7 Keys to Understanding Menopause and Skin Changes

8 min read

OCT 30, 2023
HEALTH

7 Keys to Understanding Menopause and Skin Changes

8 min read

OCT 30, 2023
HEALTH
The female body has an incredible potential for transformation, including three major hormonal shifts that occur during a woman’s lifetime: puberty, pregnancy, and menopause. As our hormones change in the years leading up to menopause, so does our skin. Let’s take a closer look at the biological triggers behind these changes – and what you can do to keep your skin healthy and comfortable from perimenopause and beyond.
The female body has an incredible potential for transformation, including three major hormonal shifts that occur during a woman’s lifetime: puberty, pregnancy, and menopause. As our hormones change in the years leading up to menopause, so does our skin. Let’s take a closer look at the biological triggers behind these changes – and what you can do to keep your skin healthy and comfortable from perimenopause and beyond.
01

What happens during menopause?

Many of the menopausal symptoms that women experience during perimenopause and menopause are due to shifts in two key hormones: estrogen and progesterone. It all starts in the hypothalamus, an area in the brain that secretes hormones. The hypothalamus stimulates the anterior pituitary gland, which releases follicle-stimulating hormone (FSH) and luteinizing hormone (LH)1. FSH and LH kickstart ovarian production of estrogen and progesterone. In the years leading up to menopause, the ovaries start to lose their sensitivity to FSH and LH, yielding lower estrogen and progesterone levels2.
01

What happens during menopause?

Many of the menopausal symptoms that women experience during perimenopause and menopause are due to shifts in two key hormones: estrogen and progesterone. It all starts in the hypothalamus, an area in the brain that secretes hormones. The hypothalamus stimulates the anterior pituitary gland, which releases follicle-stimulating hormone (FSH) and luteinizing hormone (LH)1. FSH and LH kickstart ovarian production of estrogen and progesterone. In the years leading up to menopause, the ovaries start to lose their sensitivity to FSH and LH, yielding lower estrogen and progesterone levels2.

Estrogen Levels

Normal estrogen levels plummet from 30 - 400 pg/mL before menopause to 0 - 30 pg/mL after menopause.3 Because estrogen stimulates the production of several important proteins in the skin, this massive hormonal shift can weaken skin thickness over time.4 The impacts of declining estrogen are more than skin-deep; in fact, lower levels after menopause can impact several bodily systems, including:
  1. The Cardiovascular System - Estrogen promotes healthy cholesterol levels and aids in blood clot formation. Lower levels can increase the risk of heart attack and stroke.5
  2. The Nervous System - Estrogen levels influence female cognitive function; its decline increases the risk of Alzheimer's disease.6
  3. The Musculoskeletal System - Estrogen induces calcium absorption in the body. Lower estrogen results in loss of bone density and can lead to osteoporosis.7
  4. Estrogen Levels

    Normal estrogen levels plummet from 30 - 400 pg/mL before menopause to 0 - 30 pg/mL after menopause.3 Because estrogen stimulates the production of several important proteins in the skin, this massive hormonal shift can weaken skin thickness over time.4 The impacts of declining estrogen are more than skin-deep; in fact, lower levels after menopause can impact several bodily systems, including:
    1. The Cardiovascular System - Estrogen promotes healthy cholesterol levels and aids in blood clot formation. Lower levels can increase the risk of heart attack and stroke.5
    2. The Nervous System - Estrogen levels influence female cognitive function; its decline increases the risk of Alzheimer's disease.6
    3. The Musculoskeletal System - Estrogen induces calcium absorption in the body. Lower estrogen results in loss of bone density and can lead to osteoporosis.7
    4. Progesterone Levels

      Along with estrogen, progesterone levels also decrease during perimenopause. This critical hormone is known to lower the risk of anxiety and depression, regulate blood pressure, improve sleep, and promote uterine health. 8 Plus, because progesterone is involved in the skin’s oil production, declining progesterone levels may lead to increased skin dryness and sensitivity.

      Progesterone Levels

      Along with estrogen, progesterone levels also decrease during perimenopause. This critical hormone is known to lower the risk of anxiety and depression, regulate blood pressure, improve sleep, and promote uterine health. 8 Plus, because progesterone is involved in the skin’s oil production, declining progesterone levels may lead to increased skin dryness and sensitivity.
      02

      What happens to our skin during menopause?

      Estrogen and progesterone interact with several crucial levers in skin health. During perimenopause, menopause, and post-menopause, the following factors can be affected.
      02

      What happens to our skin during menopause?

      Estrogen and progesterone interact with several crucial levers in skin health. During perimenopause, menopause, and post-menopause, the following factors can be affected.

      Collagen Production

      Collagen is a structural protein that promotes skin strength, elasticity, and firmness.9 Fibroblasts, the skin cells that stimulate collagen production, are activated when exposed to estrogen. When estrogen levels drop, so does fibroblast activation and collagen production.9 Consequently, around 30% of skin collagen is lost within the first five years following menopause, leading to a weakened skin barrier and loss of firmness and elasticity.9

      Collagen Production

      Collagen is a structural protein that promotes skin strength, elasticity, and firmness.9 Fibroblasts, the skin cells that stimulate collagen production, are activated when exposed to estrogen. When estrogen levels drop, so does fibroblast activation and collagen production.9 Consequently, around 30% of skin collagen is lost within the first five years following menopause, leading to a weakened skin barrier and loss of firmness and elasticity.9

      Oxidative Defenses

      A primary cause of skin aging is exposure to free radicals, which oxidize cellular DNA. Oxidation-induced changes lead to genomic instability and epigenetic alterations - two of the twelve hallmarks of aging
      .12 Although it’s not quite clear how, estrogen has been shown to have protective power against free radicals.13 As estrogen levels drop, this oxidative defense becomes less effective, and skin aging accelerates.

      Oxidative Defenses

      A primary cause of skin aging is exposure to free radicals, which oxidize cellular DNA. Oxidation-induced changes lead to genomic instability and epigenetic alterations - two of the twelve hallmarks of aging
      .12 Although it’s not quite clear how, estrogen has been shown to have protective power against free radicals.13 As estrogen levels drop, this oxidative defense becomes less effective, and skin aging accelerates.

