How to Incorporate OneSkin’s OS-01 Topical Supplements Into Your Skin Care Routine

Reference Lab

March 20, 2023

Ready to try OneSkin but don’t want to change your existing skin routine? No problem. Our OS-01 Topical Supplements were designed to integrate seamlessly with your existing skin care steps. Here’s how to work them into your regimen for maximum results.

01How do OS-01 EYE and OS-01 FACE fit into my skin care routine?

OS-01 EYE and OS-01 FACE were specifically formulated for the delicate and often sensitive facial skin. You can safely use OS-01 EYE and OS-01 FACE in combination with your existing skin products without worrying about adverse reactions or decreased efficacy. OS-01 EYE and OS-01 FACE are both potent moisturizers and targeted skin longevity treatments in one. 

The skin around the eyes is especially thin and delicate compared to the rest of the skin on the face and therefore experiences accelerated aging. That’s why OS-01 EYE is formulated with 25% higher concentration of the OS-01 peptide than OS-01 FACE, along with other supporting ingredients that help strengthen the eye area skin. OS-01 FACE was formulated for the rest of facial skin. Both OS-01 EYE can replace your current eye and facial moisturizers or be used alongside them.

To get maximum benefits from OS-01 EYE and OS-01 FACE, apply them after cleansing and/or toning to ensure optimal absorption of our OS-01 peptide. We recommend applying OS-01 EYE then OS-01 FACE. For maximum peptide absorption, we also recommend cleansing your face with PREP, scientifically proven to increase peptide absorption by up to two times (shown in lab studies on ex vivo human skin samples).

02How often should I use OS-01 EYE and OS-01 FACE?

Because our OS-01 peptide works within the skin over time to promote long-term skin health, consistency is key. For best results, use OS-01 EYE and OS-01 FACE twice daily, AM and PM. OS-01 EYE and OS-01 FACE have been tested on sensitive skin; unlike retinol and many other highly potent skin care ingredients, they won't cause irritation even when used both morning and night.

03What order should I apply PREP, OS-01 EYE, and OS-01 FACE with my other skin care products?

To ensure maximum absorption of our OS-01 peptide, OS-01 EYE and OS-01 FACE should be applied directly after cleansing (ideally with PREP) and toning (optional). If you are exfoliating or using a wash-off mask, use OS-01 EYE and OS-01 FACE after these steps.

In drier climates or seasons, you may choose to layer a richer moisturizer or oil on top of OS-01 EYE and OS-01 FACE. Wait a few minutes after applying your OS-01 Topical Supplements before applying additional products to give the OS-01 peptide time to absorb into the skin.

Although we recommend applying OS-01 EYE and OS-01 FACE prior to most other products, you know your skin best. Feel free to experiment and discover where our Topical Supplements work in your routine.

04Why should I apply OS-01 EYE and OS-01 FACE as the first step after cleansing?

Cleansing before applying OS-01 EYE and OS-01 FACE helps our proprietary peptide achieve maximum absorption without dirt, debris, makeup or sunscreen in the way. If you prefer, you can still apply a product like a toner or a serum prior to using OS-01 EYE and OS-01 FACE. Just keep in mind that you may not experience the complete benefits that our peptide can deliver. If your toner or serum has a thick viscosity or waxy and oily ingredients, it might form a barrier that could prevent the OS-01 peptide from fully sinking into the skin.

Pro tip: For even better results, consider using PREP, our gentle daily facial cleanser that has been scientifically proven to double the penetration of the OS-01 peptide when used before applying OS-01 FACE (shown in lab studies on ex vivo human skin samples).

