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Face

OS-01 FACE Topical Supplement

SUBSCRIPTION EXCLUSIVES

  • Plastic neutral refillable packaging
  • Exclusive early access to new products
  • Earn 2x points for free products on all recurring orders
  • Easily change, skip or cancel anytime

โœญ Youโ€™re earning 99 points with OneSkin Loyalty Program โœญ

Try it risk-free!ย 45 day money back guarantee.

  • Targets Dehydration, dullness, loss of elasticity
  • Suited to All skin types, safe for sensitive skin
  • Format Lightweight moisturizer

OS-01 FACE is a daily skin longevity treatment with the OS-01 Senescence Blocking Peptideโ„ข, scientifically proven to target a root cause of skin aging to promote healthy, youthful skin on the face and neck.01,02

OneSkin

Benefits

Multitasking moisturizer that addresses the common signs of aging on areas exposed most to the environment

Hydration

Boosts barrier function, allowing your skin retain moisture and stay hydrated.02

Firmness

Switches off the cells that degrade collagen, helping skin stay firm.01,03

Radiance

Enhances skin tone and texture, helping skin look and feel smooth and radiant.02

5-STAR REVIEWS

See why customers love OS-01 FACE

โ€œI stopped using retinol which caused me to have rough, red patches, but kept my skin supple and smoothโ€ฆand now using OneSkin I still have the wrinkle reduction effects and smooth skin without the negative effects.โ€ โ€“ Tova N.

"I love this science-backed product. It truly makes a difference to my skin and has allowed me to pare down all the other lotions, potions, & products that were more reactive in nature vs this proactive approach. Not only have I saved money on my skincare routine, but I've witnessed even skin tone, more elasticity, and a reduction in forehead wrinkles. Would recommend again and again. Can't wait to see what they think of next!" โ€“ Laura E.

"Itโ€™s working great!!! It absorbs quickly. I see and feel a significant difference in my skinโ€™s texture and radiance. My skin looks smoother and feels firmer. I highly recommend it for anyone serious about maintaining youthful, healthy glowing skin." โ€“ Ildiko C.

"One skin really loves my skin. I no longer use retinoids and put up with their side effects. One skin feels so effective as it absorbs quickly leaving my skin more even, bouncy and fresh." โ€“ Sarah B.

CLINICAL DATA

Visible results, scientifically validated

100

of participants had improved smoothness 02

95.5

of participants had improved firmness, radiance, and tone 02

90

of participants had improved elasticity 02

86

of participants had improved appearance of fine lines and wrinkles 02

The Science Behind OS-01 FACE

With age, skin becomes thinner, produces less collagen, proliferates at a slower rate, and accumulates damage. By analyzing key aging biomarkers in human skin samples before and after treatment in the lab, our scientists found that OS-01 FACE:

  1. Increases epidermal thickness 01
  2. Supports collagen biosynthesis pathways (increase in COL1A1 and collagen levels) 01,03
  3. Promotes cellular proliferation (increase in MKI67) 01


Expression of biomarkers associated with collagen production (COL1A1) and cell proliferation (MKi67) in the dermis of ex vivo human skin samples following treatment with nothing (No Treatment) or OS-01 FACE. (Zonari, A., et al. npj Aging, 2023) Note: In npj Aging publication, "Topical Pep 14" = OS-01 FACE

Getting started with OS-01 FACE

Follow these easy steps for optimal results

  • Dispense 1-2 pumps onto fingers
  • Gently massage into skin on the face and neck
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Peptideโ„ข

The only peptide scientifically proven to reverse skin aging at the cellular levelย 01,02,03

All Ingredients

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

Citations

01 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age ย  and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

02 Zonari A., et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

03 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

OS-01 FACE Topical Supplement

4.7
Rated 4.7 out of 5 stars
Based on 5,585 reviews
Total 5 star reviews: 4.5k Total 4 star reviews: 738 Total 3 star reviews: 232 Total 2 star reviews: 65 Total 1 star reviews: 56
94%would recommend these products
5,585 reviews
  • CS
    Charles S.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    3 hours ago
    Easy to refill

    Easy to refill the main container. Love the results too.

  • TS
    Teresa S.
    Verified Buyer
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    9 hours ago
    Refillable Pouch is Genius!

    As I have become more focused on reducing landfill, I am so impressed with the refillable pouch that comes with my face cream. I started using One Skin by trying your travel set, which allowed me to sample several products at one time. The face cream worked very well with my skin so I decided to subscribe for 6 months and measure the results. It has been an added bonus for me to receive my 2nd batch in the refillable pouch. It was very easy to extract the original pouch and insert the refill. I am now looking for ways to recycle some of my other hair and facial product containers.

  • AS Profile picture for A s.
    A s.
    Verified Reviewer
    Reviewing
    OS-01 FACE Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    11 hours ago
    Only a week

    Itโ€™s only been a week and I can see a difference, especially the trouble skin on my neck feels smoother and tighter. My face feels and looks greatโ€ฆ Already recommended to a friend. I am 48 and have used many high end brands to maintain skin but this instantly felt like it worked!

    OneSkin
    4 hours ago

    Hi Audrey!

    Thank you for the review! We are happy to hear you are enjoying OS-01 FACE!

  • AK
    Ashleigh K.
    Verified Buyer
    Reviewing
    Replacement OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    21 hours ago
    LOVE this product

    I have a lot of sun damage, and I have definitely noticed an improvement in my skin since using this product - can't recommend highly enough!! I'm also really excited to try the eye cream and hair product!

  • O
    Olivia
    Reviewing
    OS-01 FACE Refill Pouch
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    5 Stars

    Love the product. Skin is soft and doesnt irritate my sensitive skin.