      Sebum Production

      Due to an age-related decline in cell turnover rate, skin oil glands– specifically sebaceous glands– become less effective. This is why many people notice their skin getting drier with time. Hormonal changes in menopause can exacerbate this decline, as sebaceous glands are affected by both estrogen and progesterone.14

      Sebum Production

      Due to an age-related decline in cell turnover rate, skin oil glands– specifically sebaceous glands– become less effective. This is why many people notice their skin getting drier with time. Hormonal changes in menopause can exacerbate this decline, as sebaceous glands are affected by both estrogen and progesterone.14

      Hyaluronic Acid Production

      Estrogen stimulates the production of hyaluronic acid, a substance known for its capacity to hold water and keep the skin hydrated. Without a strong skin barrier and estrogen-stimulated production of hyaluronic acid, the skin can become dehydrated.14

      Hyaluronic Acid Production

      Estrogen stimulates the production of hyaluronic acid, a substance known for its capacity to hold water and keep the skin hydrated. Without a strong skin barrier and estrogen-stimulated production of hyaluronic acid, the skin can become dehydrated.14

      Melanin Production

      Estrogen supports the synthesis of melanin, the pigment that helps protect skin from UV radiation. As estrogen declines, melanin levels lower, and skin becomes lighter and more sensitive to sun damage.15 Even though menopause reduces melanin production, erratic hormone levels and a weakened skin barrier can actually cause or worsen hyperpigmentation.

      Wound Healing

      When your skin is wounded, cytokines in the blood recruit inflammatory cells and nearby skin cells to start the healing process. Because estrogen regulates cytokine levels, wound healing may slow after menopause. In fact, topical estrogen has been shown to accelerate wound healing in both elderly men and women.14

      Wound Healing

      When your skin is wounded, cytokines in the blood recruit inflammatory cells and nearby skin cells to start the healing process. Because estrogen regulates cytokine levels, wound healing may slow after menopause. In fact, topical estrogen has been shown to accelerate wound healing in both elderly men and women.14
      03

      How can these skin problems be best avoided to extend the longevity of healthy skin?

      Fortunately, it is possible to prepare our skin for menopause. Here are some lifestyle and skin care tips you can use to improve skin health, and extend skinspan:Anitoxidants: Eating foods rich in antioxidants or using topical skin care products with antioxidants can reduce oxidative stress and increase collagen levels! In general, topically applied antioxidants are more effective for skin health.Sunscreen: Post-menopausal skin is highly sensitive to sun damage. Wearing sunscreen can prevent accelerated skin aging and the development of age spots and skin cancer.Moisturize: Invest in a peptide moisturizer and hydrating cleanser. This can prevent skin dryness and keep your skin protected against environmental irritants. Consider Hormone Replacement Therapies (HRTs):
      Consult your physician regarding your options for hormone therapy. Even topical estrogen effectively increases skin collagen and reduces skin age.16
      Sleep
      : Sleeping at consistent times for around 7 - 9 hours daily can support hormone balance and skin health.17
      03

      How can these skin problems be best avoided to extend the longevity of healthy skin?

      Fortunately, it is possible to prepare our skin for menopause. Here are some lifestyle and skin care tips you can use to improve skin health, and extend skinspan:Anitoxidants: Eating foods rich in antioxidants or using topical skin care products with antioxidants can reduce oxidative stress and increase collagen levels! In general, topically applied antioxidants are more effective for skin health.Sunscreen: Post-menopausal skin is highly sensitive to sun damage. Wearing sunscreen can prevent accelerated skin aging and the development of age spots and skin cancer.Moisturize: Invest in a peptide moisturizer and hydrating cleanser. This can prevent skin dryness and keep your skin protected against environmental irritants. Consider Hormone Replacement Therapies (HRTs):
      Consult your physician regarding your options for hormone therapy. Even topical estrogen effectively increases skin collagen and reduces skin age.16
      Sleep
      : Sleeping at consistent times for around 7 - 9 hours daily can support hormone balance and skin health.17

      How does the OS-01 peptide address menopausal skin changes?

      Our OS-01 peptide
      is scientifically proven to counteract some of the factors caused by estrogen decline. In lab studies, OS-01 was shown to increase the activity of collagen and hyaluronic acid production genes (COL1A1 and HAS2).18 This shows that OS-01 may help to counteract decreasing levels of collagen and hyaluronic acid that occur after menopause–improving skin firmness, elasticity, strength, and hydration.19 OS-01 has also been shown to reduce
      cellular senescence
      – the central hallmark of skin aging – and improve skin health at the cellular level.18
      Our OS-01 FACE and OS-01 BODY Topical Supplements pair our star peptide with potent hydrating ingredients and antioxidants so your skin can stay supple and resilient even as its natural defenses decline.

      How does the OS-01 peptide address menopausal skin changes?

