the skin, so you don’t have to worry about them reaching your bloodstream.
Zinc oxide provides more comprehensive protection than titanium dioxide
There are two main types of mineral filters: zinc oxide and titanium dioxide. While both offer some broad spectrum sun protection, titanium dioxide is less effective at blocking UVA, the wavelength that affects the deeper layers of the skin and causes most long-term sun damage. Zinc oxide provides more comprehensive protection–effectively shielding your skin from both aging UVA and sunburn-causing UVB rays.
Zinc oxide provides more comprehensive protection than titanium dioxide
There are two main types of mineral filters: zinc oxide and titanium dioxide. While both offer some broad spectrum sun protection, titanium dioxide is less effective at blocking UVA, the wavelength that affects the deeper layers of the skin and causes most long-term sun damage. Zinc oxide provides more comprehensive protection–effectively shielding your skin from both aging UVA and sunburn-causing UVB rays.
02
OS-01 SHIELD protects against damage with antioxidants
UV filters aren’t the only piece in the sun protection puzzle. Antioxidants, molecules that prevent oxidation, can also protect your skin from the tissue-damaging effects of UV radiation. That’s why we included five super-antioxidants in OS-01 SHIELD.
Antioxidants neutralize damaging free radicals
UV exposure leads to the production of free radicals, unstable molecules that are missing an electron. Like hungry scavengers, free radicals try to steal electrons from other molecules–kickstarting a process called oxidation, which alters cell membranes, proteins, lipids and DNA. As molecules with an extra electron, antioxidants prevent oxidation and resulting tissue damage by donating their spare electron to hungry free radicals. When used in combination with SPF, antioxidants help provide an extra layer of protection against sun damage.
02
OS-01 SHIELD protects against damage with antioxidants
UV filters aren’t the only piece in the sun protection puzzle. Antioxidants, molecules that prevent oxidation, can also protect your skin from the tissue-damaging effects of UV radiation. That’s why we included five super-antioxidants in OS-01 SHIELD.
Antioxidants neutralize damaging free radicals
UV exposure leads to the production of free radicals, unstable molecules that are missing an electron. Like hungry scavengers, free radicals try to steal electrons from other molecules–kickstarting a process called oxidation, which alters cell membranes, proteins, lipids and DNA. As molecules with an extra electron, antioxidants prevent oxidation and resulting tissue damage by donating their spare electron to hungry free radicals. When used in combination with SPF, antioxidants help provide an extra layer of protection against sun damage.
OS-01 SHIELD neutralizes free radicals 4x better than leading SPFs
So how well does our formula neutralize free radicals? Like everything else, our scientists put this question to the test in the lab. Utilizing a chemical probe with a stable radical that changes color when that radical is neutralized, we found that OS-01 SHIELD neutralizes free radicals at least 4x more effectively than leading anti-aging SPFs.
OS-01 SHIELD neutralizes free radicals 4x better than leading SPFs
So how well does our formula neutralize free radicals? Like everything else, our scientists put this question to the test in the lab. Utilizing a chemical probe with a stable radical that changes color when that radical is neutralized, we found that OS-01 SHIELD neutralizes free radicals at least 4x more effectively than leading anti-aging SPFs.
Utilizing a chemical probe with a stable radical that changes colors when that radical is scavenged, levels of free radical scavenging were measured for various leading SPFs and OS-01 SHIELD.
Utilizing a chemical probe with a stable radical that changes colors when that radical is scavenged, levels of free radical scavenging were measured for various leading SPFs and OS-01 SHIELD.
