How OS-01 EYE Supports the Ultra-Thin Skin Around the Eyes

6 min read

THE ONESKIN TEAM
February 28,2023
ONESKIN PRODUCTS, SKIN CARE

How OS-01 EYE Supports the Ultra-Thin Skin Around the Eyes

6 min read

THE ONESKIN TEAM
February 28,2023
ONESKIN PRODUCTS, SKIN CARE
Just a quick look at the skin around your eyes and you can tell it’s different from the skin just inches below it on your cheek. Maybe it looks softer or crinkles more easily. Maybe you notice more fine lines and wrinkles. Or maybe you see purple or green coloring under your eyes. All of these are signs of one undeniable fact: the skin under your eyes is much thinner than the skin on the rest of your face. In fact, the skin around the eyes is among the thinnest on the entire body.[1] Let’s take a closer look at why skin thickness matters and how our new OS-01 EYE was specifically formulated to support the delicate skin around the eyes.
Just a quick look at the skin around your eyes and you can tell it’s different from the skin just inches below it on your cheek. Maybe it looks softer or crinkles more easily. Maybe you notice more fine lines and wrinkles. Or maybe you see purple or green coloring under your eyes. All of these are signs of one undeniable fact: the skin under your eyes is much thinner than the skin on the rest of your face. In fact, the skin around the eyes is among the thinnest on the entire body.[1] Let’s take a closer look at why skin thickness matters and how our new OS-01 EYE was specifically formulated to support the delicate skin around the eyes.
01

Understanding Epidermal Thickness

The epidermis is the outermost layer of our skin and the thinnest of the three main skin layers. Responsible for protecting our bodies from the outside world, the epidermis is made up of 5 layers of its own, including the stratum corneum, which is sometimes called the skin barrier. This layer of the epidermis is made up of corneocytes, dead skin cells that protect the skin from environmental aggressors like UV light, pathogens, and pollutants. These dead skin cells are “glued” together by fats that keep water inside the skin and prevent dehydration. [2]
01

Understanding Epidermal Thickness

The epidermis is the outermost layer of our skin and the thinnest of the three main skin layers. Responsible for protecting our bodies from the outside world, the epidermis is made up of 5 layers of its own, including the stratum corneum, which is sometimes called the skin barrier. This layer of the epidermis is made up of corneocytes, dead skin cells that protect the skin from environmental aggressors like UV light, pathogens, and pollutants. These dead skin cells are “glued” together by fats that keep water inside the skin and prevent dehydration. [2]
02

The Impacts of Epidermal Thickness Around the Eyes

The skin around your eyes has a stratum corneum that is on average about 3 layers thick compared to 15+ layers on other areas.¹ When the stratum corneum is weaker, it experiences higher rates of transepidermal water loss and is more vulnerable to environmental aggressors that degrade skin firmness and resilience.[1] This may be the the reason that the skin under your eyes experiences more exaggerated signs of collagen and elastin loss–namely fine lines, sagging, and crepiness. [3,4]
02

The Impacts of Epidermal Thickness Around the Eyes

The skin around your eyes has a stratum corneum that is on average about 3 layers thick compared to 15+ layers on other areas.¹ When the stratum corneum is weaker, it experiences higher rates of transepidermal water loss and is more vulnerable to environmental aggressors that degrade skin firmness and resilience.[1] This may be the the reason that the skin under your eyes experiences more exaggerated signs of collagen and elastin loss–namely fine lines, sagging, and crepiness. [3,4]
03

How to Support Epidermal Thickness Around the Eyes

So how can you help support epidermal thickness in the super thin skin around your eyes? The answer is OS-01, our breakthrough peptide that’s been scientifically proven to increase epidermal thickness. [5,6]In a study, our scientists measured the epidermal thickness of ex vivo human skin samples from 35-year-old, 55-year-old, and 79-year-old donors before and after treatment with the OS-01 peptide. The results were astounding, with the epidermal thickness increasing by 16% in the 35-year-old skin samples, 28% in the 55-year-old skin samples, and 11% in the 79-year-old skin samples after exposure to the OS-01 peptide. These improvements included noticeable changes in the stratum corneum–the outermost dark purple layer in these histological images. [5,6]
03

How to Support Epidermal Thickness Around the Eyes

So how can you help support epidermal thickness in the super thin skin around your eyes? The answer is OS-01, our breakthrough peptide that’s been scientifically proven to increase epidermal thickness. [5,6]In a study, our scientists measured the epidermal thickness of ex vivo human skin samples from 35-year-old, 55-year-old, and 79-year-old donors before and after treatment with the OS-01 peptide. The results were astounding, with the epidermal thickness increasing by 16% in the 35-year-old skin samples, 28% in the 55-year-old skin samples, and 11% in the 79-year-old skin samples after exposure to the OS-01 peptide. These improvements included noticeable changes in the stratum corneum–the outermost dark purple layer in these histological images. [5,6]
Histology images of ex vivo human skin samples from 35, 55, and 79 year old donors exposed to the OS-01 peptide (12.5uM) (Zonari, et al, npj Aging, 2023).
Histology images of ex vivo human skin samples from 35, 55, and 79 year old donors exposed to the OS-01 peptide (12.5uM) (Zonari, et al, npj Aging, 2023).
Epidermal thickness analysis of ex vivo human skin samples (35, 55 and 79yr) after 5 days of treatment with 12.5uM OS-01 peptide revealed a significant increase upon treatment (Zonari, et al, npj Aging, 2023).
Epidermal thickness analysis of ex vivo human skin samples (35, 55 and 79yr) after 5 days of treatment with 12.5uM OS-01 peptide revealed a significant increase upon treatment (Zonari, et al, npj Aging, 2023).
04

Boost Collagen & Firmness Around the Eyes with OS-01 EYE

Formulated with the highest concentration of our OS-01 peptide, our new OS-01 EYE was specifically designed to address the thin skin around the eyes. In studies, OS-01 EYE has been shown to support the production and retention of collagen around the eyes [5]–counteracting one of the main effects of a weaker stratum corneum.Our scientists exposed ex vivo human eyelid skin samples to either nothing (No Treatment) or OS-01 EYE, then performed an expression analysis to evaluate the effect of OS-01 EYE on markers associated with collagen production, COL1A1, and degradation, MMP1. Samples exposed to OS-01 EYE showed increased COL1A1 and decreased MMP1. [5] This means that OS-01 EYE supports skin’s firmness around the eyes by both promoting collagen synthesis and preventing its degradation.In a 12-week clinical study, OS-01 EYE's firming effects was confirmed. OS-01 EYE is also clinically validated to boost barrier function, hydration, elasticity, tone and texture, and radiance. [5]
04

Boost Collagen & Firmness Around the Eyes with OS-01 EYE

Formulated with the highest concentration of our OS-01 peptide, our new OS-01 EYE was specifically designed to address the thin skin around the eyes. In studies, OS-01 EYE has been shown to support the production and retention of collagen around the eyes [5]–counteracting one of the main effects of a weaker stratum corneum.Our scientists exposed ex vivo human eyelid skin samples to either nothing (No Treatment) or OS-01 EYE, then performed an expression analysis to evaluate the effect of OS-01 EYE on markers associated with collagen production, COL1A1, and degradation, MMP1. Samples exposed to OS-01 EYE showed increased COL1A1 and decreased MMP1. [5] This means that OS-01 EYE supports skin’s firmness around the eyes by both promoting collagen synthesis and preventing its degradation.In a 12-week clinical study, OS-01 EYE's firming effects was confirmed. OS-01 EYE is also clinically validated to boost barrier function, hydration, elasticity, tone and texture, and radiance. [5]
The results are the average of testing in 3 different ex vivo eyelid skin samples grown from 42y, 59y, and 84y donors.
The results are the average of testing in 3 different ex vivo eyelid skin samples grown from 42y, 59y, and 84y donors.
Key Takeaways:
  • The delicate skin around the eyes has a stratum corneum that is up to 5x thinner than other areas of the face and body.
  • The stratum corneum is a layer of the epidermis keeps water inside the skin, preventing dehydration.
  • A weaker stratum corneum leaves the skin more vulnerable to environmental aggressors which may be a reason that the skin under your eyes experiences more exaggerated signs of collagen and elastin loss.
  • The OS-01 peptide has been proven to improve epidermal thickness in ex vivo human skin samples. [5,6]
  • Our new OS-01 EYE Topical Supplement contains the highest concentration of the OS-01 peptide and has been shown to promote collagen biosynthesis and retention at the molecular level in lab studies on ex vivo eyelid skin. [5]
Key Takeaways:
  • The delicate skin around the eyes has a stratum corneum that is up to 5x thinner than other areas of the face and body.
  • The stratum corneum is a layer of the epidermis keeps water inside the skin, preventing dehydration.
  • A weaker stratum corneum leaves the skin more vulnerable to environmental aggressors which may be a reason that the skin under your eyes experiences more exaggerated signs of collagen and elastin loss.
  • The OS-01 peptide has been proven to improve epidermal thickness in ex vivo human skin samples. [5,6]
  • Our new OS-01 EYE Topical Supplement contains the highest concentration of the OS-01 peptide and has been shown to promote collagen biosynthesis and retention at the molecular level in lab studies on ex vivo eyelid skin. [5]

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin

Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.

Discover More

Navigating Skin Longevity: The Industry, The Scien...
What’s the Difference Between Dry and Dehydrated S...
How to Keep Your Hair Healthy and Strong During Pe...
Zombie Cells
What are Zombie Cells & How Can We Remove Them?
Collagen For Menopause: Why Is It Necessary For Healthy Skin Aging?
Collagen During Menopause: Is It Necessary For Hea...
Behind the Seal: How OneSkin Achieved the National...
Sun Sensitivity And Menopause: Protecting Your Cha...
Peptides Vs Growth Factors: Which is Better For Sk...
Hyperpigmentation and Menopause: Understanding and...
Skin Care is Health Care: Why Skin Care is the Key...
Full OneSkin Regimen
How Do Our Products Work Together?
Older man smiling
The Connection Between Mental Health, Age Percepti...
OneSkin launches MolClock, the first skin-specific molecular clock to determine the biological age of human skin - One Skin Technologies
MolClock: Using Epigenetics to Measure The Biologi...
How OS-01 BODY Pauses Biological Aging For Overall...
Woman holding stomach
Biohacking Healthy Aging: The Organs of Longevity
Does Niacinamide Help With Acne & Scarring?
5 Reasons Why Zinc Oxide Is Our Preferred UV Filte...
6 Common In-Office Skin Treatments to Complement y...
What is Microneedling & Are There Alternatives?
How to Protect Against and Reverse Collagen Loss
Why Your Neck, Décolletage, and Hands Need Extra C...
What's the Connection Between Dehydration and Dry ...
How to Tighten Facial Skin Without Surgery
Exploring Alternatives to Botox
Best Practices for Moisturizing After Exfoliating
Recognizing Signs of Over-Exfoliated Skin
Healing Over-Exfoliated Skin: How to Treat Over-Ex...
OS-01 BODY SPF and OS-01 BODY: Even Better Togethe...
Introducing OS-01 BODY SPF: Triple power protectio...
Is Talc Bad for Skin? 7 Things You Need to Know
How Do We Know the OS-01 Peptide is Safe?
What Is Lanolin and Is It Bad for Your Skin?
Non-Comedogenic vs Comedogenic Skin Care Products
Mineral Oil: Facts, Myths, and Effects on Skin
The Problem with Paraffin for Skin
Petrolatum: Is it Safe or Harmful for Your Skin?
How Much Sunscreen to Apply
What Do Antioxidants Do For Skin and Why Should Yo...
Making Sense of SPFs: What’s the Difference Betwee...
How to Relieve Itchy Skin: Tips for Soothing Skin ...
What is The Difference Between UVA and UVB Rays?
Decoding the Connections Between Intrinsic & Extri...
Causes of Skin Itching
Causes of Skin Itching: Understanding the Reasons ...
How to Protect Your Skin from UVA and UVB Rays
Morning vs. Night Exfoliation: Determining the Bes...
How to Tell if Acne is Hormonal or Bacterial?
How to Know if Your Skin Barrier is Damaged
Tips for Managing Hormonal Breakouts
Understanding Hormonal Acne and Its Triggers
How to Repair & Restore Your Skin Barrier
How To Get Rid of Crepey Skin: 7 Solutions
When to Apply Sunscreen: Before or After Moisturiz...
How Alcohol Impacts Your Skin’s Health
The Effects of Alcohol on Your Skin's Aging Proces...
OS-01 FACE: Clinically Validated to Support Your S...
Can Alcohol Cause Breakouts?
The Proof is in the Peptide: 12-Week Clinical Stud...
Why Is My Neck Aging So Fast?
6 Factors That Contribute to Slow Skin Healing
6 Tips and Tricks for a Youthful Neck
Woman applying sunscreen
Addressing the Need for Indoor Sun Protection
Sunburned skin
The Science of Sunburns: How to Treat and Prevent ...
Get to Know OneSkin’s Topical Supplements:
OS-01 F...
Pollution
Can Air Quality Affect Skin? Exploring the Impact ...
Close up of eye
Understanding the Relationship Between Sleep and U...
Woman not sleeping in bed
Exploring the Effects of Quality Sleep on Your Ski...
Gut microbiom illustration
How to Improve Gut Microbiome
Woman holding bowl of food
Exploring Caloric Restriction and Its Effects on A...
woman stretching in bed
What’s the Connection Between Quality Sleep and Lo...
Healthy foods
Unlocking the Skin Benefits of Intermittent Fastin...
woman exercising
Why Exercise is a Game-Changer for Longevity
The Microbiome Diet and Its Effects on Skin
The Microbiome Diet and Its Effects on Skin
cold water
Cold Exposure: Hype or Longevity Boosting?
healthy foods
Eat Better, Live Longer: Top Foods for Longevity
How Environmental Stressors Affect Skin
How to Protect Your Skin from Everyday Environment...
How Does Sunscreen Work? How Long Does it Last?
How Does Sunscreen Work? How Long Does it Last?
OS-01 BODY
Pressing the Pause Button on Aging Skin: OS-01 BOD...
How to Brighten Eyes and Under-Eyes
lip treatment
Lip Balm Ingredients: What to Look for and What to...
earth
Exploring Blue Zones: How Can We Optimize Our Heal...
Lips
Nurturing Your Lips: How to Keep Them Moisturized ...
Lips
Uncovering the 9 Causes of Dry Lips: Why Do Lips G...
How to Travel with Skin Care
How to Travel with Skin Care Products
Why is my Skin Peeling on My Face?
SHIELD on arm
The Importance of Sunscreen: Why Should You Wear I...