      Our OS-01 peptide
      is scientifically proven to counteract some of the factors caused by estrogen decline. In lab studies, OS-01 was shown to increase the activity of collagen and hyaluronic acid production genes (COL1A1 and HAS2).18 This shows that OS-01 may help to counteract decreasing levels of collagen and hyaluronic acid that occur after menopause–improving skin firmness, elasticity, strength, and hydration.19 OS-01 has also been shown to reduce
      cellular senescence
      – the central hallmark of skin aging – and improve skin health at the cellular level.18
      Our OS-01 FACE and OS-01 BODY Topical Supplements pair our star peptide with potent hydrating ingredients and antioxidants so your skin can stay supple and resilient even as its natural defenses decline.
      Shown in lab studies on human skin samples and/or cells by measuring key aging biomarker, CDKN2A, and key collagen and hyaluronic acid biomarkers, COL1A1 and HAS2. Treatment with the OS-01 peptide displayed a significant decrease in CDKN2A and a significant increase in COL1A1 and HAS2 compared to no treatment. (Zonari, A., et al. npj Aging, 2023)
      Shown in lab studies on human skin samples and/or cells by measuring key aging biomarker, CDKN2A, and key collagen and hyaluronic acid biomarkers, COL1A1 and HAS2. Treatment with the OS-01 peptide displayed a significant decrease in CDKN2A and a significant increase in COL1A1 and HAS2 compared to no treatment. (Zonari, A., et al. npj Aging, 2023)
      Key Takeaways:
      • During and after menopause, estrogen and progesterone levels decline.
      • These changing hormones reduce collagen formation, sebum, melanin, and cytokines.
      • Because of these changes, menopausal skin can often be less firm, more wrinkled, dryer, and more sensitive to external pollutants.
      • To prevent menopause-associated skin changes, use antioxidants, apply sunscreen, moisturize, and get sufficient sleep. You should consult your physician regarding your options with HRTs.
      • OneSkin’s OS-01 peptide increases the activity of collagen and hyaluronic acid genes, COL1A1 and HAS2, helping to counteract the decreased levels of collagen and hyaluronic acid caused by menopause. This improves skin elasticity and structure, strengthens the skin barrier, and keeps the skin hydrated.
      Key Takeaways:
      • During and after menopause, estrogen and progesterone levels decline.
      • These changing hormones reduce collagen formation, sebum, melanin, and cytokines.
      • Because of these changes, menopausal skin can often be less firm, more wrinkled, dryer, and more sensitive to external pollutants.
      • To prevent menopause-associated skin changes, use antioxidants, apply sunscreen, moisturize, and get sufficient sleep. You should consult your physician regarding your options with HRTs.
      • OneSkin’s OS-01 peptide increases the activity of collagen and hyaluronic acid genes, COL1A1 and HAS2, helping to counteract the decreased levels of collagen and hyaluronic acid caused by menopause. This improves skin elasticity and structure, strengthens the skin barrier, and keeps the skin hydrated.

      Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

      Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

      Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

      Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

      Discover More

      What Do Antioxidants Do For Skin and Why Should Yo...
      Making Sense of SPFs: What’s the Difference Betwee...
      How to Relieve Itchy Skin: Tips for Soothing Skin ...
      Causes of Skin Itching
      Causes of Skin Itching: Understanding the Reasons ...
      What is The Difference Between UVA and UVB Rays?
      Decoding the Connections Between Intrinsic & Extri...
      How to Protect Your Skin from UVA and UVB Rays
      Morning vs. Night Exfoliation: Determining the Bes...
      How to Tell if Acne is Hormonal or Bacterial?
      Tips for Managing Hormonal Breakouts
      How to Know if Your Skin Barrier is Damaged
      Understanding Hormonal Acne and Its Triggers
      How to Repair & Restore Your Skin Barrier
      How To Get Rid of Crepey Skin: 7 Solutions
      When to Apply Sunscreen: Before or After Moisturiz...
      How Alcohol Impacts Your Skin’s Health
      The Effects of Alcohol on Your Skin's Aging Proces...
      OS-01 FACE: Clinically Validated to Support Your S...
      Can Alcohol Cause Breakouts?
      The Proof is in the Peptide: 12-Week Clinical Stud...
      Why Is My Neck Aging So Fast?
      6 Tips and Tricks for a Youthful Neck
      Woman applying sunscreen
      Addressing the Need for Indoor Sun Protection
      Sunburned skin
      The Science of Sunburns: How to Treat and Prevent ...
      Get to Know OneSkin’s Topical Supplements:
      OS-01 F...
      Pollution
      Can Air Quality Affect Skin? Exploring the Impact ...
      Close up of eye
      Understanding the Relationship Between Sleep and U...
      Woman not sleeping in bed
      Exploring the Effects of Quality Sleep on Your Ski...
      Gut microbiom illustration
      How to Improve Gut Microbiome
      Woman holding bowl of food
      Exploring Caloric Restriction and Its Effects on A...
      woman stretching in bed
      What’s the Connection Between Quality Sleep and Lo...
      Healthy foods
      Unlocking the Skin Benefits of Intermittent Fastin...
      woman exercising
      Why Exercise is a Game-Changer for Longevity
      The Microbiome Diet and Its Effects on Skin
      The Microbiome Diet and Its Effects on Skin
      cold water
      Cold Exposure: Hype or Longevity Boosting?
      healthy foods
      Eat Better, Live Longer: Top Foods for Longevity
      How Environmental Stressors Affect Skin
      How to Protect Your Skin from Everyday Environment...
      OS-01 BODY
      Pressing the Pause Button on Aging Skin: OS-01 BOD...
      lip treatment
      Lip Balm Ingredients: What to Look for and What to...
      earth
      Exploring Blue Zones: How Can We Optimize Our Heal...
      Sunburn
      Sun Exposure and Your Skin: 6 Things You Need to K...
      Lips
      Nurturing Your Lips: How to Keep Them Moisturized ...
      Lips
      Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
      How to Travel with Skin Care
      How to Travel with Skin Care Products
      SHIELD on arm
      The Importance of Sunscreen: Why Should You Wear I...
      Lip sunscreen
      Lip Sunscreen: Do Lips Need SPF Protection?
      heart hands
      The Science of Gratitude
      prep on shoulder
      Removing Sunscreen: Tips for Clean and Healthy Ski...
      freckled skin
      Skin Explained: Is Skin An Organ?
      UV Light and Skin
      UV Light and Skin: Effects and Protection Strategi...
      What is Epidermis
      Understanding The Epidermis: Functions, Compositio...
      Diving into dermis
      Diving into Dermis: Functions and Significance
      Why Do We Get Wrinkles
      Unlocking the Science of Wrinkles: Causes, Formati...
      bentonite clay
      Ingredient Spotlight: Bentonite Uses, Benefits, & ...
      Back skin
      Why Skin Barrier is Important
      hypodermis function
      Hypodermis: Exploring Its Vital Functions
      oil-dropper-background-pink-dripping-cosmetic-product
      The EU is Limiting Retinol in Skincare: Here’s Eve...
      face+shield
      Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
      Age Gracefully: How to Manage Neck Wrinkles and Ac...
      Discover Why Our New SPF Outperforms the Rest
      How to Preserve Your Feet
      How to Preserve Your Feet: 5 Strategies for Wrinkl...
      Hands and Dermal Elasticity: Understanding and Man...
      The Lip Lineage
      The Lip Lineage: Exploring the Why Behind Wrinkled...
      A Journey Through the Skin: How UV Radiation Cause...
      How to Address Stomach Wrinkles
      How to Address Stomach Wrinkles For Smoother Skin
      How to Get Rid of Wrinkly Skin on Arms
      A Scientific Approach to Addressing Wrinkly Skin o...
      What is Skin Cycling
      What is Skin Cycling? Understanding, Embracing, an...
      How to Skin Cycle: A Guide to Optimize Your Skin C...
      How Do Our Products Work Together?
      Do You Know What Clinical Claims Really Mean?
      What is Tinted Sunscreen?
      What is Tinted Sunscreen?
      two types of face wrinkles
      2 Types of Wrinkles and Tips for Treating Them
       Zinc Oxide
      The Top 5 Benefits of Zinc Oxide for Skin
      Marionette Lines
      Understanding Marionette Lines: Causes and Prevent...
      How to Help Your Skin Act Younger
      how-much-sunscreen-to-use-on-face
      The Science of Sunscreen: Understanding the Optima...
      Better Elasticity, More Firmness: Discover OS-01 E...
      Symptoms and Causes of Melasma on Face
      Benefits of Sunscreen
      Beyond UV Protection: 7 Surprising Ways Sunscreen ...
      Mineral vs Chemical Sunscreen
      Making Sense of Sunscreen: Understanding the Diffe...
      Navigating Anti-Aging Skincare: The industry, the ...
      Sun spots
      Sun Spots: Causes & 3 Prevention Tips
      sunscreen-ingredients-to-avoid
      Navigating Sunscreen Labels: Unwanted Ingredients ...
      How to Prevent Skin Aging Before It Starts
      Face vs. Body Sunscreen: Can You Use Body Sunscreen On Your Face?
      Face vs. Body Sunscreen: Can You Use Body Sunscree...
      Sun Damaged Skin: What it is, how you can prevent ...
      Thick Skin vs Thin Skin
      A Comprehensive Guide to Understanding the Differe...
      How to Strengthen Your Skin
      How to Strengthen Your Skin: A Guide to Thicker, H...
      what-is-glycerin
      An In-Depth Look at Glycerin: What is it and What ...
      Glycerin Benefits for Skin
      Exploring the Benefits of Glycerin for Skin Health
      Difference Between Hydrating and Moisturizing
      Exploring the Difference Between Hydrating and Moi...
      3 Natural Ways to Keep Your Skin Hydrated and Glow...
      How To Create A Hydrating Skin Care Routine For Dr...
      Senotherapeutics, Senolytics, and Senomorphics -- ...
      Cleansing 101: How to Wash Your Face the Right Way...
      4 Essential Face Cleansing Steps to Achieving a Ra...
      Scientific Breakthrough: OneSkin’s scientists show...
      Dry Skin 101: How To Identify This Skin Type
      How OS-01 Can Help Your Collagen Levels As You Age...
      Developing a Skin Care Routine for Normal Skin: 4 ...
      What is Normal Skin & Do I Have This Skin Type?
      Skin Care Routine for Oily Skin
      A Step-by-Step Guide to Creating the Perfect Skin ...
      Understanding Oily Skin: Causes & Characteristics
      Menopause and Skin Changes
      7 Keys to Understanding Menopause and Skin Changes
      Is This The Root Cause of Aging?
      UV Damage Increases Cellular Senescence. Here's Ho...
      Our Research Has Been Published in npj Aging
      How To Reduce Hyperpigmentation by Targeting Cellu...
      Perfect Skin Care Routine for Combination Skin
      4 Steps to Crafting the Perfect Skin Care Routine ...
      Managing Combination Skin
      A Comprehensive Guide to Understanding and Managin...
      Benefits Of Moringa Oil
      An In-Depth Look At The Benefits Of Moringa Oil Fo...
      How to Tighten the Skin Under Your Eyes
      How to Tighten the Skin Under Your Eyes
      7 Causes For Crepey Skin Under Eyes
      Restoring Dry Skin Around The Eyes
      101 Guide To Restoring Dry Skin Around The Eyes
      How is OS-01 EYE different from OS-01 FACE?
      Woman washing her face
      How to Remove Lingering Dead Skin Cells On the Fac...
      Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
      Hallmarks Of Aging - One Skin Technologies
      Hallmarks of Aging
      What Is Sensitive Skin
      What is Sensitive Skin?
      Tight Feeling Skin
      Tight Feeling Skin: 3 Reasons Why
      Skin Tightening Ingredients
      3 Skin Tightening Ingredients To Help Boost Skin H...
      How OS-01 Works on Mature Skin
      How OS-01 Works on Mature Skin
      Is Fragrance Bad for Your Skin
      Is Fragrance Bad for Your Skin?
      Are Parabens Bad for Your Skin
      Are Parabens Bad for Your Skin?
      Target Cellular Senescence with the Highest Concen...
      Can a Plant-Based Diet Really Increase Your Health...
      Eye Skin Ages Faster: Here’s How OS-01 Can Help
      Gut Health and Skin: How Are They Connected?
      How OS-01 EYE Supports the Ultra-Thin Skin Around ...
      The Science Behind Why The Skin Around the Eyes Ag...
      How Do You Know When to Stop Using Retinol?
      How To Heal Skin From Picking Your Face Too Much
      6 Factors That Contribute to Slow Skin Healing
      4 Foods To Avoid During Wound Healing & Why
      A Complete Guide to the 4 Stages of Wound Healing
      Collagen And Elastin: What Role Do They Play In Sk...
      What is the Function of Skin as a Protective Barrier
      What is the Function of Skin as a Protective Barri...
      Why We Want Skin To Be More, Not Less
      Why We Want Skin To Be More, Not Less
      More Than Skin Deep: How Physical Touch Predicts L...
      What is Skin Inflammation? What Causes it?
      How to Reverse (or Prevent) Aging Skin
      Yes, You Need Sunscreen During Winter
      Can You Use Hyaluronic Acid with Retinol?
      Exploring the skin’s purpose in whole-body health
      Stressed Skin
      Stressed Skin: 4 Stress Effects on the Skin
      What Does Hyaluronic Acid Do For Your Skin
      What Does Hyaluronic Acid Do For Your Skin?
      Good Genes vs. Good Habits: Which Impacts Your Lon...
      How Does Sunscreen Work? How Long Does it Last?
      How Does Sunscreen Work? How Long Does it Last?
      What is the Best Skin Care Regimen for Aging Skin
      What is the Best Skin Care Regimen for Aging Skin?
      What happens to skin as a person ages?
      What Causes Dark Circles Under and Around Your Eyes?
      What Causes Dark Circles Under and Around Your Eye...
      How to Brighten Eyes and Under-Eyes
      Invasive vs. Non-Invasive Skincare: The pros and c...
      6 Benefits of Jojoba Oil
      6 Benefits of Jojoba Oil
      What are the Benefits of Sulforaphane?
      What are the Benefits of Sulforaphane?
      What is Sustainable Packaging for Cosmetic Products?
      What is Sustainable Packaging for Cosmetic Product...
      7 Benefits of Andiroba Oil For Skin
      Why is my Skin Peeling on My Face?
      What Are The Causes Of Dry, Flaky Skin On Your Fac...
      PREP enhances the effects of OS-01 FACE, and the p...
      This is the Data to Look For When Choosing Skin Ca...
      Why cellular senescence is more than just one of t...
      Allantoin For Skin: A Comprehensive Guide
      Ceramides For Skin: Everything You Need to Know
      A Simplified Guide To The Different Skin Texture Types
      A Simplified Guide To The Different Skin Texture T...
      How OS-01 Works With Different Skin Types
      How To Smooth Skin Texture On The Face: 4 Expert T...
      What Causes Crepey Skin & Can It Be Avoided Altoge...
      Does Niacinamide Help With Acne & Scarring?
      Skin Microbiome: What It Is, Why it’s Important, A...
      What Foods Cause Acne and Which Fight Against It?
      What Foods Cause Acne and Which Fight Against It?
      The 101 Guide To Understanding Acne-Prone Skin
      The Top 4 Prickly Pear Benefits for Skin
      What Is Exfoliation & Is It A Necessary Measure For Long-Term Skin Health?
      What Is Exfoliation & Is It A Necessary Measure Fo...
      OneSkin Notable Mention: Dave Asprey's The Human U...
      How to Incorporate OneSkin’s OS-01 Topical Supplem...
      Clean Beauty: What “clean” really means and why “s...
      Retinol 101: Debunking Retinol as the Gold Standar...
      Menopause & Skin: What you need to know
      Take an Inside Look into Our Cutting-Edge R&D Plat...
      101 Guide on The Benefits of Cleansing Your Face
      How OneSkin Developed the OS-01 Peptide
      a smiling woman washing her face
      Cleanser Vs. Face Wash: Which Should I Reach For?
      5 Common Perimenopause Skin Problems
      Five Common Skin Problems Experienced in Perimenop...
      You’re only as old as you feel, scientists are fin...
      Collagen For Menopause: Why Is It Necessary For Healthy Skin Aging?
      Collagen For Menopause: Why Is It Necessary For He...
      Get to Know OneSkin’s Topical Supplements:

