How chronic stress makes you age faster
3 min read
APRIL 12, 2023
LONGEVITY
How chronic stress makes you age faster
3 min read
APRIL 12, 2023
LONGEVITY
From work pressures to unexpected visits from the in-laws, daily stress is a reality of life. With a healthy lifestyle, most of us bounce back from intermittent stress and return to a balanced state. But for some of us, relief never comes. Chronic stress, defined as a persistent sense of feeling pressured and overwhelmed over a long period of time, takes an incredible toll on our bodies. [1] In fact, studies have shown that chronic stress increases multiple hallmarks of aging, speeds the rate at which we age, and increases our risk for numerous age-related diseases. Join us as we dig into the science and explore the compelling reasons why managing stress might be one of the most important things you can do for your longevity.
From work pressures to unexpected visits from the in-laws, daily stress is a reality of life. With a healthy lifestyle, most of us bounce back from intermittent stress and return to a balanced state. But for some of us, relief never comes. Chronic stress, defined as a persistent sense of feeling pressured and overwhelmed over a long period of time, takes an incredible toll on our bodies. [1] In fact, studies have shown that chronic stress increases multiple hallmarks of aging, speeds the rate at which we age, and increases our risk for numerous age-related diseases. Join us as we dig into the science and explore the compelling reasons why managing stress might be one of the most important things you can do for your longevity.
01
Chronic stress induces cellular senescence
A chronic state of mental stress is a risk factor for numerous diseases. To understand why, scientists have examined the underlying similarities between these diseases. A common feature seems to be cellular senescence, the accumulation of dead “zombie” cells that secrete harmful biochemical signals–inducing chronic inflammation, suppressing the immune system, and accelerating aging in neighboring cells. [2]With cellular senescence as a common link between stress-related diseases, scientists took a closer look to determine whether chronic stress itself functionally increases rates of cellular senescence. In a study, researchers asked 73 adults to self-report their stress levels. Each participant also donated a blood sample that scientists used to measure P16ᴵᴺᴷ⁴ᵃ, a key marker of cellular senescence. Individuals with greater chronic stress exposure showed higher levels of P16ᴵᴺᴷ⁴ᵃ, indicating higher overall levels of cellular senescence. [3]Cellular senescence is associated with cancer, cardiovascular, neurodegenerative and autoimmune disorders. While many of these diseases are age-related, there is some evidence showing that persistent, severe stress can trigger them earlier in a person’s life. This may be due in part to a phenomenon called immunosenescence, senescence in immune cells. When increasing numbers of immune cells become senescent, the body experiences a deterioration in immune response not normally seen in younger people. This can lead to the development and acceleration of two additional aging hallmarks: telomere attrition and chronic inflammation. [2]
01
Chronic stress induces cellular senescence
A chronic state of mental stress is a risk factor for numerous diseases. To understand why, scientists have examined the underlying similarities between these diseases. A common feature seems to be cellular senescence, the accumulation of dead “zombie” cells that secrete harmful biochemical signals–inducing chronic inflammation, suppressing the immune system, and accelerating aging in neighboring cells. [2]With cellular senescence as a common link between stress-related diseases, scientists took a closer look to determine whether chronic stress itself functionally increases rates of cellular senescence. In a study, researchers asked 73 adults to self-report their stress levels. Each participant also donated a blood sample that scientists used to measure P16ᴵᴺᴷ⁴ᵃ, a key marker of cellular senescence. Individuals with greater chronic stress exposure showed higher levels of P16ᴵᴺᴷ⁴ᵃ, indicating higher overall levels of cellular senescence. [3]Cellular senescence is associated with cancer, cardiovascular, neurodegenerative and autoimmune disorders. While many of these diseases are age-related, there is some evidence showing that persistent, severe stress can trigger them earlier in a person’s life. This may be due in part to a phenomenon called immunosenescence, senescence in immune cells. When increasing numbers of immune cells become senescent, the body experiences a deterioration in immune response not normally seen in younger people. This can lead to the development and acceleration of two additional aging hallmarks: telomere attrition and chronic inflammation. [2]
02
Chronic stress increases inflammaging
Like stress, inflammation is a normal part of the human experience. It’s the body’s main way of identifying harm–whether from pathogens or injury–and initiating the healing process. Acute, or short-term inflammation, is essential to our health. But when that same inflammation becomes constant, it can actually do more harm than good. [4]Age-associated chronic inflammation, also known as inflammaging, is associated with alterations in the body’s immune response. It’s now understood that these alterations occur when the body’s immune response is disrupted due to immunosenescence. This continuous, systemic inflammation can contribute to the development of several diseases including atherosclerosis, diabetes, and hypertension.In addition to its link with stress-induced cellular senescence, inflammaging is also believed to be directly tied to chronic psychological stress by altering levels of cytokines, small proteins that are important in cellular signaling. During the aging process, the body experiences a decrease in anti-inflammatory cytokines, and a simultaneous increase in pro-inflammatory cytokines, leading to overall higher levels of inflammation. Scientists now believe that chronic psychological stress further stimulates pro-inflammatory cytokines. In fact, some studies have shown that antidepressants, which are used to reduce psychological stress, actually reduce enhanced levels of these pro-inflammatory cytokines. [2]This data indicates that living in a constant state of psychological stress can actually accelerate the inflammaging that you might normally experience as a result of the aging process–hastening the cellular damage caused by inflammation so that you actually age more quickly.