05 Can I use OS-01 FACE with retinol?

If your skin tolerates retinol, you can continue using it with OS-01 FACE. In fact, OS-01 FACE may help counteract retinol’s harsher side effects, including dryness, peeling, sensitivity, itching, and redness. This is thanks to our OS-01 peptide’s ability to:
  • Increase key markers associated with hyaluronic acid and collagen production01
  • Improve skin hydration and barrier function02
  • Increase epidermal thickness01
  • Support repair pathways01

01Shown in lab studies on ex vivo human skin samples (Zonari, et al)

02Shown in a 12-week clinical study performed by a third party CRO evaluating the effects of OS-01 FACE

You can incorporate OS-01 FACE with retinol in one of two ways:

  1. Alternate OS-01 FACE and retinol: Alternating allows your skin to reap the benefits of both products without either of them interfering with the absorption of the other. Since retinol should only be applied at night, you can alternate the two by using OS-01 FACE in the mornings.
  2. Combine OS-01 FACE and retinol: When combining retinol with OS-01 FACE in the same skin care routine, it’s up to you to decide which product to apply first. Just keep in mind that the OS-01 peptide will achieve maximum penetration if it’s applied as the first step after cleansing.

No matter which method you use, the OS-01 peptide can still help to counteract retinol’s harsh side effects. If your skin is sensitive to retinol, skip it and just use OS-01 FACE instead. It delivers many of the same benefits without any of the drawbacks.

06 Can OS-01 EYE and OS-01 FACE be used with other ingredients like vitamin C and hyaluronic acid?

Yes, OS-01 EYE and OS-01 FACE are safe to use with vitamin C and hyaluronic acid. They have not been shown to cause adverse side effects when used with any other topical ingredients. This means you can safely incorporate OS-01 EYE and OS-01 FACE into your routine without worrying about contraindications.

07Can OS-01 EYE and OS-01 FACE be used after skin treatments?

Skin treatments like microneedling and chemical peels can temporarily weaken the skin barrier and leave skin especially tender. While you should always follow your dermatologist or esthetician’s recommendations for after-care, OS-01 EYE and OS-01 FACE were designed to soothe even the most sensitive skin and may actually help your skin recover faster from these treatments. That’s because our OS-01 peptide has been scientifically proven to improve key skin health markers like epidermal thickness, barrier function, and collagen production.01 The other ingredients inside OS-01 EYE and OS-01 FACE also promote skin health, supporting your skin as it recovers from injury.

01Shown in lab studies on ex vivo human skin samples (Zonari, et al)

08How does OS-01 BODY fit into my skin care routine?

Much like OS-01 EYE and OS-01 FACE, OS-01 BODY is a targeted longevity treatment formulated as a daily moisturizer, specifically for the thicker skin on your body. With OS-01 BODY, you can either:

  • Replace your existing body lotion with OS-01 BODY.
  • Apply OS-01 BODY specifically to areas where you would like to see its benefits.
  • Use OS-01 BODY before other body lotions or products.

For best results, use OS-01 BODY one to two times daily. As with our other Topical Supplements, applying OS-01 BODY to clean skin, directly after bathing, maximizes absorption of the OS-01 peptide. If you choose to use additional products after OS-01 BODY, wait a couple of minutes to give the OS-01 peptide some time to fully absorb into the skin.

Key Takeaways

  • You can seamlessly incorporate OneSkin's Topical Supplements, OS-01 EYE, OS-01 FACE, and OS-01 BODY, into your current skincare routine.
  • OS-01 EYE and OS-01 FACE work best when applied as the first products after cleansing your skin.
  • To boost the OS-01 peptide absorption, cleanse your face with PREP prior to applying OS-01 EYE and/or OS-01 FACE.
  • Wait a few minutes to layer any other products over OS-01 EYE, OS-01 FACE, and OS-01 BODY for optimal absorption.
  • The OS-01 peptide can help counteract retinol’s harsh side effects and is an excellent alternative to retinol for those with retinol-sensitive skin.
  • Because OS-01 EYE and OS-01 FACE are gentle on sensitive skin, they can be ideal for use after aesthetic skin treatments like chemical peels. Be sure to consult your dermatologist or esthetician for best after-care practices.
  • Like OS-01 EYE and OS-01 FACE, OS-01 BODY can be used as a standalone product or incorporated into your existing routine.

(Zonari, et al) 

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

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