03
OS-01 SHIELD hits the “undo” button on UV-induced aging with OS-01
When we formulated OS-01 SHIELD, we set out to create a new kind of SPF that doesn’t just protect against new sun exposure, but also reverses UV-induced aging that’s already occurred. UV damage adds up over a lifetime and most of us have already accumulated our fair share. In fact, up to 90% of the signs of aging you see on your face are actually the result of sun exposure. That’s because, on the cellular level, UV exposure causes cells to prematurely enter senescence, the end stage in a cell’s life. A central hallmark of skin aging, cellular senescence is the accumulation of aged, zombie cells that induce aging in neighboring cells, accelerating the aging process and resulting in impaired skin regeneration and chronic inflammation.While UV filters and antioxidants help prevent this damage from occurring in the first place, they can’t undo the UV-induced aging that’s already occurred. That’s where OS-01 comes in. Our breakthrough peptide has been scientifically proven to reverse the skin’s biological age.
OS-01 reduces skin’s biological age
The majority of skin aging is caused by sun damage. By reversing skin’s biological age, OS-01 has been proven to help undo this aging and restore healthier skin function. Using MolClock, OneSkin’s proprietary skin-specific molecular clock to quantify skin’s biological age, we saw a decrease of 2.6 biological years in ex vivo skin treated with the OS-01 peptide over 5 days.
03
OS-01 SHIELD hits the “undo” button on UV-induced aging with OS-01
When we formulated OS-01 SHIELD, we set out to create a new kind of SPF that doesn’t just protect against new sun exposure, but also reverses UV-induced aging that’s already occurred. UV damage adds up over a lifetime and most of us have already accumulated our fair share. In fact, up to 90% of the signs of aging you see on your face are actually the result of sun exposure. That’s because, on the cellular level, UV exposure causes cells to prematurely enter senescence, the end stage in a cell’s life. A central hallmark of skin aging, cellular senescence is the accumulation of aged, zombie cells that induce aging in neighboring cells, accelerating the aging process and resulting in impaired skin regeneration and chronic inflammation.While UV filters and antioxidants help prevent this damage from occurring in the first place, they can’t undo the UV-induced aging that’s already occurred. That’s where OS-01 comes in. Our breakthrough peptide has been scientifically proven to reverse the skin’s biological age.
OS-01 reduces skin’s biological age
The majority of skin aging is caused by sun damage. By reversing skin’s biological age, OS-01 has been proven to help undo this aging and restore healthier skin function. Using MolClock, OneSkin’s proprietary skin-specific molecular clock to quantify skin’s biological age, we saw a decrease of 2.6 biological years in ex vivo skin treated with the OS-01 peptide over 5 days.
DNA methylation age of ex vivo human skin samples (79yr) treated with 12.5uM peptide for 5 days calculated using the Skin-Specific DNA Methylation Clock, MolClok (Zonari, et al., npj Aging, 2023)
To confirm these results, we put OS-01 to the test with a number of other molecular clocks, and measured it in a head-to-head battle with another longevity molecule, rapamycin. Again, OS-01 not only reduced skin’s biological age but also outperformed rapamycin.
DNA methylation age of ex vivo human skin samples (79yr) treated with 12.5uM peptide for 5 days calculated using the Skin-Specific DNA Methylation Clock, MolClok (Zonari, et al., npj Aging, 2023)
To confirm these results, we put OS-01 to the test with a number of other molecular clocks, and measured it in a head-to-head battle with another longevity molecule, rapamycin. Again, OS-01 not only reduced skin’s biological age but also outperformed rapamycin.
Ex vivo skin samples (79 yo) maintained in basal media (NT), or treated with 100 nM Rapamycin (Rapa), or 12.5 µM OS-01 peptide for 5 days. Predicted DNA age according to Horvath Clock (Clk 1), Hannum Clock (Clk 2), Lin Clock (Clk 3)Horvath Skin & Blood Clock (Clk 4), PhenoAge Clock (Clk 5) and OneSkin’s MolClock (Clk 6). (Zonari, et al., npj Aging, 2023)
This data shows that OS-01 effectively reverses environmental aging that’s already occurred–giving you the chance to hit the undo button on all those years of accelarated skin aging from unprotected sun exposure.