02
Chronic stress increases inflammaging
Like stress, inflammation is a normal part of the human experience. It’s the body’s main way of identifying harm–whether from pathogens or injury–and initiating the healing process. Acute, or short-term inflammation, is essential to our health. But when that same inflammation becomes constant, it can actually do more harm than good. [4]Age-associated chronic inflammation, also known as inflammaging, is associated with alterations in the body’s immune response. It’s now understood that these alterations occur when the body’s immune response is disrupted due to immunosenescence. This continuous, systemic inflammation can contribute to the development of several diseases including atherosclerosis, diabetes, and hypertension.In addition to its link with stress-induced cellular senescence, inflammaging is also believed to be directly tied to chronic psychological stress by altering levels of cytokines, small proteins that are important in cellular signaling. During the aging process, the body experiences a decrease in anti-inflammatory cytokines, and a simultaneous increase in pro-inflammatory cytokines, leading to overall higher levels of inflammation. Scientists now believe that chronic psychological stress further stimulates pro-inflammatory cytokines. In fact, some studies have shown that antidepressants, which are used to reduce psychological stress, actually reduce enhanced levels of these pro-inflammatory cytokines. [2]This data indicates that living in a constant state of psychological stress can actually accelerate the inflammaging that you might normally experience as a result of the aging process–hastening the cellular damage caused by inflammation so that you actually age more quickly.
03
Chronic stress induces telomere attrition
In addition to its effects on cellular senescence and inflammation, research shows that chronic stress can have a structural impact on our chromosomes, tightly packed molecules that house our DNA.Telomeres are protective casings located at the end of each chromosome that shield our chromosomes from becoming frayed or tangled. Because our telomeres shorten every time a cell divides, our telomere length naturally shortens with age. [5] Once telomeres become too short, cells experience senescence, cell death, or oncogenic transformations where they can become cancerous. Shorter telomeres have been associated with increased risk for diseases and overall shorter lifespan. [6]When we’re young and healthy, telomere attrition is kept at bay with telomerase, an enzyme that replenishes telomere length even as our cells continue to divide. However, chronic stress–and constantly high levels of the stress hormone cortisol–decreases the body’s natural supply of telomerase. This means that chronic stress can actually speed the rate at which we experience telomere attrition, accelerating its systemic aging effects. [7]
03
Chronic stress induces telomere attrition
In addition to its effects on cellular senescence and inflammation, research shows that chronic stress can have a structural impact on our chromosomes, tightly packed molecules that house our DNA.Telomeres are protective casings located at the end of each chromosome that shield our chromosomes from becoming frayed or tangled. Because our telomeres shorten every time a cell divides, our telomere length naturally shortens with age. [5] Once telomeres become too short, cells experience senescence, cell death, or oncogenic transformations where they can become cancerous. Shorter telomeres have been associated with increased risk for diseases and overall shorter lifespan. [6]When we’re young and healthy, telomere attrition is kept at bay with telomerase, an enzyme that replenishes telomere length even as our cells continue to divide. However, chronic stress–and constantly high levels of the stress hormone cortisol–decreases the body’s natural supply of telomerase. This means that chronic stress can actually speed the rate at which we experience telomere attrition, accelerating its systemic aging effects. [7]
04
Chronic stress increases oxidative stress
You know you should be eating a lot of antioxidant-rich fruits and veggies, but do you know why? It’s because antioxidants naturally combat reactive oxygen species (ROS), unstable molecules also known as free radicals that can damage our cells, alter cellular metabolism, and increase inflammation.From the time we are born, our cells are constantly managing ROS. But our ability to neutralize ROS can wane as we age, leading to oxidative stress–a phenomenon associated with physical signs of aging. Interestingly, within the body, the main source of ROS is actually our own mitochondria, which become dysfunctional as a result of inflammaging. [2]Our ability to fend off oxidative stress becomes further impaired when we experience a constant state of psychological stress. In a study, scientists compared patients with PTSD to control individuals and discovered that people with PTSD show signs of reduced ROS metabolism. This means that they experience higher rates of oxidative stress. Because oxidative stress itself seems to trigger crosstalk between the immune and central neural systems, scientists believe that stress-induced oxidative stress may actually create a pernicious cycle that further degrades emotional wellbeing, leading to more psychological stress. [2]
04
Chronic stress increases oxidative stress
You know you should be eating a lot of antioxidant-rich fruits and veggies, but do you know why? It’s because antioxidants naturally combat reactive oxygen species (ROS), unstable molecules also known as free radicals that can damage our cells, alter cellular metabolism, and increase inflammation.From the time we are born, our cells are constantly managing ROS. But our ability to neutralize ROS can wane as we age, leading to oxidative stress–a phenomenon associated with physical signs of aging. Interestingly, within the body, the main source of ROS is actually our own mitochondria, which become dysfunctional as a result of inflammaging. [2]Our ability to fend off oxidative stress becomes further impaired when we experience a constant state of psychological stress. In a study, scientists compared patients with PTSD to control individuals and discovered that people with PTSD show signs of reduced ROS metabolism. This means that they experience higher rates of oxidative stress. Because oxidative stress itself seems to trigger crosstalk between the immune and central neural systems, scientists believe that stress-induced oxidative stress may actually create a pernicious cycle that further degrades emotional wellbeing, leading to more psychological stress. [2]
05
Putting it all together
Once you dig into the science, it’s easy to see that everything is connected. Increased cellular senescence, inflammaging, telomere attrition, and oxidative stress are all magnified by one another. In short, chronic stress kicks off a cascade of accelerated aging factors that amplify one another, creating system-wide impacts. This underlines the incredibly damaging potential of living a life with unregulated stress levels.So how can you help manage chronic stress? In addition to seeking out mental health help from a therapist, experts recommend getting regular exercise, prioritizing sleep, making time for leisure activities and practicing mindfulness. While these tactics may seem mundane in the face of major psychological stress, small daily lifestyle shifts can help the body recover both mentally and physically from a state of chronic stress. [1]
05
Putting it all together
Once you dig into the science, it’s easy to see that everything is connected. Increased cellular senescence, inflammaging, telomere attrition, and oxidative stress are all magnified by one another. In short, chronic stress kicks off a cascade of accelerated aging factors that amplify one another, creating system-wide impacts. This underlines the incredibly damaging potential of living a life with unregulated stress levels.So how can you help manage chronic stress? In addition to seeking out mental health help from a therapist, experts recommend getting regular exercise, prioritizing sleep, making time for leisure activities and practicing mindfulness. While these tactics may seem mundane in the face of major psychological stress, small daily lifestyle shifts can help the body recover both mentally and physically from a state of chronic stress. [1]
Key Takeaways:
- Studies have shown that chronic stress speeds the rate at which we age, and increases our risk for numerous age-related diseases.
- Individuals with chronic stress show higher markers of cellular senescence, a central hallmark of aging tied to cancer, cardiovascular, neurodegenerative and autoimmune disorders.
- Chronic psychological stress also stimulates pro-inflammatory cytokines and systemic inflammation, a factor linked to several diseases including atherosclerosis, diabetes, and hypertension.
- Constant exposure to the stress hormone, cortisol, decreases the body’s natural supply of telomerase, an enzyme that prevents telomere attrition, a hallmark of aging linked to diminished lifespan.
- Higher rates of psychological stress are linked to increased oxidative stress, the overproduction of free radicals that damage our cells and induce inflammation.
- Regular exercise, prioritizing sleep, making time for leisure activities and practicing mindfulness can help mitigate the psychological and physical impacts of chronic stress.
Key Takeaways:
- Studies have shown that chronic stress speeds the rate at which we age, and increases our risk for numerous age-related diseases.
- Individuals with chronic stress show higher markers of cellular senescence, a central hallmark of aging tied to cancer, cardiovascular, neurodegenerative and autoimmune disorders.
- Chronic psychological stress also stimulates pro-inflammatory cytokines and systemic inflammation, a factor linked to several diseases including atherosclerosis, diabetes, and hypertension.
- Constant exposure to the stress hormone, cortisol, decreases the body’s natural supply of telomerase, an enzyme that prevents telomere attrition, a hallmark of aging linked to diminished lifespan.
- Higher rates of psychological stress are linked to increased oxidative stress, the overproduction of free radicals that damage our cells and induce inflammation.
- Regular exercise, prioritizing sleep, making time for leisure activities and practicing mindfulness can help mitigate the psychological and physical impacts of chronic stress.
References
- https://www.yalemedicine.org/conditions/stress-disorder
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400286/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420375
- https://www.ncbi.nlm.nih.gov/books/NBK493173/
- https://www.genome.gov/genetics-glossary/Telomere
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370421/
- https://www.apa.org/monitor/2014/10/
References
- https://www.yalemedicine.org/conditions/stress-disorder
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400286/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420375
- https://www.ncbi.nlm.nih.gov/books/NBK493173/
- https://www.genome.gov/genetics-glossary/Telomere
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370421/
- https://www.apa.org/monitor/2014/10/
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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How to Skin Cycle: A Guide to Optimize Your Skin C...
How Do Our Products Work Together?
Do You Know What Clinical Claims Really Mean?
What is Tinted Sunscreen?
2 Types of Wrinkles and Tips for Treating Them
The Top 5 Benefits of Zinc Oxide for Skin
Understanding Marionette Lines: Causes and Prevent...
How to Help Your Skin Act Younger
The Science of Sunscreen: Understanding the Optima...
Better Elasticity, More Firmness: Discover OS-01 E...
Symptoms and Causes of Melasma on Face
Beyond UV Protection: 7 Surprising Ways Sunscreen ...
Making Sense of Sunscreen: Understanding the Diffe...
Navigating Anti-Aging Skincare: The industry, the ...
Sun Spots: Causes & 3 Prevention Tips
Navigating Sunscreen Labels: Unwanted Ingredients ...
How to Prevent Skin Aging Before It Starts
Face vs. Body Sunscreen: Can You Use Body Sunscree...
Sun Damaged Skin: What it is, how you can prevent ...
A Comprehensive Guide to Understanding the Differe...
How to Strengthen Your Skin: A Guide to Thicker, H...
An In-Depth Look at Glycerin: What is it and What ...
Exploring the Benefits of Glycerin for Skin Health
Exploring the Difference Between Hydrating and Moi...
3 Natural Ways to Keep Your Skin Hydrated and Glow...
How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
4 Essential Face Cleansing Steps to Achieving a Ra...
Scientific Breakthrough: OneSkin’s scientists show...
Dry Skin 101: How To Identify This Skin Type
How OS-01 Can Help Your Collagen Levels As You Age...
Developing a Skin Care Routine for Normal Skin: 4 ...
What is Normal Skin & Do I Have This Skin Type?
A Step-by-Step Guide to Creating the Perfect Skin ...
Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Are Parabens Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
The Science Behind Why The Skin Around the Eyes Ag...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
6 Factors That Contribute to Slow Skin Healing
4 Foods To Avoid During Wound Healing & Why
A Complete Guide to the 4 Stages of Wound Healing
Collagen And Elastin: What Role Do They Play In Sk...
What is the Function of Skin as a Protective Barri...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
How Does Sunscreen Work? How Long Does it Last?
What is the Best Skin Care Regimen for Aging Skin?
What happens to skin as a person ages?
What Causes Dark Circles Under and Around Your Eye...
How to Brighten Eyes and Under-Eyes
Invasive vs. Non-Invasive Skincare: The pros and c...
6 Benefits of Jojoba Oil
What are the Benefits of Sulforaphane?
What is Sustainable Packaging for Cosmetic Product...
7 Benefits of Andiroba Oil For Skin
Why is my Skin Peeling on My Face?
What Are The Causes Of Dry, Flaky Skin On Your Fac...
PREP enhances the effects of OS-01 FACE, and the p...
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
Allantoin For Skin: A Comprehensive Guide
Ceramides For Skin: Everything You Need to Know
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
What Causes Crepey Skin & Can It Be Avoided Altoge...
Does Niacinamide Help With Acne & Scarring?
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Clean Beauty: What “clean” really means and why “s...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide on The Benefits of Cleansing Your Face
How OneSkin Developed the OS-01 Peptide
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
You’re only as old as you feel, scientists are fin...
Collagen For Menopause: Why Is It Necessary For He...
Get to Know OneSkin’s Topical Supplements:
...OS-
The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Connection Between Mental Health, Age Percepti...
The Top 6 Best Antioxidants For Skin Health and Lo...
What are Zombie Cells & How Can We Remove Them?
SKIN CARE IS HEALTH CARE: WHY EXTENDING YOUR SKINS...
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
What Is Causing the Uneven Skin Tone On Your Body?
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Skin Hyperpigmentation 101: What It Is & How To Tr...
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
Celebrating Black History Month: A Discussion With...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Winter Skincare - How To Prevent Dry Skin this Sea...
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
What is a peptide?
Peptides: the first piece of th...
Peptides: the first piece of th...
Where Skin Health Meets Longevity
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
How Relationships, Community, & Social Interaction...
OneSkin launches MolClock, the first skin-specific...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging