Scientific Breakthrough: OneSkin’s scientists show that it’s possible to reverse aging in human skin
3 min read
JUNE 1, 2023
FROM THE ONESKIN LAB
Scientific Breakthrough: OneSkin’s scientists show that it’s possible to reverse aging in human skin
3 min read
JUNE 1, 2023
FROM THE ONESKIN LAB
After over 7 years of research, our team recently achieved an important milestone: getting our data published in NPJ Aging. This is significant not just for OneSkin, but for the longevity community at large, because it shows for the first time that it is possible to reverse aging in human skin. Core to this finding is our evidence that the OS-01 peptide is able to reduce biological age and senescence burden in human skin models. Because of its proven ability to block the effects of senescence while enhancing cellular renewal, OS-01 is now validated as a senotherapeutic molecule, making its development an exciting new breakthrough in the quest to promote human longevity. Curious to explore the data in our paper? We’ve summarized its key findings below.
After over 7 years of research, our team recently achieved an important milestone: getting our data published in NPJ Aging. This is significant not just for OneSkin, but for the longevity community at large, because it shows for the first time that it is possible to reverse aging in human skin. Core to this finding is our evidence that the OS-01 peptide is able to reduce biological age and senescence burden in human skin models. Because of its proven ability to block the effects of senescence while enhancing cellular renewal, OS-01 is now validated as a senotherapeutic molecule, making its development an exciting new breakthrough in the quest to promote human longevity. Curious to explore the data in our paper? We’ve summarized its key findings below.
01
Finding 1: The OS-01 Peptide Reverses Skin’s Biological Age
Utilizing MolClock, OneSkin’s proprietary, peer-reviewed, skin-specific DNA methylation clock, we measured the biological age of ex vivo skin samples before and after exposure to the OS-01 peptide.
01
Finding 1: The OS-01 Peptide Reverses Skin’s Biological Age
Utilizing MolClock, OneSkin’s proprietary, peer-reviewed, skin-specific DNA methylation clock, we measured the biological age of ex vivo skin samples before and after exposure to the OS-01 peptide.
DNA methylation age of ex vivo human skin samples (79yr) treated with 12.5uM peptide for 5 days, calculated using OneSkin’s Skin-Specific DNA Methylation Clock, MolClok. OS-01 peptide treatment significantly reduced the DNA methylation age. (Zonari, A., et al, npj Aging, 2023)
DNA methylation age of ex vivo human skin samples (79yr) treated with 12.5uM peptide for 5 days, calculated using OneSkin’s Skin-Specific DNA Methylation Clock, MolClok. OS-01 peptide treatment significantly reduced the DNA methylation age. (Zonari, A., et al, npj Aging, 2023)
Before exposure, the biological age of the skin samples measured at 70.82 years old. After exposure to the OS-01 peptide for 5 days, the biological age of the same samples measured at 68.22 years, meaning that the OS-01 peptide reduced the biological age of skin by 2.6 years in ex vivo human skin samples. [1]Besides MolClock, a reduction in the biological age of ex vivo skin treated with the OS-01 peptide was also detected using other published molecular clocks, including Horvarth Clock, Horvath Skin & Blood Clock, Hannum Clock, Lin Clock, and PhenoAge Clock, further confirming the age reversal capability of the OS-01 peptide. [1]
Before exposure, the biological age of the skin samples measured at 70.82 years old. After exposure to the OS-01 peptide for 5 days, the biological age of the same samples measured at 68.22 years, meaning that the OS-01 peptide reduced the biological age of skin by 2.6 years in ex vivo human skin samples. [1]Besides MolClock, a reduction in the biological age of ex vivo skin treated with the OS-01 peptide was also detected using other published molecular clocks, including Horvarth Clock, Horvath Skin & Blood Clock, Hannum Clock, Lin Clock, and PhenoAge Clock, further confirming the age reversal capability of the OS-01 peptide. [1]
Ex vivo skin samples (79 yo) maintained in basal media (NT), or treated with 100 nM Rapamycin (Rapa), or 12.5 µM OS-01 peptide for 5 days. Predicted DNA age according to Horvath Clock (Clk 1), Hannum Clock (Clk 2), Lin Clock (Clk 3)Horvath Skin & Blood Clock (Clk 4), PhenoAge Clock (Clk 5) and OneSkin’s MolClock (Clk 6). (Sup. Fig. 12 Zonari, et al., npj Aging, 2023).