      OS-

      ...
      The Top 3 Benefits of Peptides for Skin
      How to Use Peptides In Your Skincare Regimen to Optimize Your Health
      How to Use Peptides In Your Skincare Regimen to Op...
      peptide illustration
      Peptides vs Retinol: Is One Better For Increasing ...
      body skin
      What Is Causing the Uneven Skin Tone On Your Body?
      How To Boost Skin Moisture For Your Entire Body Fr...
      Three Ways To Extend Your Skinspan Starting With Your Body Care Routine
      Three Ways To Extend Your Skinspan Starting With Y...
      free radicals
      What Are Free Radicals and How Do They Impact Skin...
      The Connection Between Mental Health, Age Percepti...
      The Top 6 Best Antioxidants For Skin Health and Longevity
      The Top 6 Best Antioxidants For Skin Health and Lo...
      Zombie Cells
      What are Zombie Cells & How Can We Remove Them?
      SKIN CARE IS HEALTH CARE: WHY EXTENDING YOUR SKINS...
      How chronic stress makes you age faster
      What is Epidermal Thickness & Why Does it Matter?
      Cell Turnover & Why It Slows As We Age
      OneSkin Notable Mention: OneSkin Featured In Tony ...
      101 Guide To Skin Tightening
      101 Guide To Skin Tightening + 7 Noninvasive Metho...
      How to Reduce Skin Inflammation
      How to Reduce Skin Inflammation & Redness
      Niacinamide
      Niacinamide Vs Retinol: How Do They Compare?
      What Is Causing the Uneven Skin Tone On Your Body?
      illustration of nutrients being absorb
      Why Is Nutrient Absorption Key To Better Skin Heal...
      Dr. David Sinclair
      OneSkin Notable Mention: LifeSpan Episode 6 | The ...
      skin repairing foods
      The Top 10 Best Foods for Skin Repair
      Closeup of a sun spot
      Skin Hyperpigmentation 101: What It Is & How To Tr...
      Are There Dangers of Retinol Cream Use?
      What is Skin Elasticity & How Can You Improve It?
      closeup portrait of a model
      Celebrating Black History Month: A Discussion With...
      Representation of the Black Community in Skin Care and Longevity
      Representation of the Black Community in Skin Care...
      Portrait of OneSkin Founders
      Our Story: Learn more about the history of OneSkin...
      What Is Senescence & Its Relationship To Aging?
      What Is Senescence & Its Relationship To Aging?
      Winter Skincare - How To Prevent Dry Skin this Sea...
      Special Announcement: OneSkin to Donate 1% of Sale...
      Biological Age: What is Biological Age, Why Does i...
      What your skincare routine is missing (Hint. It’s ...
      What is a peptide?
      Peptides: the first piece of th...
      Where Skin Health Meets Longevity
      Health Is The New Wealth - One Skin Technologies
      Health Is The New Wealth
      Sleep: Nature’s Restart Button? - One Skin Technologies
      The Correlation Between Sleep and Skin: Why It Mat...
      How Relationships, Community, & Social Interaction...
      OneSkin launches MolClock, the first skin-specific molecular clock to determine the biological age of human skin - One Skin Technologies
      OneSkin launches MolClock, the first skin-specific...
      Calorie Restriction And Intermittent Fasting: Eati...
      Healthspan: A New Way To Think About Aging - One Skin Technologies
      Healthspan: A New Way To Think About Aging

      Discover More

      What Do Antioxidants Do For Skin and Why Should Yo...
      Making Sense of SPFs: What’s the Difference Betwee...
      How to Relieve Itchy Skin: Tips for Soothing Skin ...
      Causes of Skin Itching
      Causes of Skin Itching: Understanding the Reasons ...
      What is The Difference Between UVA and UVB Rays?
      Decoding the Connections Between Intrinsic & Extri...
      How to Protect Your Skin from UVA and UVB Rays
      Morning vs. Night Exfoliation: Determining the Bes...
      How to Tell if Acne is Hormonal or Bacterial?
      Tips for Managing Hormonal Breakouts
      How to Know if Your Skin Barrier is Damaged
      Understanding Hormonal Acne and Its Triggers
      How to Repair & Restore Your Skin Barrier
      How To Get Rid of Crepey Skin: 7 Solutions
      When to Apply Sunscreen: Before or After Moisturiz...
      How Alcohol Impacts Your Skin’s Health
      The Effects of Alcohol on Your Skin's Aging Proces...
      OS-01 FACE: Clinically Validated to Support Your S...
      Can Alcohol Cause Breakouts?
      The Proof is in the Peptide: 12-Week Clinical Stud...
      Why Is My Neck Aging So Fast?
      6 Tips and Tricks for a Youthful Neck
      Woman applying sunscreen
      Addressing the Need for Indoor Sun Protection
      Sunburned skin
      The Science of Sunburns: How to Treat and Prevent ...
      Get to Know OneSkin’s Topical Supplements:
      OS-01 F...
      Pollution
      Can Air Quality Affect Skin? Exploring the Impact ...
      Close up of eye
      Understanding the Relationship Between Sleep and U...
      Woman not sleeping in bed
      Exploring the Effects of Quality Sleep on Your Ski...
      Gut microbiom illustration
      How to Improve Gut Microbiome
      Woman holding bowl of food
      Exploring Caloric Restriction and Its Effects on A...
      woman stretching in bed
      What’s the Connection Between Quality Sleep and Lo...
      Healthy foods
      Unlocking the Skin Benefits of Intermittent Fastin...
      woman exercising
      Why Exercise is a Game-Changer for Longevity
      The Microbiome Diet and Its Effects on Skin
      The Microbiome Diet and Its Effects on Skin
      cold water
      Cold Exposure: Hype or Longevity Boosting?
      healthy foods
      Eat Better, Live Longer: Top Foods for Longevity
      How Environmental Stressors Affect Skin
      How to Protect Your Skin from Everyday Environment...
      OS-01 BODY
      Pressing the Pause Button on Aging Skin: OS-01 BOD...
      lip treatment
      Lip Balm Ingredients: What to Look for and What to...
      earth
      Exploring Blue Zones: How Can We Optimize Our Heal...
      Sunburn
      Sun Exposure and Your Skin: 6 Things You Need to K...
      Lips
      Nurturing Your Lips: How to Keep Them Moisturized ...
      Lips
      Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
      How to Travel with Skin Care
      How to Travel with Skin Care Products
      SHIELD on arm
      The Importance of Sunscreen: Why Should You Wear I...
      Lip sunscreen
      Lip Sunscreen: Do Lips Need SPF Protection?
      heart hands
      The Science of Gratitude
      prep on shoulder
      Removing Sunscreen: Tips for Clean and Healthy Ski...
      freckled skin
      Skin Explained: Is Skin An Organ?
      UV Light and Skin
      UV Light and Skin: Effects and Protection Strategi...
      What is Epidermis
      Understanding The Epidermis: Functions, Compositio...
      Diving into dermis
      Diving into Dermis: Functions and Significance
      Why Do We Get Wrinkles
      Unlocking the Science of Wrinkles: Causes, Formati...
      bentonite clay
      Ingredient Spotlight: Bentonite Uses, Benefits, & ...
      Back skin
      Why Skin Barrier is Important
      hypodermis function
      Hypodermis: Exploring Its Vital Functions
      oil-dropper-background-pink-dripping-cosmetic-product
      The EU is Limiting Retinol in Skincare: Here’s Eve...
      face+shield
      Why You Should Use OS-01 FACE & OS-01 SHIELD Toget...
      Age Gracefully: How to Manage Neck Wrinkles and Ac...
      Discover Why Our New SPF Outperforms the Rest
      How to Preserve Your Feet
      How to Preserve Your Feet: 5 Strategies for Wrinkl...
      Hands and Dermal Elasticity: Understanding and Man...
      The Lip Lineage
      The Lip Lineage: Exploring the Why Behind Wrinkled...
      A Journey Through the Skin: How UV Radiation Cause...
      How to Address Stomach Wrinkles
      How to Address Stomach Wrinkles For Smoother Skin
      How to Get Rid of Wrinkly Skin on Arms
      A Scientific Approach to Addressing Wrinkly Skin o...
      What is Skin Cycling
      What is Skin Cycling? Understanding, Embracing, an...
      How to Skin Cycle: A Guide to Optimize Your Skin C...
      How Do Our Products Work Together?
      Do You Know What Clinical Claims Really Mean?
      What is Tinted Sunscreen?
      What is Tinted Sunscreen?
      two types of face wrinkles
      2 Types of Wrinkles and Tips for Treating Them
       Zinc Oxide
      The Top 5 Benefits of Zinc Oxide for Skin
      Marionette Lines
      Understanding Marionette Lines: Causes and Prevent...
      How to Help Your Skin Act Younger
      how-much-sunscreen-to-use-on-face
      The Science of Sunscreen: Understanding the Optima...
      Better Elasticity, More Firmness: Discover OS-01 E...
      Symptoms and Causes of Melasma on Face
      Benefits of Sunscreen
      Beyond UV Protection: 7 Surprising Ways Sunscreen ...
      Mineral vs Chemical Sunscreen
      Making Sense of Sunscreen: Understanding the Diffe...
      Navigating Anti-Aging Skincare: The industry, the ...
      Sun spots
      Sun Spots: Causes & 3 Prevention Tips
      sunscreen-ingredients-to-avoid
      Navigating Sunscreen Labels: Unwanted Ingredients ...
      How to Prevent Skin Aging Before It Starts
      Face vs. Body Sunscreen: Can You Use Body Sunscreen On Your Face?
      Face vs. Body Sunscreen: Can You Use Body Sunscree...
      Sun Damaged Skin: What it is, how you can prevent ...
      Thick Skin vs Thin Skin
      A Comprehensive Guide to Understanding the Differe...
      How to Strengthen Your Skin
      How to Strengthen Your Skin: A Guide to Thicker, H...
      what-is-glycerin
      An In-Depth Look at Glycerin: What is it and What ...
      Glycerin Benefits for Skin
      Exploring the Benefits of Glycerin for Skin Health
      Difference Between Hydrating and Moisturizing
      Exploring the Difference Between Hydrating and Moi...
      3 Natural Ways to Keep Your Skin Hydrated and Glow...
      How To Create A Hydrating Skin Care Routine For Dr...
      Senotherapeutics, Senolytics, and Senomorphics -- ...
      Cleansing 101: How to Wash Your Face the Right Way...
      4 Essential Face Cleansing Steps to Achieving a Ra...
      Scientific Breakthrough: OneSkin’s scientists show...
      Dry Skin 101: How To Identify This Skin Type
      How OS-01 Can Help Your Collagen Levels As You Age...
      Developing a Skin Care Routine for Normal Skin: 4 ...
      What is Normal Skin & Do I Have This Skin Type?
      Skin Care Routine for Oily Skin
      A Step-by-Step Guide to Creating the Perfect Skin ...
      Understanding Oily Skin: Causes & Characteristics
      Menopause and Skin Changes
      7 Keys to Understanding Menopause and Skin Changes
      Is This The Root Cause of Aging?
      UV Damage Increases Cellular Senescence. Here's Ho...
      Our Research Has Been Published in npj Aging
      How To Reduce Hyperpigmentation by Targeting Cellu...
      Perfect Skin Care Routine for Combination Skin
      4 Steps to Crafting the Perfect Skin Care Routine ...
      Managing Combination Skin
      A Comprehensive Guide to Understanding and Managin...
      Benefits Of Moringa Oil
      An In-Depth Look At The Benefits Of Moringa Oil Fo...
      How to Tighten the Skin Under Your Eyes
      How to Tighten the Skin Under Your Eyes
      7 Causes For Crepey Skin Under Eyes
      Restoring Dry Skin Around The Eyes
      101 Guide To Restoring Dry Skin Around The Eyes
      How is OS-01 EYE different from OS-01 FACE?
      Woman washing her face
      How to Remove Lingering Dead Skin Cells On the Fac...
      Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
      Hallmarks Of Aging - One Skin Technologies
      Hallmarks of Aging
      What Is Sensitive Skin
      What is Sensitive Skin?
      Tight Feeling Skin
      Tight Feeling Skin: 3 Reasons Why
      Skin Tightening Ingredients
      3 Skin Tightening Ingredients To Help Boost Skin H...
      How OS-01 Works on Mature Skin
      How OS-01 Works on Mature Skin
      Is Fragrance Bad for Your Skin
      Is Fragrance Bad for Your Skin?
      Are Parabens Bad for Your Skin
      Are Parabens Bad for Your Skin?
      Target Cellular Senescence with the Highest Concen...
      Can a Plant-Based Diet Really Increase Your Health...
      Eye Skin Ages Faster: Here’s How OS-01 Can Help
      Gut Health and Skin: How Are They Connected?
      How OS-01 EYE Supports the Ultra-Thin Skin Around ...
      The Science Behind Why The Skin Around the Eyes Ag...
      How Do You Know When to Stop Using Retinol?
      How To Heal Skin From Picking Your Face Too Much
      6 Factors That Contribute to Slow Skin Healing
      4 Foods To Avoid During Wound Healing & Why
      A Complete Guide to the 4 Stages of Wound Healing
      Collagen And Elastin: What Role Do They Play In Sk...
      What is the Function of Skin as a Protective Barrier
      What is the Function of Skin as a Protective Barri...
      Why We Want Skin To Be More, Not Less
      Why We Want Skin To Be More, Not Less
      More Than Skin Deep: How Physical Touch Predicts L...
      What is Skin Inflammation? What Causes it?
      How to Reverse (or Prevent) Aging Skin
      Yes, You Need Sunscreen During Winter
      Can You Use Hyaluronic Acid with Retinol?
      Exploring the skin’s purpose in whole-body health
      Stressed Skin
      Stressed Skin: 4 Stress Effects on the Skin
      What Does Hyaluronic Acid Do For Your Skin
      What Does Hyaluronic Acid Do For Your Skin?
      Good Genes vs. Good Habits: Which Impacts Your Lon...
      How Does Sunscreen Work? How Long Does it Last?
      How Does Sunscreen Work? How Long Does it Last?
      What is the Best Skin Care Regimen for Aging Skin
      What is the Best Skin Care Regimen for Aging Skin?
      What happens to skin as a person ages?
      What Causes Dark Circles Under and Around Your Eyes?
      What Causes Dark Circles Under and Around Your Eye...
      How to Brighten Eyes and Under-Eyes
      Invasive vs. Non-Invasive Skincare: The pros and c...
      6 Benefits of Jojoba Oil
      6 Benefits of Jojoba Oil
      What are the Benefits of Sulforaphane?
      What are the Benefits of Sulforaphane?
      What is Sustainable Packaging for Cosmetic Products?
      What is Sustainable Packaging for Cosmetic Product...
      7 Benefits of Andiroba Oil For Skin
      Why is my Skin Peeling on My Face?
      What Are The Causes Of Dry, Flaky Skin On Your Fac...
      PREP enhances the effects of OS-01 FACE, and the p...
      This is the Data to Look For When Choosing Skin Ca...
      Why cellular senescence is more than just one of t...
      Allantoin For Skin: A Comprehensive Guide
      Ceramides For Skin: Everything You Need to Know
      A Simplified Guide To The Different Skin Texture Types
      A Simplified Guide To The Different Skin Texture T...
      How OS-01 Works With Different Skin Types
      How To Smooth Skin Texture On The Face: 4 Expert T...
      What Causes Crepey Skin & Can It Be Avoided Altoge...
      Does Niacinamide Help With Acne & Scarring?
      Skin Microbiome: What It Is, Why it’s Important, A...
      What Foods Cause Acne and Which Fight Against It?
      What Foods Cause Acne and Which Fight Against It?
      The 101 Guide To Understanding Acne-Prone Skin
      The Top 4 Prickly Pear Benefits for Skin
      What Is Exfoliation & Is It A Necessary Measure For Long-Term Skin Health?
      What Is Exfoliation & Is It A Necessary Measure Fo...
      OneSkin Notable Mention: Dave Asprey's The Human U...
      How to Incorporate OneSkin’s OS-01 Topical Supplem...
      Clean Beauty: What “clean” really means and why “s...
      Retinol 101: Debunking Retinol as the Gold Standar...
      Menopause & Skin: What you need to know
      Take an Inside Look into Our Cutting-Edge R&D Plat...
      101 Guide on The Benefits of Cleansing Your Face
      How OneSkin Developed the OS-01 Peptide
      a smiling woman washing her face
      Cleanser Vs. Face Wash: Which Should I Reach For?
      5 Common Perimenopause Skin Problems
      Five Common Skin Problems Experienced in Perimenop...
      You’re only as old as you feel, scientists are fin...
      Collagen For Menopause: Why Is It Necessary For Healthy Skin Aging?
      Collagen For Menopause: Why Is It Necessary For He...
      Get to Know OneSkin’s Topical Supplements:

      OS-

      ...
      The Top 3 Benefits of Peptides for Skin
      How to Use Peptides In Your Skincare Regimen to Optimize Your Health
      How to Use Peptides In Your Skincare Regimen to Op...
      peptide illustration
      Peptides vs Retinol: Is One Better For Increasing ...
      body skin
      What Is Causing the Uneven Skin Tone On Your Body?
      How To Boost Skin Moisture For Your Entire Body Fr...
      Three Ways To Extend Your Skinspan Starting With Your Body Care Routine
      Three Ways To Extend Your Skinspan Starting With Y...
      free radicals
      What Are Free Radicals and How Do They Impact Skin...
      The Connection Between Mental Health, Age Percepti...
      The Top 6 Best Antioxidants For Skin Health and Longevity
      The Top 6 Best Antioxidants For Skin Health and Lo...
      Zombie Cells
      What are Zombie Cells & How Can We Remove Them?
      SKIN CARE IS HEALTH CARE: WHY EXTENDING YOUR SKINS...
      How chronic stress makes you age faster
      What is Epidermal Thickness & Why Does it Matter?
      Cell Turnover & Why It Slows As We Age
      OneSkin Notable Mention: OneSkin Featured In Tony ...
      101 Guide To Skin Tightening
      101 Guide To Skin Tightening + 7 Noninvasive Metho...
      How to Reduce Skin Inflammation
      How to Reduce Skin Inflammation & Redness
      Niacinamide
      Niacinamide Vs Retinol: How Do They Compare?
      What Is Causing the Uneven Skin Tone On Your Body?
      illustration of nutrients being absorb
      Why Is Nutrient Absorption Key To Better Skin Heal...
      Dr. David Sinclair
      OneSkin Notable Mention: LifeSpan Episode 6 | The ...
      skin repairing foods
      The Top 10 Best Foods for Skin Repair
      Closeup of a sun spot
      Skin Hyperpigmentation 101: What It Is & How To Tr...
      Are There Dangers of Retinol Cream Use?
      What is Skin Elasticity & How Can You Improve It?
      closeup portrait of a model
      Celebrating Black History Month: A Discussion With...
      Representation of the Black Community in Skin Care and Longevity
      Representation of the Black Community in Skin Care...
      Portrait of OneSkin Founders
      Our Story: Learn more about the history of OneSkin...
      What Is Senescence & Its Relationship To Aging?
      What Is Senescence & Its Relationship To Aging?
      Winter Skincare - How To Prevent Dry Skin this Sea...
      Special Announcement: OneSkin to Donate 1% of Sale...
      Biological Age: What is Biological Age, Why Does i...
      What your skincare routine is missing (Hint. It’s ...
      What is a peptide?
      Peptides: the first piece of th...
      Where Skin Health Meets Longevity
      Health Is The New Wealth - One Skin Technologies
      Health Is The New Wealth
      Sleep: Nature’s Restart Button? - One Skin Technologies
      The Correlation Between Sleep and Skin: Why It Mat...
      How Relationships, Community, & Social Interaction...
      OneSkin launches MolClock, the first skin-specific molecular clock to determine the biological age of human skin - One Skin Technologies
      OneSkin launches MolClock, the first skin-specific...
      Calorie Restriction And Intermittent Fasting: Eati...
      Healthspan: A New Way To Think About Aging - One Skin Technologies
      Healthspan: A New Way To Think About Aging

      Related Products