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Body

OS-01 BODY Topical Supplement

SUBSCRIPTION EXCLUSIVES

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  • Suited to All skin types, safe for sensitive skin
  • Format Nourishing moisturizer
  • Targets Crepiness, dehydration, skin barrier function

OS-01 BODY is a restorative skin longevity treatment powered by the OS-01 Senescence Blocking Peptide™, designed to strengthen the skin barrier, improve hydration, and promote firm, resilient skin from the neck down.01

OneSkin

BENEFITS

Nourishing body moisturizer and targeted treatment for thin, crepey skin

Smooth texture

Improves the root cause of crepey skin by supporting epidermal thickness for a firmer look and feel.01

Deep hydration

Replenishes and locks in hydration to keep skin soft, plump, and nourished.01

Barrier support

Fortifies the skin barrier to protect against daily stressors and moisture loss.01

5-STAR REVIEWS

See why customers love OS-01 BODY

“The skin on my legs was starting to look older, dry and crepey at 46. Now it is plump and youthful like it was 10 years ago after only a few weeks.” – Jen A.

"The One skin, OS-O1 Body, has been a game changer, within a few weeks I saw a remarkable difference in the quality of my skin, and my skin's appearance continues to improve with daily application. It now has a tighter, less dry look and the texture has almost returned to my premenopause condition..more moist and fresh in appearance. Science is everything, and One Skin has got the science spot on." – Tia T.


"I love this body lotion. My crepey skin is transforming. I wish I had taken pictures before I started using it but I have tried so many different products with no results that I didn’t have much confidence that this one would be any different. Boy was I wrong. I’m hoping that it will eventually get rid of all my dark spots on my skin. I will be a forever customer..."– Myra P.

CLINICAL DATA

Visible results, scientifically validated

93

of participants reported improved hydration 01

72

of participants reported improved appearance 01

70

of participants reported improved texture 01

41

Improvement in skin barrier function was measured 01

The Science Behind OS-01 BODY

Your skin is your largest organ and plays a vital role in your overall health as you age. Over time, it becomes thinner, more fragile, and less effective at protecting you from external aggressors. While most skincare focuses on the face, the other 97% of your skin is just as essential for longevity and well-being. OS-01 BODY is designed to strengthen your skin barrier from the neck down, keeping it resilient.

To evaluate OS-01 BODY’s effectiveness, our scientists measured epidermal thickness—a key indicator of barrier strength—using human skin samples in the lab. Results showed a 40% increase in epidermal thickness compared to untreated skin. This aligns with clinical findings demonstrating OS-01 BODY enhances skin barrier function by up to 41.49%.01


Shown in lab studies on ex vivo human skin samples by measuring epidermal thickness of histology images. Skin treated with OS-01 BODY displayed a significant average increase of +40% compared to skin with no treatment. Data was measured in triplicate.

Getting started with OS-01 BODY

Follow these easy steps for optimal results

  • Apply to arms, legs, chest, back, and stomach
  • Massage until absorbed
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Peptide™

The first and only peptide scientifically proven to reverse skin’s biological age.02,03

All Ingredients

Water, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Avena Sativa (Oat) Kernel Oil, Squalane, Prunus Domestica Seed Oil, Saccharide Isomerate, Cetearyl Olivate, d-Panthenol, Mangifera Indica (Mango) Seed Butter, Tremella Fuciformis (Mushroom) Extract, Tocopheryl acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NP, Anadenanthera Colubrina Bark Extract, Lepidium Sativum Sprout Extract, Genistein, Niacinamide, Glycerol, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Citric Acid, Sodium Citrate, Pentylene Glycol, Potassium Sorbate, Ethylhexylglycerin, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

Citations

01Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

02Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

03Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1

OS-01 BODY Topical Supplement

4.7
Rated 4.7 out of 5 stars
Based on 2,471 reviews
Total 5 star reviews: 2k Total 4 star reviews: 340 Total 3 star reviews: 110 Total 2 star reviews: 30 Total 1 star reviews: 36
93%would recommend these products
2,471 reviews
  • D
    Deborah
    Reviewing
    OS-01 BODY
    I recommend this product
    Rated 5 out of 5 stars
    6 minutes ago
    5 Stars

    The best

  • CM
    Chris M.
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    1 hour ago
    Surprising

    I have been using the body cream for a little over 5 weeks. I’m on my 2nd bottle and am about to order the face cream. What surprised me at first is that it’s a thinner cream, soaks right in, and doesn’t feel greasy. How can this work too well?! I have to say, with bottles and bottles of thick, oily creams for my severely dry and damaged skin, it working very well. I have a terribly dry patch on my lower left calf and nothing smoothed it. It feels, now, so much smoother! I’m so happy! I will continue using this product and purchase again.

  • PM
    Pamela M.
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    5 hours ago
    Best Body Cream

    Never have to reapply. My skin stays smooth all day!

  • CJ
    Christine J.
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    8 hours ago
    best body moisturizer

    I've tried every retinol and glycolic acid formulation for my body, and the One Skin is the only moisturizer that minimizes crepiness. The only downside of this product is the price. Although effective, it's an investment!

  • J
    Jess
    Verified Buyer
    Reviewing
    OS-01 BODY Topical Supplement
    I recommend this product
    Rated 5 out of 5 stars
    17 hours ago
    Finally moisturized skin

    I can’t believe I’m spending this much money on lotion but this is the only lotion I’ve found that gives my skin lasting moisture. I even use it on my face and neck. I’ve tried so many other brands that would leave my skin flaking within 20 minutes of application. This stuff gives me glowing, moisturized flake-free skin all day long. It definitely makes my skin look younger but moisturized skin always looks younger than dry skin.