Ex vivo skin samples (79 yo) maintained in basal media (NT), or treated with 100 nM Rapamycin (Rapa), or 12.5 µM OS-01 peptide for 5 days. Predicted DNA age according to Horvath Clock (Clk 1), Hannum Clock (Clk 2), Lin Clock (Clk 3)Horvath Skin & Blood Clock (Clk 4), PhenoAge Clock (Clk 5) and OneSkin’s MolClock (Clk 6). (Sup. Fig. 12 Zonari, et al., npj Aging, 2023).
02
Finding 2: The OS-01 Peptide Promotes a Reduction in Senescent Cells
To confirm their findings, our scientists took a look at how OS-01 impacted levels of cellular senescence, a central hallmark of aging that largely drives the skin’s biological age.Using various senescence-inducing experimental models to reproduce both intrinsic (e.g. chronologically aged) and extrinsic (e.g. UVB radiation) stimuli, our scientists looked at whether OS-01 could reduce the total number of senescent cells. [1]
02
Finding 2: The OS-01 Peptide Promotes a Reduction in Senescent Cells
To confirm their findings, our scientists took a look at how OS-01 impacted levels of cellular senescence, a central hallmark of aging that largely drives the skin’s biological age.Using various senescence-inducing experimental models to reproduce both intrinsic (e.g. chronologically aged) and extrinsic (e.g. UVB radiation) stimuli, our scientists looked at whether OS-01 could reduce the total number of senescent cells. [1]
SA B-Gal (senescence-associated beta galactosidase) stained image of in vitro HGPS HDFs (human dermal fibroblasts from patient-derived samples with Hutchinson-Gilford progeria syndrome) treated with 50uM OS-01 peptide for 2 days compared to untreated control. (Zonari, a., et al., npj Aging, 2023)
SA B-Gal (senescence-associated beta galactosidase) stained image of in vitro HGPS HDFs (human dermal fibroblasts from patient-derived samples with Hutchinson-Gilford progeria syndrome) treated with 50uM OS-01 peptide for 2 days compared to untreated control. (Zonari, a., et al., npj Aging, 2023)
For their intrinsic aging experiments, our researchers obtained skin samples from patients with Hutchinson-Gilford progeria syndrome, a genetic condition that causes premature skin aging with a high level of cellular senescence. Treating in vitro fibroblast cultures from these patients, our team applied senescence-associated beta galactosidase, a compound that selectively stains senescent cells blue. This made it possible to count the number of senescent cells before and after exposure to the OS-01 peptide.After 2 days of treatment, our scientists found that the samples treated with the OS-01 peptide contained up to 50% fewer senescent cells than samples that were not treated. Additionally, the total number of cells remained the same after exposure to the OS-01 peptide, showing that the OS-01 peptide promoted not just the reduction of senescent cells, but also the renewal of healthier ones. [1]Across many experimental models, the OS-01 peptide decreased the level of cellular senescence, promoting tissue rejuvenation in both 2D and 3D systems, as measured by cellular and molecular markers of aging, senescence, and DNA methylation . [1]Many skin care brands claim rejuvenation and reversing aging, but OneSkin is the only brand proven to actually do it. We hope the publication of our research in NPJ Aging will serve as a model for how evidence-based science can meet clinical efficacy in the skin health industry. Want to read more about our research? You can find our full published paper, Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models, here.
For their intrinsic aging experiments, our researchers obtained skin samples from patients with Hutchinson-Gilford progeria syndrome, a genetic condition that causes premature skin aging with a high level of cellular senescence. Treating in vitro fibroblast cultures from these patients, our team applied senescence-associated beta galactosidase, a compound that selectively stains senescent cells blue. This made it possible to count the number of senescent cells before and after exposure to the OS-01 peptide.After 2 days of treatment, our scientists found that the samples treated with the OS-01 peptide contained up to 50% fewer senescent cells than samples that were not treated. Additionally, the total number of cells remained the same after exposure to the OS-01 peptide, showing that the OS-01 peptide promoted not just the reduction of senescent cells, but also the renewal of healthier ones. [1]Across many experimental models, the OS-01 peptide decreased the level of cellular senescence, promoting tissue rejuvenation in both 2D and 3D systems, as measured by cellular and molecular markers of aging, senescence, and DNA methylation . [1]Many skin care brands claim rejuvenation and reversing aging, but OneSkin is the only brand proven to actually do it. We hope the publication of our research in NPJ Aging will serve as a model for how evidence-based science can meet clinical efficacy in the skin health industry. Want to read more about our research? You can find our full published paper, Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models, here.
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Key Takeaways:
- The OneSkin team recently published key findings on the OS-01 peptide in NPJ Aging, a highly reputable scientific journal.
- For the first time, OneSkin’s scientists show that it’s possible to reverse aging in human skin
- Not only does our publication validate our research, it's also a huge milestone in advancing the science of aging
- The research published shows that the OS-01 peptide diminishes skin’s biological age by decreasing levels of cellular senescence.
- Because of its proven ability to block the effects of senescence while enhancing cellular renewal, OS-01 is an exciting breakthrough in the quest to treat aging and extend human lifespan.
Key Takeaways:
- The OneSkin team recently published key findings on the OS-01 peptide in NPJ Aging, a highly reputable scientific journal.
- For the first time, OneSkin’s scientists show that it’s possible to reverse aging in human skin
- Not only does our publication validate our research, it's also a huge milestone in advancing the science of aging
- The research published shows that the OS-01 peptide diminishes skin’s biological age by decreasing levels of cellular senescence.
- Because of its proven ability to block the effects of senescence while enhancing cellular renewal, OS-01 is an exciting breakthrough in the quest to treat aging and extend human lifespan.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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How Does Sunscreen Work? How Long Does it Last?
What is the Best Skin Care Regimen for Aging Skin?
What happens to skin as a person ages?
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Invasive vs. Non-Invasive Skincare: The pros and c...
6 Benefits of Jojoba Oil
What are the Benefits of Sulforaphane?
What is Sustainable Packaging for Cosmetic Product...
7 Benefits of Andiroba Oil For Skin
Why is my Skin Peeling on My Face?
What Are The Causes Of Dry, Flaky Skin On Your Fac...
PREP enhances the effects of OS-01 FACE, and the p...
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
Allantoin For Skin: A Comprehensive Guide
Ceramides For Skin: Everything You Need to Know
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
What Causes Crepey Skin & Can It Be Avoided Altoge...
Does Niacinamide Help With Acne & Scarring?
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide on The Benefits of Cleansing Your Face
How OneSkin Developed the OS-01 Peptide
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
You’re only as old as you feel, scientists are fin...
Collagen For Menopause: Why Is It Necessary For He...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Connection Between Mental Health, Age Percepti...
The Top 6 Best Antioxidants For Skin Health and Lo...
What are Zombie Cells & How Can We Remove Them?
SKIN CARE IS HEALTH CARE: WHY EXTENDING YOUR SKINS...
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
What Is Causing the Uneven Skin Tone On Your Body?
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Skin Hyperpigmentation 101: What It Is & How To Tr...
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
Celebrating Black History Month: A Discussion With...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Where Skin Health Meets Longevity
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
OneSkin launches MolClock, the first skin-specific...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging