Anti-Aging Reinvented

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The first Topical Supplement designed to extend skin health on the molecular level by targeting aging from within.

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We have a secret… We aren’t a skincare company

We are a longevity company. Our team is comprised of PhD-level aging experts. We’ve spent years in a lab creating the first topical skin supplement designed to extend your skinspan; the time your skin is healthy and youthful. And here you thought all supplements were pills.

Right for all skin types
(we all age, after all)
Data-backed claims
peptide, OS-01
Developed by longevity Scientists
Vegan and cruelty free
Safe and clean ingredients

Healthy skin looks great on everyone

(Just take it from our customers!)


“My very sensitive and reactive skin looks and feels better than it has in years!”

-Danielle T.

“With OS-01, my skin had slight improvement in skin tone in 4 weeks. I like how light it is! Since, I have very sensitive skin- I was pleased to see it didn't cause any irritation.”

-Sharika S.

“My rosacea has improved using this product. My hyperpigmentation has improved as well which was a surprise because I never expected to ever see my normal skin color again after a failed IPL years ago. This is the best product I've ever used, my skin barrier and wrinkles have improved and I look years younger after only more than a month of usage. I can only imagine as time goes on my skin will only look more healthy. Thanks Oneskin for your amazing product, and customer support.”

-Joshua C.

“I have been using the lotion for 3 weeks consistently and I definitely feel my skin is softer and the skin under my eyes seem smoother. And, it doesn’t irritate my under eye area, which a lot of creams do.”


“I love that this is a one-step skincare process and that it WORKS. My skin is healthier and clearer than it has been in a very long time. It doesn’t irritate the way products with retinol do.”

-Lisa T.

“I am seeing a huge improvement in texture. I was using Retin-A for years but this stuff seems to do the same thing without the irritation.”

-Tania S.

“This is by far the most effective product I’ve used to date. I have tried all sorts of anti-aging moisturizers and this has them all best hands down. Luxurious feel and scent!”

-Megan L.

“My friend gave it to me as a gift. At first I thought, "Ugh, another useless skincare," but then she told me about all the great scientific proofs and results, so I gave it a try. It really made my skin look better, softer, and small wrinkles disappeared. I can't wait to make another order!"

-Arzu A.

"In a space that is so saturated with overhyped products, it's refreshing to see a brand that stands for evidence, efficacy, and holistic health. My skin feels brighter, softer, and overall smoother, it's my new go-to!"

-Dara E.

“I have always been obsessed with products that have both a health benefit and positive physical impact. And while there are tons of products that claim to do this on the market today, none that I’ve tried have even come close to the visibly measurable improvement in my skin I’ve seen in just 8 weeks! OneSkin is the one product I don’t see ever leaving my skin care routine!”

-Brandon S.

Scientifically and Clinically backed

OS-01 Supporting Data

We performed a 12-week clinical study to validate and quantify the impact of OS-01 in improving skin health. Our results showed that OS-01 is clinically proven to strengthen the skin barrier in addition to providing remarkable visual benefits.

12 Weeks
Base Line
  • Improved Skin Barrier (Average Improvement + 15%)*
  • Improved Skin Elasticity (Shown in 90% of users)**
  • Improved Skin Evenness,
    Radiance, Pores, & Firmness (Shown in 95.5% of users)**
  • Less Wrinkles (Shown in 87% of users)
  • Improved Skin Smoothness
    & Overall Appearance (Shown in 100% of users)

*Instrumental Evaluation - Vapometer analysis

*Double-blind expert clinical grader evaluation

Shop OS-01

Meet OS-O1, the first ingredient to target the root causes of skin aging

Our product acts at the molecular level. Our proprietary peptide, OS-O1, is scientifically proven to

Plus, it will leave you with healthier, stronger, and more hydrated skin that is better equipped to fight external irritants and aggressors, making it the perfect aging cream for sensitive skin.

Healthy skin is happy skin

(Just take it from our beta testers)


As a brand whose mission is to inspire healthy aging, we don’t identify with the term “anti-aging” and here’s why:

Much of the anti-aging skincare industry has been built on empty promises with top anti-aging products lacking validated claims and exploiting age-related anxiety and fear.

At OneSkin, we recognize that the goal of the best anti-aging skincare products shouldn't be only to improve appearances, which often forces consumers to compromise on long-term skin health, but rather to treat the underlying source of skin aging, a consequence of which will be improved appearances.

We are developing best-in-class solutions to aging with a new mindset - one that’s not anti-aging, but pro-aging in the healthiest and most beautiful way possible. We believe the best anti-aging treatment is one that is rooted in science, with data-backed claims. That’s why our Topical Supplement goes beyond placing a metaphorical band-aid on aging skin — it addresses the molecular changes associated with aging to not only boost skin health, but overall health as well.

Skin health is a marathon, not a sprint

In the same way you take daily vitamins to keep yourself healthy, daily application of our science-backed topical supplement promotes long-lasting effects to keep your skin healthy, strong, and hydrated.

Unlike other top-rated anti-aging treatments, which can irritate skin and may even be damaging in the long run, OneSkin promotes long-term health at the molecular level, so skin feels soothed, balanced, and hydrated. Our topical supplement works over time, penetrating the deepest layer of the skin to stimulate change and restore skin’s resilience, making OneSkin the best aging cream for sensitive skin. Most users start seeing healthier, stronger, and better looking skin in 4-8 weeks with daily use.

Learn about our Topical Supplement

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