Ex vivo skin samples (79 yo) maintained in basal media (NT), or treated with 100 nM Rapamycin (Rapa), or 12.5 µM OS-01 peptide for 5 days. Predicted DNA age according to Horvath Clock (Clk 1), Hannum Clock (Clk 2), Lin Clock (Clk 3)Horvath Skin & Blood Clock (Clk 4), PhenoAge Clock (Clk 5) and OneSkin’s MolClock (Clk 6). (Zonari, et al., npj Aging, 2023)
This data shows that OS-01 effectively reverses environmental aging that’s already occurred–giving you the chance to hit the undo button on all those years of accelarated skin aging from unprotected sun exposure.
OS-01 prevents skin cells from UVB-induced cellular senescence
In addition to reversing UV aging that’s already occurred, OS-01 actually prevents skin cells from falling into senescence when they are exposed to UVB radiation. In lab studies, our scientists exposed in vitro human skin cells to UVB radiation, then immediately treated them with the OS-01 peptide. The skin that was immediately treated with the OS-01 peptide showed 42.5% less UV-induced senescent cells than the skin that was not treated with OS-01.
OS-01 prevents skin cells from UVB-induced cellular senescence
In addition to reversing UV aging that’s already occurred, OS-01 actually prevents skin cells from falling into senescence when they are exposed to UVB radiation. In lab studies, our scientists exposed in vitro human skin cells to UVB radiation, then immediately treated them with the OS-01 peptide. The skin that was immediately treated with the OS-01 peptide showed 42.5% less UV-induced senescent cells than the skin that was not treated with OS-01.
In vitro human dermal fibroblasts (HDFs) isolated from 30 yo donors were exposed to UVB radiation (0.1J/cm^2) then immediately treated with the OS-01 peptide (12.5uM) and stained with senescence-associated beta galactosidase (SA-Bgal). Senescence levels were analyzed by counting the number of UVB-induced senescent cells. Data normalized to control. (Zonari, et al., npj Aging, 2023)
This data shows that the OS-01 peptide offers the skin yet another layer of protection against UV-induced aging.
In vitro human dermal fibroblasts (HDFs) isolated from 30 yo donors were exposed to UVB radiation (0.1J/cm^2) then immediately treated with the OS-01 peptide (12.5uM) and stained with senescence-associated beta galactosidase (SA-Bgal). Senescence levels were analyzed by counting the number of UVB-induced senescent cells. Data normalized to control. (Zonari, et al., npj Aging, 2023)
This data shows that the OS-01 peptide offers the skin yet another layer of protection against UV-induced aging.
04
Give your skin the best protection with OS-01 SHIELD
Unlike other sunscreens, OS-01 SHIELD offers not just one, but three layers of protection form UV aging in the form of zinc oxide, powerful antioxidants, and the OS-01 peptide. This means that our peptide sunscreen works harder to keep your skin safe from the aging effects of sun exposure. Plus, thanks to the power of OS-01, our SPF may reduce the signs of aging that are already occurring from sun exposure– helping your skin look, feel, and behave like younger skin for longer.
04
Give your skin the best protection with OS-01 SHIELD
Unlike other sunscreens, OS-01 SHIELD offers not just one, but three layers of protection form UV aging in the form of zinc oxide, powerful antioxidants, and the OS-01 peptide. This means that our peptide sunscreen works harder to keep your skin safe from the aging effects of sun exposure. Plus, thanks to the power of OS-01, our SPF may reduce the signs of aging that are already occurring from sun exposure– helping your skin look, feel, and behave like younger skin for longer.
Key Takeaways:
- Our new SPF, OS-01 SHIELD, not only protects against UV rays with Zinc Oxide, but may actually reverse UV-induced aging that’s already occurred with a powerful trifecta of ingredients.
- Formulated with mineral zinc oxide, OS-01 SHIELD provides broad spectrum UV protection that’s gentle enough for even sensitive skin.
- Packed with a high concentration of five antioxidants, OS-01 SHIELD neutralizes UV-induced free radicals better than other leading sunscreens.
- By reversing existing UV-induced skin aging, our proprietary OS-01 peptide reduces skin’s biological age AND protects against new signs of UV aging.
Key Takeaways:
- Our new SPF, OS-01 SHIELD, not only protects against UV rays with Zinc Oxide, but may actually reverse UV-induced aging that’s already occurred with a powerful trifecta of ingredients.
- Formulated with mineral zinc oxide, OS-01 SHIELD provides broad spectrum UV protection that’s gentle enough for even sensitive skin.
- Packed with a high concentration of five antioxidants, OS-01 SHIELD neutralizes UV-induced free radicals better than other leading sunscreens.
- By reversing existing UV-induced skin aging, our proprietary OS-01 peptide reduces skin’s biological age AND protects against new signs of UV aging.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
Age Gracefully: How to Manage Neck Wrinkles and Ac...
Discover Why Our New SPF Outperforms the Rest
How to Preserve Your Feet: 5 Strategies for Wrinkl...
Hands and Dermal Elasticity: Understanding and Man...
The Lip Lineage: Exploring the Why Behind Wrinkled...
A Journey Through the Skin: How UV Radiation Cause...
How to Address Stomach Wrinkles For Smoother Skin
A Scientific Approach to Addressing Wrinkly Skin o...
What is Skin Cycling? Understanding, Embracing, an...
How to Skin Cycle: A Guide to Optimize Your Skin C...
How Do Our Products Work Together?
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
The Top 5 Benefits of Zinc Oxide for Skin
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
Beyond UV Protection: 7 Surprising Ways Sunscreen ...
Making Sense of Sunscreen: Understanding the Diffe...
Navigating Anti-Aging Skincare: The industry, the ...
Sun Spots: Causes & 3 Prevention Tips
Navigating Sunscreen Labels: Unwanted Ingredients ...
How to Prevent Skin Aging Before It Starts
Face vs. Body Sunscreen: Can You Use Body Sunscree...
Sun Damaged Skin: What it is, how you can prevent ...
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
4 Essential Face Cleansing Steps to Achieving a Ra...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Are Parabens Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
The Science Behind Why The Skin Around the Eyes Ag...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
6 Factors That Contribute to Slow Skin Healing
4 Foods To Avoid During Wound Healing & Why
A Complete Guide to the 4 Stages of Wound Healing
Collagen And Elastin: What Role Do They Play In Sk...
What is the Function of Skin as a Protective Barri...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
How Does Sunscreen Work? How Long Does it Last?
What is the Best Skin Care Regimen for Aging Skin?
What happens to skin as a person ages?
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Invasive vs. Non-Invasive Skincare: The pros and c...
6 Benefits of Jojoba Oil
What are the Benefits of Sulforaphane?
What is Sustainable Packaging for Cosmetic Product...
7 Benefits of Andiroba Oil For Skin
Why is my Skin Peeling on My Face?
What Are The Causes Of Dry, Flaky Skin On Your Fac...
PREP enhances the effects of OS-01 FACE, and the p...
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
Allantoin For Skin: A Comprehensive Guide
Ceramides For Skin: Everything You Need to Know
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
What Causes Crepey Skin & Can It Be Avoided Altoge...
Does Niacinamide Help With Acne & Scarring?
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide on The Benefits of Cleansing Your Face
How OneSkin Developed the OS-01 Peptide
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
You’re only as old as you feel, scientists are fin...
Collagen For Menopause: Why Is It Necessary For He...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Connection Between Mental Health, Age Percepti...
The Top 6 Best Antioxidants For Skin Health and Lo...
What are Zombie Cells & How Can We Remove Them?
SKIN CARE IS HEALTH CARE: WHY EXTENDING YOUR SKINS...
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
What Is Causing the Uneven Skin Tone On Your Body?
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Skin Hyperpigmentation 101: What It Is & How To Tr...
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
Celebrating Black History Month: A Discussion With...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Where Skin Health Meets Longevity
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
OneSkin launches MolClock, the first skin-specific...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging